Ignacio  Mata,  PhD

Ignacio Mata, PhD

Assistant Staff

Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195

 

It is a very exciting time to be in the field of human genetics. Since the sequencing of the human genome in 2003, genetics have tremendously improved the understanding of many human diseases, as well as nominated new targets for future therapies.

Dr. Mata's primary research goals are directed toward understanding the genetic component of neurological disorders, in particular Parkinson’s disease (PD), Parkinson’s Disease Dementia (PDD) and Dementia with Lewy Bodies (DLB). Most neurological disorders are very complex, both clinically and genetically, thus proposing a very interesting challenge. In most cases they are the result of a complex interaction between one’s genetics and the environment. Dr. Mata's lab uses approaches like case-control and family studies to identify those genetic risk factors that modify risk or cause the disease.

A significant focus of Dr. Mata's research has also been performing genetic studies in non-European populations, especially those with a minority ethnic background such as Latinos. For this Dr. Mata created and coordinated the Latin American Research consortium on the Genetics of PD (LARGE-PD), a collaboration of more than 37 institutions across many countries in Latin America. The reason behind it is that there is a tremendous lack of diversity in genetic research, with most large-genetic studies including only people of European ancestry, despite the fact that most diseases affect people from all genetic backgrounds. This is increasing the already existing health disparities in these populations.

Our lab and study aims include:

  • Identifying unique genetic and environmental exposure factors that may impact Hispanic populations and their risk of developing PD, as well as disease severity.
  • Leveraging Cleveland Clinic’s large patient population and mass electronic health record data with genetic data from patient samples to create predictive PD severity and progression models using machine learning.
  • Creating a novel questionnaire in order to address gender-based disparities in genetic and PD research, and using women’s health factor data in severity prediction models.
  • Extending these models and aims to other neurological disorders and patient populations.
  • Creating a patient registry, database, and biorepository as a “one stop shop” for PD research at Cleveland Clinic.
  • Applying these results to improve patient treatment and outcomes for these neurological disorders.

Lay Summary

Every person inherits information (genes) from their parents that determines characteristics like height, eye and hair or skin tone. But these genes also carry information that can protect or increase our chances of developing certain diseases. Dr. Mata's lab is working toward identifying and understanding the genes that play a role in those diseases that affect the brain (neurological disorders). These include the very well-known Parkinson’s disease (PD), but also other, less common, disorders, such as a form of PD that presents with severe cognitive problems/dementia (PDD) and another type of dementia called Dementia with Lewy Bodies (DLB). Identifying these genes is very important as they represent candidates for novel therapies that can help treat these disorders.

Dr. Mata's lab tries to include patients from all ethnicities in its studies, and is privileged to coordinate the Latin American Research consortium on the Genetics of PD (LARGE-PD). This consortium is trying to understand if these genetic factors are the same between populations or specific to certain populations. This inclusion of patients from all genetic backgrounds will be a key factor in developing genetic-based, personalized treatments.

Current Research Projects

LARGE-PD USA
Our U.S. cohort has been approved and is actively recruiting through Cleveland Clinic, the Genomic Medicine Institute and other associated organizations. Our goal is to learn more about the genetic risk factors that play a role in the development of PD in Latinos. The entire recruitment process is conducted remotely, with the consenting process done by phone, questionnaires distributed online and by email, and saliva samples collected by mail. Saliva collection kits are mailed to participants with additional study materials at no cost to the participant.

Constructing a Prediction Tool for Severity in Women with Parkinson’s Disease
Parkinson’s disease (PD) is the second fastest growing neurodegenerative disorder worldwide, with an estimated 13 million people being diagnosed by 2040. For PD, men are almost two times more likely to get it than women, however, women experience a faster progression and lower survival rate. Women also tend to be diagnosed much later, long after symptoms are present. There is little being done in clinical care or research to address the stark differences observed between sexes. The current questionnaires being used in PD research and clinical care are gender-neutral or only focus on hormone replacement therapy. The goal of this study is to deploy our novel women’s health questionnaire to all women with PD being seen at Cleveland Clinic, LARGE-PD, PDGENEration within and throughout the Americas to elucidate the role of women-specific health factors alongside other factors in the severity and progression of PD. This involves building multivariate predictive health models via machine learning.

Genetic-Based Precision Medicine in Migraine Treatment
Migraine is a highly heritable complex brain disorder that impacts approximately a billion people worldwide. A novel preventative treatment for migraines are calcitonin gene-related peptide (CGRP) inhibiting monoclonal antibodies (MABs). The goal of this project is to understand the clinical, demographic, and quality of life factors that correlate with CGRP MABs treatment outcomes (defined as reduction in migraine frequency), and assess if a model including genetics can help predict those outcomes. We will do this by developing stepwise multivariable logistic regression models with and without genetic data from patient saliva/blood samples. Multivariate predictive health models will also be built via machine learning.

Cleveland Clinic Comprehensive Parkinsonian disorders Registry, Biorepository and Database
The purpose of this registry is three-fold:

  1. To compile a list of patients with Parkinsonian disorders being seen Cleveland Clinic and other partner organizations interested in participating in current and future research. This will provide researchers with a list of interested candidates, and necessary information about their symptoms.
  2. To collect and store human biological samples (e.g. biofluids) from Parkinson’s patients, their family members, and healthy controls receiving care at Cleveland Clinic and partner institutions. An environmental exposures questionnaire will be an option for these patients.
  3. To establish a database of genetic, clinical, demographic, environmental, and women’s health data associated with Cleveland Clinic and partner organization patients diagnosed with a Parkinsonian disorder.

This will allow our team, and other IRB approved research teams to view, analyze, and create clinical studies from this de-identified aggregated PD data. It will also allow us to learn more about the many risk factors that play a role in the development, progression, and outcomes of Parkinson’s disease. We are collecting environmental exposure, and other life event data, that may allow Cleveland Clinic teams to determine if specific factors are also implicated in the development and/or progression of PD, and how those life events interact with the genetic factors identified in our cohort. This will allow our team to create multivariable predictive models of PD progression that may help future clinical and research efforts in treating PD through additional sub-studies.

Cleveland Clinic Latino Epidemiology Cohort
Cleveland Clinic researchers Stephanie Schmit, PhD, MPH, and Ignacio Mata, PhD, from the Genomic Medicine Institute are establishing the Cleveland Clinic Latino Epidemiology (CCLE) Cohort. The aim is to recruit Latino patients from Cleveland Clinic’s Ohio and Florida locations to build the initial CCLE Cohort. The CCLE Cohort will be utilized to study the biological causes for disease risk and outcomes. The initial focus will be on Parkinson’s disease and colorectal cancer. The CCLE Cohort will serve as a resource for additional Cleveland Clinic locations, and its leaders hope it can be harnessed to investigate other disorders in Latino populations. The CCLE Cohort will leverage Cleveland Clinic’s large patient volumes and sophisticated electronic health record to build a research infrastructure that additional institutes and locations will be able to access when conducting health disparities research in the future.


Key Publications: (from newer to older)

  1. Genome-wide Analysis of Copy Number Variation in Latin American Parkinson's Disease Patients

Sarihan IE et al. Pre-Print

The overall identification of copy number variants (CNV) at a genome-wide level has been understudied in PD patients since most studies only screen a few known PD genes. Here we used genome-wide genotyping data from 747 PD patients and 632 ancestry matched controls from LARGE-PD to understand the genome-wide burden of copy number variants in Latinos and its association with disease:

  • Genome-wide copy number burden analysis showed no difference between patients vs. controls

  • Patients were significantly enriched for CNVs overlapping known PD genes (OR: 3.97 [1.69 - 10.5], P = 0.018), with PARK2 showing the strongest burden

  • Patients carrying a CNV in known PD genes present disease symptoms 26 years earlier compared to patients with CNVs in other genes 

  • In Latin America 5.6% of Early-Onset PD patients carry a CNV in PARK2


  1. The distribution and risk effect of GBA variants in a large cohort of PD patients from Colombia and Peru

Velez-Pardo C, Lorenzo-Betancor O, Jimenez-Del-Rio M, Moreno S, Lopera F, Cornejo-Olivas M, Torres L, Inca-Martinez M, Mazzetti P, Cosentino C, Yearout D, Waldherr SM, Zabetian CP, Mata IF. Parkinsonism Relat Disord. 2019 Jun;63:204-208. doi: 10.1016/j.parkreldis.2019.01.030. Epub 2019 Feb 4.

GBA is the most important risk factor for PD, however little is known about its effects in Latinos. Here we screened 602 PD patients and 319 controls from Colombia and Peru. The key findings were:

  • GBA is an important risk factor in this populations too, increase the risk to develop PD around 4.5 and 6.2 fold in Peru and Colombia respectively

  • While frequency in PD patients from Peru is similar to frequency in other countries (5.5%), frequency in Colombia is double (9.9%) due to the presence of a newly described population-specific mutation (p.K198E)

  • Mutations in GBA not only increase the risk to develop PD, but also advances the age at onset by about 8 years.


  1. LARGE-PD: Examining the Genetics of Parkinson’s Disease in Latin America

Zabetial CP, Mata IF on behalf of the Latin American Research Consortium on the Genetics of PD (LARGE-PD). Mov Disord . 2017 Sep;32(9):1330-1331. doi: 10.1002/mds.27081. Epub 2017 Jun 28.

Mutations located in codons G2019 and R1441 of the leucine-rich repeat kinase 2 (LRRK2) gene represent the most common genetic cause of PD in patients of European origin.Here, we show that, in the LARGE-PD cohort, the combined frequency of these LRRK2 mutations varies substantially across countries in Latin America and is directly  correlated with the estimated proportion of European ancestry at each site. This indicates that the genetic architecture of PD might differ between Latinos and other population groups, as it has been shown in several other diseases, including cancer.

 

See a complete list of publications for Ignacio Mata, PhD on PubMed.


07/27/2021 |  

Characterizing the Genetic Architecture of Parkinson’s Disease in Latinos

To address the lack of diversity in Parkinson’s disease genetic research, Dr. Mata and colleagues conducted the first ever genome-wide association study of Latino Parkinson’s disease patients from South America.




04/26/2021 |  

Precision Medicine in Migraine Treatment

With their Co-Laboratories Award, Drs. Mata and Ahmed will team up to develop a way to predict patient response to FDA-approved treatments for migraine prevention.




08/10/2020 |  

NIH Awards $3.1M to Identify Novel Parkinson’s Disease Genes in Latinos

Dr. Mata and collaborators aim to pinpoint therapeutic targets for treatment and improve diagnosis and risk prediction in Latino populations.










05/04/2022 |  

New Research Collaborative Aims at Closing Minority Health Disparities

With a Cleveland Clinic research co-laboratories award, Drs. Schmit and Mata will establish the Cleveland Clinic Latino Epidemiology (CCLE) Cohort to help close the gap in research participation and health disparities for the Latino population.