Scott J. Cameron,  PhD, MD, RPVI

Scott J. Cameron, PhD, MD, RPVI

Assistant Staff / Staff Cardiologist

Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195


We are a basic and translational research laboratory that studies the adaptive platelet phenotype in vascular and thrombotic disorders. Platelets are small anucleate blood particles which play an important role in thrombosis, hemostasis, and inflammation.

Our laboratory was the first to identify that platelets are reprogrammed from their native, healthy state to a dysregulated state in the circulation at the time of acute myocardial infarction. We have since demonstrated that the anucleate platelet is sensitive to its external environment in vivo and ex vivo, and capable of altering post-receptor signal transduction events. This changes the response of platelets to anti-platelet medications. Current and recent work has focused on sex-dependent differences in vascular and thrombotic diseases, bidirectional communication between blood vessels and platelets, and capitalizing on platelets as circulating biosensors in diseases.

Our primary observations are made in humans and in privileged human tissue accessible through our academic clinical practice. An advantage of this approach is that it assures translatibility since many mechanistic studies in animals do not translate into a human therapeutic intervention. We create murine models of diseases to further explore mechanisms and use a variety of molecular, biochemical, and cellular assays for a comprehensive and mechanistic investigation.

Diseases we study: aneurysmal disease, aortic rupture, myocardial infarction, peripheral artery disease, venous insufficiency, pulmonary embolism, deep vein thrombosis, rare vascular and metabolic disorders (fibromuscular dysplasia, Klippel-Trenaunay Syndrome, lipedema), SARS-CoV-2.

Disease mechanisms we study: acute and chronic alterations in the circulating platelet phenotype, platelet-mediated remodeling of distant vascular and cardiac tissue, sex-dependent differences in aneurysmal disease, sex-dependent differences in platelet responses to medications, biomechanical platelet activation, signal transduction, utilization of platelets as circulating biosensors, thrombus resolution, outcomes in thrombotic and vascular diseases, protein kinases and signal transduction, proteomics.

Biomedical focus: pharmacology, biochemistry, vascular medicine, cardiology, thrombosis, clinical chemistry, biomarker discovery.

We are a friendly, collaborative laboratory with a keen interest in the happiness and career development of all laboratory members. The training environment is particularly well-suited for aspiring translational scientists and physician scientists. A position is available for a highly motivated Ph.D. student.

Lay Summary

I treat patients with thrombi (blood clots) in the heart, the brain, the lung, and the legs.  Small particles in the blood called platelets start the process of forming blood clots.  My laboratory discovered that platelets become reprogrammed in diseases such as heart attack and peripheral artery disease.  When platelets are reprogrammed, they do not respond as predicted to medications.  Platelets can also be considered as circulating messengers, carrying information back and forth between blood vessels and organs in the body.  A major goal of my research to understand the process of platelet reprogramming, and to identify additional proteins on platelets which could be targets for new medications.

Recent Peer-Reviewed Publications:

Publications in 2022

Sedhom R, Elbadawi A, Megaly M, Jaber WA, Cameron SJ, Weinberg I, Mamas MA, Elgendy IY. Hospital procedural volume and outcomes with catheter-directed intervention for pulmonary embolism: a nationwide analysis. Eur Heart J Acute Cardiovasc Care. 2022 Jul 13:zuac082. doi10.1093/ehjacc/zuac082. Epub ahead of print. PMID: 35830539.

Morgan S, Lee LH, Halu A, Nicolau JS, Higashi H, Wen JR, Ha AH, Daugherty A, Libby P, Cameron SJ, Mix D, Aikawa E, Owens AP III, Singh SA Aikawa M. Exploring novel mechanisms of abdominal aortic. In Press.

Morrell CN, Mix D*, Aggarwal A*, Bhandari R*, Godwin M, Owens Iii AP, Lyden SP, Doyle A, Krauel K, Rondina MT, Mohan A, Lowenstein CJ, Shim S, Stauffer S, Josyula VP, Ture SK, Yule DI, Wagner Iii LE, Ashton JM,Elbadawi A, Cameron SJ. Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms. Journal of Clinical Investigation. 2022 Mar 24:e152373. doi: 10.1172/JCI152373. Epub ahead of print. PMID: 35324479.* Equal contribution.

Battle S, Gogonea V, Willard B, Wang Z, Fu X, Huang Y, Graham LM, Cameron SJ, DiDonato JA, Crabb JW, Hazen SL. The pattern of apolipoprotein A-I lysine carbamylation reflects its lipidation state and the chemical environment within human atherosclerotic aorta. Journal of Biological Chemistry. 2022:101832. doi:

Groth CM, Acquisto NM, Wright C, Marinescu M, McNitt S, Goldenberg I, Cameron SJ. Pharmacists as Members of an Interdisciplinary Pulmonary Embolism Response Team (PERT). Journal of the American College of Clinical Pharmacy. J Am Coll Clin Pharm. 2022 Apr;5(4):390-397.

Iskandar JP Hariri E, Kanaan C, Kassis N, Kamran H, Sese D, Wright C, Marinescu M, Cameron SJ.  The Safety and Efficacy of Systemic versus Catheter-Based Therapies: Application of a Prognostic Model by a Pulmonary Embolism Response Team. J Thromb Thrombolysis. In Press 2022.

Elbadawi A, Mahmoud AA, Mahmoud K, Elgendy IY, Omer MA, Elsherbeny A, Ogunbayo GO, Cameron SJ, Ghanta R, Paniagua D, Jimenez E, Jneid H. Temporal Trends and Outcomes of Elective Thoracic Aortic Repair and Acute Aortic Syndromes in Bicuspid Aortic Valves: Insights from a National Database. Cardiol Ther. In press 2022.

Godwin MD, Aggarwal A, Hilt Z, Shah S, Gorski J, Cameron SJ. Sex-Dependent Effect of Platelet Nitric Oxide: Production and Platelet Reactivity in Healthy Individuals. JACC Basic Transl Sci . 2021 Dec 8;7(1):14-25. doi: 10.1016/j.jacbts.2021.10.009. eCollection 2022 Jan.

Auron M, Aguilar MP, Cameron SJ. COVID-19 and Elevated D-Dimer: A Tale of Caution. J Gen Intern Med. 2022 Jan 6:1–2. 

Publications in 2021

Wright C, Goldenberg I, Schleede S, McNitt S, Gosev I, Pietropaoli A,  Barrus B, Elbadawi A, Chen Y, Mazzillo J, Acquisto N, Van Galen J, Hamer A, Marinescu M, Delehanty J and Cameron SJ.  Effect of a Multidisciplinary Pulmonary Embolism Response Team on Patient Mortality.  American Journal of CardiologyAmerican Journal of Cardiology 2021 Dec 15;161:102-107.

Elbadawi A,  Elgend IY, Joseph D,   Eze-Nliam C, Rampersad P, Ouma G , Bhandari R, Kirksey L, Chaudhury P, Chung MK, Kalra A, Mehta N, Bartholomew JR, Sahai A, Svensson  LG, Cameron SJ. Racial differences, clinical presentation, and outcomes among hospitalized patients with COVID-19.  Journal of Racial and Ethnic Health Disparities. In press 2021.

Kamran H, Hariri E, Iskandar JP, Sahai A, Haddadin I, Campbell J, Harb SC, Delehanty JM, Bartholomew JR, Heresi G, Cameron SJ. Simultaneous Pulmonary Artery Pressure and Left Ventricle Stroke Volume Assessment Predicts Adverse Events in Patients with Pulmonary Embolism. J American Heart Association. In press 2021.

Sahai A, Bhandari B, Koupenova M, Freedman J, Godwin M, McIntyre M, Chung M, Iskander JP, Kamran H, Hariri E, Aggarwal A, Kalra A, Bartholomew JR, McCrae KR, Elbadawi A, Svensson LG, Kapadia S, Cameron SJ. The Effect of Aspirin on Short-term Outcomes in Hospitalized Patients with SARS-CoV-2.  Vascular Medicine. In press 2021. *Equally-contributing

Tefera L and Cameron SJ Vaccine-Induced Thrombocytopenia with Thrombosis.  Vascular Medicine. In press 2021.

Koupenova M, Corkrey HA, Vitseva O, Tanriverdi K, Somasundaran M, Liu P, Soofi S, Bhandari R, Godwin M, Parsi KM, Cousineau A, Maehr R, Wang J, Cameron SJ, Rade JJ, Finberg RW, Freedman JE. SARS-CoV-2 Initiates Programmed Cell Death in Platelets. Circ Res. 2021 Jul 23. doi: 10.1161/CIRCRESAHA.121.319117. Epub ahead of print. PMID: 34293929.

Bhandari R and Cameron SJ Breaking the cycle: Succinate in aortic diseases.  European Heart Journal. In press 2021.

Cameron, SJ and Engel, R Keeping an Eye on Vascular Disease.  Vascular Medicine. In press 2021.

Chung MK, Zidar D, Bristow M, Cameron SJ, Chan T, Harding III CV, Kwon DH Singh T, Tilton J, Tsai EJ, Tucker NR,  Barnard J,  Loscalzo J. Update on COVID-19 and Cardiovascular Disease: from Bench to Bedside. Circ Res. 2021 Apr 16;128(8):1214-1236

Xu S,  Ilyas I,. Little PJ, Li H,  Kamato D, Watts S, Ebong E, Cameron SJ, Stewart AG, Weng J. Endothelial dysfunction in atherosclerotic cardiovascular diseases and beyond: from mechanism to pharmacotherapies. Pharmacol Rev. 2021 Jul;73(3):924-967

Kim BS, Auerbach DA, *Sadhra H, Godwin M, Bhandari R, Ling FS, Mohan A, Yule DI, Wagner II L, Rich DQ,  Ture SK, Morrell CN, Timpanaro-Perrotta, Younis A, Goldenberg I, Cameron SJ.  Sex-specific platelet activation through Protease-Activated Receptors Reverses in Myocardial Infarction. ATVB  2021 Jan;41(1):390-400.

Elbadawi A, Eldendy IY, Sahai A, Bhandari R, McCarthy M, Gomes M, Bishop GJ, Bartholomew JR, Kapadia S, Cameron SJ. Incidence and Outcomes of Thrombotic Events in Symptomatic Patients with COVID-19. ATVB 2021 Jan;41(1):545-547.

Van Galen J, Pava L, Wright C, Elbadawi A, Chaturvedi A, Cameron SJ. Effect of platelet inhibitors on thrombus burden in patients with acute pulmonary embolism. Platelets. 2021 Jan 2;32(1):138-140.

Publications in 2020

Tran M, Sheth C , Bhandari R Cameron SJ, Hornacek D. SARS-CoV-2 and Pulmonary Embolism: who stole the platelets? Thromb J. 2020 Sep 3;18:16. doi: 10.1186/s12959-020-00229-8. eCollection Thromb J. 2020 Sep 3;18:16

Barnes GD, Muzikansky A, Cameron S et al. Comparison of 4 Acute Pulmonary Embolism Mortality Risk Scores in Patients Evaluated by Pulmonary Embolism Response Teams. JAMA Network Open 2020 Aug 3;3(8):e2010779.

Lachant D, Bach C, Wilson B, Chengazi V, Goldman B, Lachant N, Pietropaoli A, Cameron S, James White R. Clinical and imaging outcomes after intermediate- or high-risk pulmonary embolus. Pulm Circ. 2020 Sep 21

Chung MK,  Karnik S, Saef J, Bergmann C,  Barnard J, Lederman MM,  Tilton J, Cheng F, Harding CV,  Young JB, Mehta N, Cameron SJ, McCrae KR,  Schmaier, AH, Smith JD,  Kalra A, Surafel GK, Thomas G, Hawkins ES, Svensson LG.  SARS-CoV-2 and ACE2: The Biology and Clinical Data Behind the ARB and ACEI Controversy.  EBioMedicine 2020 Aug;58:102907

Bennett J, Mastrangelo M, Ture S, Smith C, Loelius S, Berg R, Shi X, Burke R,  Spinelli S,  Cameron SJ,  Carey T, Brookes P, Gerszten R, Sabater-Lleal M, De Vries P,  Huffman J, Smith N, Morrell C, and  Lowenstein CJ.  The choline transporter Slc44a2 controls platelet activation and thrombosis by regulating mitochondrial function.  Nature Communications 2020 Jul 13;11(1):3479.

Elbadawi A, Omer M, Ogunbayo G,  Owens III, AP, Mix D, Lyden SP and Cameron  SJ. Anti-platelet Medications Protect against Aortic Dissection and Rupture in Patients with Abdominal Aortic Aneurysms. Journal of the American College of Cardiology. 2020 Apr 7;75(13):1609-1610. doi: 10.1016/j.jacc 

Ayers B, Wood K, Cameron SJ, Marinescu M, Bjelic M, Barrus B  and Gosev I.  Surgical Pulmonary Embolectomy with No Systemic Anticoagulation for Patient with Recent Stroke. In Press, Annals of Thoracic Surgery (2020)

Kamran H, Hornacek D, Mix M, Wright C, Cameron SJ. The Teachable Art of the Vascular Physical Exam.  Vasc Med. 2020 Aug;25(4):351-353.

Stewart L, Beam B, Casciani T, Cameron SJ and Kline JE.  Effect of metabolic syndrome on mean pulmonary arterial pressures in patients with acute pulmonary embolism treated with catheter-directed thrombolysis. International Journal of Cardiology.  Int J Cardiol. 2020 Mar 1;302:138-142. doi: 10.1016/j.ijcard.2019

Wu MQ, Preslar M, Katerji H, Palma C, and Cameron SJ, Fibrosis, Thrombosis, and Dacrocytosis: An Unusual Case of Male Systemic Lupus Erythematosus". American J Medicine, In Press 2020.

Publications in 2019

Chen YL, Wright C, Pietropaoli AP, Elbadawi A, Delehanty J, Barrus B, Gosev I, Trawick D, Patel D, Cameron SJRight ventricular dysfunction is superior and sufficient for risk stratification by a pulmonary embolism response team. J Thromb Thrombolysis2019 Aug 2;doi: 10.1007/s11239-019-01922-w.  PubMed PMID: 31375993.

Wang M, Hopke PK, Masiol M, Thurston SW, Cameron SJ, Ling F, van Wijngaarden E, Croft D, Squizzato S,Thevenet-Morrison K, Chalupa D, Rich, DQ  Triggering of ST-elevation myocardial infarction by particulate air pollution in Monroe County, New York; before, during, and after multiple air quality policies and economic changes.  Environ Health. 2019 Sep 6;18(1):82.

Wright C, Elbadawi A, Chen YL, Patel D, Mazzillo J, Acquisto N, Groth C, Van Galen J, Delehanty J, Pietropaoli A, Trawick D, James White R, Cameron P, Gosev I, Barrus B, Kumar NG, Cameron SJThe impact of a pulmonary embolism response team on the efficiency of patient care in the emergency department. J Thromb Thrombolysis2019 Aug;48(2):331-335doi: 10.1007/s11239-019-01875-0. PubMed PMID: 31102160.

Elbadawi A, Mentias A, Elgendy IY, Mohamed AH, Syed MH, Ogunbayo GO, Olorunfemi O, Gosev I, Prasad S, Cameron SJNational trends and outcomes for extra-corporeal membrane oxygenation use in high-risk pulmonary embolism. Vasc Med2019 Jun;24(3):230-233doi: 10.1177/1358863X18824650. Epub 2019 Mar 5. PubMed PMID: 30834824.

Publications in 2018

Elbadawi A, Wright C, Patel D, Chen YL, Mazzillo J, Cameron P, Barnes GD, Cameron SJThe impact of a multi-specialty team for high risk pulmonary embolism on resident and fellow education. Vasc Med2018 Aug;23(4):372-376doi: 10.1177/1358863X18767753. Epub 2018 May 22. PubMed PMID: 29786477.

Hilt ZT, Pariser DN, Ture SK, Mohan A, Quijada P, Asante A, Cameron SJ, Sterling JA, Merkel AR, Johanson AL, Jenkins JL, Small EM, McGrath KE, Palis J, Elliott MR, Morrell CN. Platelet-derived β2M regulates monocyte inflammatory responses. JCI Insight. 2019 Mar 7;4(5). PMID: 30702442

Schmidt RA, Morrell CN, Ling FS, Simlote P, Fernandez G, Rich DQ, Adler D, Gervase J, Cameron SJ. The platelet phenotype in patients with ST-segment elevation myocardial infarction is different from non-ST-segment elevation myocardial infarction. Transl Res2018 May;195:1-12doi: 10.1016/j.trsl.2017.11.006. Epub 2017 Dec 2. PubMed PMID: 29274308.

Gleber C, Yoruk A, Eastburg L, Goldman BI, Cameron SJ. Conduction Dysfunction and Near Expunction: Giant Cell Myocarditis. Am J Med2018 Nov;131(11):1317-1320doi: 10.1016/j.amjmed.2018.04.011. Epub 2018 May 3. PubMed PMID: 29729236.

Cameron SJ, Mix D, Ture S, Schmidt R, Mohan A, Pariser D, Stoner M, Shah P, Chen L, Zhang H, Field DJ, Modjeski KL, Toth S, Morrell CN. "Hypoxia and Ischemia Promote a Maladaptive PlateletPhenotype". Atherosclerosis Thrombosis and Vascular Biology. 2018; 38(7): 1594-1606. 

Croft D, Block R, Cameron SJ, Evans K, Lowenstein CJ, Ling F, Zareba W, Hopke PK, Utell MJ, Thurston SW, Thevenet-Morrison K, Rich DQ. Do elevated blood levels of omega-3 fatty acids modify effects of particulate air pollutants on fibrinogen?. Air Qual Atmos Health2018;11(7):791-799doi: 10.1007/s11869-018-0586-0. Epub 2018 Jun 3. PubMed PMID: 30147809.

Yang M, Cooley BC, Li W, Chen Y, Vasquez-Vivar J, Scoggins NO, Cameron SJ, Morrell CN, Silverstein RL. Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions. Blood2017 May 25;129(21):2917-2927doi: 10.1182/blood-2016-11-750133. Epub 2017 Mar 23. PubMed PMID: 28336528

Miller EO, Krishnamoorthy VK, Ling FSK, Chaturvedi A, Cameron SJA man with chest pain and acute ST elevations on electrocardiogram. BMJ2017 May 18;357:j2198doi: 10.1136/bmj.j2198. PubMed PMID: 28522610.

Croft DP, Cameron SJ, Morrell CN, Lowenstein CJ, Ling F, Zareba W, Hopke PK, Utell MJ, Thurston SW, Thevenet-Morrison K, Evans KA, Chalupa D, Rich DQ. Associations between ambient wood smoke and other particulate pollutants and biomarkers of systemic inflammation, coagulation and thrombosis in cardiac patients. Environ Res2017 Apr;154:352-361doi: 10.1016/j.envres.2017.01.027. Epub 2017 Feb 4. PubMed PMID: 28167447.

Cameron SJ, Morrell CN, Bao C, Swaim AF, Rodriguez A, Lowenstein CJ. A Novel Anti-Inflammatory Effect for High Density Lipoprotein. PLoS One2015;10(12):e0144372doi: 10.1371/journal.pone.0144372. eCollection 2015. PubMed PMID: 26680360

Cameron SJ, Ture SK, Mickelsen D, Chakrabarti E, Modjeski KL, McNitt S, Seaberry M, Field DJ, Le NT, Abe JI, Morrell CN. "Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion." Circulation.. 2015 Jul 7; 132(1):47-58. Epub 2015 May 01.

Gardner B, Ling, FL Hopke PK, Frampton MW, Utell MJ, Zareba W, Cameron SJ, Chalupa D, Kane C, Kulandhaisamy S, Topf M, Rich, DQ. Ambient fine particulate air pollution triggers ST elevationmyocardial infarction, but not non-ST-elevation myocardial infarction: a case-crossover study. Part Fibre Toxicol. 2014 Jan 2;11(1):1. PMID: 24382024

Jeong Y, Chaupin DF, Matsushita K, Yamakuchi M, Cameron SJ, Morrell CN, Lowenstein CJ. Aldosterone activates endothelial exocytosis. Proc Natl Acad Sci U S A2009 Mar 10;106(10):3782-7doi: 10.1073/pnas.0804037106. Epub 2009 Feb 17. PubMed PMID: 19223584.

Frame MD, Rivers RJ, Altland O, Cameron SJ Mechanisms initiating integrin-stimulated flow recruitment in arteriolar networks. J Applied Physiology 2007 Jun;102(6):2279-87. PMID: 17379749.

09/23/2022 |  

New Cleveland Clinic Centers of Excellence Target “Long COVID,” Myeloid Leukemia, Gut Microbiome

The program, which has funded 21 research teams since 2015, has a proven record of supporting projects that go on to attract large external grants.

09/21/2021 |  

Researchers to Study Link Between Platelets and Asymptomatic Abdominal Aortic Aneurysms

Dr. Cameron will study the mechanistic interaction between platelets and how they emerge as circulating biosensors, releasing proteins that are useful biomarkers for distinguishing fast- from slow-growing aneurysms.