The Future of Cancer Treatment

While traditional methods for treating cancer, including chemotherapy and radiation, are often effective at killing cancer cells, they can also kill healthy cells, as well. Cancer researchers around the world are searching for more effective therapies that do not compromise patients’ long-term health and wellness. One of the most promising research areas is immunotherapy, which has shown great promise in treating many types of cancer.


Immunotherapies, including immune checkpoint modulators and cell therapy, have revolutionized the treatment of many human diseases. They have improved the outcomes of many cancers to a level thought impossible even a few years ago and comprise a new family of treatments that are quickly becoming a foundation of modern medicine. Classic immunotherapies such as vaccines are becoming increasingly important in a world threatened by emerging pathogens and antibodies that target discrete molecules have helped patients control various autoimmune ailments.

The Center for Immunotherapy & Precision Immuno-Oncology (CITI) is a state-of-the-art center dedicated to immunotherapy research, discovery and developmental therapeutics, with the ultimate goal to make precision immuno-oncology available for every patient. Learn more about our mission and goals.

Our Research Programs

Cellular Therapy

We are building a state-of-the-art cell engineering and immunotherapy program to enhance cell therapy clinical trials and research.

Immunologic Medicine

We run innovative immunotherapy trials across Cleveland Clinic, prioritizing precision design and biomarker correlatives.

Chan Lab

Precision & Developmental Therapeutics

We provide enterprise-level precision immunogenomic profiling, driven by data and translated to patients.

Precision Immuno-Oncology

Our investigators are experts in critical topics in translational immunology, immune-oncology and immunotherapy development.

Computational Immunology
Discovery Lab
Immunomonitoring Lab

What is Immunogenomics?

We are using immunogenomics—the combined study of tumor and immune cell genomics—to learn more about the body’s immune response to cancer, and how it can be imitated or amplified.

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What is Precision Immuno-Oncology?

It is our ultimate goal to offer immunogenomic profiling to all patients receiving immunotherapy treatment, either through clinical trials or commercial treatments.

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Cleveland Clinic Joins Multi-site Study and International Network to Study Parkinson’s Disease
10/14/2020

Dr. Chan will serve as the core investigator at Cleveland Clinic, one of four institutions working together as part of this collaborative study funded through Aligning Science Across Parkinson’s.

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VIDEO: New Center for Immunotherapy and Precision Immuno-Oncology to Help Advance Head and Neck Cancer Research
09/28/2020

Researchers from the new Center for Immunotherapy and Precision Immuno-Oncology will leverage their expertise with Cleveland Clinic’s world-class resources to help advance patient care and research into new therapies related to many cancer types, including head and neck cancers.

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Cleveland Clinic Names Chair of Department of Cancer Biology
08/10/2020

Jae Jung, PhD, a renowned expert in virus-induced cancers and immunology research, will lead Lerner Research Institute’s Department of Cancer Biology and will also serve as director of Cleveland Clinic’s Center for Global and Emerging Pathogens Research.

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Highlighted Studies

View studies showcasing our latest discoveries and findings.


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Join Us

Exciting investigation and groundbreaking discovery happens every day at Cleveland Clinic. Join our team of expert researchers at the Center for Immunotherapy & Precision Immuno-Oncology.


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