Serpil Erzurum, M.D.
Chairman

Serpil C. Erzurum, M.D.
Chair, Department of Pathobiology
Joint Staff with Respiratory Institute
The Alfred Lerner Memorial Chair in Innovative Biomedical Research

  • Department of Pathobiology
  • Lerner Research Institute (NC22)
  • The Cleveland Clinic Foundation
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • Tel.: (216) 445-7191
  • Fax: (216) 636-0104
  • Email: erzurus@ccf.org
  • Fellowship - National Heart, Lung and Blood Institute
    Senior Staff Fellow, Pulmonary
    Bethesda, MD
    1992
  • Fellowship - University of Colorado Health Sciences Center
    Pulmonary/Critical Care
    Denver, CO
    1990
  • Residency - Baylor College of Medicine
    Internal Medicine
    Houston, TX
    1986
  • Medical School - Northeastern Ohio Universities College of Medicine
    Rootstown, OH
    1983
  • Internal Medicine
  • Internal Medicine- Pulmonary Disease
  • Internal Medicine- Critical Care Medicine
  • Asthma
  • Exhaled markers in lung disease
  • Lung biology and physiology
  • Pulmonary hypertension
  • Nitric oxide (NO) in lung physiology and disease

PubMed Publications


  • Bronchial thermoplasty: Long-term safety and effectiveness in patients with severe persistent asthma.
    Wechsler ME, Laviolette M, Rubin AS, Fiterman J, Lapa e Silva JR, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Hales JB, McEvoy C, Slebos DJ, Holmes M, Phillips MJ, Erzurum SC, Hanania NA, Sumino K, Kraft M, Cox G, Sterman DH, Hogarth K, Kline JN, Mansur AH, Louie BE, Leeds WM, Barbers RG, Austin JH, Shargill NS, Quiring J, Armstrong B, Castro M, Asthma Intervention Research 2 Trial Study Group
    PubMed:23998657 :: 2013
  • Asthma outcomes: biomarkers.
    Szefler SJ, Wenzel S, Brown R, Erzurum SC, Fahy JV, Hamilton RG, Hunt JF, Kita H, Liu AH, Panettieri RA, Schleimer RP, Minnicozzi M
    PubMed:22386512 :: 2010
  • Safety of investigative bronchoscopy in the Severe Asthma Research Program.
    Moore WC, Evans MD, Bleecker ER, Busse WW, Calhoun WJ, Castro M, Chung KF, Erzurum SC, Curran-Everett D, Dweik RA, Gaston B, Hew M, Israel E, Mayse ML, Pascual RM, Peters SP, Silveira L, Wenzel SE, Jarjour NN, National Heart, Lung, and Blood Institute's Severe Asthma Research Group
    PubMed:21496892 :: 2011
  • Determinants of exhaled breath condensate pH in a large population with asthma.
    Liu L, Teague WG, Erzurum S, Fitzpatrick A, Mantri S, Dweik RA, Bleecker ER, Meyers D, Busse WW, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Israel E, Jarjour WN, Moore W, Peters SP, Wenzel S, Hunt JF, Gaston B, National Heart, Lung, and Blood Institute Severe Asthma Research Program (SARP)
    PubMed:20966042 :: 2011
  • Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report.
    Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn GW, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Humbert M, Kaminski N, Kawut SM, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R, Yoder MC, Zhao Y, Gail D, Moore TM
    PubMed:20833821 :: 2010

Moore WC, Meyers DA, Wenzel SE, Teague WG, Li H, Li X, D'Agostino R Jr, Castro M, Curran-Everett D, Fitzpatrick AM, Gaston B, Jarjour NN, Sorkness R, Calhoun WJ, Chung KF, Comhair SA, Dweik RA, Israel E, Peters SP, Busse WW, Erzurum SC, Bleecker ER; National Heart, Lung, and Blood Institute's Severe Asthma Research Program.
Identification of asthma phenotypes using cluster analysis in the severe asthma research program.
Am J Respir Crit Care Med. 2010 Feb 15;181(4):315-23.

Dweik RA, Sorkness RL, Wenzel S, Hammel J, Curran-Everett D, Comhair SA, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Israel E, Jarjour N, Moore W, Peters S, Teague G, Gaston B, Erzurum SC.
Use of Exhaled Nitric Oxide Measurement to Identify a Reactive, At-risk Phenotype Among Patients With Asthma.
Am J Respir Crit Care Med. 2010 Feb 4.

Beall CM, Strohl KP, Laskowski D, Hutte R, Erzurum SC.
"Lower exhaled nitric oxide in acute hypobaric than in normobaric hypoxia" by T. Hemmingsson and D. Linnarsson.
[Respir. Physiol. Neurobiol. 169 (2009) 74-77]. Respir Physiol Neurobiol. 2010 Feb 1.

Ebrahem Q, Chaurasia SS, Vasanji A, Qi JH, Klenotic PA, Cutler A, Asosingh K, Erzurum S, Anand-Apte B.
Cross-talk between vascular endothelial growth factor and matrix metalloproteinases in the induction of neovascularization in vivo.
Am J Pathol. 2010 Jan;176(1):496-503.

Laskowski D, Beall CM, Dweik R, Strohl KP, Hutte R, Erzurum SC.
Response to Hemmingsson, Horn and Linnarsson article "Measuring exhaled nitric oxide at high altitude" .
Resp. Physiol. Neurobiol. 167(3), 292-298. Respir Physiol Neurobiol. 2010 Jan 31;170(1):1-2; author reply 3-4.

Fijalkowska I, Xu W, Comhair SA, Janocha AJ, Mavrakis LA, Krishnamachary B, Zhen L, Mao T, Richter A, Erzurum SC, Tuder RM.
Hypoxia Inducible-Factor1{alpha} Regulates the Metabolic Shift of Pulmonary Hypertensive Endothelial Cells.
Am J Pathol. 2010 Jan 28.

Puwanant S, Park M, Popovic ZB, Tang WH, Farha S, George D, Sharp J, Puntawangkoon J, Loyd JE, Erzurum SC, Thomas JD.
Ventricular geometry, strain, and rotational mechanics in pulmonary hypertension. Circulation.
2010 Jan 19;121(2):259-66.

Castro M, Rubin AS, Laviolette M, Fiterman J, De Andrade Lima M, Shah PL, Fiss E, Olivenstein R, Thomson NC, Niven RM, Pavord ID, Simoff M, Duhamel DR, McEvoy C, Barbers R, Ten Hacken NH, Wechsler ME, Holmes M, Phillips MJ, Erzurum S, Lunn W, Israel E, Jarjour N, Kraft M, Shargill NS, Quiring J, Berry SM, Cox G; AIR2 Trial Study Group. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial.
Am J Respir Crit Care Med. 2010 Jan 15;181(2):116-24.

Comhair SA, Erzurum SC.
Redox control of asthma: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal.
2010 Jan;12(1):93-124.

Khatri SB, Holguin FC, Ryan PB, Mannino D, Erzurum SC, Teague WG.
Association of ambient ozone exposure with airway inflammation and allergy in adults with asthma. J Asthma.
2009 Oct;46(8):777-85.

Asosingh K, Erzurum SC.
Angioplasticity in asthma. Biochem Soc Trans.
2009 Aug;37(Pt 4):805-10. Review.

Farha S, Asosingh K, Laskowski D, Hammel J, Dweik RA, Wiedemann HP, Erzurum SC. Effects of the Menstrual Cycle on Lung Function Variables in Women with Asthma. Am J Respir Crit Care Med. 2009 Aug 15; 180(4):304-10.

Asosingh K, Erzurum SC, Yoder MC, Tuder RM. Letter by asosingh et Al regarding article, "circulating endothelial progenitor cells in patients with eisenmenger syndrome and idiopathic pulmonary arterial hypertension". Circulation. 2009, 119(9):e230

Chambellan A, Leahy R, Xu W, Cruickshank PJ, Janocha A, Szabo K, Cannady SB, Comhair SA, Erzurum SC. Pivotal role of c-Fos in nitric oxide synthase 2 expression in airway epithelial cells. Nitric Oxide. 2009 May;20(3):143-9.

Lauer ME, Fulop C, Mukhopadhyay D, Comhair S, Erzurum SC, Hascall VC. Airway smooth muscle cells synthesize hyaluronan cable structures independent of inter-alpha-inhibitor heavy chain attachment. J Biol Chem. 2009 Feb 20;284(8):5313-23.

Aytekin M, Comhair SA, de la Motte C, Bandyopadhyay SK, Farver CF, Hascall VC, Erzurum SC, Dweik RA. High levels of hyaluronan in idiopathic pulmonary arterial hypertension. Am J Physiol Lung Cell Mol Physiol. 2008 Nov;295(5):L789-99.

Lauer ME, Erzurum SC, Mukhopadhyay D, Vasanji A, Drazba J, Wang A, Fulop C, Hascall VC. Differentiated murine airway epithelial cells synthesize a leukocyte-adhesive hyaluronan matrix in response to endoplasmic reticulum stress. J Biol Chem. 2008 Sep 19;283(38):26283-96.

Lara A, Khatri SB, Wang Z, Comhair SA, Xu W, Dweik RA, Bodine M, Levison BS, Hammel J, Bleecker E, Busse W, Calhoun WJ, Castro M, Chung KF, Curran-Everett D, Gaston B, Israel E, Jarjour N, Moore W, Peters SP, Teague WG, Wenzel S, Hazen SL, Erzurum SC. National Heart, Lung, and Blood Institute's Severe Asthma Research Program. Alterations of the arginine metabolome in asthma. Am J Respir Crit Care Med. 2008 Oct 1;178(7):673-81.

Asosingh K, Aldred MA, Vasanji A, Drazba J, Sharp J, Farver C, Comhair SAA, Xu W, Licina L, Tuder RM, Erzurum SC. Increased Numbers of Circulating Proliferative CD34+CD133+ Multipotential Progenitor Cells in Idiopathic Pulmonary Arterial Hypertension. AM J PATH 2008 Mar;172(3):615-27.

Erzurum SC, Ghosh S, Janocha AJ, Xu W, Bauer S, Bryan NS, Tejero J, Hemann C, Hille R, Stuehr DJ, Feelisch M. Beall CM. Higher blood flow and circulating NO products offset high-altitude hypoxia among Tibetans. PROC NATL ACAD SCI USA 2007 Nov 6;104(45):17593-8.

Cannady SB, Batra PS, Leahy R, Citardi MJ, Janocha A, Ricci K, Comhair SAA, Wang Z, Hazen SL, Erzurum SC. Signal transduction and oxidative processes in sinonasal polyposis. J ALLERGY CLIN IMMUNOL 2007 Dec;120(6):1346-53.

Farha S, Asosingh K, Laskowski D, Licina L, Sekigushi H, Losordo DW, Dweik RA Wiedemann HP, Erzurum SC. Pulmonary Gas Transfer and Angiogenesis during the Menstrual Cycle. J APPL PHYSIOL 2007 Nov;103(5):1789-95.

Masri FA, Xu W, Comhair SAA, Asosingh K, Koo M, Vasanji A, Drazba J, Anand-Apte B, Erzurum SC. Proliferative Phenotype of Idiopathic Pulmonary Artery Hypertension Endothelial Cells. AM J PHYSIOL Lung Cell Mol Physiol 2007 Sep;293(3):L548-54.

Asosingh K, Swaidani S, Aronica M, Erzurum SC. Th1- and Th2-dependent endothelial progenitor cell recruitment and angiogenic switch in asthma. J Immunol. 2007; 178(10):6482-94.

Yared JP, Bakri MH, Erzurum SC, Moravec CS, Laskowski DM, Van Wagoner DR, Mascha E, Thornton J. Effect of dexamethasone on atrial fibrillation after cardiac surgery: prospective, randomized, double-blind, placebo-controlled trial. J Cardiothorac Vasc Anesth. 2007; Feb;21(1):68-75.

Xu W, Koeck T, Lara AR, Neumann D, DiFilippo FP, Koo M, Janocha AJ, Masri FA, Arroliga AC, Jennings C, Dweik RA, Tuder RM, Stuehr DJ, Erzurum SC. Alterations of cellular bioenergetics in pulmonary artery endothelial cells. Proc Natl Acad Sci U S A. 2007; Jan 23;104(4):1342-7.

Nethery DE, Ghosh S, Erzurum SC, Kern JA. Inactivation of neuregulin-1 by nitration. Am J Physiol Lung Cell Mol Physiol. 2007; Jan;292(1):L287-93.

Xu W, Zheng S, Goggans TM, Kiser P, Quinones-Mateu ME, Janocha AJ, Comhair SA, Slee R, Williams BR, Erzurum SC. Cystic fibrosis and normal human airway epithelial cell response to influenza a viral infection. J Interferon Cytokine Res. 2006; Sep;26(9):609-27.

Xu W, Zheng S, Dweik RA, Erzurum SC. Role of epithelial nitric oxide in airway viral infection. Free Radic Biol Med. 2006; Jul 1;41(1):19-28.

Erzurum, SC. Inhibition of Tumor Necrosis Factor for Refractory Asthma. N Engl J Med 2006;354:754-757.

Peikert T, Specks U, Farver C, Erzurum SC, Comhair SAA. Melanoma Antigen A4 is Expressed in Non-Small Cell Lung Cancers and Promotes Apoptosis. CANCER RES 2006 May 1;66(9):4693-700.

Ghosh S, Janocha AJ, Aronica MA, Swaidani S, Comhair SAA, Xu W, Zheng L, Kinter MT, Hazen SL, Erzurum SC. Nitrotyrosine Proteome Survey In Experimental Asthma Identifies Oxidative Modifications and Catalase Inactivation J IMMUNOL 2006 May 1;176(9):5587-97.

Lara A, Erzurum SC. A Urinary Test for Pulmonary Hypertension? Am J Resp Crit Care Med 2005;172:262-263.

Comhair SAA, Ricci KS, Arroliga M, Lara AR, Dweik RA, Song W, Hazen SL, Bleecker ER, Busse WW, Chung KF, Gaston B, Hastie A, Hew M, Jarjour N, Moore W, Peters S, Teague WG, Wenzel SE and Erzurum SC for the NHLBI Severe Asthma Research Program. Correlation of systemic superoxide dismutase deficiency to airflow obstruction in asthma. AM J RESP CRIT CARE MED 2005;172:306-13.

Machado RF, Laskowski D, Mazzone PJ, Zheng S, Deffendorfer O, Burch T, Mekhail T, Stoller JK, Dweik RA, Erzurum SC. Detection of lung cancer by sensor array analyses of exhaled breath. AM J RESP CRIT CARE MED 2005 Jun 1;171(11):1286-91.

American Thoracic Society and European Respiratory Society: Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide. Am J Respir Crit Care Med 2005 171: 912-930.

Comhair SAA, Xu W, Arroliga M, Khatri SB, Thunnissen FBJM, Almasan A, Calhoun WJ, Janocha AJ , Song W, Hazen SL, Erzurum SC. Superoxide Dismutase Inactivation in pathophysiology of asthmatic airway remodeling and reactivity AM J PATH 2005;166:663-674.

Zheng, S, De BP, Choudhary S, Comhair SAA, Pilewski J, Haque SJ, Erzurum, SC. Impaired Innate Host Defense causes susceptibility to respiratory virus infections in cystic fibrosis. Immunity 2003; 18: 619-630.

Beall C, Laskowski D, Strohl KP, Soria R, Villena M, Vargas E, Alarcon AM, Gonzales C, Erzurum SC. Pulmonary nitric oxide in mountain dwellers: populations living at high altitudes have an adaptive mechanism to offset hypoxia. Nature 2001;414:411-412.

Dweik RA, Comhair SAA, Gaston B, Thunnissen FBJM, Farver C, Thomassen MJ, Kavuru M, Hammel J, Abu-Soud HM, Erzurum SC. Nitric Oxide Chemical Events in the Human Airway During the Immediate and Late Antigen Induced Asthmatic Response. Proc Natl Acad Sci USA 2001;98:2622-2627.

Comhair SAA, Bhathena PR, Farver C, Thunnissen FBJM, Erzurum SC. Extracellular Glutathione Peroxidase Induction in Asthmatic Lungs: Evidence for Redox Regulation of Expression in Human Airway Epithelial Cells. Faseb J 2001;15:70-78.

Guo FH, Comhair SAA, Zheng S, Dweik RA, Eissa NT, Thomassen MJ, Calhoun W, Erzurum SC. Molecular Mechanisms of Increased Nitric Oxide (NO) in Asthma: Evidence for Transcriptional and Post-translational Regulation of NO Synthesis. J Immunol 2000;164:5970-5980.

Comhair SAA, Bhathena PR, Dweik RA, Kavuru MS, Erzurum SC. Rapid Loss of Superoxide Dismutase Activity during Antigen-Induced Asthmatic Response. Lancet 2000;355:624.

Dweik RA, Laskowski D, Abu-Soud HM, Kaneko FT, Hutte R, Stuehr DJ, Erzurum SC. Nitric oxide synthesis in the lung: regulation by oxygen through a kinetic mechanism. J Clin Invest 1998;101:660-666.

Guo FH, Uetani K, Haque J, Williams BRG, Dweik RA, Thunnisen F, Calhoun W, Erzurum SC. Interferon g and Interleukin-4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators. J Clin Invest 1997;100:829-838.

Guo FH, DeRaeve H, Rice TW, Stuehr D, Thunnissen FBJM, Erzurum SC Continuous NO synthesis by inducible nitric oxide synthase in normal human airways in vivo. Proc Natl Acad Sci 1995; 92:7809-7813.