Stem Cell Biology and Regenerative Medicine
Emina Huang, M.D.
Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Phone: (216) 445-4631
Fax: (216) 636-5454
The development of cancer in the face of chronic inflammation has long been recognized. However, the precise pathogenetic mechanisms have been poorly defined. Our laboratory seeks to define how elements of the epithelia and the surrounding microenvironment interact to promote progression to cancer, or conversely, to mitigate the progression. We have unique tools derived directly from patients, as well as unique models, including colitis-derived tumor initiating cells and colitis-derived fibroblasts. The laboratory interrogates the relationships to understand the progression to delineate unique targets and mechanisms to both prevent the inexorable progression along with the devastating symptoms.
- Dalerba P, Dylla SJ, Park, IK, Liu, R, Wang X, Cho RW, Hoey T, Gurney A, Huang EH, Simeone DM, Shelton AA, Parmiani G, Castelli C, Clarke MF. Phenotypic characterization of human colorectal “cancer stem cells”. PNAS 2007;104:10158-63. PMC1891215.
- Shenoy AK, Fisher RC, Butterworth EA, Pi L, Chang LJ, Appelman HD, Chang M, Scott EW, Huang EH. Transition from colitis to cancer: High Wnt activity sustains the tumor-initiating potential of colon cancer stem cell precursors. Cancer Research 2012 Oct 1; 72:5091-5100. PMC3463774.
- Fearon ER, Huang EH. CDX2: Linking cell and patient fates in colon cancer. Cell Stem Cell 2016 18(2):168-9. PMID 26849302.
- Chen HJ, Wei Z, Sun J, Bhattacharya A, Savage DJ, Serda R, Mackeyev Y, Curley SA, Bu P, Wang L, Chen S, Cohen-Gould L, Huang E, Shen X, Lipkin SM, Copeland NG, Jenkins NA, Shuler ML. Engineering an organotypic colon through recellularization for studying cancer driver genes using transposon-based mutagenesis. Nat Biotech 2016 Aug;34(8):845-51.
- Chen S, Fisher RC, Signs S, Molina LA, Shenoy AK, Lopez MC, Baker HV, Koomen JM, Gittleman H, Barnholtz-Sloan J, Berg A, Appelman HD, Huang EH. Inhibition of PI3K/Akt/mTOR signaling in PI3KR2-overexpressing colon cancer stem cells reduces tumor growth due to apoptosis. Oncotarget, 2016, epub June 8, in press.