Director, Program for Advanced Musculoskeletal Imaging
Location: Cleveland Clinic Main Campus
Our laboratory’s focus is on exploring and developing advanced musculoskeletal imaging techniques for a range of orthopaedic and rheumatologic disorders. Collaborations originating in my laboratory and in the new Program in Advanced Medical Imaging will establish Cleveland Clinic as a source of advanced translational imaging, with the aim of providing better healthcare to patients with musculoskeletal conditions.
My team’s multidisciplinary research focuses on developing advanced imaging and image processing techniques to improve early diagnosis and treatment for significant musculoskeletal diseases, including osteoarthritis, inflammatory arthritis, sports injury, and osteoporosis.
We develop sophisticated quantitative magnetic resonance (MRI) and magnetic resonance spectroscopic (MRSI) imaging techniques (new pulse sequences, fast imaging with novel reconstruction) and image‑/data‑processing methodologies. These techniques enable us to: 1) detect early cartilage degeneration and inflammation-related abnormalities/lesions; 2) quantify bone shapes; 3) link MRI and nuclear magnetic resonance (NMR) measures with molecular activities in tissues; 4) quantify bone marrow adiposity, and; 5) explore the relationship with bone quantity/quality.
We have also begun performing research in applying machine-learning/deep-learning techniques for novel reconstruction of accelerated MRI acquisition, automatic tissue segmentation and lesion detection, and automatic diagnostic grading and prediction of patient outcomes.
I am also founding director of the collaborative Program in Advanced Medical Imaging (PAMI), with Carl S. Winalski, MD, Diagnostic Radiology, as Clinical Director. PAMI brings together a number of disciplines, within and outside Cleveland Clinic, to advance musculoskeletal imaging for orthopaedics and rheumatology through technology development, translational research, and education. We aim to establish the PAMI center as a robust global resource for musculoskeletal imaging-based research.
Dr. Li seeks to identify a faster and more efficient non-invasive method to identify patients at risk for osteoarthritis by improving magnetic resonance imaging techniques.