Pre-Analytical Laboratory

The CRU Pre-Analytic Sample Processing Laboratory provides consistent, high-quality sample processing.  By conforming to detailed procedures, as specified by each protocol, the lab aims to greatly reduce confounding variations that could occur due to differences in specimen handling. This detail-oriented handling is an essential element of the pre-analytical phase to ensure the most robust results can be obtained.

Laboratory Services include, but are not limited to:

  • Pre-proposal study logistics planning
  • Pre study initiation lab specimen logistics
  • Creation of detailed processing checklists
  • Laboratory technical support to conduct basic or complex processing of the highest consistency and quality, including documentation of variations and observations made during the procedures
  • Specialized processing techniques at the direction of the PI
  • Receipt of samples either collected by CRU nursing staff, or from other clinical environments where human research specimens are procured, such as surgical suites, outpatient clinics, or family health centers or collaborating institutions.
  • Peripheral blood mononuclear cell isolations
  • Elutriation services, yielding high numbers of purified platelets, lymphocytes and monocytes distributed to basic science researchers
  • Shipment or courier transport of samples to other locations (DOT/IATA certified)
  • Training in sample processing and collection

The M51 Core Lab Team has demonstrated dedication to the accurate and rigorous processing of every human research sample. They received the Cleveland Clinic Caregiver Excellence Award 2011 Q3 for their attention to details, an essential element of high quality research results. Their dedication has resulted in repeated instances in which investigators all over the country remark that samples processed by the Cleveland Clinic's M51 Core Lab are of consistently of better quality.

Publication Acknowledgement

All publications resulting from the utilization of CTSA resources are required to credit the CTSA grant by including the NIH funding acknowledgement and must comply with the NIH Public Access Policy. All researchers should cite grant UL1TR000439, as follows: " This publication was made possible by the Case Western Reserve University/Cleveland Clinic CTSA Grant Number UL1TR000439 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health. Its contents are solely the responsibility of the authors and do not necessarily represent the official view of NCATS or NIH."
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