Jillian Beveridge, Ph.D.
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
Phone: (216) 299-3993
Joint injury, and especially anterior cruciate ligament (ACL) tear, is a known risk factor for post-traumatic osteoarthritis (PTOA), which develops 10-15 years after injury in up to 80% of patients.
Because ACL injuries are most prevalent in physically active adolescents and young adults, these individuals can develop symptomatic PTOA by the time they’re just 30 years old. Afflicted individuals must manage their condition over the majority of their lifespans, without disease-modifying drugs or treatments.
Our research group’s interest is to understand how the mechanobiology of the joint and its component tissues is affected by ACL injury in order to reduce the risk and severity of PTOA. Our lab works with translational models of joint injury and with patients, using a combination of traditional marker-based motion capture, force data, and electromyography to quantify joint biomechanics and neuromuscular function.
While our translational studies allow us to perform biological analyses of the tissues and joint fluid, we employ biplane videoradiography, a sophisticated x-ray imaging technique that yields highly accurate (≤0.5˚/mm) 3D motion of the underlying bones during dynamic activities, to explore functional changes in our clinical patients. In both research cases, we use quantitative magnetic resonance imaging to gain insight into tissue function, structure and composition that complements measures of joint motion.
To meet our goals, we collaborate with orthopaedic surgeons, fellows, imaging scientists, and biologists.
On Twitter: @jill_beveridge
Our lab works with surgeons and other scientists to discover the causes of post-traumatic arthritis in people who sustain joint injuries, especially anterior cruciate ligament injuries. We use this information to test new solutions and treatments that improve long-term recovery.
- Howard, RA, Rosvold, JM, Tapper, JE, Darcy, SP, Beveridge, JE, Corr, DT, Marchuk, LL, Ronsky, JL, Frank, CB, Shrive, NG. (2007). Reproduction of ovine gait using a parallel robot. Journal of Biomechanical Engineering, 129(5), p.743-749.
- Darcy, SP, Rosvold, JM, Beveridge, JE, Corr, DT, Sutherland, CA, Brown, JJY, Marchuk, LL, Frank, CB, and Shrive, NG. (2008). A Comparison of passive flexion-extension to normal gait in the ovine stifle joint. J Biomech, 41, p.854-860.
- Beveridge, JE, Shrive, NG, Frank, CB. (2011). Meniscectomy causes significant in vivo kinematic changes and mechanically induced focal chondral lesions in a sheep model. JOR, 29(9), p.1397-405.
- Frank, CB, Beveridge, JE, Huebner, KD, Heard, BJ, Tapper, JE, O’Brien, EJO, Shrive, NG. (2012). Complete ACL/MCL deficiency induces variable degrees of instability in sheep with kinematic abnormalities correlating with degrees of early osteoarthritis. JOR, 30(3), p.384-92.
- O'Brien, EJO, Beveridge, JE, Huebner, KD, Heard, BJ, Tapper, JE, Shrive, NG, CB Frank. (2013). Osteoarthritis develops in the operated joint of an ovine model following ACL reconstruction with immediate anatomic reattachment of the native ACL. JOR, 31(1), p. 35-43.
- Beveridge, JE, Shrive, NG, Frank, CB. Repeatability and precision of a weighted centroid method for estimating dynamic in vivo tibiofemoral surface interactions in sheep. (2013). CMBBE, 17(16), p.1853-1863.
- Beveridge, JE, Heard, BJ, Brown, JJY, Shrive, NG, Frank, CB. (2014). Tibiofemoral centroid velocity correlates more consistently with cartilage damage than does contact path length in two ovine models of stifle injury. JOR, 31(11), p.1745-1756.
- Beveridge, JE, Heard, BJ, Brown, JJY, Shrive, NG, Frank, CB. (2014). A new measure of tibiofemoral subchondral bone surface interactions that correlates with early cartilage damage in injured sheep. JOR, 32(10), p.1371-1380.
- Lichti, DD, Sharma, GB, Kuntze, G, Mund, B, Beveridge, JE, Ronsky, JL. (2015). Rigorous geometrical self-calibrating bundle adjustment for a dual fluoroscopic imaging system. IEEE Transactions on Medical Imaging, 32(2), p. 589-98.
- Beveridge, JE, Atarod, M, Heard, BJ, O’Brien, EJ, Frank, CB, Shrive NG. (2016). Relationship between increased in vivo meniscal loads and abnormal tibiofemoral surface alignment in ACL deficient sheep is varied. J Biomech, 49(16), p.3824-3832.
- Heard, BJ*, Beveridge, JE*, Atarod, M, O’Brien, EJ, Rolian, C, Frank, CB, Hart, DA, Shrive, NG. (2017). Analysis of change in gait in the ovine stifle: normal, injured, and anterior cruciate ligament reconstructed. BMC Musculoskeletal Disorders, 18(1), p. 212-222. *Co-first authors
- Beveridge, JE, Walsh, EG, Murray, MM, Fleming, BC. (2017). Sensitivity of ACL volume and T2* relaxation time to magnetic resonance imaging scan conditions. J Biomech, 56, p.117-121.
- Beveridge, JE, Machan, JT, Walsh, EG, Kiapour, AM, Karamchedu, NP, Chin, KE, Proffen, BL, Sieker, JT, Murray, MM, Fleming, BC. (2018). Magnetic resonance measurements of tissue quantity and quality using T2* relaxometry predict temporal changes in the biomechanical properties of the healing ACL. JOR, 36(6), p.1701-1709.
- Shekarfoursh, M, Beveridge, JE, Hart, DA, Frank, CB, Shrive NG. (2018). Correlation between translational and rotational kinematic abnormalities and osteoarthritis-like damage in two in vivo sheep injury models. J Biomech, 75, p.67-76.
- Shekarfoursh, M, Barton, KI, Beveridge, JE, Scott, M, Martin, CR, Muench, G, Heard, BJ, Sevick, JL, Hart, DA, Frank, CB, Shrive, NG. (2019). Alterations in joint angular velocity following traumatic knee injury in ovine models. Ann Biomed Eng. 2019 Mar;47(3):790-801. doi: 10.1007/s10439-019-02203-6.
- Beveridge, JE, Proffen, BL, Karamchedu, NP, Chin, KE, Sieker, JT, Badger, GJ, Kiapour, AM, Murray, MM, Fleming, BC. Cartilage Damage is Related to ACL Stiffness in a Porcine Model of ACL Repair. J Orthop Res. 2019 Oct;37(10):2249-2257. doi: 10.1002/jor.24381.
- Behnke AL, Parola LR, Karamchedu NP, Badger GJ, Fleming BC, Beveridge JE. Neuromuscular function in anterior cruciate ligament reconstructed patients at long-term follow-up. Clin Biomech (Bristol, Avon). 2021 Jan;81:105231. doi: 10.1016/j.clinbiomech.2020.105231.
The conventional wisdom regarding patients who have had reconstructive surgery of the anterior cruciate ligament (ACL) has always been that the surgery leaves them with less overall function in that leg, and that diminished muscle function likely influences long-term outcomes. However, in a new study in the journal Clinical Biomechanics, Jillian Beveridge, PhD, of the Department of Biomedical Engineering, and colleagues have found that muscle coordination in patients who had ACL reconstructive surgery was similar to that of uninjured control subjects 10 years after the surgery.