STUDYING CANCER EVOLUTION
through computation, experiment, and theory
Jacob Scott, MD, DPhilPrincipal Investigator
Associate Staff, Departments of Translational Hematology and Oncology Research and Radiation Oncology
I'm a radiation oncologist who specializes in the care of patients with Sarcoma and a theoretical oncologist who thinks about the fundamental evolutionary mechanisms driving therapeutic resistance. When I'm in the lab, I think about the evolution of resistance and spends my time working with, and mentoring my lab mates - with whom I feel incredibly lucky and honored to work. When I'm not working I like to spend time reading to, and playing with my kids, spending time with my wife and walking in the woods with my dog.
LAB MEMBERS (LISTED ALPHABETICALLY)
I am currently a PGY-1 Neurology resident in the Cleveland Clinic Neurology Institute, and have just completed a DPhil in Oncology at the University of Oxford, co-supervised by Dr. Jacob Scott, Dr. Francesca Buffa, and Dr. Adrian Harris. My DPhil thesis was focused on the roles of non-coding RNA (microRNA and circular RNA) in cancer. As I have trained in medicine and mathematics, my interests span clinical neurology and oncology, medical genetics, computational biology, and mathematical biology. I also love to learn about people and cultures, spend time with friends, run, and read!
I am a postdoctoral research fellow studying how we can use spatial heterogeneity to steer evolution in complex ecological communities. My background is in computer science, ecology, and evolutionary biology, and I enjoy simultaneously applying all of these lenses to my research. For my PhD, I studied these questions at an abstract level using digital ecosystems at the BEACON center for evolution in action. For my post-doc, I'm modeling the evolution of therapy resistance in cancer - specifically, the effects of spatial oxygen gradients, which play an important role in the evolution of resistance. Outside of the lab, I enjoy walking my ferrets, playing board games, and learning new tin whistle music.
I am currently a first year Ph.D. student at Case Western Reserve University in the Systems Biology and Bioinformatics program. I am currently doing research on modeling fitness landscapes and evolutionary trajectories of drug resistance eventually aiming for predictions applicable in therapeutical settings. Besides work, cooking, reading and thinking about exercising is what I usually do.
Patrick Ellsworth, BAEmail: email@example.com
I am a medical student at Case Western Reserve University School of Medicine who is interested in cancer research. I am trying to answer some questions in cancer using dynamical systems modelling for cell population growth. Right now, I am particularly interested in spatial structure of cell populations and how this structure could affect the development of cancer. Before I started working on this project, I thought I would have to stop doing math while being a med student. Now I realize I can do both! When I'm not doing research or enjoying medical school, I love playing sports, in particular soccer, tennis, or any sport where effort can make up for lack of talent.
Nathan FarrokhianEmail: firstname.lastname@example.org
I am a 2nd year medical student in the University Program at Case Western Reserve University School of Medicine. I am currently working to apply evolutionary game assay techniques to quantitatively characterize the range of pairwise interactions that occur between cells within the tumor microenvironment. Outside of the lab, I enjoy running, hiking, and most racquet sports.
Vishvaan GopalakrishnanEmail: email@example.com
I am a 4th year medical student at the Cleveland Clinic Lerner College of Medicine with an engineering background. I like to set up servers, write code, and occasionally grow some cells. In the lab, I'm working with a team to develop an automated culture machine with the intention of using it with cancer cells. Our lab bench looks quite different from other traditional biology benches! Outside the lab, I enjoy watching movies, finding music, and expanding the enterprise-grade network and servers in my parent's basement.
Dena GuoEmail: firstname.lastname@example.org
I am a 1st year medical student at the Cleveland Clinic Lerner College of Medicine, interested in applying my background in physics and computational biology to translational oncology research. In the lab, I’m working with a great team to develop the evolutionary bioreactor (EVE). The ultimate goal of the EVE project is to study the genotypic changes in cancer cells as they develop resistance to various cancer therapies. Outside of the lab, I enjoy knitting, swimming, and petting dogs.
Masahiro Hitomi, MD, PhDEmail: email@example.com
The first patient, whom I saw as a medical student, was suffering with an incurable disease. This experience motivated me to step into the field of scientific research trying to find something new that may benefit medical treatment. My research interest is to understand how extrinsic environment modifies intrinsic molecular programs that control critical cellular decisions such as cell cycle progression, cell death, and cell fate choice. Currently I am studying the asymmetric cell division in cancer stem cells and the therapeutic resistance in cancer cells. In daily life, I occasionally find that the pair of socks I am wearing are asymmetrical.
Linh HuynhEmail: firstname.lastname@example.org
I am a first-year PhD student in Applied Mathematics at Case Western Reserve University (CWRU). I am working with Dr. Jacob Scott and Dr. Peter Thomas (CWRU) on stochastic methods in cancer dynamics. In addition to doing research, I also love teaching and mentoring students.
Artem is developing algorithmic biology: using theoretical computer science to structure evolutionary theory. Algorithmic biology doesn’t rely on simple well-controlled systems but abstracts over arbitrary micro-dynamics. As such, Artem views poorly-characterized cancer cells not as a domain in which to apply existing biological knowledge, but an experimental system with which to learn about evolution. You can find him working on his DPhil in Computer Science with Peter Jeavons at the University of Oxford. Artem is also interested in evolutionary game theory and philosophy of science. Learn more about his interests at the Theory, Evolution, and Games Group blog.
Nikhil is a second year medical student who can not decide if he wants to be an infectious disease doctor or an energy healer. He can usually be found with an aquarium pump and an arduino - but to what end?
Erin McClureEmail: email@example.com
I am a research technician for Dr. Scott. My background is in experimental evolutionary biology. One of my primary roles is helping build a morbidostat. In addition to assisting lab members with the microbiology aspects of their projects, I am preparing to apply to medical school. When I am not performing scientific miracles, I enjoy spending time with my dog, horseback riding, and reading.
Julia PeleskoEmail: firstname.lastname@example.org
I am an undergraduate student at Case Western Reserve University studying Mathematics and Physics. My favorite reads are The Odyssey and QED by Feynman. When the weather is nice, I enjoy horseback riding and hiking. On rainier days, I’m usually hidden away in a coffee shop somewhere writing.
I’m an MD/PhD student in the Medical Scientist Training Program at Case Western Reserve University. In lab, I’m researching the evolution of cancer cell resistance to therapy using open-source databases and R software. When I’m not in class, I can usually be found feeding my dog way too many treats or trying restaurants around town.
Geoff SedorEmail: email@example.com
Geoff is another wayward physicist who found his way into our lab from the hallowed halls of the Case Western School of Medicine. While he isn't in lab he is busy commuting back and forth to NYC and playing Chopin etudes at his parent's house. He is currently working on helping us deconstruct our underlying models of radiation oncology.
I am a medical student interested in the application of mathematical and computational tools in medicine. Currently, I am working on using topological data analysis to gain new insights from genomics datasets. In my free time, I enjoy playing racquet sports, particularly racquetball, squash, and tennis.
I am a medical student at CWRU hoping to pursue a career as a physician scientist in the field of Oncology. I graduated from Duke University in 2016 with a degree in Biology and a minor in Chemistry. After graduation, I spent two years learning to build mathematical models in a health outcomes lab in Boston. My current work is focused on developing mathematical models to identify optimal regimens and schedules for the treatment of Ewing’s Sarcoma. In my free time, I love to play soccer, listen to improv comedy, or obsess over my Kansas City Chiefs.
I am a postdoctoral research fellow working on dynamical modeling of tumor cell populations using a combination of dyanmical systems theory and stochastic models. My principle interest is the study of the emergence of resistance in the tumors developed during cancer therapy. The main purpose of the research is to find optimal strategies of utilizing available treatments to cure cancers.
LAB ALUMNI (LISTED ALPHABETICALLY)
Drew has moved to a residency at Brigham and Womens in the Harvard medical school program in Anatomic Pathology. Drew worked on evolutionary game theory, RNA-Seq data analysis using network theory, and helped start the morbidostat project. We're proud of Drew and wish him all the success in the world in Boston - who knows, with luck he might come back!
Inom Mirzaev, PhDEmail: firstname.lastname@example.org
Personal Homepage, Google Scholar, GitHub
Inom has moved on from our group taking a machine learning job with an HR company in San Francisco called Workday, where he is currently living the dream. When he is not coding and doing math, he likes to bike, play basketball/soccer and watch soccer games.
Elena has moved to Boston to pursue a career in industry in biomedicine, where she is currently a a scientist in immuno-oncology/bioinformatics at emd serono/Merck kgaa. We're jealous that they have her, and wish her the best.
- Email: email@example.com
- Cleveland Clinic
Department of Translational Hematology and Oncology Research
Lerner Research Institute
2111 E. 96th Street NE6
Cleveland, Ohio 44106