• Amino acid position 11 of HLA-DRβ1 is a major determinant of chromosome 6p association with ulcerative colitis.
  Achkar JP, Klei L, Bakker PI, Bellone G, Rebert N, Scott R, Lu Y, Regueiro M, Brzezinski A, Kamboh MI, Fiocchi C, Devlin B, Trucco M, Ringquist S, Roeder K, Duerr RH
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• Ulcerative colitis.
  Danese S, Fiocchi C
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• Inflammation-induced endothelial-to-mesenchymal transition: a novel mechanism of intestinal fibrosis.
  Rieder F, Kessler SP, West GA, Bhilocha S, de la Motte C, Sadler TM, Gopalan B, Stylianou E, Fiocchi C
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• Early and late inflammatory bowel disease: why and how are they different?
  Fiocchi C
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• Themes in fibrosis and gastrointestinal inflammation.
  Fiocchi C, Lund PK
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• Probiotic sonicates selectively induce mucosal immune cells apoptosis through ceramide generation via neutral sphingomyelinase.
  Angulo S, Morales A, Danese S, Llacuna L, Masamunt MC, Pultz N, Cifone MG, De Simone C, Delgado S, Vila J, Panés J, Donskey C, Fernández-Checa JC, Fiocchi C, Sans M
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• Targeting the innate immune system in pediatric inflammatory bowel disease.
  Schirbel A, Fiocchi C
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• News from the "5th International Meeting on Inflammatory Bowel Diseases" CAPRI 2010.
  Latella G, Fiocchi C, Caprili R
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• Pathogenesis of postoperative recurrence in Crohn's disease.
  Ahmed T, Rieder F, Fiocchi C, Achkar JP
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• First international summit on fibrosis in intestinal inflammation: mechanisms and biological therapies.
  Rieder F, Fiocchi C
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• Inflammatory bowel disease: Established and evolving considerations on its etiopathogenesis and therapy.
  Schirbel A, Fiocchi C
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• HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes.
  Ma J, Altomare A, de la Monte S, Tong M, Rieder F, Fiocchi C, Behar J, Shindou H, Biancani P, Harnett KM
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• Current perspectives in inflammatory bowel disease: stress response and autophagy, host-microbe mutualism, immune duality and plasticity, and early versus late disease.
  Fiocchi C
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• The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8.
  Im E, Choi YJ, Kim CH, Fiocchi C, Pothoulakis C, Rhee SH
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• Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritis.
  Pastorelli L, Garg RR, Hoang SB, Spina L, Mattioli B, Scarpa M, Fiocchi C, Vecchi M, Pizarro TT
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• Corticotropin-releasing hormone family of peptides regulates intestinal angiogenesis.
  Im E, Rhee SH, Park YS, Fiocchi C, Taché Y, Pothoulakis C
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• Susceptibility genes and overall pathogenesis of inflammatory bowel disease: where do we stand?
  Fiocchi C
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• Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines.
  de la Motte C, Nigro J, Vasanji A, Rho H, Kessler S, Bandyopadhyay S, Danese S, Fiocchi C, Stern R
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• Gene-gene interactions in inflammatory bowel disease: biological and clinical implications.
  Achkar JP, Fiocchi C
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• Intestinal fibrosis in IBD--a dynamic, multifactorial process.
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• Intestinal fibrosis in inflammatory bowel disease - Current knowledge and future perspectives.
  Rieder F, Fiocchi C
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• VEGF-A links angiogenesis and inflammation in inflammatory bowel disease pathogenesis.
  Scaldaferri F, Vetrano S, Sans M, Arena V, Straface G, Stigliano E, Repici A, Sturm A, Malesci A, Panes J, Yla-Herttuala S, Fiocchi C, Danese S
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• What is "physiological" intestinal inflammation and how does it differ from "pathological" inflammation?
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• Future of IBD pathogenesis: how much work is left to do?
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• Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science.
  Rieder F, Fiocchi C
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• Mucosal T cell proliferation and apoptosis in inflammatory bowel disease.
  Sturm A, de Souza HS, Fiocchi C
  PubMed:18473766 :: 2008

• Hyaluronan (HA) deposition precedes and promotes leukocyte recruitment in intestinal inflammation.
  Kessler S, Rho H, West G, Fiocchi C, Drazba J, de la Motte C
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• Isolation of human intestinal mucosal mononuclear cells.
  Fiocchi C, Youngman KR
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• Inflammatory bowel disease: progress and current concepts of etiopathogenesis.
  Scaldaferri F, Fiocchi C
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• Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease.
  Kugathasan S, Saubermann LJ, Smith L, Kou D, Itoh J, Binion DG, Levine AD, Blumberg RS, Fiocchi C
  PubMed:17682002 :: 2007

• Progress in basic inflammatory bowel disease research.
  Kugathasan S, Fiocchi C
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• Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation.
  Danese S, Dejana E, Fiocchi C
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• Critical role of the CD40 CD40-ligand pathway in regulating mucosal inflammation-driven angiogenesis in inflammatory bowel disease.
  Danese S, Scaldaferri F, Vetrano S, Stefanelli T, Graziani C, Repici A, Ricci R, Straface G, Sgambato A, Malesci A, Fiocchi C, Rutella S
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• Late-breaking news from the "4th International Meeting on Inflammatory Bowel Diseases" Capri, 2006.
  Latella G, Fiocchi C, Caprilli R
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• Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities.
  Rieder F, Cheng L, Harnett KM, Chak A, Cooper GS, Isenberg G, Ray M, Katz JA, Catanzaro A, O'Shea R, Post AB, Wong R, Sivak MV, McCormick T, Phillips M, West GA, Willis JE, Biancani P, Fiocchi C
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• Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease.
  Sans M, Danese S, de la Motte C, de Souza HS, Rivera-Reyes BM, West GA, Phillips M, Katz JA, Fiocchi C
  PubMed:17241867 :: 2007

• Eosinophilic esophagitis: new insights into an emerging disease.
  Nonevski I, Fiocchi C, Falk GW
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• Probiotics in inflammatory bowel disease: yet another mechanism of action?
  Fiocchi C
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• Angiogenesis blockade as a new therapeutic approach to experimental colitis.
  Danese S, Sans M, Spencer DM, Beck I, Doñate F, Plunkett ML, de la Motte C, Redline R, Shaw DE, Levine AD, Mazar AP, Fiocchi C
  PubMed:17170016 :: 2007

• Management consensus of inflammatory bowel disease for the Asia-Pacific region.
  Ouyang Q, Tandon R, Goh KL, Pan GZ, Fock KM, Fiocchi C, Lam SK, Xiao SD
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• Inflammatory bowel disease: genetics and much more.
  Fiocchi C
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• Immunology of inflammatory bowel disease.
  Levine AD, Fiocchi C
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• Pathogenesis of inflammatory bowel disease.
  Katz JA, Itoh J, Fiocchi C
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• Challenges in pediatric inflammatory bowel disease.
  Bousvaros A, Sylvester F, Kugathasan S, Szigethy E, Fiocchi C, Colletti R, Otley A, Amre D, Ferry G, Czinn SJ, Splawski JB, Oliva-Hemker M, Hyams JS, Faubion WA, Kirschner BS, Dubinsky MC,
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• Etiopathogenesis of inflammatory bowel diseases.
  Danese S, Fiocchi C
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• Acid-induced release of platelet-activating factor by human esophageal mucosa induces inflammatory mediators in circular smooth muscle.
  Cheng L, Cao W, Behar J, Fiocchi C, Biancani P, Harnett KM
  PubMed:16807360 :: 2006

• Angiogenesis as a novel component of inflammatory bowel disease pathogenesis.
  Danese S, Sans M, de la Motte C, Graziani C, West G, Phillips MH, Pola R, Rutella S, Willis J, Gasbarrini A, Fiocchi C
  PubMed:16762629 :: 2006

• Non-stop progress in inflammatory bowel disease: new players, new understanding, new therapies.
  Fiocchi C
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• Alterations of mesenchymal and endothelial cells in inflammatory bowel diseases.
  Fiocchi C, Ina K, Danese S, Leite AZ, Vogel JD
  PubMed:16620018 :: 2006

• Inflammatory bowel disease. Current concepts of pathogenesis and implications for therapy.
  Fiocchi C
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• TNF-alpha blockade down-regulates the CD40/CD40L pathway in the mucosal microcirculation: a novel anti-inflammatory mechanism of infliximab in Crohn's disease.
  Danese S, Sans M, Scaldaferri F, Sgambato A, Rutella S, Cittadini A, Piqué JM, Panes J, Katz JA, Gasbarrini A, Fiocchi C
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• HCl-induced inflammatory mediators in cat esophageal mucosa and inflammatory mediators in esophageal circular muscle in an in vitro model of esophagitis.
  Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, Harnett KM
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• Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis.
  Cheng L, Harnett KM, Cao W, Liu F, Behar J, Fiocchi C, Biancani P
  PubMed:16285965 :: 2005

• One commensal bacterial molecule--all we need for health?
  Fiocchi C
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• Redox equilibrium in mucosal T cells tunes the intestinal TCR signaling threshold.
  Reyes BM, Danese S, Sans M, Fiocchi C, Levine AD
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• In vitro model of acute esophagitis in the cat.
  Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, Harnett KM
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• Intestinal fibroblast-derived IL-10 increases survival of mucosal T cells by inhibiting growth factor deprivation- and Fas-mediated apoptosis.
  Ina K, Kusugami K, Kawano Y, Nishiwaki T, Wen Z, Musso A, West GA, Ohta M, Goto H, Fiocchi C
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• Production of IL-1beta, hydrogen peroxide, and nitric oxide by colonic mucosa decreases sigmoid smooth muscle contractility in ulcerative colitis.
  Cao W, Fiocchi C, Pricolo VE
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• Platelet activation and the CD40/CD40 ligand pathway: mechanisms and implications for human disease.
  Danese S, Fiocchi C
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• The emergence of inflammatory bowel disease in the Asian Pacific region.
  Ouyang Q, Tandon R, Goh KL, Ooi CJ, Ogata H, Fiocchi C
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• Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis.
  Cheng L, Cao W, Fiocchi C, Behar J, Biancani P, Harnett KM
  PubMed:15890711 :: 2005

• An oral supplement enriched with fish oil, soluble fiber, and antioxidants for corticosteroid sparing in ulcerative colitis: a randomized, controlled trial.
  Seidner DL, Lashner BA, Brzezinski A, Banks PL, Goldblum J, Fiocchi C, Katz J, Lichtenstein GR, Anton PA, Kam LY, Garleb KA, Demichele SJ
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• Introduction: First International Symposium on: pediatric inflammatory bowel disease: September 16-18, 2003; Irvington, Virginia, U.S.A.
  Fiocchi C, Cucchiara S, Czinn SJ, Grand RJ, Levine AD, Seidman EG,
  PubMed:15805828 :: 2005

• Significance of glucocorticoid receptor expression in colonic mucosal cells of patients with ulcerative colitis.
  Zhang H, Ouyang Q, Wen ZH, Fiocchi C, Liu WP, Chen DY, Li FY
  PubMed:15793862 :: 2005

• Inflammatory bowel disease: new insights into mechanisms of inflammation and increasingly customized approaches to diagnosis and therapy.
  Fiocchi C
  PubMed:15703657 :: 2004

• More answers and more questions in inflammatory bowel disease.
  Fiocchi C
  PubMed:15703572 :: 2003

• Signal transducers and activators of transcription 3 signaling pathway: an essential mediator of inflammatory bowel disease and other forms of intestinal inflammation.
  Musso A, Dentelli P, Carlino A, Chiusa L, Repici A, Sturm A, Fiocchi C, Rizzetto M, Pegoraro L, Sategna-Guidetti C, Brizzi MF
  PubMed:15677901 :: 2005

• Inflammatory bowel disease pathogenesis: therapeutic implications.
  Fiocchi C
  PubMed:15667551 :: 2005

• Inflammatory bowel disease: autoimmune or immune-mediated pathogenesis?
  Wen Z, Fiocchi C
  PubMed:15559364 :: 2004

• Divergent cell cycle kinetics underlie the distinct functional capacity of mucosal T cells in Crohn's disease and ulcerative colitis.
  Sturm A, Leite AZ, Danese S, Krivacic KA, West GA, Mohr S, Jacobberger JW, Fiocchi C
  PubMed:15479683 :: 2004

• Dual function of the extracellular matrix: stimulatory for cell cycle progression of naive T cells and antiapoptotic for tissue-derived memory T cells.
  Sturm A, Krivacic KA, Fiocchi C, Levine AD
  PubMed:15356137 :: 2004

• Inflammatory bowel disease: the role of environmental factors.
  Danese S, Sans M, Fiocchi C
  PubMed:15288007 :: 2004

• Proinflammatory cytokines alter/reduce esophageal circular muscle contraction in experimental cat esophagitis.
  Cao W, Cheng L, Behar J, Fiocchi C, Biancani P, Harnett KM
  PubMed:15271650 :: 2004

• Interleukin 1beta-induced production of H2O2 contributes to reduced sigmoid colonic circular smooth muscle contractility in ulcerative colitis.
  Cao W, Vrees MD, Potenti FM, Harnett KM, Fiocchi C, Pricolo VE
  PubMed:15205451 :: 2004

• The CD40/CD40L costimulatory pathway in inflammatory bowel disease.
  Danese S, Sans M, Fiocchi C
  PubMed:15194658 :: 2004

• Platelets in inflammatory bowel disease: clinical, pathogenic, and therapeutic implications.
  Danese S, Motte Cd Cde L, Fiocchi C
  PubMed:15128364 :: 2004

• Paradoxical decrease of mitochondrial DNA deletions in epithelial cells of active ulcerative colitis patients.
  Fukushima K, Fiocchi C
  PubMed:15068964 :: 2004

• Closing fistulas in Crohn's disease--should the accent be on maintenance or safety?
  Fiocchi C
  PubMed:14985492 :: 2004

• Cutting edge: T cells trigger CD40-dependent platelet activation and granular RANTES release: a novel pathway for immune response amplification.
  Danese S, de la Motte C, Reyes BM, Sans M, Levine AD, Fiocchi C
  PubMed:14764664 :: 2011

• A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B.
  Lawrance IC, Wu F, Leite AZ, Willis J, West GA, Fiocchi C, Chakravarti S
  PubMed:14724828 :: 2003

• CD40-mediated immune-nonimmune cell interactions induce mucosal fibroblast chemokines leading to T-cell transmigration.
  Vogel JD, West GA, Danese S, De La Motte C, Phillips MH, Strong SA, Willis J, Fiocchi C
  PubMed:14699489 :: 2004

• Hydrogen peroxide contributes to motor dysfunction in ulcerative colitis.
  Cao W, Vrees MD, Kirber MT, Fiocchi C, Pricolo VE
  PubMed:14670823 :: 2004

• Inflammatory bowel disease-associated gene expression in intestinal epithelial cells by differential cDNA screening and mRNA display.
  Fukushima K, Yonezawa H, Fiocchi C
  PubMed:14555912 :: 2003

• Activated platelets are the source of elevated levels of soluble CD40 ligand in the circulation of inflammatory bowel disease patients.
  Danese S, Katz JA, Saibeni S, Papa A, Gasbarrini A, Vecchi M, Fiocchi C
  PubMed:12970136 :: 2003

• Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients.
  Danese S, de la Motte C, Sturm A, Vogel JD, West GA, Strong SA, Katz JA, Fiocchi C
  PubMed:12730866 :: 2003

• Atherosclerosis and inflammatory bowel disease: sharing a common pathogenic pathway?
  Danese S, Fiocchi C
  PubMed:12600930 :: 2003

• p53 negatively regulates intestinal immunity by delaying mucosal T cell cycling.
  Sturm A, Itoh J, Jacobberger JW, Fiocchi C
  PubMed:12045262 :: 2002

• Inflammatory bowel disease: dogmas and heresies.
  Fiocchi C
  PubMed:12038817 :: 2002

• Critical role of caspases in the regulation of apoptosis and proliferation of mucosal T cells.
  Sturm A, Mohr S, Fiocchi C
  PubMed:11984520 :: 2002

• Inflammatory bowel disease.
  Gurudu S, Fiocchi C, Katz JA
  PubMed:11977930 :: 2002

• Etiopathogenesis of inflammatory bowel disease: the importance of the pediatric perspective.
  Oliva-Hemker M, Fiocchi C
  PubMed:11854610 :: 2002

• Life and death in the gut: more killing, less Crohn's.
  Sturm A, Fiocchi C
  PubMed:11788550 :: 2002

• TGF-beta/Smad signaling defects in inflammatory bowel disease: mechanisms and possible novel therapies for chronic inflammation.
  Fiocchi C
  PubMed:11518725 :: 2001

• Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease.
  Itoh J, de La Motte C, Strong SA, Levine AD, Fiocchi C
  PubMed:11413108 :: 2001

• Pharmacokinetic evaluation of oral levofloxacin in human immunodeficiency virus-infected subjects receiving concomitant antiretroviral therapy.
  Villani P, Viale P, Signorini L, Cadeo B, Marchetti F, Villani A, Fiocchi C, Regazzi MB, Carosi G
  PubMed:11408245 :: 2001

• Regulation of life and death in lamina propria T cells.
  Levine AD, Fiocchi C
  PubMed:11394962 :: 2001

• Hierarchical cleavage of focal adhesion kinase by caspases alters signal transduction during apoptosis of intestinal epithelial cells.
  Grossmann J, Artinger M, Grasso AW, Kung HJ, Schölmerich J, Fiocchi C, Levine AD
  PubMed:11208716 :: 2001

• Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes.
  Lawrance IC, Fiocchi C, Chakravarti S
  PubMed:11181568 :: 2001

• Selective resistance of mucosal T-cell activation to immunosuppression in Crohn's disease.
  Matsuura T, West GA, Levine AD, Fiocchi C
  PubMed:11057923 :: 2000

• Clinical pharmacokinetics of nelfinavir combined with efavirenz and stavudine during rescue treatment of heavily pretreated HIV-infected patients.
  Regazzi MB, Villani P, Maserati R, Seminari E, Pan A, LoCaputo F, Gambarana E, Fiocchi C
  PubMed:10702554 :: 2000

Themes in fibrosis and gastrointestinal inflammation.
Claudio Fiocchi1 and P. Kay Lund2
AJP - GI May 2011 vol. 300 no. 5 G677-G683
http://ajpgi.physiology.org/cgi/content/full/ajpgi.00104.2011?ijkey=8U5YE72T8JM6Q&keytype=ref&siteid=physiology

Fiocchi C. Susceptibility genes and overall pathogenesis of inflammatory bowel disease: where do we stand? Dig Dis. 2009;27(3):226-35. Review.

Im E, Choi YJ, Kim CH, Fiocchi C, Pothoulakis C, Rhee SH. The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8. Am J Physiol Gastrointest Liver Physiol. 2009 Sep 3.

de la Motte C, Nigro J, Vasanji A, Rho H, Kessler S, Bandyopadhyay S, Danese S, Fiocchi C, Stern R. Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines. Am J Pathol. 2009 Jun;174(6):2254-64.

Achkar JP, Fiocchi C. Gene-Gene Interactions in Inflammatory Bowel Disease: Biological and Clinical Implications. Am J Gastroenterol. 2009 May 12.

de la Motte C, Nigro J, Vasanji A, Rho H, Kessler S, Bandyopadhyay S, Danese S, Fiocchi C, Stern R. Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines. Am J Pathol. 2009 Jun;174(6):2254-64.

Rieder F, Fiocchi C. Intestinal fibrosis in IBD--a dynamic, multifactorial process. Nat Rev Gastroenterol Hepatol. 6(4):228-35. 2009

Scaldaferri F, Vetrano S, Sans M, Arena V, Straface G, Stigliano E, Repici A, Sturm A, Malesci A, Panes J, Yla-Herttuala S, Fiocchi C, Silvio D. VEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis. Gastroenterology. 136(2):585-95.e5. 2009

Rieder F, Fiocchi C. Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science. Curr Opin Gastroenterol. 24(4):462-8, 2008.

Fiocchi C. Future of IBD pathogenesis: How much work is left to do? Inflamm Bowel Dis. 14(S2):S145-S147, 2008.

Fiocchi C. What is "physiological" intestinal inflammation and how does it differ from "pathological" inflammation? Inflamm Bowel Dis. 14(S2):S77-S78, 2008.

Sturm A, de Souza HS, Fiocchi C. Mucosal T cell proliferation and apoptosis in inflammatory bowel disease. Curr Drug Targets. 9(5):381-7. Review, 2008.

Scaldaferri F, Fiocchi C. Inflammatory bowel disease: progress and current concepts of etiopathogenesis. J Dig Dis. 8(4):171-8. Review, 2007.

Kugathasan S, Saubermann LJ, Smith L, Kou D, Itoh J, Binion DG, Levine AD, Blumberg RS, Fiocchi C. Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Gut. 56(12):1696-705, 2007.

Kugathasan S, Fiocchi C. Progress in basic inflammatory bowel disease research. Semin Pediatr Surg. 16(3):146-53. Review, 2007.

Rieder F, Cheng L, Harnett KM, Chak A, Cooper GS, Isenberg G, Ray M, Katz JA, Catanzaro A, O'Shea R, Post AB, Wong R, Sivak MV, McCormick T, Phillips M, West GA, Willis JE, Biancani P, Fiocchi C. Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Gastroenterology 132:154-165, 2007.

Sans M, Danese S, De La Motte C, de Souza HSP, Rivera-Reyes BM, West GA, Phillips M, Katz JA, Fiocchi C. Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease. Gastroenterology 132:139-153, 2007.

Danese S, et al. Critical role of the CD40 CD40-ligand pathway in regulating mucosal inflammation-driven angiogenesis in inflammatory bowel disease. Gut 2007;56:1248-56.

Danese S, et al. Angiogenesis blockade as a new therapeutic approach to experimental colitis. Gut 2007;56:855-62.

Danese S, Dejana E, Fiocchi C. Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation. J Immunol 2007;178:6017-22.

Fiocchi C. Probiotics in inflammatory bowel disease: yet another mechanism of action? Gastroenterology 131:2009-2012, 2006.

Danese S, Fiocchi C. The etiopathogenesis of inflammatory bowel diseases. World J Gastroenterology 14:4807-4812, 2006.

Danese S, Sans, M, de la Motte C, Graziani C, West G, Phillips MH, Pola R, Rivera-Reyes BM, Willis J, Gasbarrini A, Fiocchi C. Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology 130:2060-2073, 2006.

Fiocchi C. One commensal bacterial molecule - All we need for health? N Engl J Med 353:2078-2080, 2005.

Ina K, Kusugami K, Kawano Y, Nishiwaki T, Wen Z, Musso A, West GA, Ohta M, Goto H, Fiocchi C. Intestinal fibroblast-derived IL-10 increases survival of mucosal T-cells by inhibiting growth factor deprivation- and Fas-mediated apoptosis. J Immunol 175:2000-2009, 2005.

Fiocchi C. Closing fistulas in Crohn's disease - Should the accent be on maintenance or safety? N Engl J Med 350:934-936, 2004.

Sturm A, Leite AZ, Danese S, Krivacic KA, West GA, Mohr S, Jacobberger JW, Fiocchi C. Divergent cell cycle kinetics underlie the pathogenesis of chronic inflammatory diseases. Gut 53:1624-1631, 2004.

Vogel JD, West GA. Danese S, de la Motte C, Phillips MH, Strong SA, Willis J, Fiocchi C. CD40-mediated immune-nonimmune cell interactions trigger mucosal fibroblast chemokine production causing T-cell transmigration. Gastroenterology 126:63-80, 2004.

Lawrance IC, Wu F, Willis J, West GA, Fiocchi C, Chakravarti S. A murine model of chronic inflammation-induced intestinal fibrosis. Gastroenterology 125:1750-1761, 2003.

Danese S, de la Motte C, Sturm A, West GA, Strong SA, Katz JA, Fiocchi C. Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology 124:1249-1264, 2003.

Sturm A, Itoh J, Jacobberger JW, Fiocchi C. p53 acts as a negative regulator of intestinal immunity by delaying the cell cycle kinetics of mucosal T-cells. J Clin Invest 109:1481-1492, 2002.