Satish C. Kalhan, M.D.

Satish C. Kalhan, M.D.

Staff, Department of Pathobiology

  • Department of Pathobiology
  • Lerner Research Institute (NC22)
  • The Cleveland Clinic Foundation
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • Phone: 216) 444-4225
  • Fax: (216)636-0104
  • Email:
  • Fellowship - MetroHealth Medical Center
    Cleveland, OH
  • Fellowship - MetroHealth Medical Center
    Pediatric Metabolism
    Cleveland, OH
  • Residency - MetroHealth Medical Center
    Cleveland, OH
  • Residency - The City Hospital/Children's Hospital
    Nottingham/Sheffield, United Kingdom
  • Internship - All India Institute of Medical Sciences
    New Delhi, India
  • Medical School - All India Institute of Medical Sciences
    New Delhi, India
  • Undergraduate - University of Delhi
    New Delhi, India
  • Pediatrics
  • Pediatrics- Neonatal-Perinatal Medicine
  • Royal College of Physicians of London
  • Royal College of Physicians & Surgeons of Glasgow
  • Whole body metabolism, stable isotopic tracers, specifically amino acid metabolism in health and disease
  • Modeling integrated metabolic systems

PubMed Publications

Dasarathy J, Gruca LL, Bennett C, Parimi PS, Duenas C, Marczewski S, Fierro JL, Kalhan SC. Methionine metabolism in human pregnancy. Am J Clin Nutr. 2010 Feb;91(2):357-65.

Agostoni C, Buonocore G, Carnielli VP, De Curtis M, Darmaun D, Decsi T, Domellöf M, Embleton ND, Fusch C, Genzel-Boroviczeny O, Goulet O, Kalhan SC, Kolacek S, Koletzko B, Lapillonne A, Mihatsch W, Moreno L, Neu J, Poindexter B, Puntis J, Putet G, Rigo J, Riskin A, Salle B, Sauer P, Shamir R, Szajewska H, Thureen P, Turck D, van Goudoever JB, Ziegler EE; ESPGHAN Committee on Nutrition. Enteral nutrient supply for preterm infants: commentary from the European Society of Paediatric Gastroenterology, Hepatology and Nutrition Committee on Nutrition. J Pediatr Gastroenterol Nutr. 2010 Jan;50(1):85-91.

Hay WW Jr, Raju TN, Higgins RD, Kalhan SC, Devaskar SU. Knowledge gaps and research needs for understanding and treating neonatal hypoglycemia: workshop report from Eunice Kennedy Shriver National Institute of Child Health and Human Development. J Pediatr. 2009 Nov;155(5):612-7. Review.

Kalhan SC. Fatty acids, insulin resistance, and protein metabolism. J Clin Endocrinol Metab. 2009 Aug;94(8):2725-7.

Kasumov T, Gruca LL, Dasarathy S, Kalhan SC. Simultaneous assay of isotopic enrichment and concentration of guanidinoacetate and creatine by gas chromatography-mass spectrometry. Anal Biochem. 2009 Dec 1;395(1):91-9.

Yang J, Kalhan SC, Hanson RW. What is the metabolic role of phosphoenolpyruvate carboxykinase? J Biol Chem. 2009 Oct 2;284(40):27025-9.

Kalhan SC. Nonglucose carbohydrates and infant nutrition and metabolism. J Nutr. 2009 Sep;139(9):1611-2.

Dasarathy S, Kasumov T, Edmison JM, Gruca LL, Bennett C, Duenas C, Marczewski S, McCullough AJ, Hanson RW, Kalhan SC. Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion. Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G567-75.

Kalhan SC. Optimal protein intake in healthy infants. Am J Clin Nutr. 2009 Jun;89(6):1719-20.

Edmison JM, Kalhan SC, McCullough AJ. Obesity, Hepatic Metabolism and Disease. Nestle Nutr Workshop Ser Pediatr Program. 2009;63:163-176.

Kalhan SC. Metabolism of Methionine in Vivo: Impact of Pregnancy, Protein Restriction, and Fatty Liver Disease. Nestle Nutr Workshop Ser Pediatr Program. 2009; 63:121-133.

Nye C, Kim J, Kalhan SC, Hanson RW. Reassessing triglyceride synthesis in adipose tissue. Trends Endocrinol Metab. 2008 Dec;19(10):356-61.

Nye CK, Hanson RW, Kalhan SC. Glyceroneogenesis is the dominant pathway for triglyceride glycerol synthesis in vivo in the rat. J Biol Chem. 2008 Oct 10;283(41):27565-74.

Thomas B, Gruca LL, Bennett C, Parimi PS, Hanson RW, Kalhan SC. Metabolism of methionine in the newborn infant: response to the parenteral and enteral administration of nutrients. Pediatr Res. 2008 Oct;64(4):381-6.

Kalhan SC. Re: "alternative equations for whole-body protein synthesis and for fractional synthetic rates of proteins" by Ramakrishnan (Metabolism 2007;56:1550-60). Metabolism. 2008 Jun;57(6):871

Kalhan SC, Bier DM. Protein and amino acid metabolism in the human newborn. Annu Rev Nutr. 2008;28:389-410. Review PDF

Kalhan SC, Bugianesi E, McCullough AJ, Hanson RW, Kelley DE. Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans. Metabolism. 2008 Mar;57(3):305-12.

Kim J, Saidel GM, Kalhan SC.A computational model of adipose tissue metabolism: evidence for intracellular compartmentation and differential activation of lipases. J Theor Biol. 2008 Apr 7;251(3):523-40.

Lawton KA, Berger A, Mitchell M, Milgram KE, Evans AM, Guo L, Hanson RW, Kalhan SC, Ryals JA, Milburn MV. Analysis of the adult human plasma metabolome. Pharmacogenomics. 2008 Apr;9(4):383-97.

Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wilson DL, Kirwan JP, Kalhan SC, Hanson RW. Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J Biol Chem. 2007 Nov 9;282(45):32844-55.

Jadhav P, Parimi PS, Kalhan SC.Parenteral amino acid and metabolic acidosis in premature infants. JPEN J Parenter Enteral Nutr. 2007 Jul-Aug;31(4):278-83.

Kalhan SC, Edmison JM. Effect of intravenous amino acids on protein kinetics in preterm infants. Curr Opin Clin Nutr Metab Care  2007;10:69-74.

Dasarathy S, Muc S, Hisamuddin K, Edmison JM, Dodig M, McCullough AJ, Kalhan SC. Altered expression of genes regulating skeletal muscle mass in the portacaval anastamosis rat.   Am. J. Physiol. Gastrointest. Liver Physiol. 2007 Apr;292:G1105-G1113.

Catalano PM, Hoegh M, Minium J, Huston-Presley L, Bernard S, Kalhan S, Hauguel-De Mouzon S. Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism.  Diabetologia. 2006 Jul;49(7):1677-85.

Kalhan SC, Parimi PS. Transamination of leucine and nitrogen accretion in human pregnancy and the newborn infant.  J Nutr. 2006 Jan;136(1 Suppl):281S-7S. Review.

Kadrofske MM, Parimi PS, Gruca LL, Kalhan SC. Effect of intravenous amino acids on glutamine and protein kinetics in low-birth-weight preterm infants during the immediate neonatal period.  Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E622-30.

Parimi PS, Kadrofske MM, Gruca LL, Hanson RW, Kalhan SC.  Amino acids, glutamine, and protein metabolism in very low birth weight infants.  Pediatr Res. 2005 Dec;58(6):1259-64.

Hakimi P, Johnson MT, Yang J, Lepage DF, Conlon RA, Kalhan SC, Reshef L, Tilghman SM, Hanson RW.  Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism.  Nutr Metab (Lond). 2005 Nov 21;2:33.

Parimi PS, Gruca LL, Kalhan SC. Metabolism of threonine in newborn infants.   Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E981-5.

Kalhan SC, Parimi PS, Gruca LL, Hanson RW. Glutamine supplement with parenteral nutrition decreases whole body proteolysis in low birth weight infants.  J Pediatr. 2005 May;146(5):642-7.

Smith CE, Styn NR, Kalhan S, Pinchak AC, Gill IS, Kramer RP, Sidhu T.  Intraoperative glucose control in diabetic and nondiabetic patients during cardiac surgery.  J Cardiothorac Vasc Anesth. 2005 Apr;19(2):201-8.

Parimi PS, Cripe-Mamie C, Kalhan SC.  Metabolic responses to protein restriction during pregnancy in rat and translation initiation factors in the mother and fetus.  Pediatr Res. 2004 Sep;56(3):423-31. PDF

Parimi PS, Devapatla S, Gruca LL, Amini SB, Hanson RW, Kalhan SC. Effect of enteral glutamine or glycine on whole-body nitrogen kinetics in very-low-birth-weight infants.  Am J Clin Nutr. 2004 Mar;79(3):402-9.