Mark A. Aronica, MD
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
Phone: (216) 445-3080
Asthma, an epidemic that affects more than 155 million people in the world, is a chronic disease characterized by exacerbations and progressive loss of lung function. Despite the field’s understanding of asthma as an inflammatory disease and the mechanisms that drive and initiate inflammation, little is known about the mechanisms related to resolution of inflammation or its impact on lung function and structural changes. The Aronica lab investigates the role of several components of the extracellular matrix (ECM) in the development and pathogenesis of asthma.
Specific areas of study in the Aronica lab include:
- Mechanisms by which specific ECM proteins contribute to the onset of asthma. The group studies how TSG-6 (tumor necrosis factor-stimulated gene-6) and IaI (inter-alpha-trypsin inhibitor) participate in the development of asthma in vivo. They also investigate their roles in the organization of the hyaluronan matrix, recruitment of inflammatory cells within the matrix and maintaining the structural integrity of the lung.
These studies will help to determine the distribution and changes in matrix composition in the airways and if these changes are permanent or resolve after antigen withdrawal and resolution of inflammation, as well as providing insight into the mechanisms by which hyaluronan is synthesized and degraded in the airway.
The lab’s long-term goal is to define mechanisms that regulate the synthesis, degradation and organization of hyaluronan, TSG-6 and IaI within the lung, how these matrix components affect inflammation and their effects on lung structure and function.
-Asosingh K, Hanson JD, Cheng G, Aronica MA, Erzurum SC. Allergen-induced, eotaxin-rich, proangiogenic bone marrow progenitors: a blood-borne cellular envoy for lung eosinophilia. J Allergy Clin Immunol. 2010 Apr;125(4):918-25. Epub 2010 Mar 15.
-Zhu, L., Zhuo, L., Kimata, K., Yamaguchi, E., Watanabe, H., Aronica, M.A., Hascall, V.C., and Baba, K.. Deficiency of the SHAP-hyaluronan Complex Enhances Airway Hyperresponsiveness in a Murine Model of Asthma. Int Arch Allergy Immunol. May 18;153(3):223-233, 2010.
-Cheng G, Swaidani S, Sharma M, Lauer ME, Hascall VC, Aronica MA. Hyaluronan deposition and correlation with inflammation in a murine ovalbumin model of asthma. Matrix Biol. 2011 Mar;30(2):126-34.
- Cheng G, Swaidani S, Sharma M, Lauer ME, Hascall VC, Aronica MA. Correlation of Hyaluronan Deposition with Infiltration of Eosinophils and Lymphocytes in a Cockroach-Induced Murine Model of Asthma. Glycobiology. 2012 Aug 23.
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