Jeremy N. Rich, M.D.

Staff

Lerner Research Institute
9500 Euclid Avenue
Cleveland, Ohio 44195
Location:NE3-301
richj@ccf.org
Phone: (216) 636-0790
Fax: (216) 636-5454



Cancer research has rediscovered the complexity of nervous system cancers through the incorporation of cellular heterogeneity into tumor models with cellular subsets displaying stem cell characteristics. The cancer stem cell hypothesis posits that tumor cells are organized in a hierarchy with cancer stem cells at the apex and functionally defined by the ability to self renew and propagate tumors similar to the parental tumors from which they are derived. The clinical relevance of cancer stem cells has been supported by cancer stem cell resistance to cytotoxic therapies and promotion of tumor angiogenesis. Cancer stem cells reside in specific functional niches in perivascular and hypoxic niches that may offer the ability to disrupt tumor maintenance and therapeutic resistance through targeting the niche. The cancer stem cell phenotype is regulated by both cell intrinsic and microenvironmental influences that may further increase the complexity of tumor modeling. The study of cellular heterogeneity and cancer stem cells has already yielded novel molecular targets and pathways that are amenable to therapeutic targeting, perhaps permitting attenuation of tumor resistance. The conventional pyramidal unidirectional differentiation cascade with cancer stem cells at the apex has been called into question by studies demonstrating plasticity of the cancer stem cell phenotype, thus suggesting that targeting only cancer stem cells will likely fail to cure patients and require simultaneous targeting of cancer stem cells and the bulk tumor. The field of cancer stem cell biology holds promise for the development of novel patient therapies.


Deobrat  Dixit Ph.D.
Deobrat Dixit Ph.D.
Postdoctoral Research Fellow

Location:NE3-256
Phone:(216) 636-1008
dixitd@ccf.org
Fax:(216) 636-5454
laboratory

Zhen  Dong Ph.D.
Zhen Dong Ph.D.
Postdoctoral Research Fellow

Location:NE3-256
Phone:(216) 636-1008
dongz2@ccf.org
Fax:(216) 636-5454
laboratory

Ryan  Gimple
Ryan Gimple
Graduate Student

Location:NE3-256
Phone:(216) 636-1008
gimpler@ccf.org
Fax:(216) 636-5454
laboratory

Chris  Hubert Ph.D.
Chris Hubert Ph.D.
Postdoctoral Research Fellow

Location:NE3-256
Phone:(216) 636-1008
hubertc@ccf.org
Fax:(216) 636-5454
laboratory

Xun  Jin Ph.D.
Xun Jin Ph.D.
Research Scholar

Location:NE3-256
Phone:(216) 636-1008
jinx2@ccf.org
Fax:(216) 636-5454
laboratory

Leo  Kim
Leo Kim
Graduate Student

Location:NE3-256
Phone:(216) 636-1008
kiml@ccf.org
Fax:(216) 636-5454
laboratory

Jongmyung (John)  Kim M.D., Ph.D.
Jongmyung (John) Kim M.D., Ph.D.
Postdoctoral Research Fellow

Location:NE3-256
Phone:(216) 636-1008
kimj9@ccf.org
Fax:(216) 636-5454
laboratory

Sisi  Lai
Sisi Lai
Graduate Student

Location:NE3-256
Phone:(216) 636-1008
lais@ccf.org
Fax:(216) 636-5454
laboratory

Christine   Lee
Christine Lee
Graduate Student

Location:NE3-256
Phone:(216) 636-1008
leec2@ccf.org
Fax:(216) 636-5454
laboratory

Stephen  Mack Ph.D.
Stephen Mack Ph.D.
Postdoctoral Research Fellow

Location:NE3-256
Phone:(216) 636-1008
macks2@ccf.org
Fax:(216) 636-5454
laboratory

Tyler  Miller
Tyler Miller
Graduate Student

Location:NE3-256
Phone:(216) 636-1008
millert10@ccf.org
Fax:(216) 636-5454
laboratory

Andrew  Morton
Andrew Morton
Graduate Student

Location:NE3-256
Phone:(216) 636-1008
mortona2@ccf.org
Fax:(216) 636-5454
laboratory

Tanwarat (May)  Sanvoranart
Tanwarat (May) Sanvoranart
Predoctoral Research Fellow

Location:NE3-256
Phone:(216) 636-1008
sanvort@ccf.org
Fax:(216) 636-5454
laboratory

Claudia  Valentim Ph.D.
Claudia Valentim Ph.D.
Postdoctoral Research Fellow

Location:NE3-256
Phone:(216) 636-1008
valentc2@ccf.org
Fax:(216) 636-5454
laboratory

Lisa Christine Wallace
Lisa Christine Wallace
Senior Research Technologist

Location:NE3-256
Phone:(216) 636-1008
wallacl3@ccf.org
Fax:(216) 636-5454
laboratory

Xiuxing  Wang Ph.D.
Xiuxing Wang Ph.D.
Postdoctoral Research Fellow

Location:NE3-256
Phone:(216) 636-1008
wangx7@ccf.org
Fax:(216) 636-5454
laboratory

Qiulian  Wu
Qiulian Wu
Principal Technologist

Location:NE3-256
Phone:(216) 636-1008
wuq2@ccf.org
Fax:(216) 636-5454
laboratory

Qi  Xie Ph.D.
Qi Xie Ph.D.
Postdoctoral Research Fellow

Location:NE3-256
Phone:(216) 636-1008
xieq@ccf.org
Fax:(216) 636-5454
laboratory

Zhe  Zhu M.D., Ph.D.
Zhe Zhu M.D., Ph.D.
Postdoctoral Research Fellow

Location:NE3-256
Phone:(216) 636-1008
zhuz2@ccf.org
Fax:(216) 636-5454
laboratory


Kim Y … Rich JN. Platelet-derived growth factor receptors differentially inform intertumoral and intratumoral heterogeneity. Genes Dev. 2012 Jun 1;26(11):1247-62.

Eyler CE … Rich JN. Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. Cell. 2011 Jul 8;146(1):53-66.

Guryanova OA … Rich JN, Bao S. Non-receptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. Cancer Cell. 2011 Apr 12;19(4):498-511.

Bao S … Rich JN. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.  Nature 2006;444(7120):756-60.