Jay  Alberts,  Ph.D.

Jay Alberts, Ph.D.

Staff

The Edward F. and Barbara A. Bell Family Endowed Chair

Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195
Phone: (216) 445-3222

 

The aim of my research is to understand structure-function relationships within the central nervous system and the upper extremity. In particular, my research is focused on determining how grasping forces and torques are controlled and coordinated during functional dexterous manipulations. Investigation of movement patterns produced by different patient groups and healthy adults provides a window into the brain and the control of voluntary movement.

Our current studies work with Parkinson’s disease (PD) patients to determine the role of the basal ganglia in movement control. For instance, we have shown that unilateral deep brain stimulation provides long-term bilateral motor benefits. We are also evaluating the effects of assisted and voluntary exercise on PD motor function. These studies suggest that assisted exercise increases activation patterns within the brain. The objective and quantitative assessment of motor function will aid in disease diagnostic capability and specificity, disease progression and intervention efficacy for patients in whom movement is compromised.

Lay Summary

Our laboratory studies how the brain controls skilled movements, and how changes in the ways the brain works can affect movement. Our first step is to understand how diseases or conditions such as Parkinson's disease, stroke or concussion affect movement and thinking. Once we identify the specific problems associated with these conditions, we then develop and test treatments or ways of monitoring to improve movement and thinking. Our treatment options range from exercise to deep brain stimulation (inserting an electrode that provides an electrical impulse in the brain), a newer treatment for Parkinson’s disease.


View publications for Jay Alberts, PhD.

Seidler RD, Alberts JL, Stelmach GE. Changes in multi-joint performance with age. Motor Control. 2002 Jan;6(1):19-31. doi: 10.1123/mcj.6.1.19.PMID: 11842268

Alberts JL, Saling M, Stelmach GE. Alterations in transport path differentially affect temporal and spatial movement parameters. Exp Brain Res. 2002 Apr;143(4):417-25. doi: 10.1007/s00221-002-1005-0. Epub 2002 Feb 20. PMID: 11914786

Park SW, Butler AJ, Cavalheiro V, Alberts JL, Wolf SL. Changes in serial optical topography and TMS during task performance after constraint-induced movement therapy in stroke: a case study. Neurorehabil Neural Repair. 2004 Jun;18(2):95-105. doi: 10.1177/0888439004265113. PMID: 15228805 

Alberts JL, Elder CM, Okun MS, Vitek JL. Comparison of pallidal and subthalamic stimulation on force control in patient's with Parkinson's disease. Motor Control. 2004 Oct;8(4):484-99. doi: 10.1123/mcj.8.4.484. PMID: 15585903

Alberts JL, Butler AJ, Wolf SL. The effects of constraint-induced therapy on precision grip: a preliminary study. Neurorehabil Neural Repair. 2004 Dec;18(4):250-8. doi: 10.1177/1545968304271370. PMID: 15537995.

Wolf SL, Butler AJ, Alberts JL, Kim MW. Contemporary linkages between EMG, kinetics and stroke rehabilitation. J Electromyogr Kinesiol. 2005 Jun;15(3):229-39. doi: 10.1016/j.jelekin.2005.01.002. PMID: 15763670

Voelcker-Rehage C, Alberts JL. Age-related changes in grasping force modulation. Exp Brain Res. 2005 Sep;166(1):61-70. doi: 10.1007/s00221-005-2342-6. Epub 2005 Aug 12. PMID: 16096780

Voelcker-Rehage C, Stronge AJ, Alberts JL. Age-related differences in working memory and force control under dual-task conditions. Neuropsychol Dev Cogn B Aging Neuropsychol Cogn. 2006 Sep-Dec;13(3-4):366-84. doi: 10.1080/138255890969339. PMID: 16887779

Frick EM, Alberts JL. Combined use of repetitive task practice and an assistive robotic device in a patient with subacute stroke. Phys Ther. 2006 Oct;86(10):1378-86. doi: 10.2522/ptj.20050149. PMID: 17012642

Voelcker-Rehage C, Alberts JL. Effect of motor practice on dual-task performance in older adults. J Gerontol B Psychol Sci Soc Sci. 2007 May;62(3):P141-8. doi: 10.1093/geronb/62.3.p141. PMID: 17507581

Rosenstein L, Ridgel AL, Thota A, Samame B, Alberts JL. Effects of combined robotic therapy and repetitive-task practice on upper-extremity function in a patient with chronic stroke. Am J Occup Ther. 2008 Jan-Feb;62(1):28-35. doi: 10.5014/ajot.62.1.28. PMID: 18254428

Alberts JL, Hass CJ, Vitek JL, Okun MS. Are two leads always better than one: an emerging case for unilateral subthalamic deep brain stimulation in Parkinson's disease. Exp Neurol. 2008 Nov;214(1):1-5. doi: 10.1016/j.expneurol.2008.07.019. Epub 2008 Jul 31. PMID: 18718469 

Mera TO, Johnson MD, Rothe D, Zhang J, Xu W, Ghosh D, Vitek J, Alberts JL. Objective quantification of arm rigidity in MPTP-treated primates. J Neurosci Methods. 2009 Feb 15;177(1):20-9. doi: 10.1016/j.jneumeth.2008.09.017. Epub 2008 Sep 26. PMID: 18930079  

Alberts JL, Voelcker-Rehage C, Hallahan K, Vitek M, Bamzai R, Vitek JL. Bilateral subthalamic stimulation impairs cognitive-motor performance in Parkinson's disease patients. Brain. 2008 Dec;131(Pt 12):3348-60. doi: 10.1093/brain/awn238. Epub 2008 Oct 7. PMID: 18842609

Alberts, J.L., Voelcker-Rehage C., Hallahan, K., Vitek, M., Bamzai, R., and Vitek, J.L. (2008) Bilateral subthalamic stimulation impairs cognitive-motor performance in Parkinson’s disease patients. Brain, 131(12)3348-60.

Ridgel, A., Thota, A., Vitek, J.L. and Alberts, J.L. (2009)  Forced, not voluntary, exercise improves motor function in Parkinson’s disease patients. Journal of Neurorehabilitation and Neural Repair, PMID: 19131578.

Mera, T.O., Johnson, M.D., Rothe, D., Zhang, J., Xu, W., Ghosh, D., Vitek, J.L., and Alberts, J.L. (2009) Objective quantification of arm rigidity in MPTP-treated primates.. Journal of Neuroscience Methods, 177(1):20-9.

Alberts JL, Wolf SL. The use of kinetics as a marker for manual dexterity after stroke and stroke recovery. Top Stroke Rehabil. 2009 Jul-Aug;16(4):223-36. doi: 10.1310/tsr1604-223.

McIntyre CC, Frankenmolle AM, Wu J, Noecker AM, Alberts JL. Customizing deep brain stimulation to the patient using computational models. Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:4228-9. doi: 10.1109/IEMBS.2009.5334592.

Stewart KC, Fernandez HH, Okun MS, Alberts JL, Malaty IA, Rodriguez RL, Hass CJ. Effects of dopaminergic medication on objective tasks of deftness, bradykinesia and force control. J Neurol. 2009 Dec;256(12):2030-5. doi: 10.1007/s00415-009-5235-y.

Frankemolle AM, Wu J, Noecker AM, Voelcker-Rehage C, Ho JC, Vitek JL, McIntyre CC, Alberts JL. Reversing cognitive-motor impairments in Parkinson's disease patients using a computational modelling approach to deep brain stimulation programming. Brain. 2010 Mar;133(Pt 3):746-61. doi: 10.1093/brain/awp315.

Kutner NG, Zhang R, Butler AJ, Wolf SL, Alberts JL. Quality-of-life change associated with robotic-assisted therapy to improve hand motor function in patients with subacute stroke: a randomized clinical trial. Phys Ther. 2010 Apr;90(4):493-504. doi: 10.2522/ptj.20090160.

Alberts JL, Hallahan K, Thota A, Noecker AM, Vitek JL, McIntyre CC. Reducing cognitive-motor declines associated with bilateral subthalamic deep brain stimulation through computational modelling in a Parkinson's disease patient. J Neurol Neurosurg Psychiatry. 2010 Oct;81(10):1170-2. doi: 10.1136/jnnp.2008.160093.

Ridgel AL, Kim CH, Fickes EJ, Muller MD, Alberts JL. Changes in executive function after acute bouts of passive cycling in Parkinson's disease. J Aging Phys Act. 2011 Apr;19(2):87-98. doi: 10.1123/japa.19.2.87.

Alberts JL, Linder SM, Penko AL, Lowe MJ, Phillips M. It is not about the bike, it is about the pedaling: forced exercise and Parkinson's disease. Exerc Sport Sci Rev. 2011 Oct;39(4):177-86. doi: 10.1097/JES.0b013e31822cc71a.

McIntyre CC, Richardson SJ, Frankemolle AM, Varga G, Noecker AM, Alberts JL. Improving postural stability via computational modeling approach to deep brain stimulation programming. Annu Int Conf IEEE Eng Med Biol Soc. 2011;2011:675-6. doi: 10.1109/IEMBS.2011.6090151.

Mera T, Vitek JL, Alberts JL, Giuffrida JP. Kinematic optimization of deep brain stimulation across multiple motor symptoms in Parkinson's disease. J Neurosci Methods. 2011 Jun 15;198(2):280-6. doi: 10.1016/j.jneumeth.2011.03.019.

Glielmi CB, Butler AJ, Niyazov DM, Darling WG, Epstein CM, Alberts JL, Hu XP. Assessing low-frequency repetitive transcranial magnetic stimulation with functional magnetic resonance imaging: a case series. Physiother Res Int. 2014 Jun;19(2):117-25. doi: 10.1002/pri.518. Epub 2011 Jul 18. PMID: 21766399

Ridgel AL, Abdar HM, Alberts JL, Discenzo FM, Loparo KA. Variability in cadence during forced cycling predicts motor improvement in individuals with Parkinson's disease. IEEE Trans Neural Syst Rehabil Eng. 2013 May;21(3):481-9. doi: 10.1109/TNSRE.2012.2225448. Epub 2012 Oct 24.PMID: 23144045  

Linder SM, Rosenfeldt AB, Reiss A, Buchanan S, Sahu K, Bay CR, Wolf SL, Alberts JL. The home stroke rehabilitation and monitoring system trial: a randomized controlled trial. Int J Stroke. 2013 Jan;8(1):46-53. doi: 10.1111/j.1747-4949.2012.00971.x. PMID: 23280269

Beall EB, Lowe MJ, Alberts JL, Frankemolle AM, Thota AK, Shah C, Phillips MD. The effect of forced-exercise therapy for Parkinson's disease on motor cortex functional connectivity. Brain Connect. 2013;3(2):190-8. doi: 10.1089/brain.2012.0104. Epub 2013 Feb 25. PMID: 23316956

Gorniak SL, Alberts JL. Effects of task complexity on grip-to-load coordination in bimanual actions. Exp Brain Res. 2013 Apr;225(4):559-67. doi: 10.1007/s00221-012-3395-y. Epub 2013 Jan 10. PMID: 23307159

Plow M, Moore SM, Kirwan JP, Frost F, Katzan I, Jaeger S, Alberts J. Randomized controlled pilot study of a SystemCHANGE™ weight management intervention in stroke survivors: rationale and protocol. Trials. 2013 May 7;14:130. doi: 10.1186/1745-6215-14-130. PMID: 23782741 

Gorniak SL, Machado AG, Alberts JL.  Force coordination during bimanual task performance in Parkinson's disease. Exp Brain Res. 2013 Aug;229(2):261-71. doi: 10.1007/s00221-013-3608-z. Epub 2013 Jun 29. PMID: 23811728

Gorniak SL, Alberts JL. Effects of aging on force coordination in bimanual task performance. Exp Brain Res. 2013 Aug;229(2):273-84. doi: 10.1007/s00221-013-3644-8. Epub 2013 Jul 14 PMID: 23852325

Linder SM, Reiss A, Buchanan S, Sahu K, Rosenfeldt AB, Clark C, Wolf SL, Alberts JL. Incorporating robotic-assisted telerehabilitation in a home program to improve arm function following stroke. J Neurol Phys Ther. 2013 Sep;37(3):125-32. doi: 10.1097/NPT.0b013e31829fa808. PMID: 23872687 

Gorniak SL, McIntyre CC, Alberts JL. Bimanual force coordination in Parkinson's disease patients with bilateral subthalamic deep brain stimulation. PLoS One. 2013 Nov 11;8(11):e78934. doi: 10.1371/journal.pone.0078934. eCollection 2013. PMID: 24244388  

Gorniak SL, Plow M, McDaniel C, Alberts JL. Impaired Object Handling during Bimanual Task Performance in Multiple Sclerosis. Mult Scler Int. 2014;2014:450420. doi: 10.1155/2014/450420. Epub 2014 Aug 6. PMID: 25170424

Ringenbach SD, Albert AR, Chen CC, Alberts JL. Acute bouts of assisted cycling improves cognitive and upper extremity movement functions in adolescents with Down syndrome. Intellect Dev Disabil. 2014 Apr;52(2):124-35. doi: 10.1352/1934-9556-52.2.124 PMID: 24725111

Rudick RA, Miller D, Bethoux F, Rao SM, Lee JC, Stough D, Reece C, Schindler D, Mamone B, Alberts J. The Multiple Sclerosis Performance Test (MSPT): an iPad-based disability assessment tool. J Vis Exp. 2014 Jun 30;(88):e51318. doi: 10.3791/51318. PMID: 25046650

Mills KA, Markun LC, San Luciano M, Rizk R, Allen IE, Racine CA, Starr PA, Alberts JL, Ostrem JL. Effect of subthalamic nucleus deep brain stimulation on dual-task cognitive and motor performance in isolated dystonia. J Neurol Neurosurg Psychiatry. 2015 Apr;86(4):404-9. doi: 10.1136/jnnp-2014-307942. Epub 2014 Jul 10. PMID: 25012202

Nock NL, Dimitropoulos A, Rao SM, Flask CA, Schluchter M, Zanotti KM, Rose PG, Kirwan JP, Alberts J. Rationale and design of REWARD (revving-up exercise for sustained weight loss by altering neurological reward and drive): a randomized trial in obese endometrial cancer survivors. Contemp Clin Trials. 2014 Nov;39(2):236-45. doi: 10.1016/j.cct.2014.08.008. Epub 2014 Aug 17. PMID: 25139726  

Ozinga SJ, Alberts JL. Quantification of postural stability in older adults using mobile technology. Exp Brain Res. 2014 Dec;232(12):3861-72. doi: 10.1007/s00221-014-4069-8. Epub 2014 Aug 24. PMID: 25150554

Penko AL, Hirsch JR, Voelcker-Rehage C, Martin PE, Blackburn G, Alberts JL. Asymmetrical pedaling patterns in Parkinson's disease patients. Clin Biomech (Bristol, Avon). 2014 Dec;29(10):1089-94. doi: 10.1016/j.clinbiomech.2014.10.006. Epub 2014 Oct 29. PMID: 25467810

Linder SM, Rosenfeldt AB, Bay RC, Sahu K, Wolf SL, Alberts JL. Improving Quality of Life and Depression After Stroke Through Telerehabilitation. Am J Occup Ther. 2015 Mar-Apr;69(2):6902290020p1-10. doi: 10.5014/ajot.2015.014498. PMID: 26122686 

Wolf SL, Sahu K, Bay RC, Buchanan S, Reiss A, Linder S, Rosenfeldt A, Alberts J. The HAAPI (Home Arm Assistance Progression Initiative) Trial: A Novel Robotics Delivery Approach in Stroke Rehabilitation. Neurorehabil Neural Repair. 2015 Nov-Dec;29(10):958-68. doi: 10.1177/1545968315575612. Epub 2015 Mar 17. PMID: 25782693 

Ozinga SJ, Machado AG, Miller Koop M, Rosenfeldt AB, Alberts JL. Objective assessment of postural stability in Parkinson's disease using mobile technology. Mov Disord. 2015 Aug;30(9):1214-21. doi: 10.1002/mds.26214. Epub 2015 Mar 25. PMID: 25809137

Alberts JL, Hirsch JR, Koop MM, Schindler DD, Kana DE, Linder SM, Campbell S, Thota AK. Using Accelerometer and Gyroscopic Measures to Quantify Postural Stability. J Athl Train. 2015 Jun;50(6):578-88. doi: 10.4085/1062-6050-50.2.01. Epub 2015 Apr 6. PMID: 25844853

Rosenfeldt AB, Rasanow M, Penko AL, Beall EB, Alberts JL. The cyclical lower extremity exercise for Parkinson's trial (CYCLE): methodology for a randomized controlled trial. BMC Neurol. 2015 Apr 24;15:63. doi: 10.1186/s12883-015-0313-5.PMID: 25902768 

Linder SM, Rosenfeldt AB, Rasanow M, Alberts JL. Forced Aerobic Exercise Enhances Motor Recovery After Stroke: A Case Report. Am J Occup Ther. 2015 Jul-Aug;69(4):6904210010p1-8. doi: 10.5014/ajot.2015.015636. PMID: 26114455

Alberts JL, Thota A, Hirsch J, Ozinga S, Dey T, Schindler DD, Koop MM, Burke D, Linder SM. Quantification of the Balance Error Scoring System with Mobile Technology. Med Sci Sports Exerc. 2015 Oct;47(10):2233-40. doi: 10.1249/MSS.0000000000000656. PMID: 26378948

Shah C, Beall EB, Frankemolle AM, Penko A, Phillips MD, Lowe MJ, Alberts JL. Exercise Therapy for Parkinson's Disease: Pedaling Rate Is Related to Changes in Motor Connectivity. Brain Connect. 2016 Feb;6(1):25-36. doi: 10.1089/brain.2014.0328. Epub 2015 Oct 20. PMID: 26414696

Rosenfeldt AB, Dey T, Alberts JL. Aerobic Exercise Preserves Olfaction Function in Individuals with Parkinson's Disease. Parkinsons Dis. 2016;2016:9725089. doi: 10.1155/2016/9725089. Epub 2016 Nov 23. PMID: 27999706

Alberts JL, Phillips M, Lowe MJ, Frankemolle A, Thota A, Beall EB, Feldman M, Ahmed A, Ridgel AL. Cortical and motor responses to acute forced exercise in Parkinson's disease. Parkinsonism Relat Disord. 2016 Mar;24:56-62. doi: 10.1016/j.parkreldis.2016.01.015. Epub 2016 Jan 22. PMID: 26857399

Burke D, Linder S, Hirsch J, Dey T, Kana D, Ringenbach S, Schindler D, Alberts J. Characterizing Information Processing With a Mobile Device: Measurement of Simple and Choice Reaction Time. Assessment. 2017 Oct;24(7):885-895. doi: 10.1177/1073191116633752. Epub 2016 Mar 1.PMID: 26933140 

Xiao R, Miller JA, Lubelski D, Alberts JL, Mroz TE, Benzel EC, Krishnaney AA, Machado AG. Quality of life outcomes following cervical decompression for coexisting Parkinson's disease and cervical spondylotic myelopathy. Spine J. 2016 Nov;16(11):1358-1366. doi: 10.1016/j.spinee.2016.07.530. Epub 2016 Aug 2. PMID: 27496286

Ozinga SJ, Linder SM, Alberts JL. Use of Mobile Device Accelerometry to Enhance Evaluation of Postural Instability in Parkinson Disease. Arch Phys Med Rehabil. 2017 Apr;98(4):649-658. doi: 10.1016/j.apmr.2016.08.479. Epub 2016 Sep 23. PMID: 27670925

Penko AL, Barkley JE, Koop MM, Alberts JL. Borg scale is valid for ratings of perceived exertion for individuals with Parkinson's disease. Int J Exerc Sci. 2017 Jan 1;10(1):76-86. eCollection 2017. PMID: 28479949

Ozinga SJ, Koop MM, Linder SM, Machado AG, Dey T, Alberts JL. Three-dimensional evaluation of postural stability in Parkinson's disease with mobile technology. NeuroRehabilitation. 2017;41(1):211-218. doi: 10.3233/NRE-171473. PMID: 28527232

Rao SM, Losinski G, Mourany L, Schindler D, Mamone B, Reece C, Kemeny D, Narayanan S, Miller DM, Bethoux F, Bermel RA, Rudick R, Alberts J. Processing speed test: Validation of a self-administered, iPad®-based tool for screening cognitive dysfunction in a clinic setting. Mult Scler. 2017 Dec;23(14):1929-1937. doi: 10.1177/1352458516688955. Epub 2017 Jan 12. PMID: 28080262

Linder SM, Rosenfeldt AB, Dey T, Alberts JL. Forced Aerobic Exercise Preceding Task Practice Improves Motor Recovery Poststroke. Am J Occup Ther. 2017 Mar/Apr;71(2):7102290020p1-7102290020p9. doi: 10.5014/ajot.2017.020297. PMID: 28218596

van der Kolk NM, de Vries NM, Penko AL, van der Vlugt M, Mulder AA, Post B, Alberts JL, Bloem BR. A remotely supervised home-based aerobic exercise programme is feasible for patients with Parkinson's disease: results of a small randomised feasibility trial.  J Neurol Neurosurg Psychiatry. 2018 Sep;89(9):1003-1005. doi: 10.1136/jnnp-2017-315728. Epub 2017 Jun 12. PMID: 28607121.

Nock NL, Minnes S, Alberts JL. Neurobiology of substance use in adolescents and potential therapeutic effects of exercise for prevention and treatment of substance use disorders. Birth Defects Res. 2017 Dec 1;109(20):1711-1729. doi: 10.1002/bdr2.1182. PMID: 29251846 Review.

Baron EI, Miller Koop M, Streicher MC, Rosenfeldt AB, Alberts JL. Altered kinematics of arm swing in Parkinson's disease patients indicates declines in gait under dual-task conditions. Parkinsonism Relat Disord. 2018 Mar;48:61-67. doi: 10.1016/j.parkreldis.2017.12.017. Epub 2017 Dec 19. PMID: 29276008

Linder SM, Rosenfeldt AB, Bazyk AS, Koop MM, Ozinga S, Alberts JL. Improved lower extremity pedaling mechanics in individuals with stroke under maximal workloads. Top Stroke Rehabil. 2018 May;25(4):248-255. doi: 10.1080/10749357.2018.1437935. Epub 2018 Feb 15. PMID: 29447080

Penko AL, Streicher MC, Koop MM, Dey T, Rosenfeldt AB, Bazyk AS, Alberts JL. Dual-task Interference Disrupts Parkinson's Gait Across Multiple Cognitive Domains. Neuroscience. 2018 May 21;379:375-382. doi: 10.1016/j.neuroscience.2018.03.021. Epub 2018 Mar 22. PMID: 29577998

Miller Koop M, Ozinga SJ, Rosenfeldt AB, Alberts JL. Quantifying turning behavior and gait in Parkinson's disease using mobile technology. IBRO Rep. 2018 Jun 21;5:10-16. doi: 10.1016/j.ibror.2018.06.002. eCollection 2018 Dec. PMID: 30135951

Ozinga SJ, Linder SM, Koop MM, Dey T, Figler R, Russman AN, So R, Rosenthal AH, Cruickshank J, Alberts JL. Normative Performance on the Balance Error Scoring System by Youth, High School, and Collegiate Athletes. J Athl Train. 2018 Jul;53(7):636-645. doi: 10.4085/1062-6050-129-17. Epub 2018 Aug 15. PMID: 30109948

Linder SM, Ozinga SJ, Koop MM, Dey T, Figler R, Cruickshank J, Alberts JL. Cleveland Clinic Postural Stability Index Norms for the Balance Error Scoring System. Med Sci Sports Exerc. 2018 Oct;50(10):1998-2006. doi: 10.1249/MSS.0000000000001660. PMID: 29794620

Wojcik CM, Rao SM, Schembri AJ, Drake AS, Maruff P, Schindler D, Alberts J, Yasin F, Pol J, Weinstock-Guttman B, Benedict RH. Necessity of technicians for computerized neuropsychological assessment devices in multiple sclerosis.  Mult Scler. 2020 Jan;26(1):109-113. doi: 10.1177/1352458518813287. Epub 2018 Nov 22. PMID: 30465463

Combined Aerobic Exercise and Task Practice Improve Health-Related Quality of Life Poststroke: A Preliminary Analysis. Rosenfeldt AB, Linder SM, Davidson S, Clark C, Zimmerman NM, Lee JJ, Alberts JL. Arch Phys Med Rehabil. 2019 May;100(5):923-930. doi: 10.1016/j.apmr.2018.11.011. Epub 2018 Dec 10. PMID: 30543801 

Alberts JL, Modic MT, Udeh B, Dey T, Cherian K, Lu X, Figler R, Russman A, Linder SM. Development and Implementation of a Multi-Disciplinary Technology Enhanced Care Pathway for Youth and Adults with Concussion. J Vis Exp. 2019 Jan 20;(143). doi: 10.3791/58962. PMID: 30735197

Miller Koop M, Rosenfeldt AB, Alberts JL. Mobility improves after high intensity aerobic exercise in individuals with Parkinson's disease. J Neurol Sci. 2019 Apr 15;399:187-193. doi: 10.1016/j.jns.2019.02.031. Epub 2019 Feb 21. PMID: 30826715

Linder SM, Koop MM, Ozinga S, Goldfarb Z, Alberts JL. A Mobile Device Dual-Task Paradigm for the Assessment of mTBI. Mil Med. 2019 Mar 1;184(Suppl 1):174-180. doi: 10.1093/milmed/usy334. PMID: 30901418

Linder SM, Cruickshank J, Zimmerman NM, Figler R, Alberts JL. A technology-enabled electronic incident report to document and facilitate management of sport concussion: A cohort study of youth and young adults. Medicine (Baltimore). 2019 Apr;98(14):e14948. doi: 10.1097/MD.0000000000014948. PMID: 30946318

Maldonado-Naranjo A, Koop MM, Hogue O, Alberts J, Machado A. Kinematic Metrics from a Wireless Stylus Quantify Tremor and Bradykinesia in Parkinson's Disease. Parkinsons Dis. 2019 Apr 2;2019:6850478. doi: 10.1155/2019/6850478. eCollection 2019. PMID: 31061696

Gorodeski EZ, Rosenfeldt AB, Fang K, Kubu C, Rao SM, Jansen EA, Dey T, Alberts JL. An iPad-based Measure of Processing Speed in Older Adults Hospitalized for Heart Failure. J Cardiovasc Nurs. 2019 May/Jun;34(3):E9-E13. doi: 10.1097/JCN.0000000000000568.PMID: 30921170

Rhodes JK, Schindler D, Rao SM, Venegas F, Bruzik ET, Gabel W, Williams JR, Phillips GA, Mullen CC, Freiburger JL, Mourany L, Reece C, Miller DM, Bethoux F, Bermel RA, Krupp LB, Mowry EM, Alberts J, Rudick RA. Multiple Sclerosis Performance Test: Technical Development and Usability. Adv Ther. 2019 Jul;36(7):1741-1755. doi: 10.1007/s12325-019-00958-x. Epub 2019 May 3. PMID: 31054035

Rosenfeldt AB, Penko AL, Streicher MC, Zimmerman NM, Koop MM, Alberts JL. Improvements in temporal and postural aspects of gait vary following single- and multi-modal training in individuals with Parkinson's disease.  Parkinsonism Relat Disord. 2019 Jul;64:280-285. doi: 10.1016/j.parkreldis.2019.05.021. Epub 2019 May 14. PMID: 31103489

Bartsch AJ, McCrea MM, Hedin DS, Gibson PL, Miele VJ, Benzel EC, Alberts JL, Samorezov S, Shah A, Stemper BS. Laboratory and On-field Data Collected by a Head Impact Monitoring Mouthguard. Annu Int Conf IEEE Eng Med Biol Soc. 2019 Jul;2019:2068-2072. doi: 10.1109/EMBC.2019.8856907. PMID: 31946308

Linder SM, Rosenfeldt AB, Davidson S, Zimmerman N, Penko A, Lee J, Clark C, Alberts JL. Forced, Not Voluntary, Aerobic Exercise Enhances Motor Recovery in Persons With Chronic Stroke. Neurorehabil Neural Repair. 2019 Aug;33(8):681-690. doi: 10.1177/1545968319862557. Epub 2019 Jul 17.PMID: 31313626 

Miller DM, Moss B, Rose S, Li H, Schindler D, Weber M, Planchon SM, Alberts J, Boissy A, Bermel R. Obtaining Patient Priorities in a Multiple Sclerosis Comprehensive Care Center: Beyond Patient-Reported Outcomes. J Patient Exp. 2020 Aug;7(4):541-548. doi: 10.1177/2374373519864011. Epub 2019 Jul 24. PMID: 33062876

Nock NL, Dimitropoulos A, Zanotti KM, Waggoner S, Nagel C, Golubic M, Michener CM, Kirwan JP, Alberts J. Sleep, quality of life, and depression in endometrial cancer survivors with obesity seeking weight loss. Support Care Cancer. 2020 May;28(5):2311-2319. doi: 10.1007/s00520-019-05051-1. Epub 2019 Sep 2. PMID: 31478164

Penko AL, Barkley JE, Rosenfeldt AB, Alberts JL. Multimodal Training Reduces Fall Frequency as Physical Activity Increases in Individuals With Parkinson's Disease. J Phys Act Health. 2019 Dec 1;16(12):1085-1091. doi: 10.1123/jpah.2018-0595. Epub 2019 Oct 24. PMID: 31648204

Rachitskaya A, Yuan A, Davidson S, Streicher M, DeBenedictis M, Rosenfeldt AB, Alberts J. Computer-Assisted Immersive Visual Rehabilitation in Argus II Retinal Prosthesis Recipients. Ophthalmol Retina. 2020 Jun;4(6):613-619. doi: 10.1016/j.oret.2019.11.007. Epub 2019 Nov 15. PMID: 31937474

Linder SM, Davidson S, Rosenfeldt A, Penko A, Lee J, Koop MM, Phelan D, Alberts JL. Predictors of Improved Aerobic Capacity in Individuals With Chronic Stroke Participating in Cycling Interventions. Arch Phys Med Rehabil. 2020 Apr;101(4):717-721. doi: 10.1016/j.apmr.2019.10.187. Epub 2019 Nov 25.PMID: 31778659 

Rosenfeldt AB, Penko AL, Bazyk AS, Streicher MC, Dey T, Alberts JL. The Two Minute Walk Test Overground and on a Self-Paced Treadmill Detects Dual Task Deficits in Individuals With Parkinson's Disease. J Aging Phys Act. 2019 Dec 1;27(4):843-847. doi: 10.1123/japa.2018-0264. PMID: 31034314 

Alberts JL, Rosenfeldt AB. The Universal Prescription for Parkinson's Disease: Exercise. J Parkinsons Dis. 2020;10(s1):S21-S27. doi: 10.3233/JPD-202100. PMID: 32925109 Review.

McGrath MK, Linder SM, Koop MM, Zimmerman N, Ballantyne MAJ, Ahrendt DM, Alberts JL. Military-Specific Normative Data for Cognitive and Motor Single- and Dual-Task Assessments for Use in Mild Traumatic Brain Injury Assessment. Mil Med. 2020 Jan 7;185(Suppl 1):176-183. doi: 10.1093/milmed/usz261. PMID: 32074318

Bartsch A, Dama R, Alberts J, Samorezov S, Benzel E, Miele V, Shah A, Humm J, McCrea M, Stemper B. Measuring Blunt Force Head Impacts in Athletes. Mil Med. 2020 Jan 7;185(Suppl 1):190-196. doi: 10.1093/milmed/usz334. PMID: 32074346

Alberts JL, Modic MT, Udeh BL, Zimmerman N, Cherian K, Lu X, Gray R, Figler R, Russman A, Linder SM. A Technology-Enabled Concussion Care Pathway Reduces Costs and Enhances Care. Phys Ther. 2020 Jan 23;100(1):136-148. doi: 10.1093/ptj/pzz141. PMID: 31584666

Chakraborty S, Dey T, Mukherjee A, Alberts JL, Linder SM. Functional modeling of pedaling kinematics for the Stroke patients. J Biopharm Stat. 2020 Jul 3;30(4):674-688. doi: 10.1080/10543406.2020.1730872. Epub 2020 Mar 4. PMID: 32129143

Macaron G, Moss BP, Li H, Baldassari LE, Rao SM, Schindler D, Alberts JL, Weber M, Ayers M, Bethoux F, Boissy A, Chizmadia D, Conway DS, Fink C, Fox RJ, Gales S, Green B, Hara-Cleaver C, Jordan N, Mahajan KR, McGinley MP, Miller DM, Namey M, Rae-Grant A, Rensel M, Young H, Willis MA, Ontaneda D, Cohen JA, Bermel RA. Technology-enabled assessments to enhance multiple sclerosis clinical care and research. Neurol Clin Pract. 2020 Jun;10(3):222-231. doi: 10.1212/CPJ.0000000000000710. PMID: 32642324

Nock NL, Jiang H, Borato L, Alberts J, Dimitropoulos A. Insights to the neural response to food cues in class III compared with class I and II obese adults using a sample of endometrial cancer survivors seeking weight loss. Nutr Diabetes. 2020 Jun 15;10(1):21. doi: 10.1038/s41387-020-0124-7. PMID: 32541652

Penko AL, Streicher MC, Dey T, Rosenfeldt AB, Alberts JL. Parkinson's gait kinematics deteriorates across multiple cognitive domains under dual-task paradigms. Clin Neurol Neurosurg. 2020 Oct;197:106083. doi: 10.1016/j.clineuro.2020.106083. Epub 2020 Jul 10. PMID: 32683199

Pascoe M, Alberts J, Wang L, Bruton M, Rogen B, Rehm SJ, McHugh L, Katzan I, Foldvary-Schaefer N. Feasibility of electronic sleep disorder screening in healthcare workers of a large healthcare system. Sleep Med. 2020 Sep;73:181-186. doi: 10.1016/j.sleep.2020.07.028. Epub 2020 Aug 4. PMID: 32846280

Linder SM, Davidson S, Rosenfeldt A, Lee J, Koop MM, Bethoux F, Alberts JL. Forced and Voluntary Aerobic Cycling Interventions Improve Walking Capacity in Individuals With Chronic Stroke. Arch Phys Med Rehabil. 2021 Jan;102(1):1-8. doi: 10.1016/j.apmr.2020.08.006. Epub 2020 Sep 9. PMID: 32918907 

Bartsch AJ, Hedin D, Alberts J, Benzel EC, Cruickshank J, Gray RS, Cameron K, Houston MN, Rooks T, McGinty G, Kozlowski E, Rowson S, Maroon JC, Miele VJ, Ashton JC, Siegmund GP, Shah A, McCrea M, Stemper B. High Energy Side and Rear American Football Head Impacts Cause Obvious Performance Decrement on Video. Ann Biomed Eng. 2020 Nov;48(11):2667-2677. doi: 10.1007/s10439-020-02640-8. Epub 2020 Oct 27. PMID: 33111969

Rosenfeldt AB, Koop MM, Fernandez HH, Alberts JL. High intensity aerobic exercise improves information processing and motor performance in individuals with Parkinson's disease. Exp Brain Res. 2021 Mar;239(3):777-786. doi: 10.1007/s00221-020-06009-0. Epub 2021 Jan 4. PMID: 33394100

Penko AL, Zimmerman NM, Crawford M, Linder SM, Alberts JL. Effect of Aerobic Exercise on Cardiopulmonary Responses and Predictors of Change in Individuals With Parkinson's Disease. Arch Phys Med Rehabil. 2021 May;102(5):925-931. doi: 10.1016/j.apmr.2020.12.011. Epub 2021 Jan 14. PMID: 33453190

Penko AL, Linder SM, Miller Koop M, Dey T, Alberts JL. Quantification of Dual-task Performance in Healthy Young Adults Suitable for Military Use. Mil Med. 2021 Jan 25;186(Suppl 1):58-64. doi: 10.1093/milmed/usaa404. PMID: 33499500

Linder SM, Koop MM, Tucker D, Guzi K, Gray DC, Alberts JL. Development and Validation of a Mobile Application to Detect Visual Dysfunction Following Mild Traumatic Brain Injury. Mil Med. 2021 Jan 25;186(Suppl 1):584-591. doi: 10.1093/milmed/usaa360. PMID: 33499531

Alberts JL, Koop MM, McGinley MP, Penko AL, Fernandez HH, Shook S, Bermel RA, Machado A, Rosenfeldt AB. Use of a Smartphone to Gather Parkinson's Disease Neurological Vital Signs during the COVID-19 Pandemic. Parkinsons Dis. 2021 Apr 8;2021:5534282. doi: 10.1155/2021/5534282. eCollection 2021. PMID: 33868630

Ozinga SJ, Baron E, Koop MM, Bazyk A, Alberts JL. Errors in cognitive performance trigger postural instability in Parkinson's disease. Parkinsonism Relat Disord. 2021 Apr 20;86:91-96. doi: 10.1016/j.parkreldis.2021.04.002. Online ahead of print. PMID: 33895539

Jansen AE, Koop MM, Rosenfeldt AB, Alberts JL. High intensity aerobic exercise improves bimanual coordination of grasping forces in Parkinson's disease. Parkinsonism Relat Disord. 2021 Apr 20;87:13-19. doi: 10.1016/j.parkreldis.2021.04.005. Online ahead of print. PMID: 33932704 

Bernick C, Shan G, Bennett L, Alberts J, Cummings J. Assessing Clinical Change in Individuals Exposed to Repetitive Head Impacts: The Repetitive Head Impact Composite Index. Front Neurol. 2021 Jul 6;12:605318. doi: 10.3389/fneur.2021.605318. PMID: 34295295; PMCID: PMC8290321.

Rosenfeldt AB, Miller Koop M, Penko AL, Alberts JL. Individuals With Parkinson Disease Are Adherent to a High-Intensity Community-Based Cycling Exercise Program. J Neurol Phys Ther. 2021 Aug 5. doi: 10.1097/NPT.0000000000000370. Epub ahead of print. PMID: 34369453.


US Patent Patent Title Issue Date First-Named Inventor
8,608,622 Systems and Methods for Improving Motor Function with Assisted Exercise 12/17/2013 Jay Alberts Ph.D.
8,562,488 Systems and Methods for Improving Motor Function with Assisted Exercise 10/22/2013 Jay Alberts Ph.D.

07/14/2021 |  

High-Intensity Exercise Facilitates Better Manual Dexterity in Parkinson’s Disease Patients

Researchers in the Department of Biomedical Engineering have found that high-intensity aerobic exercise may help improve bimanual dexterity among patients with Parkinson’s disease (PD). Patients who have PD commonly have tremors in their limbs and/or difficulty with muscular coordination.




03/18/2021 |  

New Smartphone App Could Transform Concussion Management of Military Personnel

Researchers from the Department of Biomedical Engineering, led by Jay Alberts, PhD, have developed a mobile application that can accurately quantify cognitive and motor functions, which may be used in the management of mild traumatic brain injury (mTBI, or concussion). In an article in Military Medicine, the researchers report that the application has the potential to be extremely helpful in assessing performance in military personnel, who may experience mTBI in the field.




03/01/2021 |  

Aerobic Exercise Can Help Parkinson’s Patients Improve Heart Health

In a new study published in the Archives of Physical Medicine and Rehabilitation, investigators in the lab of Jay Alberts, PhD, have shown that high-intensity aerobic exercise (on a stationary bike) confers significant cardiopulmonary benefits for patients with Parkinson’s disease (PD)—a disorder of the nervous system that most commonly affects movement and motor control.




02/16/2021 |  

Using Artificial Intelligence to Tackle Cognitive Impairment in Former NFL Players

Cleveland Clinic, in collaboration with the National Football League Players Association (NFLPA), is launching a research initiative to use artificial intelligence (AI) and machine learning to better characterize neurological disease, and ultimately improve diagnosis, prognosis prediction, and disease intervention and prevention.




01/19/2021 |  

CYCLE-AD Trial: Testing High-Intensity Exercise to Stave Off Alzheimer’s Disease

The National Institute on Aging, part of the National Institutes of Health, has awarded Cleveland Clinic a five-year, $6.7 million grant to evaluate the effect of high-intensity exercise—using a home-based, internet-connected indoor cycle—on preventing Alzheimer’s disease (AD) in people at high genetic risk of the disease.




11/13/2019 |  

Obesity Has Negative Effect On Sleep, Quality of Life of Endometrial Cancer Survivors

Endometrial cancer survivors who are more obese have an overall lower quality of life, including poorer sleep and higher levels of depression, according to a new study in the journal Supportive Care in Cancer. The study—led by Jay Alberts, PhD, Lerner Research Institute Department of Biomedical Engineering, and funded by the National Institutes of Health—was a collaboration between Cleveland Clinic and Case Western Reserve University (CWRU). Nora Nock, PhD, Department of Population and Quantitative Health Sciences, CWRU, was first author on the study.




09/03/2019 |  

$2M DoD Grant for Augmented Reality Protocols to Help Troops Return to Duty After Brain Injury

Jay Alberts, PhD, Department of Biomedical Engineering, was awarded a $2 million grant from the Department of Defense to create a series of augmented reality assessment modules to help determine when military personnel who have sustained a mild traumatic brain injury (mTBI) can safely return to duty. Augmented reality, unlike virtual reality, allows the user to maintain contact with the physical world and people in it while interacting with virtual objects.




05/29/2019 |  

New NIH Grant to Study Effects of Exercise on Parkinson’s Progression

The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, has awarded Jay Alberts, PhD, Department of Biomedical Engineering, a five-year, $3 million grant to conduct a multi-site clinical trial to study the long-term effects of aerobic exercise on slowing the progression of Parkinson’s disease.




03/07/2018 |  

Exercise May Help Reinforce Underdeveloped Connections in the Brain: Implications for Preventing, Treating Adolescent Substance Abuse

In a review article recently published in Birth Defects Research, scientists from Case Western Reserve University School of Medicine and Cleveland Clinic Lerner Research Institute Department of Biomedical Engineering make the case for the use of exercise, particularly assisted exercise, in the prevention and adjunctive treatment of substance abuse disorders—including alcohol, marijuana, cocaine, opioids and heroine—in adolescents.