The Center for Immunotherapy & Precision Immuno-Oncology brings together researchers from multiple disciplines to develop innovative immune system-based personalized cancer treatments utilizing genomic analysis and high-throughput immunoprofiling.

Our department includes research laboratories, shared research platforms, developmental therapeutics and precision medicine programs. Learn more about our research and investigators below.


Immunologic Medicine Division

The Immunologic Medicine Division is aimed at advancing translational immunology research. Our principal investigators and laboratories specialize in the areas of immuno-oncology, regenerative medicine, auto-immunoty, developmental therapeutics, computational immunology and population immunology.


The Chan Lab investigates the genomic and immunologic drivers of tumor development and treatment response. We have a special interest in tumor immunology and immunotherapy development.

Chan Lab

The Chan Lab investigates the genomic and immunologic drivers of tumor development and treatment response. We have a special interest in tumor immunology and immunotherapy development.

The Diaz lab studies the mechanisms that promote or inhibit anti-tumor immune responses and how they could be targeted with immunotherapies.

Diaz Lab

The Diaz lab studies the mechanisms that promote or inhibit anti-tumor immune responses and how they could be targeted with immunotherapies.

The Wu Lab focuses on understanding the fundamental mechanism of innate immunity and its impact on adaptive immunity, inflammation and cancer.

Wu Lab

The Wu Lab focuses on understanding the fundamental mechanism of innate immunity and its impact on adaptive immunity, inflammation and cancer.

Precision Immuno-Oncology Program

The Precision Immuno-Oncology Program is comprised of faculty, scientists and shared resource platforms that establish enhanced discovery and translational capabilities at Cleveland Clinic and the Case Comprehensive Cancer Center. The Program offers enhanced clinical trial correlates for a wide range of basic and clinical areas of investigation.


The Computational Immunology Division uses genomic technologies to process and analyze data from high-throughput next-generation sequencing and large-scale immune profiling. Our efforts encompass basic research, clinical trial correlates and algorithm development.

Computational Immunology Platform

The Computational Immunology Division uses genomic technologies to process and analyze data from high-throughput next-generation sequencing and large-scale immune profiling. Our efforts encompass basic research, clinical trial correlates and algorithm development.

The Discovery Lab works to develop the latest state-of-the-art molecular and genomic discovery platforms for translational immunology.

Discovery Lab

The Discovery Lab works to develop the latest state-of-the-art molecular and genomic discovery platforms for translational immunology.

The Immunomonitoring Lab provides cutting-edge technology platforms for the comprehensive immunophenotyping of blood and tissues.

Immunomonitoring Lab

The Immunomonitoring Lab provides cutting-edge technology platforms for the comprehensive immunophenotyping of blood and tissues.

Cellular Therapy Program

The Cellular Therapy Program advances state-of-the-art cell engineering and T cell therapy developmental therapeutics, focusing on clinical development and research. We run cell therapy trials and develop new cell therapy approaches.


Precision & Developmental Therapeutics Program

The Precision & Developmental Therapeutics Program collaborates with the Cleveland Clinic Cancer Center and Case Comprehensive Cancer Center to provide precision approaches, including immunogenomic profiling, and new immunotherapy trials to patients and investigators.


Highlighted Studies

View studies showcasing our latest discoveries and findings.


VIEW STUDIES