Location: Cleveland Clinic Main Campus
Two transmembrane signaling receptors mediate the in vivo effects of the renin angiotensin system. Of these two, the Angiotensin II (AngII) type 1 receptor (AT1R) plays an indispensable role in physiological regulation of blood pressure and water-electrolyte balance. Pathological states such as hypertension, cardiac hypertrophy and heart failure (HF) are observed when AT1R activation becomes chronic. The AT1R is a target for classical sartan-family of antihypertensive drugs. Currently these drugs are indicated for treatment of additional disease conditions such as myocardial infarction, aortic aneurism, Marfan syndrome and diabetic nephropathy and retinopathy, which makes the sartans a target for continued drug development. AT1R is a member of G-protein coupled receptor (GPCR) family, which are transmembrane proteins that transform extracellular hormonal or physical cues into specific amplified intracellular signals. We study all aspects of AT1R structure, function, physiology, genetics and signaling. The approaches we use include transgenesis, molecular pharmacology, ligand design, membrane protein biochemistry, protein-protein interaction, signal transduction, gene regulation, micoRNA regulation, proteomics and post-translational modifications.
Sadashiva S. Karnik, PhD, MSc, is a Professor in the Department of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland. He is also full staff in the Department of Cardiovascular & Metabolic Sciences at Cleveland Clinic's Research Institute and is adjunct professor of chemistry and biology, Cleveland State University, Cleveland. Dr. Karnik joined Cleveland Clinic in 1990 after serving as a research associate at the Massachusetts Institute of Technology (MIT), Cambridge, Mass.
Dr. Karnik graduated with a master’s of science degree from Kasturba Medical College, Manipal, India, and PhD in molecular genetics from the Indian Institute of Science, Bangalore, India. Dr. Karnik also completed post-doctoral work in molecular genetics at University of Zurich, Zurich, Switzerland.
A researcher with nearly 80 published papers to his credit, Dr. Karnik earned a National Merit Scholarship from the Government of India from 1969 to 1976. He has won many research awards, landed numerous grants and given lectures worldwide. In 2006, Dr. Karnik was a visiting professor and national lecturer for the Japanese Hypertension Society, Tokyo.
Education & Fellowships
Medical Education - Indian Institute of Science
Undergraduate - S.P. College of Sciences
Fellowship - University of Zurich Institute for Molecular Biology
Fellowship - Massachusetts Institute of Technology
Cambridge, MA USA
Cardiac Hypertrophy, Hypertension, Renin-angiotensin System
Awards & Honors
View publications for Sadashiva Karnik, PhD
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