Biomedical Engineering

Cleveland Clinic’s Department of Biomedical Engineering is committed to investigation, innovation and translation of scientific discoveries to enhance patient care. Medical innovation is at the heart of our mission – indeed, our "calling" – and we have a proven track record of patenting and product commercialization.

Cleveland Clinic Innovations, the commercialization arm of Cleveland Clinic, has helped Biomedical Engineering patent therapies in cardiology, urology and neurology. Medical Device Solutions designs and manufactures innovative medical devices and products, and has assisted Biomedical Engineering in the creation of such therapies as the oxygen tension telemetry system and the continuous flow artificial heart.

Success Story

Cleveland Clinic, working with Volcano (now Philips), helped create the industry-leading intravascular ultrasound (IVUS) product line for coronary plaque characterization. This technology uses advanced, proprietary spectral analysis techniques to classify plaque into four tissue types, with 93-97% accuracy.

Success Story

The Regenerative Medicine Laboratory, led by George Muschler, MD, is using advanced imaging and robotic tools to create a novel platform for optimizing tissue-derived, colony-founding connective tissue progenitors. The work will advance the field of cell manufacturing, specifically the expansion of human mesenchymal stromal cells (MSCs), and will greatly improve the quality and reproducibility of MSC manufacturing and use in clinical therapies, drug development and research. Dr. Muschler was awarded $3.3 million from the National Institutes of Health to fund this innovative research.

Department News


Researchers Develop Bionic Arm that Restores Natural Behaviors in Patients with Amputations

Dr. Marasco and his collaborators designed a novel system that combines intuitive motor control, touch and grip kinesthesia for patients with upper-limb amputations.

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High-Intensity Exercise Facilitates Better Manual Dexterity in Parkinson’s Disease Patients

In addition to improving grasping control and coordination, Dr. Alberts and his lab found that an eight-week lower extremity exercise intervention may enhance central nervous system functioning.

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Researchers Look to Enhance Disease-Monitoring Techniques for Multiple Sclerosis

Dr. Nakamura and his team are exploring the expanded use of MRI to be able to improve detection of cortical lesions in the brains of MS patients.

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