Jae Jung, PhD
Director, Global Center for Pathogen & Human Health Research
Department Chair, Cancer Biology
Director, Infection Biology
Betsy B. deWindt Endowed Chair in Cancer Biology
Email: [email protected]
Location: Cleveland Clinic Main Campus
Research
Dr. Jung leads the Department of Cancer Biology, the Infection Biology Program, and the newly-established Global Center for Pathogen & Human Health Research, which is focused on understanding of viral pathogens and the human immune responses toward preparing and protecting future public health threats. My research is divided into four areas: (1) virus-induced cancer (gamma-2 herpesvirus and hepatitis B virus); (2) emerging virus: mosquito-borne flavivirus (Dengue virus and Zika virus), tick-borne bunyavirus (Severe Fever with Thrombocytopenia virus and Heartland virus) and air-borne virus (severe acute respiratory syndrome coronavirus 2 and influenza virus); (3) therapeutic/vaccine development and stabilization, and (4) inflammation and immunity (host-pathogen standoff, programmed cell death, immune atlas of pregnancy and inflammation). The overarching goal of my research is to uncover new ways to understand infection and immunity and to rapidly develop and distribute vaccines and therapeutics to improve global health.
Biography
Dr. Jung joined Cleveland Clinic from the University of Southern California, where he was chair of Molecular Microbiology and Immunology and director of the Institute of Emerging Pathogens and Immune Diseases. He earned his PhD in microbiology from the University of California, Davis. He completed post-doctoral training and was later promoted to professor at Harvard Medical School. He is an elected fellow of the American Association for the Advancement of Science and the American Academy of Microbiology.
Education & Professional Highlights
Fellowship - Harvard University
Virology
Cambridge, MA USA
1992
Fellowship - Harvard Medical School
Virology
Boston, MA USA
1992
Medical Education - University of California Davis Medical Center
Sacramento, CA USA
1989
Graduate School - Seoul National University
Food Microbiology
Seoul, Korea
1984
Undergraduate - Seoul National University
Food Science
Seoul, Korea
1982
Awards
- National Cancer Institute Outstanding Investigator Award, 2016
"CIMER Trained Mentor" indicates the principal investigator has completed mentorship training based on curriculum from the Center for the Improvement of Mentored Experiences in Research, aimed at advancing mentoring relationships and promoting cultural change in research.
Research
Overview
My research is divided into four areas: (1) virus-induced cancer (gamma-2 herpesvirus and hepatitis B virus); (2) emerging virus: mosquito-borne flavivirus (Dengue virus and Zika virus), tick-borne bunyavirus (Severe Fever with Thrombocytopenia virus and Heartland virus) and air-borne virus (severe acute respiratory syndrome coronavirus 2 and influenza virus); (3) therapeutic/vaccine development and stabilization, and (4) inflammation and immunity (host-pathogen standoff, programmed cell death, immune atlas of pregnancy and inflammation). The overarching goal of my research is to uncover new ways to understand infection and immunity and to rapidly develop and distribute vaccines and therapeutics to improve global health.
Our Team
Selected Publications
View publications for Jae Jung, PhD
(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)
- Choi et al. MCEMP1 potentiates KIT-mediated mast cell proliferation and chronic lung inflammation. 2023 Nature Comm revision.
- Lee et al. OASL phase condensation induces amyloid-like fibrillation of RIPK3 to promote virus-induced necroptosis. 2023 Nature Cell Biology 25:92.
- Kim et al. Age-dependent pathogenic characteristics of SARS-CoV-2 infection in ferrets. 2022 Nature Comm 13:21.
- Liu Z et al. PINLYP regulates type I interferon responses. 2022 Proc Natl Acad Sci U S A. 119: No. 1 e2111115119
- Foo et al. The systemic inflammatory landscape of COVID19 in pregnant women and their infants. 2021 Cell Report Medicine 2:100453.
- Chen et al. Zika virus NS3 protease induces fetal brain calcification. 2021 Nature Microbiology 6:455.
- Lee et al. An IFITM3-dependent amplification loop enables antibody responses and oncogenic signaling in B cells. 2020 Nature 588:491.
- Brasil et al. Zika virus vertical transmission in children with confirmed antenatal exposure. 2020 Nature Comm. 11:3510.
- Kim et al. Infection and Rapid Transmission of the 2019 Novel Coronavirus in Ferrets. 2020 Cell Host & Microbe 27:704.
- Park et al. Global epigenomic analysis of KSHV-infected primary effusion lymphoma identifies functional MYC super-enhancers and enhancer RNAs. 2020 Proc Natl Acad Sci U S A.117:21618.
- Choi et al. Oncogenic human herpesvirus hijacks proline metabolism for tumorigenesis. 2020 Proc Natl Acad Sci U S A 117:8083
- Kwak et al. Development of a DNA vaccine for SFTSV that confers complete protection against lethal infection in ferrets. 2019 Nature Comm 10:3836.
- Chen et al. NLRP12 regulates anti-viral RIG-I activation via interaction with TRIM25. 2019 Cell Host & Microbe 25:602-616.
- Choi et al. SerpinB1-mediated checkpoint of inflammatory caspase activation. 2019 Nature Immunology 20(3):276-287.
- Srikanth et al. STIM1 regulates type I interferon response by retaining STING at the endoplasmic reticulum. 2019 Nature Immunology 20(2):152-62.
- Choi et al. SFTSV nonstructural protein activates TPL2 signalling pathway for viral immunopathogenesis. 2019 Nature Microbiology 4(3):429-437.
- Park et al. Ferret model of severe fever with thrombocytopenia syndrome virus infection that recapitulates human clinical manifestations. 2019 Nature Microbiology 4:438-446.
- Eoh H, Jung JU. Bacterial protein reshapes host defense toward antiviral responses. 2018. Mol Cell 71:483.
- Choi YJ et al. A Talented Duo: IFIT1 and IFIT3 Patrol Viral RNA Caps. 2018 Immunity 48:474
- Seo et al. TRIM56-mediated monoubiquitination of cGAS for cytosolic DNA sensing. 2018 Nature Comm. 9:613.
- Choi et al. Double-edged sword of autophagy for viral replication and pathogenesis. 2018 Nature Rev Microbiol.
- Foo et al. Differential immunomodulatory responses of CD14+ blood monocytes upon infection with different lineages of Zika virus. 2017 Nature Microbiology 2:1558-1570.
- Chen et al. Unexpected alliance of WHIP-TRIM14-PPP6C to Combat Viruses. 2017 Mol Cell 19: 259-261.
- Choi et al. Double the trouble When two herpesviruses join hands. 2017 Cell Host & Microbe 22:5-6.
- Kwak et al. Identification and structure of the substrate-recognition module in the Dot/Icm type IV coupling protein complex of L. pneumophila. 2017. Nature Microbiology 2:1-13.
- Chen et al. Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2. 2017 Nature Comm. 9:13882.
- Liang et al. Zika Virus NS4A-NS4B inhibition of Akt-mTOR pathway contributes to neurogenesis defect and autophagy induction of human fetal neural stem cells. 2016 Cell Stem Cell 19:663.
- Lee et al. Transformation of glutamyl-prolyl tRNA synthetase into an antiviral molecule via infection-specific modification. 2016 Nature Immunology 7:1252.
- Seo et al. No Trifling matter on STING. 2016 Cell Host & Microbe. 20: 277.
- Yoo et al. The mitochondrial E3 ubiquitin ligase MARCH5 negatively regulates the MAVS-mediated innate immune response. 2015 Nature Comm 6:7910.
- Chen et al. Harnessing negative B cell selection to overcome drug-resistance in Ph+ acute lymphoblastic leukemia. 2015 Nature 521:357.
- He et al. Herpesviral Pseudo-enzymes Induce RIG-I Deamination and Ligand-independent Activation. 2015 Mol Cell 58:134.
- Liang et al. Novel functions of viral anti-apoptotic factors. 2015 Nat Rev Microbiol. 13:7.
- Shi et al. Negative regulation of NF-kB activity by brain-specific TRIpartite Motif protein 9. 2014 Nature Comm. 5:4820.
- Fan et al. USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase. 2014 Journal of Experimental Medicine. 211:313.
- Rodgers et al. Ubiquitination-mediated activation of NLRP3-inflammasome activity. 2014 Journal of Experimental Medicine 211:1333.
- Liang Q et al. cGAS and Beclin-1 interaction shapes innate immune responses by regulating cGAMP production and autophagy pathway. 2014 Cell Host & Microbe 15: 228.
- Amini-Bavil-Olyaee S, et al. A novel mechanism of IFITM-mediated anti-viral activity. 2013 Cell Host Microbe 13:452.
- Yang CS et al. Rubicon autophagic protein is a feedback inhibitor of CARD9-mediated host innate immunity. 2012 Cell Host & Microbe 11:277.
- Yang CS et al. Rubicon autophagic protein is a positive regulator of the reactive oxygen species generating NADPH oxidase complex. 2012 Cell Host & Microbe 11:262.
- Lee HR et al. Viral peptide inhibitors of HAUSP to induce apoptosis. 2011 Nature Structural & Molecular Biology 18:1336.
- Inn KS et al. Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction. 2011 Mol Cell. 41:354.
- Gack et al. Inhibition of TRIM25-mediated RIG-I anti-viral activity by Influenza A virus. 2009 Cell Host & Microbes 5(5):439.
- Myong et al. Cytosolic viral sensor RIG-I is a 5’-triphosphate dependent translocase on double stranded RNA. 2009 Science 323:1070.
- Lee et al. FLIP-mediated cell death control. 2009 Nature Cell Biology 11:1355.
- Gack et al. Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. 2008 Proc Natl Acad Sci U S A. 105: 16743.
- Liang et al. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. 2008 Nature Cell Biology 10:776.
- Takahashi et al. Bif-1 interacts with Beclin1 through UVRAG and regulates autophagy and tumorigenesis. 2007 Nature Cell Biology. 9:1142.
- Gack et al. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. 2007 Nature. 2007 446:916.
- Liang et al. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. 2006 Nature Cell Biology. 8:688.
- Cho et al. Inhibition of T cell receptor signal transduction by tyrosine kinase-interacting protein of Herpesvirus saimiri. 2004 J Exp Med. 200:681.
- Park et al. Herpesviral protein targets a cellular WD repeat endosomal protein to downregulate T lymphocyte receptor expression. 2002 Immunity.17:221.
- Means et al. Multiple endocytic trafficking pathways of MHC class I molecules induced by a Herpesvirus protein. 2002 EMBO J. 21:1638.
- Ishido et al. Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein. 2000 Immunity. 13:365.
- Lee et al. Inhibition of intracellular transport of B cell antigen receptor complexes by Kaposi's sarcoma-associated herpesvirus K1. 2000 J Exp Med.192:11.
- Lee et al. Deregulation of cell growth by the K1 gene of KSHV. 1998. Nature Medicine. 4:435.
- Yoon et al. Tap; a novel cellular protein that interacts with tip of herpesvirus saimiri and induces lymphocyte aggregation. 1997 Immunity 6:571.
- Duboise et al. Use of virion DNA as a cloning vector for the construction of mutant and recombinant herpesviruses. 1996 Proc. Natl. Acad. Sci. 93:11389.
- Du et al. Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. 1995 Cell 82:665.
- Jung et al. Identification of transforming genes of subgroup A and C strains of Herpesvirus saimiri. 1991 Proc. Natl. Acad. Sci. USA 88:7051.
Careers
Research News
Drs. Jae Jung and Jun Zhao were awarded $8.3 and $2.3 million each to learn how a herpesvirus causes cancer with the goal of making a herpes vaccine and antiviral.
These findings challenge the current diagnostic criteria for congenital Zika syndrome, expanding the definition beyond skull or brain abnormalities.
Putting forth multiple candidates with different side effects and dosing schedules aims to provide more options for preventing public health threats.
The improved mRNA vaccine takes inspiration from the herpes virus to “trick” our cells into responding better to the shot.
Nanoparticle vaccines are designed to effectively deliver a lower dose with fewer side effects for at-risk people.
Using therapeutics to target the protein on the surface of mast cells could provide relief for patients with severe asthma.
The gift from the United Arab Emirates will advance cancer and pathogen research globally.
Cleveland Clinic research into anti-viral immunity identified a novel mechanism in necroptosis, a form of programmed cell death.
Dr. Jae Jung will study the natural course of infection and viral reassortment of the emerging pathogen, Severe Fever with Thrombocytopenia Syndrome Virus (SFTSV).
Cleveland Clinic researchers to participate in NIH consortium focused on antiviral drug development.