Kathleen A. Derwin,  Ph.D.

Kathleen A. Derwin, Ph.D.

Associate Staff

Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195
Location: ND2-26

Phone: (216) 445-5982
Fax: (216) 444-9198

 

Our research program focuses on identifying the demographic, disease, and surgical factors, as well as local biologic factors such as stem and progenitor cell characteristics and inflammatory biomarkers, which influence healing and clinical outcomes following rotator cuff repair. Our aim is modification of key factors, either pre-operatively or through surgical treatment, leading to better clinical decision making, patient selection and improved outcomes.

We also investigate extracellular matrix scaffold technologies as a surgical treatment strategy for enhancing healing following rotator cuff repair. We utilize traditional MRI together with novel CT-based imaging of radiopaque markers to measure tendon retraction and understand the relationship between structural healing of the tendon and clinical outcomes following rotator cuff repair. Further, we are currently developing imaging biomarkers to quantify local bone marrow "quality" and guide decision-making about tissue-healing potential and the need for cell-based therapies.


View publications for Kathleen A. Derwin, Ph.D.

  1. Ma J, Sahoo S, Imrey PB, Jin Y, Baker AR, Entezari V, Ho JC, Iannotti JP, Ricchetti ET, Polster JM, Winalski CS, Derwin KA. Inter-rater agreement of rotator cuff tendon and muscle MRI parameters evaluated preoperatively and during the first postoperative year following rotator cuff repair. J Shoulder Elbow Surg. 2021 Apr 27:S1058-2746(21)00401-8. doi: 10.1016/j.jse.2021.04.021. Online ahead of print.
  2. Ricchetti ET, Jun BJ, Jin Y, Ho JC, Patterson TE, Dalton JE, Derwin KA, Iannotti JP. Relationship Between Glenoid Component Shift and Osteolysis After Anatomic Total Shoulder Arthroplasty: Three-Dimensional Computed Tomography Analysis. J Bone Joint Surg Am. 2021 Apr 8. doi: 10.2106/JBJS.20.00833.
  3. Jun BJ, Sahoo S, Imrey PB, Baker AR, Erdemir A, Jin Y, Iannotti JP, Entezari V, Ricchetti ET, Bey MJ, Derwin KA. Variability of glenohumeral positioning and bone-to-tendon marker length measurements in repaired rotator cuffs from longitudinal computed tomographic imaging. JSES Int. 2020 Sep 12;4(4):838-847. doi: 10.1016/j.jseint.2020.08.001. eCollection 2020 Dec.
  4. Associations of preoperative patient mental health status and sociodemographic and clinical characteristics with baseline pain, function, and satisfaction in patients undergoing primary shoulder arthroplasty. Sahoo S, Derwin KA, Zajichek A; Cleveland Clinic Shoulder Group, Entezari V, Imrey PB, Iannotti JP, Ricchetti ET. J Shoulder Elbow Surg. 2021 May;30(5):e212-e224. doi: 10.1016/j.jse.2020.08.003. Epub 2020 Aug 26.
  5. Ricchetti ET, Jun BJ, Jin Y, Entezari V, Patterson TE, Derwin KA, Iannotti JP. Three-dimensional computed tomography analysis of pathologic correction in total shoulder arthroplasty based on severity of preoperative pathology. J Shoulder Elbow Surg. 2021 Feb;30(2):237-249. doi: 10.1016/j.jse.2020.07.033. Epub 2020 Aug 7.
  6. Guevara JA, Entezari V, Ho JC, Derwin KA, Iannotti JP, Ricchetti ET. An Update on Surgical Management of the Repairable Large-to-Massive Rotator Cuff Tear. J Bone Joint Surg Am. 2020 Oct 7;102(19):1742-1754. doi: 10.2106/JBJS.20.00177.
  7. Sahoo S, Ricchetti ET, Zajichek A; Cleveland Clinic Shoulder Group, Evans PJ, Farrow LD, McCoy BW, Jones MH, Miniaci AA, Sabesan VJ, Schickendantz MS, Seitz WH, Spindler KP, Stearns KL, Strnad G, Turan A, Entezari V, Imrey PB, Iannotti JP, Derwin KA. Associations of Preoperative Patient Mental Health and Sociodemographic and Clinical Characteristics With Baseline Pain, Function, and Satisfaction in Patients Undergoing Rotator Cuff Repairs. Am J Sports Med. 2020 Feb;48(2):432-443. doi: 10.1177/0363546519892570. Epub 2019 Dec 18.
  8. Derwin KA, Thomopoulos S. Discovery to delivery in tendon research. J Orthop Res. 2020 Jan;38(1):5-6. doi: 10.1002/jor.24549.
  9. Sahoo S, Baker AR, Jun BJ, Erdemir A, Ricchetti ET, Iannotti JP, Derwin KA. A novel radiopaque tissue marker for soft tissue localization and in vivo length and area measurements. PLoS One. 2019 Oct 18;14(10):e0224244. doi: 10.1371/journal.pone.0224244. eCollection 2019.

  10. Sahoo S, Ma J, Tastaldi L, Baker AR, Loftis J, Rosen MJ, Derwin KA: Biodegradable hyaluronan hydrogel coatings on acellular dermis grafts - a potential strategy to improve biologic graft durability in hernia repair application: Resorbable hyaluronan hydrogel coatings on acellular dermis grafts - a potential strategy to improve biologic graft durability in hernia repair applications. J Biomed Mater Res B Appl Biomater. 2019 Nov;107(8):2664-2672. doi: 10.1002/jbm.b.34357 (PMID: 30860665)
  11. Sahoo S, Mohr J, Strnad GJ, Vega J, Jones M, Schickendantz MS, Farrow L, Spindler KP, Iannotti JP, Ricchetti ET, Derwin KA: Validity and efficiency of a smartphone-based electronic data collection tool for operative data in rotator cuff repair. J Shoulder Elbow Surg. 2019 Jul;28(7):1249-1256. doi: 10.1016/j.jse.2018.12.009 (PMID: 31056396)
  12. Derwin KA, Sahoo S, Zajichek A, Strnad G, Spindler KP, Iannotti JP, Ricchetti ET: Tear characteristics and surgeon predict repair technique and suture anchor usage in repair of superior-posterior rotator cuff tendon tears. J Shoulder Elbow Surg. 2019 Jan;28(1):227-236. doi.org/10.1016/j.jse.2018.07.028 (PMID: 30318274)
  13. Derwin KA, Galatz LM, Ratcliffe A, Thomopolous S: Enthesis repair: Challenges and opportunities for effective tendon-to-bone healing. J Bone Joint Surg Am. 2018 Aug 15;100(16):e109. doi: 10.2106/JBJS.18.00200 (PMID: 30106830)
  14. Ma J, Piuzzi NS, Muschler GF, Iannotti JP, Ricchetti ET, Derwin KA: Biomarkers of Rotator Cuff Disease Severity and Repair Healing. JBJS Rev. 2018 Sep;6(9):e9. doi: 10.2106/JBJS.RVW.17.00178 (PMID: 30252720)
  15. Mahylis JM, Entezari V, Karichu J, Richter S, Derwin KA, Iannotti JP, Ricchetti ET. Hemolytic strains of Propionibacterium acnes do not demonstrate greater pathogenicity in periprosthetic shoulder infections. J Shoulder Elbow Surg. 2018 Jun;27(6):1097-1104. doi: 10.1016/j.jse.2017.12.025. Epub 2018 Feb 19. PMID: 29472140
  16. Milks RA, Kolmodin JD, Ricchetti ET, Iannotti JP, Derwin KA. Augmentation with a reinforced acellular fascia lata strip graft limits cyclic gapping of supraspinatus repairs in a human cadaveric model. J Shoulder Elbow Surg. 2018 Jun;27(6):1105-1111. doi: 10.1016/j.jse.2017.12.016.
  17. Sahoo S, Haskins IN, Huang LC, Krpata DM, Derwin KA, Poulose BK, Rosen MJ. Early Wound Morbidity after Open Ventral Hernia Repair with Biosynthetic or Polypropylene Mesh. J Am Coll Surg. 2017 Oct;225(4):472-480.e1. doi: 10.1016/j.jamcollsurg.2017.07.1067. Epub 2017 Aug 4. PMID: 28826804
  18. Sahoo S, Baker AR, Haskins IN, Krpata DM, Rosen MJ, Derwin KA. Assessment of Human Acellular Dermis Graft in Porcine Models for Ventral Hernia Repair. Tissue Eng Part C Methods. 2017 Nov;23(11):718-727. doi: 10.1089/ten.TEC.2017.0238. Epub 2017 Aug 3. PMID: 28602151
  19. Ma J, Baker AR, Calabro A, Derwin KA. Exploratory study on the effect of osteoactivin on muscle regeneration in a rat volumetric muscle loss model. PLoS One. 2017 Apr 20;12(4):e0175853. doi: 10.1371/journal.pone.0175853. eCollection 2017. PMID: 28426701 Free PMC article.
  20. Sahoo S, Baker AR, Haskins IN, Krpata DM, Rosen MJ, Derwin KA. Development of a critical-sized ventral hernia model in the pig. J Surg Res. 2017 Apr;210:115-123. doi: 10.1016/j.jss.2016.10.026. Epub 2016 Nov 4. PMID: 28457317 
  21. Frangiamore SJ, Saleh A, Grosso MJ, Farias Kovac M, Zhang X, Daly TM, Bauer TW, Derwin KA, Iannotti JP, Ricchetti ET.Neer Award 2015: Analysis of cytokine profiles in the diagnosis of periprosthetic joint infections of the shoulder. J Shoulder Elbow Surg. 2017 Feb;26(2):186-196. doi: 10.1016/j.jse.2016.07.017. Epub 2016 Oct 5. PMID: 27720413 
  22. Kovacevic D, Baker AR, Staugaitis SM, Kim MS, Ricchetti ET, Derwin KA. Development of an Arthroscopic Joint Capsule Injury Model in the Canine Shoulder. PLoS One. 2016 Jan 25;11(1):e0147949. doi: 10.1371/journal.pone.0147949. eCollection 2016. PMID: 26808837 Free PMC article. 
  23. Kim MS, Kovacevic D, Milks RA, Jun BJ, Rodriguez E, DeLozier KR, Derwin KA, Iannotti JP. Bone Graft Substitute Provides Metaphyseal Fixation for a Stemless Humeral Implant. Orthopedics. 2015 Jul 1;38(7):e597-603. doi: 10.3928/01477447-20150701-58. PMID: 26186322
  24. Thomopoulos S, Parks WC, Rifkin DB, Derwin KA. Mechanisms of tendon injury and repair. J Orthop Res. 2015 Jun;33(6):832-9. doi: 10.1002/jor.22806. Epub 2015 Mar 2. PMID: 25641114 Free PMC article. Review.
  25. Leigh DR, Kim MS, Kovacevic D, Baker AR, Tan CD, Calabro A, Derwin KA. Human fascia lata ECM scaffold augmented with immobilized hyaluronan: inflammatory response and remodeling in the canine body wall and shoulder implantation sites. J Biomater Sci Polym Ed. 2015;26(1):1-15. doi: 10.1080/09205063.2014.975394. Epub 2014 Nov 17. PMID: 25400204 Free PMC article. 
  26. Sahoo S, DeLozier KR, Erdemir A, Derwin KA. Clinically relevant mechanical testing of hernia graft constructs. J Mech Behav Biomed Mater. 2015 Jan;41:177-88. doi: 10.1016/j.jmbbm.2014.10.011. Epub 2014 Oct 27. PMID: 25460414
  27. Ma J, Sahoo S, Baker AR, Derwin KA. Investigating muscle regeneration with a dermis/small intestinal submucosa scaffold in a rat full-thickness abdominal wall defect model. J Biomed Mater Res B Appl Biomater. 2015 Feb;103(2):355-64. doi: 10.1002/jbm.b.33166. Epub 2014 May 29.PMID: 24889422
  28. Sahoo S, DeLozier KR, Dumm RA, Rosen MJ, Derwin KA. Fiber-reinforced dermis graft for ventral hernia repair. J Mech Behav Biomed Mater. 2014 Jun;34:320-9. doi: 10.1016/j.jmbbm.2014.03.001. Epub 2014 Mar 15. PMID: 24704969


US Patent Patent Title Issue Date First-Named Inventor
8,080,260 Molecular Enhancement of Extracellular Matrix and Methods of Use 12/20/2011 Kathleen Derwin Ph.D.

10/12/2018 |  

Musculoskeletal Research Center Co-Director Receives $6M NIH Grant for ACL Surgery Research

Kurt Spindler, MD, co-director of Cleveland Clinic’s Musculoskeletal Research Center, was awarded a five-year, $6 million grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases to study techniques used for anterior cruciate ligament (ACL) reconstruction.