ALCOHOL AND TISSUE INJURY
Call for Pilot Project Research Proposals
Clinical and Basic/Translational Projects

Website: http://www.lerner.ccf.org/alcoholcenter/

Submission Deadlines:
Letter of Intent:	February 1, 2019 (email to Thomas McIntyre (mcintyt@ccf.org)
Proposal:	March 1, 2019
Awards: Sponsors:	2 pilot projects with direct costs up to $25,000 Northern Ohio Alcohol Center/Center for Liver Disease Research

Purpose
The NIAAA/NIH-funded P50 Northern Ohio Alcohol Center (NOAC) is seeking applications for basic/translational or clinical projects related to the pathophysiological effects of alcohol on health. The Center seeks to expand the research community and to provide essential support necessary for a successful research application by Assistant to Full Staff/Professor. Topics may include:
1. Measuring biochemical and molecular markers of ethanol-induced stress
2. Assessing cellular responses to ethanol-induced stress
3. Understanding the integrative organismal adaptations to ethanol
4. Translating advances from the laboratory to human clinical experiments

Eligibility
Clinical and basic / translational Assistant to Full Staff/Professor are encouraged to apply.

Award Details
Funding range:                                               $25,000 directs costs, only
Funding start date:                                         Spring 2019, dependent on active IRB/IACUC approvals for the project
Principal investigator and personnel salary:  Allowed
Length of support:                                       1-2 years; funding for the second year is contingent upon evidence of satisfactory progress during year 1, as documented in a progress report
Submission Guidelines
1. A letter of intent comprising no more than one half of one page to include: Investigator(s); Title; Problem; Aims; Anticipated outcomes and conclusions.

2. If invited after review of the letter of intent, a formal proposal will include:

1)	Cover Page	Title of proposal and contact information of PI
2)	Detailed Budget Page	Detailed justification for first year and second year, if requested
3)	Biographical Sketch/Other Support	NIH style Biosketch
4)	Research Plan	Maximum 2 pages, including a) Specific Aims b) Significance, c) Innovation, d) Approach e) how this award supports future research plans

Submission
Please email Letter of Intent, and if invited, applications to: Thomas McIntyre (mcintyt@ccf.org)

Investigators may only submit one application per cycle as Principal Investigator.

Selection Criteria and Review Process
Projects will be assessed based on l: a) relevance to NOAC themes and goals; b) scientific quality; c) likelihood of receiving R01 funding in the future; d) Collaborations/synergies with other NOAC investigators and use of NOAC Cores.

Proposals will be reviewed by the Executive Committee of the NOAC.  Based on these reviews and programmatic goals, the Executive Committee will make recommendations for funding.

For questions please contact Laura Nagy at nagyL3@ccf.org or 444-4021 or Tom McIntyre at mcintyt@ccf.org

Pilot Core Table 1
Year	PI	Title
2019	Jeannette Messer, DVM, PhD Inflammation and Immunology, Cleveland Clinic New Investigator, new to alcohol research	The role of gut antimicrobial defense in alcoholic liver disease
2018	Andrei Ivanov , PhD Inflammation and Immunology, Cleveland Clinic Established Investigator, new to alcohol research	Role of redox-dependent actin filament depolymerization in ethanol-induced disruption of the gut barrier
2016	David Brigstock, PhD Pediatric Surgery, Nationwide Children’s, Established investigator, new to alcohol research	Exosomes in Alcoholic Liver Disease
2016	Christopher A. Flask, PhD Radiology, Pediatrics, CWRU Clinical Investigator, new to alcohol research	Development of Magnetic Resonance Fingerprinting to Assess Alcoholic Liver and Kidney Disease