Facilities & Cores

The Cleveland Clinic Florida Research and Innovation Center (FRIC) is dedicated to the discovery and advancement of innovative translational research focused on infectious diseases and immuno-oncology. The Center spans approximately 100,000 sq. ft of dedicated research and support spaces, including state-of-the-art shared resource facilities in flow cytometry, imaging, and bioinformatics. Each of these cores support the capabilities of biosafety level (BSL) 2 and 3 research facilities, providing scientists access to advanced technologies in both research environments.

Flow Cytometry Core

The Flow Cytometry Core provides state-of-the-art instrumentation and technical support. The principal assets of the core consist of analytical equipment and cell sorting capabilities. The sorting equipment is located in Class I Biobubbles to allow for sorting infectious samples. The core will also provide access to data analysis software and analysis expertise.

Imaging Core

The Imaging Core at the FRIC provides access to advanced imaging technologies, including:

  • Wide-field and confocal fluorescent microscopes
  • FLIM capability
  • Live-cell imaging microscopes
  • Pre-clinical imaging microscopes
  • BSL-3 imaging platforms for pre-clinical and basic research microscopy projects

The core also offers support for researchers and projects beyond hardware. Our expert staff can provide consultation on experimental design and optimization, post-acquisition image processing, and support for analysis, visualization and interpretation of data. The analysis workstation in the facility runs a full suite of analysis and visualization software packages for getting the most rigorous quantification and representation of imaging data.

BSL-3 Core

The BSL-3 facilities provide dedicated, trained scientific staff to execute BSL-3 projects in a high-containment environment. This facility contains multiple different laboratories each with their own anteroom and autoclave allowing for separation of research activities and is designed to enable select agent research. All laboratories in the BSL-3 suite contain Class II Type A2 biological biosafety cabinets, pass-through autoclaves, CO2 incubators, centrifuges, ultralow freezers, and shower in/out facilities. In addition, the core provides access to high end instrumentation for flow cytometry, wide-field microscopy, and pre-clinical imaging.

Bioinformatics Core

The Bioinformatics Core provides access to various software platforms, pipeline development and information systems to analyze complex data sets.