Edward J. Mascha, PhD

Associate Staff
(Joint appointment with Department of Outcomes Research in the Anesthesiology Institute)

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Location:P77-007
maschae@ccf.org
Phone: (216) 445-7805
Fax: (216) 444-6135



Research Description

Dr. Mascha has led Biostatistical collaboration and research methodology for the Cleveland Clinic’s Anesthesiology Institute since 2005 and has over 25 years of experience as collaborative Biostatistician in perioperative medicine and various disease areas. His interests include design and monitoring of clinical trials, causal inference, inference on multiple correlated outcomes, mediation analysis, and complex equivalence and noninferiority designs. His current research involves expanding methods for analyzing composite endpoints containing binary, ordinal or mixed data types (see binary event design software), estimating heterogeneity of individual treatment effects using potential outcomes and mediation analysis for multiple mediators & outcomes. His journal publications are listed here.

Service

Lecturer: Anesthesiology Institute’s Fundamentals of Clinical Research series, Comprehensive Anesthesiology Review and Resident Education classes; Introduction to Clinical Trials (CMED450)

Statistical Editor: Anesthesia and Analgesia

Statistical Reviewer: Anesthesia and Analgesia, Anesthesiology, Vascular Surgery.


Allen  Collins  AAB
Allen Collins AAB
Programmer Analyst II
Location:P77-0091
Phone:(216) 444-7479
collinsa@ccf.org
Sven  Halvorson  MS
Sven Halvorson MS
Statistical Programmer
Location:P7-009
Phone:(216) 444-4633
halvors@ccf.org
Chen  Liang  MS
Chen Liang MS
Biostatistician
Location:P7-0031
Phone:(216) 442-5589
liangc@ccf.org
Liu  Liu  MS
Liu Liu MS
Statistical Programmer I
Location:P77-0092
Phone:(216) 444-4633
liul4@ccf.org
Chao  Ma  MS
Chao Ma MS
Statistical Programmer I
Location:P77-0095
Phone:(216) 636-5868
mac@ccf.org
Natalya  Makarova  MS
Natalya Makarova MS
Sr. Biostatistician
Location:P77-054E
Phone:(216) 442-5225
makaron@ccf.org
Guangmei  Mao  MS
Guangmei Mao MS
Biostatistician
Location:P77-054A
Phone:(216) 444-7479
maog@ccf.org
Dongsheng  Yang  MS
Dongsheng Yang MS
Statistical Programmer III
Location:P77-0093
Phone:(216) 636-5418
yangd@ccf.org

Mascha EJ.  Alpha, Beta, Meta: Guidelines for assessing Power and Type I error in meta-analyses.  (Editorial) Anesth Analg 2015, 121(6):1430-3.

Mascha EJ, Mazo V. Predicting in-hospital postoperative mortality for the practitioner: Beyond the numbers. (Editorial) Anesthesiology 2016, 124(3):523-5.

Mascha EJ, Yang D, Weiss S, Sessler DI: Intraoperative Mean Arterial Pressure Variability and 30-day Mortality in Patients Having Noncardiac Surgery. Anesthesiology 2015; 123: 79-91.

Mascha EJ, Dalton J, Kurz A, Saager L. Understanding the mechanism: Mediation analysis in randomized and non-randomized studies. Anesth Analg 2013, 117: 980-94.

Mascha EJ, Turan A. Joint hypothesis testing and gatekeeping procedures for studies with multiple outcomes. Anesth Analg 2012, 114(6):1304-1317.

Mascha EJ, Sessler DI.  Design and Analysis of Binary-Event Composite Endpoint Studies: Guidelines for Anesthesia Research. Anesthesia and Analgesia 2011, 112 (6):1461-71.

Mascha EJ, Sessler DI.  Statistical grand rounds: Equivalence and noninferiority testing for regression models and repeated measures designs. Anesth Analg 2011, 112: 678–687.

Mascha EJ.  Equivalence and Noninferiority Testing in Anesthesiology Research.  Anesthesiology 2010, 113: 779-781.

Mascha EJ, Imrey PB: Factors affecting power of tests for multiple binary outcomes. Statistics in Medicine 2010; 29: 2890-2904.

Mascha E, Albert J. Estimating treatment effect heterogeneity for binary outcomes via Dirichlet multinomial constraints. Biometrical Journal 2007; 49 (3): 378-393.

Mascha E, Albert J.  Statistical properties of bound estimators on treatment effect heterogeneity for binary outcomes. Journal of Modern Applied Statistical Methods 2006; 5(1), 181-193.

Dalton JE, Glance LG, Mascha EJ, Ehrlinger J, Chamoun N, Sessler DI (2013). Impact of present-on-admission indicators on risk-adjusted hospital mortality measurement. Anesthesiology 118, 1298-1306.

Abdelmalak BB, Bonilla A, Mascha EJ, Maheshwari A, Tang WH, You J, Ramachandran M, Kirkova Y, Clair D, Walsh RM, Kurz A, Sessler DI (2013). Dexamethasone, light anaesthesia, and tight glucose control (DeLiT) randomized controlled trial. Br J Anaesth 111, 209-221.

 

 


No news currently found.