Laura Nagy, Ph.D.

Staff

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Location:NE4-207
nagyl3@ccf.org
Phone: (216) 444-4021
Fax: (216) 636-1493



The research in my laboratory is aimed at understanding how chronic alcohol consumption contributes to chronic diseases, such as liver disease and diabetes. Recent data indicate that alcoholic liver disease affects over 10 million Americans and chronic, heavy alcohol consumption is an independent risk factor for type 2 diabetes. We’ve been particularly involved in understanding the effects of ethanol on hormone and cytokine receptor-dependent signal transduction. It has been our working hypothesis that disruption of signalling by hormones and cytokines contributes to the development of specific pathologies associated with chronic alcohol consumption Several projects in the laboratory address the pathophysiological mechanisms of ethanol-induced liver injury. In particular, we are interested in the contributions of the innate immune system, including the resident macrophage in the liver (Kupffer cells) and the complement pathway, in the initiation and progression of ethanol-induced liver injury. Recent work in the laboratory has also implicated ethanol-induced changes in adipose tissue metabolism and regulatory activity as a contributor to ethanol-induced insulin resistance and liver injury. Making use of cell and animal models, my laboratory group addresses some of the fundamental questions of how ethanol exposure injures the liver, with a goal ofidentifying the individual targets of ethanol-induced injury and the specific responses of the key cell types within the liver, as well as the integrated, organismal response to this ethanol-induced injury.

In other words ...

The research in my laboratory is aimed at understanding how chronic alcohol consumption contributes to chronic diseases, such as liver disease and diabetes. Recent data indicate that alcoholic liver disease affects over 10 million Americans and chronic, heavy alcohol consumption is an independent risk factor for type 2 diabetes. Making use of cell and animal models, my laboratory group addresses some of the fundamental questions of how ethanol exposure injures the liver, with a goal of identifying the individual targets of ethanol-induced injury and the specific responses of the key cell types within the liver, as well as the integrated, organismal response to this ethanol-induced injury.


Damien  Bellos
Damien Bellos
Graduate Student

Location:NE4-214
Phone:(216) 444-8632
bellosd@ccf.org
laboratory

Gail  Cresci Ph.D.
Gail Cresci Ph.D.
Associate Staff

Location:NE4-212
Phone:(216) 445-8317
CRESCIG@ccf.org
laboratory

Doug  Czarnecki
Doug Czarnecki
Animal Husbandry Technician

Location:NE4-214
Phone:(216) 444-8632
czarned@ccf.org
Fax:(216) 636-0104
laboratory

Bryan  Glueck B.S.
Bryan Glueck B.S.
Research Technician

Location:NE4-214
Phone:(216) 444-8632
glueckb@ccf.org
Fax:(216) 636-1493
laboratory

Veronica  Marin
Veronica Marin
Predoctoral Fellow

Location:NE4-214
Phone:(216) 444-8632
marinv@ccf.org
laboratory

Becky   McCullough  Ph.D.
Becky McCullough Ph.D.
Postdoctoral Fellow

Location:NE4-214
Phone:(216) 444-8632
smatheb@ccf.org
laboratory

Megan  McMullen
Megan McMullen
Project Manager

Location:NE4-214
Phone:(216) 444-8632
mcmullm2@ccf.org
laboratory

Katherine  Pollard B.S.
Katherine Pollard B.S.
Research Technologist

Location:NE4-214
Phone:(216) 444-8632
pollark@ccf.org
laboratory

Kyle  Poulsen PhD
Kyle Poulsen PhD
Postdoctoral Research Fellow

Location:NE4-214
Phone:(216) 444-8632
poulsek@ccf.org
Fax:(216) 636-0104
laboratory

Sanjoy  Roychowdhury Ph.D.
Sanjoy Roychowdhury Ph.D.
Project Staff

Location:NE4-206
Phone:(216) 444-4201
roychos@ccf.org
laboratory

Paramananda  Saikia Ph.D.
Paramananda Saikia Ph.D.
Research Associate

Location:NE4-214
Phone:(216) 444-8632
saikiap@ccf.org
Fax:(216) 636-0104
laboratory

Carlos  Sanz Garcia Ph.D.
Carlos Sanz Garcia Ph.D.
Postdoctoral Research Fellow

Location:NE4-214
Phone:(216) 444-8632
sanzc@ccf.org
laboratory

Jeanette  Wat
Jeanette Wat

Location:NE4-214
Phone:(216) 444-8632
watj@ccf.org
laboratory


Myeloid-Mixed Lineage Kinase 3 contributes to chronic ethanol-induced inflammation and hepatocyte injury in mice.

McCullough RL, Saikia P, Pollard KA, McMullen MR, Nagy LE, Roychowdhury S.

Gene Expr. 2016 Jun 9. [Epub ahead of print]

 

Receptor interacting protein 3 protects mice from high fat diet-induced liver injury.

Roychowdhury S, McCullough RL, Sanz-Garcia C, Saikia P, Alkhouri N, Matloob A, Pollard K, McMullen MR, Croniger CM, Nagy LE.

Hepatology. 2016 Jun 15. doi: 10.1002/hep.28676. [Epub ahead of print]

 

Differential contribution of complement receptor C5aR in myeloid and non-myeloid cells in chronic ethanol-induced liver injury in mice.

McCullough RL, McMullen MR, Das D, Roychowdhury S, Strainic MG, Medof ME, Nagy LE.

Mol Immunol. 2016 Jul;75:122-32. doi: 10.1016/j.molimm.2016.05.006. Epub 2016 Jun 6.

 

Soluble IgM links apoptosis to complement activation in early alcoholic liver disease in mice.

Smathers RL, Chiang DJ, McMullen MR, Feldstein AE, Roychowdhury S, Nagy LE.

Mol Immunol. 2016 Apr;72:9-18. doi: 10.1016/j.molimm.2016.02.008. Epub 2016 Feb 27.

 

Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes.

Nagy LE, Ding WX, Cresci G, Saikia P, Shah VH.

Gastroenterology. 2016 Jun;150(8):1756-68. doi: 10.1053/j.gastro.2016.02.035. Epub 2016 Feb 23.

 

Adiponectin as an anti-fibrotic and anti-inflammatory adipokine in the liver.

Park PH, Sanz-Garcia C, Nagy LE.

Curr Pathobiol Rep. 2015 Dec 1;3(4):243-252. Epub 2015 Sep 30.

 

The Role of Innate Immunity in Alcoholic Liver Disease.

Nagy LE.

Alcohol Res. 2015;37(2):237-50. Review.

 

Alternative complement pathway component Factor D contributes to efficient clearance of tissue debris following acute CCl₄-induced injury.

Cresci GA, Allende D, McMullen MR, Nagy LE.

Mol Immunol. 2015 Mar;64(1):9-17. doi: 10.1016/j.molimm.2014.10.017. Epub 2014 Nov 15.

 

Macrophage migration inhibitory factor is required for recruitment of scar-associated macrophages during liver fibrosis.

Barnes MA, McMullen MR, Roychowdhury S, Madhun NZ, Niese K, Olman MA, Stavitsky AB, Bucala R, Nagy LE.

J Leukoc Biol. 2015 Jan;97(1):161-9. doi: 10.1189/jlb.3A0614-280R. Epub 2014 Nov 14.

 

Innate immunity and cell death in alcoholic liver disease: role of cytochrome P4502E1.

Barnes MA, Roychowdhury S, Nagy LE.

Redox Biol. 2014 Aug 1;2:929-35. doi: 10.1016/j.redox.2014.07.007. eCollection 2014. Review.