Cleveland Clinic Lerner Research Institute Logo
Cleveland Clinic Lerner Research Institute Logo
  • About
  • Science
    • Laboratories
    • Clinical & Translational Research
    • Departments
      Biomedical Engineering Cancer Biology Cardiovascular & Metabolic Sciences Florida Research & Innovation Center Genomic Medicine Immunotherapy & Precision Immuno-Oncology
      Infection Biology Inflammation & Immunity Neurosciences Ophthalmic Research Quantitative Health Sciences Translational Hematology & Oncology Research
    • Centers & Programs
      Advanced Musculoskeletal Imaging Angiogenesis Center Cardiovascular Diagnostics & Prevention Computational Life Sciences Genitourinary Malignancies Research Microbiome & Human Health
      Musculoskeletal Research Northern Ohio Alcohol Center Pathogen & Human Health Research Populations Health Research Therapeutics Discovery
  • Core Services
    • Ohio
      3D Printing BioRobotics & Mechanical Testing Cell Culture Cleveland Clinic BioRepository Computational Immunology Platform Computing Services Discovery Lab Electron Microscopy Electronics Engineering Flow Cytometry
      Genomic Medicine Institute Biorepository Genomics Glassware Histology Hybridoma Immunohistochemistry Immunomonitoring Lab Instrument Refurbishing & Repair Laboratory Diagnostic Lerner Research Institute BioRepository
      Light MicroscopyMechanical Prototyping Microbial Culturing & Engineering Microbial Sequencing & Analytics Resources Media Preparation Molecular Biotechnology Nitinol Polymer Proteomics & Metabolomics Therapeutics Discovery
    • Florida
      Bioinformatics
      Flow Cytometry
      Imaging
  • Education & Training
    • Graduate Programs Molecular Medicine PhD Program Postdoctoral Program
      Research Intensive Summer Experience (RISE) Undergraduate & High School Programs
  • News
  • Careers
    • Faculty Positions Research Associate & Project Staff Postdoctoral Positions
      Technical & Administrative
  • Donate
  • Contact
  • About
  • Science
    • Scientific Programs
    • Laboratories
    • Clinical & Translational Research
    • Departments
      Biomedical Engineering Cancer Biology Cardiovascular & Metabolic Sciences Florida Research & Innovation Center Genomic Medicine Immunotherapy & Precision Immuno-Oncology
      Infection Biology Inflammation & Immunity Neurosciences Ophthalmic Research Quantitative Health Sciences Translational Hematology & Oncology Research
    • Centers & Programs
      Advanced Musculoskeletal Imaging Angiogenesis Center Cardiovascular Diagnostics & Prevention Computational Life Sciences Genitourinary Malignancies Research Microbiome & Human Health
      Musculoskeletal Research Northern Ohio Alcohol Center Pathogen & Human Health Research Populations Health Research Therapeutics Discovery
  • Core Services
    • All Cores
    • Ohio
      3D Printing BioRobotics & Mechanical Testing Cell Culture Cleveland Clinic BioRepository Computational Immunology Platform Computing Services Discovery Lab Electron Microscopy Electronics Engineering Flow Cytometry
      Genomic Medicine Institute BiorepositoryGenomics Glassware Histology Hybridoma Immunohistochemistry Immunomonitoring Lab Instrument Refurbishing & Repair Laboratory Diagnostic Lerner Research Institute BioRepository
      Light MicroscopyMechanical Prototyping Microbial Culturing & Engineering Microbial Sequencing & Analytics Resources Media Preparation Molecular Biotechnology Nitinol Polymer Proteomics & Metabolomics Therapeutics Discovery
    • Florida
      Bioinformatics
      Flow Cytometry
      Imaging
  • Education & Training
    • Research Education & Training Center
    • Graduate Programs Molecular Medicine PhD Program Postdoctoral Program
      Research Intensive Summer Experience (RISE) Undergraduate & High School Programs
  • News
  • Careers
    • Faculty Positions Research Associate & Project Staff Postdoctoral Positions
      Technical & Administrative
  • Donate
  • Contact
  • Search

Christine Moravec Laboratory

❮Cardiovascular & Metabolic Sciences Christine Moravec Laboratory
  • Christine Moravec Laboratory
  • Principal Investigator
  • Research
  • Our Team
  • Publications
  • Research News

Principal Investigator

Christine Moravec Headshot

Christine Moravec, PhD

Staff
Director, Research Education & Training Center, Lerner Research Institute
Email: moravec@ccf.org
Location: Cleveland Clinic Main Campus

Research

Research in my laboratory focuses on human heart failure (HF), using 2 different approaches. First, we investigate the physiological and biochemical changes during HF, and ask if these changes can be reversed by current therapies. We collaborate with clinical colleagues to obtain patient information and perform laboratory studies on tissue samples from patients. Ongoing work focuses on the Sympathetic and Parasympathetic Nervous Systems and their roles in human HF, as well as differences between males and females in HF. Secondly, we investigate the role of psychophysiologic remodeling in HF, utilizing biofeedback-assisted stress management (BFSM) and testing the hypothesis that this type of intervention can also impact the cellular and molecular phenotype in HF patients. Our goal is to demonstrate biologic remodeling of the failing heart following BFSM.  The newest project in our lab tests the effects of several different stress management techniques in patients with coronary artery disease, again using biologic and clinical endpoints.  Collaborative research also tests the hypothesis that BFSM will improve clinical status and quality of life in patients with diabetes and multiple sclerosis.  Funding from the CCF Product Development Fund is helping us to create a handheld biofeedback device for patient use at home.


Biography


Education & Professional Highlights

Appointed
1993

Education & Fellowships

Medical Education - Cleveland State University
Cleveland, OH USA
1988

Graduate School - John Carroll University
University Heights, OH USA
1984

Undergraduate - John Carroll University
University Heights, OH USA
1978

Additional Training
  • Postdoctoral Fellowship, Cell Physiology, Cleveland Clinic
Professional Highlights
  • Director of Basic Research, Kaufman Center for Heart Failure, Cleveland Clinic
  • Director of Basic Science Education, Cleveland Clinic Lerner College of Medicine
  • Outstanding Educator Award, Lerner Research Institute, Cleveland Clinic
  • Kaiser Permanente Teaching Award, Cleveland Clinic Lerner College of Medicine
  • Excellence in Research Education Award, Cleveland Clinic Lerner College of Medicine
Awards & Honors
  • Established Investigator of the American Heart Association
  • Outstanding Educator Award, Lerner Research Institute
  • Kaiser Permanente Teaching Award, Cleveland Clinic Lerner College of Medicine
  • Excellence in Research Education Award, Cleveland Clinic Lerner College of Medicine
Memberships
  • American Heart Association
  • Heart Failure Society of America
  • American Psychosomatic Society
  • American Physiological Society
  • American Association for Applied Psychophysiology and Biofeedback

Research

Research

Research in my laboratory focuses on human heart failure (HF), using 2 different approaches. First, we investigate the physiological and biochemical changes during HF, and ask if these changes can be reversed by current therapies. We collaborate with clinical colleagues to obtain patient information and perform laboratory studies on tissue samples from patients. Ongoing work focuses on the Sympathetic and Parasympathetic Nervous Systems and their roles in human HF, as well as differences between males and females in HF. Secondly, we investigate the role of psychophysiologic remodeling in HF, utilizing biofeedback-assisted stress management (BFSM) and testing the hypothesis that this type of intervention can also impact the cellular and molecular phenotype in HF patients. Our goal is to demonstrate biologic remodeling of the failing heart following BFSM.  The newest project in our lab tests the effects of several different stress management techniques in patients with coronary artery disease, again using biologic and clinical endpoints.  Collaborative research also tests the hypothesis that BFSM will improve clinical status and quality of life in patients with diabetes and multiple sclerosis.  Funding from the CCF Product Development Fund is helping us to create a handheld biofeedback device for patient use at home.

Our Team

Our Team

frenchj@ccf.org

Brittany Goldstein

Medical Student
goldstb@ccf.org

,

gotowkc@ccf.org

Samantha Stefl

Research Technologist
stefls@ccf.org

Read Bio

Ms. Stefl earned her Master’s degree in molecular and cellular biology from the University of Toledo, where she studied the roles of Mixed Lineage Kinases and interferons in viral detection pathways. She earned her Bachelor’s degree from Kent State University where she studied the role of PKC delta in ischemic stroke.

Wendy Sweet, MS

Lead Technologist
sweetw@ccf.org

Publications

Selected Publications

View publications for Christine Moravec, PhD
(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)


  1. Barrows ... Moravec, et al. Robust gene expression with amplified RNA from biopsy-sized human heart tissue.  J Mol Cell Cardiol 42:260-264, 2007.
  2. Huang ... Moravec, et al.  Co-expression of skeletal and cardiac troponin T decreases mouse cardiac function.  Am J Physiol 294:C213-222, 2008.
  3. Moravec.  Biofeedback therapy in cardiovascular disease: rationale and research overview. Cleve Clin J Med 75:S35-S38, 2008.
  4. Pilbrow ... Moravec, et al.  Genomic selection of reference genes for real-time PCR in human myocardium.  BMC Medical Genomics 2008: 1:64: doi:10.1186/1755-8794-1-64. 

Research News

Research News

...
Cleveland Clinic, Cleveland State University Receive $1.2 Million NIH Award to Recruit Underrepresented Minority PhD Students

With new federal support for this longstanding cross-city collaboration in education and training, research teams at Lerner Research Institute and CSU seek to increase the number of minority scientists in the Cleveland area.



About Lerner

About Us Careers Contact Us Donate People Directory

Science

Clinical & Translational Research Core Services Departments, Centers & Programs Laboratories Research News

Education & Training

Graduate Programs Molecular Medicine PhD Program Postdoctoral Program RISE Program Undergraduate & High School Programs

Site Information & Policies

Search Site Site Map Privacy Policy Social Media Policy

9500 Euclid Avenue, Cleveland, Ohio 44195 | © 2023 Lerner Research Institute