D. Geoffrey Vince,  Ph.D.

D. Geoffrey Vince, Ph.D.

Department Chair

The Virginia Lois Kennedy Endowed Chair in Biomedical Engineering and Applied Therapeutics

Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195
Phone: (216) 445-6980

 

Stroke is a major cause of morbidity and mortality among patients with cardiovascular disease, and the leading cause of long-term disability in the United States. Current imaging modalities are primarily used to determine the severity of luminal stenosis caused by carotid plaque. However, cerebrovascular accidents (CVA) are often associated with the rupture of plaques from regions with non-significant luminal stenosis. Accurate identification of these high-risk, rupture-prone plaques could prevent CVA in a significant number of patients.

Plaque composition is an additional and perhaps more important risk factor for CVA. Unfortunately, in clinical implementation, duplex ultrasound images are not cost-effective, and are technically unreliable and often invasive.

There isa clear unmet clinical need for a non-invasive, low-cost method to accurately characterize the composition of carotid plaques. My team is developing mathematical algorithms based upon quantitative ultrasound and acoustic radiation force impulse imaging that can better analyze ultrasound images of carotid arteries. The new system creates a spectrum in which different colors indicate where and how bad the plaque build-up is by using information from scattered ultrasound points during the creation of standard ultrasound images. Our goal is to provide a tool that will predict which patients are at increased risk for stroke.

Lay Summary

Each year, about 800,000 Americans have a new or recurrent stroke, or “brain attack.” Many strokes are caused by carotid stenosis, a build-up of plaque in the carotid arteries on either side of the neck that carry blood and oxygen to the brain; the result is brain damage and often other physical harm. My team is developing software that analyzes ultrasound images. Different  s in the ultrasound images indicate where the plaque is located, and how severe it is. Our goal is to provide a tool that will predict which patients are at greater risk of stroke, which will help the physician decide on the best way to treat it.


View publications for D. Geoffrey Vince, Ph.D.

Muppala S, Rahman MT, Krukovets I, Verbovetskiy D, Pluskota E, Fleischman A, Vince DG, Plow EF, Stenina-Adognravi O. The P387 thrombospondin-4 variant promotes accumulation of macrophages in atherosclerotic lesions. FASEB J. 2020 Sep;34(9):11529-11545. doi: 10.1096/fj.201901434RRRR. Epub 2020 Jul 20. PMID: 32686880

Fedewa R, Puri R, Fleischman E, Lee J, Prabhu D, Wilson DL, Vince DG, Fleischman A. Artificial Intelligence in Intracoronary Imaging. Curr Cardiol Rep. 2020 May 29;22(7):46. doi: 10.1007/s11886-020-01299-w. PMID: 32472189 Review.

Klingensmith JD, Haggard A, Fedewa RJ, Qiang B, Cummings K 3rd, DeGrande S, Vince DG, Elsharkawy H. Spectral Analysis of Ultrasound Radiofrequency Backscatter for the Detection of Intercostal Blood Vessels. Ultrasound Med Biol. 2018 Jul;44(7):1411-1422. doi: 10.1016/j.ultrasmedbio.2018.03.007. Epub 2018 Apr 19. PMID: 29681422

Antman EM, Di Corleto PE, Freeman MW, Ganz T, Golan DE, Kitterman R, Loscalzo J, Low M, McKenna E, O'Connor AC, Palazzolo M, Parrish J, Reizes O, Ross RS, Vaughan C, Vince DG, Watts L; NIH Centers for Accelerated Innovations. NIH Centers for Accelerated Innovations Program: principles, practices, successes and challenges. Nat Rev Drug Discov. 2017 Oct;16(10):663-664. doi: 10.1038/nrd.2017.131. Epub 2017 Aug 4. PMID: 28775338 Free PMC article.

Campos CM, Fedewa RJ, Garcia-Garcia HM, Vince DG, Margolis MP, Lemos PA, Stone GW, Serruys PW, Nair A. Ex vivo validation of 45 MHz intravascular ultrasound backscatter tissue characterization. Eur Heart J Cardiovasc Imaging. 2015 Oct;16(10):1112-9. doi: 10.1093/ehjci/jev039. Epub 2015 Mar 1. PMID: 25733210

Schoenhagen P, Vince DG. Intravascular photoacoustic tomography of coronary atherosclerosis: riding the waves of light and sound. J Am Coll Cardiol. 2014 Jul 29;64(4):391-3. doi: 10.1016/j.jacc.2014.05.018.PMID: 25060375

Shen ZL, Vince DG, Li ZM. In vivo study of transverse carpal ligament stiffness using acoustic radiation force impulse (ARFI) imaging. PLoS One. 2013 Jul 5;8(7):e68569. doi: 10.1371/journal.pone.0068569. Print 2013. PMID: 23861919 

Fumoto H, Gillinov AM, Saraiva RM, Horai T, Anzai T, Takaseya T, Shiose A, Arakawa Y, Vince DG, Dessoffy R, Fukamachi K. Left atrial appendage occlusion: pilot study of a fourth-generation, minimally invasive device. Innovations (Phila). 2012 May-Jun;7(3):195-200. doi: 10.1097/IMI.0b013e3182618feb. PMID: 22885461

Fumoto H, Gillinov AM, Vince DG, Akiyama M, Saeed D, Fukamachi K. Histologic evaluation of stapled right atrial appendages with fabric buttressing. Innovations (Phila). 2010 Sep;5(5):359-63. doi: 10.1097/IMI.0b013e3181f63b00. PMID: 22437522

Chandrana C, Kharin N, Vince DG, Roy S; Fleischman A; Demonstration of Second Harmonic IVUS feasibility with Focused Broadband Miniature Transducers. IEEE UFFC, 2010.

García-García HM, Mintz GS, Lerman A, Vince DG, Margolis MP, van Es GA, Morel MA, Nair A, Virmani R, Burke AP, Stone GW, Serruys PW. Tissue characterisation using intravascular radiofrequency data analysis: recommendations for acquisition, analysis, interpretation and reporting. EuroIntervention. 2009 Jun;5(2):177-89. doi: 10.4244/eijv5i2a29. PMID: 20449928 Review.

Sareen M, Waters K, Nair A, Vince DG. Normalization and backscatter spectral analysis of human carotid arterial data acquired using a clinical linear array ultrasound imaging system. Annu Int Conf IEEE Eng Med Biol Soc. 2008;2008:2968-71. doi: 10.1109/IEMBS.2008.4649826. PMID: 19163329

Fumoto H, Gillinov AM, Ootaki Y, Akiyama M, Saeed D, Horai T, Ootaki C, Vince DG, Popović ZB, Dessoffy R, Massiello A, Catanese J, Fukamachi K. A novel device for left atrial appendage exclusion: the third-generation atrial exclusion device. J Thorac Cardiovasc Surg. 2008 Oct;136(4):1019-27. doi: 10.1016/j.jtcvs.2008.06.002. Epub 2008 Jul 24. PMID: 18954645

Serruys PW, García-García HM, Buszman P, Erne P, Verheye S, Aschermann M, Duckers H, Bleie O, Dudek D, Bøtker HE, von Birgelen C, D'Amico D, Hutchinson T, Zambanini A, Mastik F, van Es GA, van der Steen AF, Vince DG, Ganz P, Hamm CW, Wijns W, Zalewski A; Integrated Biomarker and Imaging Study-2 Investigators. Effects of the direct lipoprotein-associated phospholipase A(2) inhibitor darapladib on human coronary atherosclerotic plaque. Circulation. 2008 Sep 9;118(11):1172-82.

Nasu K, Tsuchikane E, Katoh O, Vince DG, Margolis PM, Virmani R, Surmely JF, Ehara M, Kinoshita Y, Fujita H, Kimura M, Asakura K, Asakura Y, Matsubara T, Terashima M, Suzuki T. Impact of intramural thrombus in coronary arteries on the accuracy of tissue characterization by in vivo intravascular ultrasound radiofrequency data analysis. Am J Cardiol. 2008 Apr 15;101(8):1079-83. 

Nair A, Margolis MP, Kuban BD, Vince DG. Automated coronary plaque characterisation with intravascular ultrasound backscatter: ex vivo validation. EuroIntervention. 2007 May;3(1):113-20. PMID: 19737694

Kamohara K, Fukamachi K, Ootaki Y, Akiyama M, Cingoz F, Ootaki C, Vince DG, Popović ZB, Kopcak MW Jr, Dessoffy R, Liu J, Gillinov AM. Evaluation of a novel device for left atrial appendage exclusion: the second-generation atrial exclusion device. J Thorac Cardiovasc Surg. 2006 Aug;132(2):340-6. doi: 10.1016/j.jtcvs.2006.04.021 PMID: 16872960

Nasu K, Tsuchikane E, Katoh O, Vince DG, Virmani R, Surmely JF, Murata A, Takeda Y, Ito T, Ehara M, Matsubara T, Terashima M, Suzuki T. Accuracy of in vivo coronary plaque morphology assessment: a validation study of in vivo virtual histology compared with in vitro histopathology. J Am Coll Cardiol. 2006 Jun 20;47(12):2405-12. doi: 10.1016/j.jacc.2006.02.044. Epub 2006 May 30. PMID: 16781367

Rodriguez-Granillo GA, Serruys PW, McFadden EP, van Mieghem CA, Goedhart D, Bruining N, van der Steen AF, van der Giessen WJ, de Jaegere P, Vince DG, Sianos G, Kaplow J, Zalewski A, de Feyter PJ. First-in-man prospective evaluation of temporal changes in coronary plaque composition by in vivo intravascular ultrasound radiofrequency data analysis: an Integrated Biomarker and Imaging Study (IBIS) substudy. EuroIntervention. 2005 Nov;1(3):282-8. PMID: 19758918

Nair A, Klingensmith JD, Vince DG. Real-time plaque characterization and visualization with spectral analysis of intravascular ultrasound data. Stud Health Technol Inform. 2005;113:300-20. PMID: 15923746

Tajaddini A, Kilpatrick DL, Schoenhagen P, Tuzcu EM, Lieber M, Vince DG. Impact of age and hyperglycemia on the mechanical behavior of intact human coronary arteries: an ex vivo intravascular ultrasound study. Am J Physiol Heart Circ Physiol. 2005 Jan;288(1):H250-5. doi: 10.1152/ajpheart.00646.2004. Epub 2004 Aug 26. PMID: 15331362

Jeremias A, Dusa C, Forudi F, Jacobsen DW, Vince DG, Nissen SE, Tuzcu EM. N-acetyl-cysteine in the prevention of vascular restenosis after percutaneous balloon angioplasty. Int J Cardiol. 2004 Jun;95(2-3):255-60. doi: 10.1016/j.ijcard.2003.05.024. PMID: 15193829

Vince DG, Davies SC. Peripheral application of intravascular ultrasound virtual histology. Semin Vasc Surg. 2004 Jun;17(2):119-25. doi: 10.1053/j.semvascsurg.2004.03.008. PMID: 15185177  

Nair A, Calvetti D, Vince DG. Regularized autoregressive analysis of intravascular ultrasound backscatter: improvement in spatial accuracy of tissue maps. IEEE Trans Ultrason Ferroelectr Freq Control. 2004 Apr;51(4):420-31. doi: 10.1109/tuffc.2004.1295427. PMID: 15139543 

Kharin NA, Vince DG.Moderately nonlinear ultrasound propagation in blood-mimicking fluid. Ultrasound Med Biol. 2004 Apr;30(4):501-9. doi: 10.1016/j.ultrasmedbio.2004.01.003. PMID: 15121252

Schoenhagen P, Stone GW, Nissen SE, Grines CL, Griffin J, Clemson BS, Vince DG, Ziada K, Crowe T, Apperson-Hanson C, Kapadia SR, Tuzcu EM. Coronary plaque morphology and frequency of ulceration distant from culprit lesions in patients with unstable and stable presentation. Arterioscler Thromb Vasc Biol. 2003 Oct 1;23(10):1895-900. 

Klingensmith JD, Schoenhagen P, Tajaddini A, Halliburton SS, Tuzcu EM, Nissen SE, Vince DG. Automated three-dimensional assessment of coronary artery anatomy with intravascular ultrasound scanning. Am Heart J. 2003 May;145(5):795-805. doi: 10.1016/S0002-8703(03)00089-9.

Klingensmith JD, Tuzcu EM, Nissen SE, Vince DG. Validation of an automated system for luminal and medial-adventitial border detection in three-dimensional intravascular ultrasound. Int J Cardiovasc Imaging. 2003 Apr;19(2):93-104. doi: 10.1023/a:1022843104297. PMID: 12749389 

Tsutsui H, Schoenhagen P, Ziada KM, Crowe TD, Klingensmith JD, Vince DG, Bott-Silverman C, Starling R, Hobbs RE, Young J, Nissen SE, Tuzcu EM. Early constriction or expansion of the external elastic membrane area determines the late remodeling response and cumulative lumen loss in transplant vasculopathy: an intravascular ultrasound study with 4-year follow-up. J Heart Lung Transplant. 2003 May;22(5):519-25. doi: 10.1016/s1053-2498(02)01228-7. PMID: 12742413 

Tajaddini A, Kilpatrick DL, Vince DG. A novel experimental method to estimate stress-strain behavior of intact coronary arteries using intravascular ultrasound (IVUS). J Biomech Eng. 2003 Feb;125(1):120-3. doi: 10.1115/1.1536929. PMID: 12661205 

Schoenhagen P, Sapp SK, Tuzcu EM, Magyar WA, Popovich J, Boumitri M, Vince DG, Crowe T, Nissen SE. Variability of area measurements obtained with different intravascular ultrasound catheter systems: Impact on clinical trials and a method for accurate calibration. J Am Soc Echocardiogr. 2003 Mar;16(3):277-84. doi: 10.1067/mje.2003.45. PMID: 12618737

Tsutsui H, Schoenhagen P, Crowe TD, Klingensmith JD, Vince DG, Nissen SE, Tuzcu EM. Influence of coronary pulsation on volumetric intravascular ultrasound measurements performed without ECG-gating. Validation in vessel segments with minimal disease. Int J Cardiovasc Imaging. 2003 Feb;19(1):51-7. doi: 10.1023/a:1021784107536. PMID: 12602482

Veress AI, Weiss JA, Gullberg GT, Vince DG, Rabbitt RD. Strain measurement in coronary arteries using intravascular ultrasound and deformable images. J Biomech Eng. 2002 Dec;124(6):734-41. doi: 10.1115/1.1519279. PMID: 12596642

Klingensmith JD, Vince DG. B-spline methods for interactive segmentation and modeling of lumen and vessel surfaces in three-dimensional intravascular ultrasound. Comput Med Imaging Graph. 2002 Nov-Dec;26(6):429-38. doi: 10.1016/s0895-6111(02)00025-3. PMID: 12453506

Nair A, Kuban BD, Tuzcu EM, Schoenhagen P, Nissen SE, Vince DG. Coronary plaque classification with intravascular ultrasound radiofrequency data analysis. Circulation. 2002 Oct 22;106(17):2200-6. doi: 10.1161/01.cir.0000035654.18341.5e. PMID: 12390948

Yamani MH, Starling RC, Young JB, Cook D, Yu Y, Vince DG, McCarthy P, Ratliff NB. Acute vascular rejection is associated with up-regulation of vitronectin receptor (alphavbeta3), increased expression of tissue factor, and activation of the extracellular matrix metalloproteinase induction system. J Heart Lung Transplant. 2002 Sep;21(9):983-9. doi: 10.1016/s1053-2498(02)00408-4. PMID: 12231369

Schoenhagen P, Vince DG, Ziada KM, Kapadia SR, Lauer MA, Crowe TD, Nissen SE, Tuzcu EM. Relation of matrix-metalloproteinase 3 found in coronary lesion samples retrieved by directional coronary atherectomy to intravascular ultrasound observations on coronary remodeling. Am J Cardiol. 2002 Jun 15;89(12):1354-9. doi: 10.1016/s0002-9149(02)02346-9. PMID: 12062727

Yamani MH, Tuzcu EM, Starling RC, Ratliff NB, Yu Y, Vince DG, Powell K, Cook D, McCarthy P, Young JB. Myocardial ischemic injury after heart transplantation is associated with upregulation of vitronectin receptor (alpha(v)beta3), activation of the matrix metalloproteinase induction system, and subsequent development of coronary vasculopathy. Circulation. 2002 Apr 23;105(16):1955-61. doi: 10.1161/01.cir.0000014971.09169.bc. PMID: 11997283


US Patent Patent Title Issue Date First-Named Inventor
8630492 System and Method for Identifying a Vascular Border 1/14/2014 D. Geoffrey Vince Ph.D.
8622910 System and Method of Acquiring Blood-Vessel Data 1/7/2014 D. Geoffrey Vince Ph.D.
6,200,268 Vascular Plaque Characterization 3/13/2001 D. Geoffrey Vince Ph.D.

05/26/2021 |  

D. Geoffrey Vince, PhD, Appointed Executive Director of Cleveland Clinic Innovations

Cleveland Clinic has named D. Geoffrey Vince, PhD, as Executive Director of Cleveland Clinic Innovations.




01/07/2020 |  

Using Machine Learning to Better Assess Stroke Risk

D. Geoffrey Vince, PhD, Chair, Department of Biomedical Engineering, has received a four-year, $4 million grant from the Department of Defense to study the relationship between the composition of carotid artery plaque and the risk of a future cerebrovascular accident (CVA) (i.e., stroke).