Call for Pilot Project Research Proposals
Clinical and Basic/Translational Projects


Submission Deadlines:


Letter of Intent:

February 1, 2019 (email to Thomas McIntyre (


March 1, 2019

Awards: Sponsors:

2 pilot projects with direct costs up to $25,000
Northern Ohio Alcohol Center/Center for Liver Disease Research

The NIAAA/NIH-funded P50 Northern Ohio Alcohol Center (NOAC) is seeking applications for basic/translational or clinical projects related to the pathophysiological effects of alcohol on health. The Center seeks to expand the research community and to provide essential support necessary for a successful research application by Assistant to Full Staff/Professor. Topics may include:
1. Measuring biochemical and molecular markers of ethanol-induced stress
2. Assessing cellular responses to ethanol-induced stress
3. Understanding the integrative organismal adaptations to ethanol
4. Translating advances from the laboratory to human clinical experiments

Clinical and basic / translational Assistant to Full Staff/Professor are encouraged to apply.

Award Details
Funding range:                                               $25,000 directs costs, only
Funding start date:                                         Spring 2019, dependent on active IRB/IACUC approvals for the project
Principal investigator and personnel salary:  Allowed
Length of support:                                       1-2 years; funding for the second year is contingent upon evidence of satisfactory progress during year 1, as documented in a progress report
Submission Guidelines
1. A letter of intent comprising no more than one half of one page to include: Investigator(s); Title; Problem; Aims; Anticipated outcomes and conclusions.

2. If invited after review of the letter of intent, a formal proposal will include:


Cover Page

Title of proposal and contact information of PI


Detailed Budget Page

Detailed justification for first year and second year, if requested


Biographical Sketch/Other Support

NIH style Biosketch


Research Plan

Maximum 2 pages, including a) Specific Aims b) Significance, c) Innovation, d) Approach e) how this award supports future research plans

Please email Letter of Intent, and if invited, applications to: Thomas McIntyre (

Investigators may only submit one application per cycle as Principal Investigator.

Selection Criteria and Review Process
Projects will be assessed based on l: a) relevance to NOAC themes and goals; b) scientific quality; c) likelihood of receiving R01 funding in the future; d) Collaborations/synergies with other NOAC investigators and use of NOAC Cores.

Proposals will be reviewed by the Executive Committee of the NOAC.  Based on these reviews and programmatic goals, the Executive Committee will make recommendations for funding.

For questions please contact Laura Nagy at or 444-4021 or Tom McIntyre at

Pilot Core Table 1





Jeannette Messer, DVM, PhD
Inflammation and Immunology, Cleveland Clinic
New Investigator, new to alcohol research

The role of gut antimicrobial defense in alcoholic liver disease


Andrei Ivanov , PhD
Inflammation and Immunology, Cleveland Clinic
Established Investigator, new to alcohol research

Role of redox-dependent actin filament depolymerization in ethanol-induced disruption of the gut barrier


David Brigstock, PhD
Pediatric Surgery, Nationwide Children’s,
Established investigator, new to alcohol research

Exosomes in Alcoholic Liver Disease


Christopher A. Flask, PhD
Radiology, Pediatrics, CWRU
Clinical Investigator, new to alcohol research

Development of Magnetic Resonance Fingerprinting to Assess Alcoholic Liver and Kidney Disease