Location: Cleveland Clinic Main Campus
Our multifaceted approach offers unique opportunities to explore many of the unresolved question underlying kidney development and human kidney diseases, to develop novel therapeutic approaches and to shorten the time to translate potential cures from bench to bedside.
Dr. Wessely is an Associate Staff in the Department of Cardiovascular & Metabolic Sciences in the Lerner Research Institute. Dr. Wessely received his Magister in Molecular Genetics in 1992 and his Ph.D. in Natural Sciences in 1997 from the University of Vienna in Austria. He then continued his research education as a postdoctoral fellow in the laboratory of E. M. De Robertis at UCLA in Los Angeles, CA. In November 2003 he joined the Departments of Cell Biology & Anatomy and Genetics at LSUHSC for his first faculty position. In 2011 he joined the Cleveland Clinic as an Associate Staff, continuing his research on kidney development and disease.
The kidney is an essential organ for water and solute homeostasis as well as excretion of waste products. Our research interests lie in the understanding of the molecular mechanisms governing the formation and maintenance of a functional kidney and how these processes are perturbed during diseases such as Polycystic Kidney Disease (PKD), Focal Segmental Glomerulosclerosis (FSGS) and Renal Cell Carcinoma (RCC).
The initial study of kidney development was focused on the role of the RNA-binding molecule Bicc1 in Polycystic Kidney Disease. Since then, we have branched out to multiple aspects of kidney development using both mouse and the amphibian Xenopus as model organisms. In addition, we use human pluripotent stem cells with the aim to study kidney development and diseases in the human setting. In particular, we strive to identify conditions that can drive cells homogenously towards the multiple terminally differentiated renal epithelial cells found in the nephron for regenertive medice approaches and how these cells are maintained in adults and whether endogenous repair mechanisms can be augmented to improve kidney function upon injury or aging. To this end, we use in vivo and in vitro systems and combine them with cutting-edge approaches (e.g. single cell studies, high-dimensional screening) to identify process critical parameters.
Our education and training programs offer hands-on experience at one of the nationʼs top hospitals. Travel, publish in high impact journals and collaborate with investigators to solve real-world biomedical research questions.Learn More
Drs. Lee, Ting and Wessely will examine human ureter and bladder tissues in males and females at various ages and construct a cellular and molecular anatomical map of the organs.