Arthur McCullough, M.D.
Staff

Arthur J. McCullough, M.D.

Staff, Department of Pathobiology

  • Department of Pathobiology
  • Lerner Research Institute (NC22)
  • The Cleveland Clinic Foundation
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • Phone: (216) 444-2766
  • Fax: (216)636-0104
  • Email: mcculla@ccf.org
  • Fellowship - Mayo Clinic
    NIH Fellow in Gastroenterology
    Rochester, MN
    1980
  • Residency - Cleveland Clinic
    Internal Medicine
    Cleveland, OH
    1977
  • Internship - Cleveland Clinic
    Internal Medicine
    Cleveland, OH
    1975
  • Medical School - SUNY Upstate Medical University
    Syracuse, NY
    1974
  • Undergraduate - Fordham University
    Bronx, NY
    1970
  • Internal Medicine
  • Internal Medicine- Gastroenterology
  • Biliary disorders, biliary tract disease, clinical epidemiology, Diagnostic and therapeutic EGD (upper endoscopy) and colonoscopy, diagnostic and therapeutic endoscopy, diagnostic/therapeutic endoscopy, drug induced liver disease
  • Education of Fellows/Residents, end stage liver disease, Endoscopy, Eval and management of Hepatobiliary Malignancies, general hepatology, insulin resistance, liver, liver and biliary tract disease, Liver Disease, Liver Transplantation, liver-biliary tract disease, Medical School Education, Metabolic Syndrome, non alcoholic fatty liver disease, skeletal muscle loss in liver disease

PubMed Publications



O'Shea RS, Dasarathy S, McCullough AJ; Practice Guideline Committee of the American Association for the Study of Liver Diseases; Practice Parameters Committee of the American College of Gastroenterology. Alcoholic liver disease. Hepatology. 2010 Jan;51(1):307-28. Review.

Pagadala M, Dasarathy S, Eghtesad B, McCullough AJ. Posttransplant metabolic syndrome: an epidemic waiting to happen. Liver Transpl. 2009 Dec;15(12):1662-70. Review.

O'Shea RS, Dasarathy S, McCullough AJ. Alcoholic liver disease. Am J Gastroenterol. 2010 Jan;105(1):14-32; quiz 33.

Dasarathy S, Dasarathy J, Khiyami A, Joseph R, Lopez R, McCullough AJ. Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study. J Hepatol. 2009 Dec;51(6):1061-7.

Pagadala M, Zein CO, McCullough AJ. Predictors of steatohepatitis and advanced fibrosis in non-alcoholic fatty liver disease. Clin Liver Dis. 2009 Nov;13(4):591-606.

Carter-Kent C, Yerian LM, Brunt EM, Angulo P, Kohli R, Ling SC, Xanthakos SA, Whitington PF, Charatcharoenwitthaya P, Yap J, Lopez R, McCullough AJ, Feldstein AE. Nonalcoholic steatohepatitis in children: a multicenter clinicopathological study. Hepatology. 2009 Oct;50(4):1113-20.

Dasarathy S, Kasumov T, Edmison JM, Gruca LL, Bennett C, Duenas C, Marczewski S, McCullough AJ, Hanson RW, Kalhan SC. Glycine and urea kinetics in nonalcoholic steatohepatitis in human: effect of intralipid infusion. Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G567-75.

Feldstein AE, Wieckowska A, Lopez AR, Liu YC, Zein NN, McCullough AJ. Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study. Hepatology. 2009 May 1.

Edmison JM, Kalhan SC, McCullough AJ. Obesity, hepatic metabolism and disease. Nestle Nutr Workshop Ser Pediatr Program. 2009;63:163-72; discussion 172-6, 259-68.

Mahajan D, Miller C, Hirose K, McCullough A, Yerian L. Incidental reduction in the size of liver hemangioma following use of VEGF inhibitor bevacizumab. J Hepatol. 2008 Nov;49(5):867-70.

Hanouneh IA, Feldstein AE, McCullough AJ, Miller C, Aucejo F, Yerian L, Lopez R, Zein NN. The significance of metabolic syndrome in the setting of recurrent hepatitis C after liver transplantation. Liver Transpl. 2008 Sep;14(9):1287-93.

Parsi MA, Saadeh SN, Zein NN, Davis GL, Lopez R, Boone J, Lepe MR, Guo L, Ashfaq M, Klintmalm G, McCullough AJ. Ascitic fluid lactoferrin for diagnosis of spontaneous bacterial peritonitis. Gastroenterology. 2008 Sep;135(3):803-7.

Kalhan SC, Bugianesi E, McCullough AJ, Hanson RW, Kelley DE. Estimates of hepatic glyceroneogenesis in type 2 diabetes mellitus in humans. Metabolism. 2008 Mar;57(3):305-12.

Wieckowska A, McCullough AJ, Feldstein AE. Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology. 2007 Aug;46(2):582-9. Review.

Edmison J, McCullough AJ. Pathogenesis of non-alcoholic steatohepatitis: human data. Clin Liver Dis. 2007 Feb;11(1):75-104, ix. Review.

Dodig M, Ogunwale B, Dasarathy S, Li M, Wang B, McCullough AJ. Differences in regulation of type I collagen synthesis in primary and passaged hepatic stellate cell cultures: the role of alpha5beta1-integrin. Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G154-64.

Edmison JM, McCullough AJ. How good is transjugular liver biopsy for the histological evaluation of liver disease? Nat Clin Pract Gastroenterol Hepatol. 2007 Jun;4(6):306-7.

Sanaka MR, Shah N, Mullen KD, Ferguson DR, Thomas C, McCullough AJ. Afternoon colonoscopies have higher failure rates than morning colonoscopies. Am J Gastroenterol. 2006 Dec;101(12):2726-30.

Dasarathy S, Muc S, Hisamuddin K, Edmison JM, Dodig M, McCullough AJ, Kalhan SC. Altered expression of genes regulating skeletal muscle mass in the portacaval anastomosis rat. Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G1105-13.

Zein CO, Beatty K, Post AB, Logan L, Debanne S, McCullough AJ. Smoking and increased severity of hepatic fibrosis in primary biliary cirrhosis: A cross validated retrospective assessment. Hepatology. 2006 Dec;44(6):1564-71.

Raguso C, McCullough AJ. Leptin and the gastrointestinal tract. Curr Opin Gastroenterol. 2000 Mar;16(2):160-5.

Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE. In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology. 2006 Jul;44(1):27-33.

Dasarathy S, Mullen KD, Dodig M, Donofrio B, McCullough AJ. Inhibition of aromatase improves nutritional status following portacaval anastomosis in male rats. J Hepatol. 2006 Aug; 45(2):214-20.

McCullough AJ. Pathophysiology of nonalcoholic steatohepatitis. J Clin Gastroenterol. 2006 Mar;40 Suppl 1:S17-29. Review.

Sanaka MR, Super DM, Mullen KD, Ferguson DR, McCullough AJ. Use of tegaserod along with polyethylene glycol electrolyte solution for colonoscopy bowel preparation: a prospective, randomized, double-blind, placebo-controlled study. Aliment Pharmacol Ther. 2006 Mar 1;23(5):669-74.

Sanaka MR, Super DM, Feldman ES, Mullen KD, Ferguson DR, McCullough AJ. Improving compliance with postpolypectomy surveillance guidelines: an interventional study using a continuous quality improvement initiative. Gastrointest Endosc. 2006 Jan;63(1):97-103.

O'Shea RS, McCullough AJ. Treatment of alcoholic hepatitis. Clin Liver Dis. 2005 Feb;9(1):103-34. Review.

McCullough AJ. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis. 2004 Aug;8(3):521-33, viii. Review.

Dasarathy S, Dodig M, Muc SM, Kalhan SC, McCullough AJ. Skeletal muscle atrophy is associated with an increased expression of myostatin and impaired satellite cell function in the portacaval anastamosis rat. Am J Physiol Gastrointest Liver Physiol. 2004 Dec;287(6):G1124-30.

Gramlich T, Kleiner DE, McCullough AJ, Matteoni CA, Boparai N, Younossi ZM. Pathologic features associated with fibrosis in nonalcoholic fatty liver disease. Hum Pathol. 2004 Feb;35(2):196-9.

Younossi ZM, Mullen KD, Hodnick S, Barnes DS, Carey WD, McCullough AC, Easley K, Gramlich T, Liebermann BY. Triple combination of interferon alpha-2b, ribavirin, and amantadine for treatment of chronic hepatitis C. J Clin Gastroenterol. 2003 May-Jun;36(5):427-30.

Youssef WI, McCullough AJ. Steatohepatitis in obese individuals. Best Pract Res Clin Gastroenterol. 2002 Oct;16(5):733-47. Review.

Dasarathy S, Mullen KD, Conjeevaram HS, Kaminsky-Russ K, Wills LA, McCullough AJ. Preservation of portal pressure improves growth and metabolic profile in the male portacaval-shunted rat. Dig Dis Sci. 2002 Sep;47(9):1936-42.

Youssef W, McCullough AJ. Diabetes mellitus, obesity, and hepatic steatosis. Semin Gastrointest Dis. 2002 Jan;13(1):17-30. Review.

McCullough AJ. Update on nonalcoholic fatty liver disease. J Clin Gastroenterol. 2002 Mar;34(3):255-62. Review.

Falck-Ytter Y, Kale H, Mullen KD, Sarbah SA, Sorescu L, McCullough AJ. Surprisingly small effect of antiviral treatment in patients with hepatitis C. Ann Intern Med. 2002 Feb 19;136(4):288-92.

Falck-Ytter Y, Younossi ZM, Marchesini G, McCullough AJ. Clinical features and natural history of nonalcoholic steatosis syndromes. Semin Liver Dis. 2001;21(1):17-26. Review.

Younossi ZM, Mullen KD, Zakko W, Hodnick S, Brand E, Barnes DS, Carey WD, McCullough AC, Easley K, Boparai N, Gramlich T. A randomized, double-blind controlled trial of interferon alpha-2b and ribavirin vs. interferon alpha-2b and amantadine for treatment of chronic hepatitis C non-responder to interferon monotherapy. J Hepatol. 2001 Jan;34(1):128-33.

Falck-Ytter Y, McCullough AJ. Nutritional effects of alcoholism. Curr Gastroenterol Rep. 2000 Aug;2(4):331-6. Review.

McCullough AJ. Malnutrition in liver disease. Liver Transpl. 2000 Jul;6(4 Suppl 1):S85-96. Review.