The Center for Immunotherapy & Precision Immuno-Oncology brings together researchers from multiple disciplines to develop innovative immune system-based personalized cancer treatments utilizing genomic analysis and high-throughput immunoprofiling.

Our department includes research laboratories, shared research platforms, developmental therapeutics and precision medicine programs. Learn more about our research and investigators below.


Immunologic Medicine Division

The Immunologic Medicine Division is aimed at advancing translational immunology research. Our principal investigators and laboratories specialize in the areas of immuno-oncology, regenerative medicine, auto-immunity, developmental therapeutics, computational immunology and population immunology.


The Chan Lab investigates the genomic and immunologic drivers of tumor development and treatment response. We have a special interest in tumor immunology and immunotherapy development.

Chan Lab

The Chan Lab investigates the genomic and immunologic drivers of tumor development and treatment response. We have a special interest in tumor immunology and immunotherapy development.

The Diaz lab studies the mechanisms that promote or inhibit anti-tumor immune responses and how they could be targeted with immunotherapies.

Diaz Lab

The Diaz lab studies the mechanisms that promote or inhibit anti-tumor immune responses and how they could be targeted with immunotherapies.

The Gastman lab investigates tumor immunology and the novel inhibitory strategies that enhance current immunotherapeutic approaches, as well as cancer therapy resistance and oncogenes that will ultimately have clinical utility.

Gastman Lab

The Gastman lab investigates tumor immunology and the novel inhibitory strategies that enhance current immunotherapeutic approaches, as well as cancer therapy resistance and oncogenes that will ultimately have clinical utility.

The Babal Kant Jha lab studies the functional basis of cancer-promoting genetic and epigenetic defects to help develop therapeutics.

Jha Lab

The Babal Kant Jha lab studies the functional basis of cancer-promoting genetic and epigenetic defects to help develop therapeutics.

Research in the McGrail lab integrates systems-level analyses with controlled experimental models to advance precision medicine in oncology and other diseases.

McGrail Lab

Research in the McGrail lab integrates systems-level analyses with controlled experimental models to advance precision medicine in oncology and other diseases.

The Ni lab investigates alterations in metabolism-related genes and metabolites could have direct impact in cancer predisposition, tumor progression and immunotherapy treatment response.

Ni Lab

The Ni lab investigates alterations in metabolism-related genes and metabolites could have direct impact in cancer predisposition, tumor progression and immunotherapy treatment response.

The Nikolaev lab investigates molecular and cellular pathways in tumor progression and resistance to chemo-radiation and immunotherapy in head and neck cancers.

Nikolaev Lab

The Nikolaev lab investigates molecular and cellular pathways in tumor progression and resistance to chemo-radiation and immunotherapy in head and neck cancers.

The Silver lab is exploring novel ways to reprogram the tumor immune microenvironment to develop therapeutics for head and neck cancers.

Silver Lab

The Silver lab is exploring novel ways to reprogram the tumor immune microenvironment to develop therapeutics for head and neck cancers.

The Wu Lab focuses on understanding the fundamental mechanism of innate immunity and its impact on adaptive immunity, inflammation and cancer.

Wu Lab

The Wu Lab focuses on understanding the fundamental mechanism of innate immunity and its impact on adaptive immunity, inflammation and cancer.

Precision Immuno-Oncology Program

The Precision Immuno-Oncology Program is comprised of faculty, scientists and shared resource platforms that establish enhanced discovery and translational capabilities at Cleveland Clinic and the Case Comprehensive Cancer Center. The Program offers enhanced clinical trial correlates for a wide range of basic and clinical areas of investigation.


Cell Therapy & Immuno-Engineering Program

The Cellular Therapy Program advances state-of-the-art cell engineering and T cell therapy developmental therapeutics, focusing on clinical development and research. We run cell therapy trials and develop new cell therapy approaches.


The goal of the Melenhorst lab is to develop potent, safe T cell-based gene therapies for hematologic and solid organ malignancies.

Melenhorst Lab

The goal of the Melenhorst lab is to develop potent, safe T cell-based gene therapies for hematologic and solid organ malignancies.

Precision & Developmental Therapeutics Program

The Precision & Developmental Therapeutics Program collaborates with the Cleveland Clinic Cancer Center and Case Comprehensive Cancer Center to provide precision approaches, including immunogenomic profiling, and new immunotherapy trials to patients and investigators.


Highlighted Studies

View studies showcasing our latest discoveries and findings.


VIEW STUDIES