Laura E. Nagy, Ph.D.

Laura E. Nagy, Ph.D.

Staff, Department of Pathobiology

  • Department of Pathobiology
  • Lerner Research Institute (NC22)
  • The Cleveland Clinic Foundation
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • Phone: (216) 444-4021
  • Fax: (216)636-0104
  • Doctorate - University of California-Berkeley
    Berkeley, CA
  • Graduate - University of California at Berkeley
    Berkeley, CA
  • Undergraduate - Yale University
    New Haven, CT

PubMed Publications

Mandal P, Park PH, McMullen MR, Pratt BT, Nagy LE. The anti-inflammatory effects of adiponectin are mediated via a heme oxygenase-1-dependent pathway in rat Kupffer cells. Hepatology. 2009 Nov 13.

Li W, Laird JM, Lu L, Roychowdhury S, Nagy LE, Zhou R, Crabb JW, Salomon RG. Isolevuglandins covalently modify phosphatidylethanolamines in vivo: detection and quantitative analysis of hydroxylactam adducts. Free Radic Biol Med. 2009 Dec1;47(11):1539-52.

Roychowdhury S, McMullen MR, Pritchard MT, Li W, Salomon RG, Nagy LE. Formation of gamma-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice. Free Radic Biol Med. 2009 Dec 1;47(11):1526-38.

Breitkopf K, Nagy LE, Beier JI, Mueller S, Weng H, Dooley S. Current experimental perspectives on the clinical progression of alcoholic liver disease. Alcohol Clin Exp Res. 2009 Oct;33(10):1647-55.

Cohen, J.I., Roychowdhury, S., DiBello, P.M., Jacobsen, D.W. and L.E. Nagy. Exogenous thioredoxin prevents ethanol-induced oxidative damage and apoptosis in mouse liver. Hepatology. 2009 May;49(5):1709-17.

Chen, X., Sebastian, B.M., Tang, H., McMullen, M.R., Axhemi, A., Jacobsen, D.W. and L.E. Nagy. Taurine supplementation prevents ethanol-induced decrease in serum adiponectin and reduces hepatic steatosis in rats. Hepatology. 2009 May;49(5):1554-62.

Roychowdhury, S., McMullen, M.R., Pritchard, M.T., Hise, A.G., van Rooijen, N., Medof, M.E., Stavitsky, A.B. and L.E. Nagy. An early complement-dependent and TLR-4 independent phase in the pathogenesis of ethanol-induced liver injury. Hepatology. 2009 Apr;49(4):1326-34.

Beidelschies, M.A., Huang, H., McMullen, M.R., Smith, M.V., Islam, A.S., Goldbergy, V.M., Chen, X., Nagy, L.E. and E.M. Greenfield. Stimulation of macrophage TNF-α production by orthopaedic wear particles requires activation of the ERK1/2/Egr-1 and NFκB pathways but is independent of p38 and JNK. J. Cell. Physiol., 217:652-666, 2008.

Pritchard, M.T., McMullen, M.R., Medof, M.E., Stavitsky, A., and Nagy L.E. Role of complement in ethanol-induced liver injury. Adv Expt Biol and Med, 632:175-86, 2008.

Park PH, Huang H, McMullen MR, Mandal P, Sun L, Nagy LE. Suppression of Lipopolysaccharide-stimulated Tumor Necrosis Factor-alpha Production by Adiponectin Is Mediated by Transcriptional and Post-transcriptional Mechanisms.J Biol Chem. 283(40):26850-8, 2008.

Park, P., Huang, H., McMullen, M.R., Bryan, K., and L.E. Nagy. Activation of cAMP response element binding protein contributes to adiponectin-stimulated interleukin-10 expresssion in RAW264.7 macrophages. J. Leuk. Biol.,83:158-1266, 2008.

Nagy, L.E. (editor) Alcohol: Methods in Molecular Medicine, Humana Press, vol 447, 2008.

McMullen, M.R., Pritchard, M.T., and Nagy, L.E. Isolation of Kupffer Cells from Rats fed Chronic Ethanol. In Alcohol: Methods in Molecular Medicine (ed L.E. Nagy), Humana Press, 447:199-212, 2008.

Sebastian, B.M., Kang, L, Chen, X., and Nagy, L.E. Methods to Investigate the Effects of Chronic Ethanol on Adipocytes. In Alcohol: Methods in Molecular Medicine (ed L.E. Nagy), Humana Press, 447:357-366, 2008.

Huang, H., Park, P., McMullen, M.R. and L.E. Nagy. Mechanisms for the anti-inflammatory effects of adiponectin in macrophages. J. Gastroenterol. Hepatol. 23: S50-53, 2008.

Pritchard, M., Roychowdhury, S., McMullen, M., Guo, L., Arteel, G. and L.E. Nagy. Critical role of Egr-1 in galactosamine/lipopolysaccharide-induced liver injury. Am. J. Phys. 293:G1124-G1133, 2007.

Kang, L., Chen, X., Sebastian, B.M., Pratt, B.T., Bederman, I.R., Alexander, J.C., Previs, S.F., and L.E Nagy. Chronic ethanol and triglyceride turnover in white adipose tissue in rats. Inhibition of the anti-lipolytic action of insulin after chronic ethanol contributes to increased triglyceride degradation. J.Biol. Chem. 282:28465-28473, 2007.