Physician-researcher Stanley Hazen, MD, PhD, discusses his COVID-19 research and the evidence that suggests there may be a link between SARS-CoV-2 and the gut microbiome.

The nomogram developed by Lara Jehi, MD, and Michael Kattan, PhD, to predict a patient’s likelihood of testing positive for COVID-19 is mentioned as a tool that may provide clinicians a clearer sense of individual disease risk for their patients.

Serpil Erzurum, MD, comments on the effect the pandemic has had on the status of research studies and trials, and explains how LRI was able to adapt to avoid complete shutdown, unlike some other universities and research institutions.

Vijay Krishna, PhD, comments on the feasibility of engineering and treating patients with nanoparticles, called nanosponges, which attract and essentially inactivate SARS-CoV-2, the virus that causes COVID-19.

Raed Dweik, MD, PhD, comments on the accuracy of COVID-19 antibody tests, helping to clarify the difference in reliability of COVID-19 antibody and viral tests.

Feixiong Cheng, PhD, comments on new images showing how coronavirus creates tentacles that branch out and may transmit infection to neighboring cells.

Officials are talking about implementing a new strategy that tests groups of people together. Brian Rubin, MD, PhD, comments.

Lara Jehi, MD, explains how Cleveland Clinic is using the model—the first to predict a patient’s likelihood of testing positive for COVID-19—including to inform researchers and clinicians which patients should be followed more closely or hospitalized, and how resources should be allocated.

Lara Jehi, MD, explains how to interpret findings from the team’s recent study of a new predictive model, including that taking some medications is associated with lower risk for a positive COVID-19 test. She cautions that, at this point, the data does not suggest the medications are protective.

Christine McDonald, PhD, and Shaun Stauffer, PhD, share details about their work on COVID-19, including exploring how the disease occurs, what drives some of the complications and how they hope to target some of the body’s natural defenses.

Researchers Michael Kattan, PhD, and Lara Jehi, MD, discuss how their research builds on Cleveland Clinic’s model of clinical and scientific collaboration; how clinical data is facilitating unique investigations; and why waiting for government funding will hinder COVID-19 research.

Michael Kattan, PhD, joins Philanthropy Institute Chair Lara Kalafatis to discuss how predictive analytics are shaping care for patients with COVID-19, how his own battle with cancer inspired his life’s work and how Virtual VeloSano will support cancer research.

Tom Mihaljevic, MD, Cleveland Clinic CEO and President, and Serpil Erzurum, MD, Chair of Lerner Research Institute, discuss key COVID-19 research, including testing, vaccine development and anti-viral medications, as well as the importance of philanthropy in advancing COVID-19 treatments.

Early research about COVID-19 shows men have higher death rates and worse symptoms compared to women. Nima Sharifi, MD, is investigating whether that could be linked to sex hormones.

Antibody testing, which shows who has already been infected with COVID-19 and may have developed some levels of immunity, is not as straight forward as it sounds. Thaddeus Stappenbeck, MD, PhD, (beginning around minute 11) comments on the value of antibody testing during the COVID-19 pandemic.

Serpil Erzurum, MD, Chair of the Lerner Research Institute, and Philanthropy Institute Chair Lara Kalafatis discuss the race to develop a vaccine and promising research that is harnessing the power of big data to discover effective COVID-19 treatments.

Scientists are working to create a vaccine against SARS-CoV-2, but experts say it could take 12 to 18 months to develop and mass-produce. Thaddeus Stappenbeck, MD, PhD, provides insight on the complex process of vaccine development.