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Satish C. Kalhan, M.D.
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Area of general research interest:
- Whole body metabolism, stable isotopic tracers, specifically amino acid metabolism in health and disease
- Modeling integrated metabolic systems
Specific projects include:
- Methionine metabolism in non-alcoholic steatohepatitis
- Glutamine metabolism in the human newborn
- Glyceroneogenesis in vivo and its regulation
- Modeling adipose tissue metabolism
Investigators:
- Amir Aminoshariae
- Carole Bennett
- John Edmison, M.D.
- Clarita Duenas
- Jaeyeon Kim, Graduate Student
- Lourdes Gruca
- Joyce Nolan
- Colleen Nye, Graduate Student
Grant Support:
- NIH/NICHD, RO1 HD042154, (S. Kalhan, P.I.)
Title: “Glutamine Metabolism in the Human Newborn”
The objective is to examine glutamine N kinetics and their relation to whole body protein metabolism in full term and low birth weight infants. - NIH/NIGMS, P50 GM066309-05, (G. Saidel, P.I.)
Title: “Center for Modeling Integrated Metabolic Systems”
The objective of the MIMS Center is the mathematical modeling and computer simulation of metabolic systems in response to stresses associated with hypoxia, exercise and dietary inputs. - NIH/NIDDK RO1 DK58620, (R.W. Hanson, P.I.)
Title: “Metabolic Role of PEPCK Isozymes”
These studies examine the role of phosphoenolpyruvate carboxykinase and its isozymes in whole body and specific tissue metabolism. The studies employ various transgenic models of enzyme deletion and over-expression
Key References:
Kalhan SC, Bugianesi E, McCullough AJ, Hanson RW, Kelley DE. Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans. Metabolism. 2008 Mar;57(3):305-12. PDF
Kim J, Saidel GM, Kalhan SC.A computational model of adipose tissue metabolism: evidence for intracellular compartmentation and differential activation of lipases. J Theor Biol. 2008 Apr 7;251(3):523-40. PDF
Lawton KA, Berger A, Mitchell M, Milgram KE, Evans AM, Guo L, Hanson RW, Kalhan SC, Ryals JA, Milburn MV. Analysis of the adult human plasma metabolome. Pharmacogenomics. 2008 Apr;9(4):383-97. PDF
Hakimi P, Yang J, Casadesus G, Massillon D, Tolentino-Silva F, Nye CK, Cabrera ME, Hagen DR, Utter CB, Baghdy Y, Johnson DH, Wilson DL, Kirwan JP, Kalhan SC, Hanson RW. Overexpression of the cytosolic form of phosphoenolpyruvate carboxykinase (GTP) in skeletal muscle repatterns energy metabolism in the mouse. J Biol Chem. 2007 Nov 9;282(45):32844-55. PDF
Jadhav P, Parimi PS, Kalhan SC.Parenteral amino acid and metabolic acidosis in premature infants. JPEN J Parenter Enteral Nutr. 2007 Jul-Aug;31(4):278-83. PDF
Kalhan SC, Edmison JM. Effect of intravenous amino acids on protein kinetics in preterm infants. Curr Opin Clin Nutr Metab Care 2007;10:69-74. PDF
Dasarathy S, Muc S, Hisamuddin K, Edmison JM, Dodig M, McCullough AJ, Kalhan SC. Altered expression of genes regulating skeletal muscle mass in the portacaval anastamosis rat. Am. J. Physiol. Gastrointest. Liver Physiol. 2007 Apr;292:G1105-G1113. PDF
Catalano PM, Hoegh M, Minium J, Huston-Presley L, Bernard S, Kalhan S, Hauguel-De Mouzon S. Adiponectin in human pregnancy: implications for regulation of glucose and lipid metabolism. Diabetologia. 2006 Jul;49(7):1677-85. PDF
Kalhan SC, Parimi PS. Transamination of leucine and nitrogen accretion in human pregnancy and the newborn infant. J Nutr. 2006 Jan;136(1 Suppl):281S-7S. Review. PDF
Kadrofske MM, Parimi PS, Gruca LL, Kalhan SC. Effect of intravenous amino acids on glutamine and protein kinetics in low-birth-weight preterm infants during the immediate neonatal period. Am J Physiol Endocrinol Metab. 2006 Apr;290(4):E622-30. PDF
Parimi PS, Kadrofske MM, Gruca LL, Hanson RW, Kalhan SC. Amino acids, glutamine, and protein metabolism in very low birth weight infants. Pediatr Res. 2005 Dec;58(6):1259-64. PDF
Hakimi P, Johnson MT, Yang J, Lepage DF, Conlon RA, Kalhan SC, Reshef L, Tilghman SM, Hanson RW. Phosphoenolpyruvate carboxykinase and the critical role of cataplerosis in the control of hepatic metabolism. Nutr Metab (Lond). 2005 Nov 21;2:33. PDF
Parimi PS, Gruca LL, Kalhan SC. Metabolism of threonine in newborn infants. Am J Physiol Endocrinol Metab. 2005 Dec;289(6):E981-5. PDF
Kalhan SC, Parimi PS, Gruca LL, Hanson RW. Glutamine supplement with parenteral nutrition decreases whole body proteolysis in low birth weight infants. J Pediatr. 2005 May;146(5):642-7. PDF
Smith CE, Styn NR, Kalhan S, Pinchak AC, Gill IS, Kramer RP, Sidhu T. Intraoperative glucose control in diabetic and nondiabetic patients during cardiac surgery. J Cardiothorac Vasc Anesth. 2005 Apr;19(2):201-8. PDF
Parimi PS, Cripe-Mamie C, Kalhan SC. Metabolic responses to protein restriction during pregnancy in rat and translation initiation factors in the mother and fetus. Pediatr Res. 2004 Sep;56(3):423-31. PDF
Parimi PS, Devapatla S, Gruca LL, Amini SB, Hanson RW, Kalhan SC. Effect of enteral glutamine or glycine on whole-body nitrogen kinetics in very-low-birth-weight infants. Am J Clin Nutr. 2004 Mar;79(3):402-9. PDF