Inflammation and Immunity : Careers

Research in the Department of Inflammation and Immunity considers how the immune system may cause certain diseases and how it may be used to treat others. Our work addresses both basic mechanisms and clinical objectives.


Faculty 1

Date Contact Description
04/18/2019 Christina Stuart
stuartc2@ccf.org

Director, Immuno-Oncology Center

 

The Lerner Research Institute, home to laboratory, translational and clinical research at Cleveland Clinic, in collaboration with the nationally ranked Taussig Cancer Institute, invites applications for the position of Director of the Immuno-Oncology Center. 

The Director will be responsible for the design and implementation of clinical trials testing the efficacy of immunotherapy-based strategies in cancer patients at the Cleveland Clinic. The Director will also be responsible for establishing a translational research program focused on mechanistic- and discovery-based studies to support ongoing and future trials within the Center and will work closely with investigators leading ongoing pre-clinical and immuno-oncology clinical trials.  The ideal candidate for this leadership position will be a recognized physician-scientist with a distinguished record of accomplishment and leadership in leading clinical trials in immuno-oncology. Candidates must have a MD/PhD or MD degree, a strong publication record, and current external research support and will be eligible for the rank of Professor at Cleveland Clinic Lerner College of Medicine.  The position offers generous start-up funds and competitive resources to develop a clinical program in immuno-oncology and a team of 4-5 investigators focused on research in the application of immune therapy in cancer patients.

The Center will be expected to establish close collaborations with clinicians and researchers in the Taussig Cancer Institute (https://my.clevelandclinic.org/departments/cancer), including the Translational Hematology and Oncology Research program (https://my.clevelandclinic.org/departments/cancer/depts/thor#overview-tab). The Taussig Cancer Institute (TCI), ranked #5 in the US in the 2018 US News and World Report survey, is one of largest cancer centers in the United States, serving 8500 new patients yearly with 21 multidisciplinary programs and more than 300 open interventional clinical trials. Together the Lerner Research Institute (LRI) and TCI comprise a strongly collaborative research environment with substantial core facilities and translational research potential and are an important and integral component of the National Cancer Institute (NCI) funded Case Comprehensive Cancer Center of Cleveland.

With 170 independent fundamental laboratories, over 2000 employees, and research expenditures of $300 million per year, the Lerner Research Institute (https://www.lerner.ccf.org) is at the forefront of discovery science, fosters translational research and accelerates innovation for patient care.  The LRI is undergoing an exciting period of strategic expansion with major new initiatives including the Center for Therapeutics Discovery, the Center for Microbiome and Human Health, and a new enterprise-wide biorepository that will expand translational research capacity.

Interested Candidates should submit a cover letter, CV, and names of three references to:

 

Christina Stuart

stuartc2@ccf.org

 

Direct Inquiries can be made to the Immuno-Oncology Search Committee Chair:

 

Robert Fairchild, PhD

fairchr@ccf.org

Cleveland Clinic is pleased to be an equal employment/affirmative action employer: Women/Minorities/Veterans/Individuals with Disabilities.  Smoke/drug free environment. 



Postdoctoral 7

Date Contact Description
05/01/2019 Florian Rieder, MD
riederf@ccf.org

Immediate opening for a Projext Scientist position in the Rieder Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in molecular biology and biochemistry, and with expertise in cell, animal, or human models of inflammatory bowel diseases are encouraged to apply.

The applicant should be familiar with cultivation of cell lines, Western blotting, and RNA based methods including quantitative PCR, ELISA, analysis of RNA sequencing results. Experience in lenti- retro- and adenoviral systems of shRNA delivery and functional cellular assays, such as proliferation, migration is an advantage. In addition, experience in lipid and/or muscle biology would be advantageous.  Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing the mesenteric fat with muscle interface in the context of stricturing Crohn’s disease.  The appointee will be expected to take advantage of this career opportunity and will receive support to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. Ph.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter, CV and contact information for 3 references to: Florian Rieder M.D.; Department of Inflammation & Immunity; Lerner Research Institute / NC22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-4916; riederf@ccf.org. 

04/19/2019 Feng Lin, PhD
linf2@ccf.org

Immediate opening for a Postdoctoral Fellow position (or higher) in the Lin Laboratory at the Cleveland Clinic Lerner Research Institute for highly motivated candidates who are interested in translational medical research. Candidates with prior experience and knowledge of techniques in molecular Immunology, and with expertise in cell and animal models of autoimmune diseases are encouraged to apply.

Must be familiar with cultivation of multiple cell lines and primary cells.  Flow cytometry, Western blotting, ELISA, lenti- retro- and adenoviral systems of shRNA delivery, expression of exogenous proteins, and the Casp9/Crispr system. Experience in murine models of autoimmune diseases such as EAE is an advantage. The successful candidate will be expected to design, implement and manage research projects addressing roles of complement or CD6 in human diseases.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Candidates at both junior and senior levels are welcome to apply. Interested candidates should send a single PDF file, including 1) Cover letter indicating current and future research interests; 2)Expected starting date; 3)Curriculum vitae, and 4) Brief summary of previous research experience (2-3 pages) by email to Feng Lin, Ph.D., Department of Inflammation & Immunity; Lerner Research Institute / NE4; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. linf2@ccf.org

04/16/2019 Florian Rieder, MD
riederf@ccf.org

Immediate opening for a Postdoctoral Fellow position in the Rieder Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in molecular biology and biochemistry, and with expertise in cell, animal, or human models of inflammatory bowel diseases are encouraged to apply.

The applicant should be familiar with cultivation of cell lines, Western blotting, and RNA based methods including quantitative PCR, ELISA, analysis of RNA sequencing results. Experience in lenti- retro- and adenoviral systems of shRNA delivery and functional cellular assays, such as proliferation, migration is an advantage. In addition, experience in lipid and/or musclce biology would be advantageous.  Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing the mesenteric fat with muscle interface in the context of stricturing Crohn’s disease.  The appointee will be expected to take advantage of this career opportunity and will receive support to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. Ph.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter, CV and contact information for 3 references to: Florian Rieder M.D.; Department of Inflammation & Immunity; Lerner Research Institute / NC22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-4916; riederf@ccf.org. 

03/12/2019 Amy Lightner, MD
lightna@ccf.org

Immediate opening for a project scientist position in the Lightner Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in regenerative medicine, with expertise in mesenchymal stem cell culture, extracellular/exesome extraction, murine models of colitis/Crohn’s disease are encouraged to apply.

Must be familiar with cultivation of multiple cell lines, Western blotting, and RNA based methods including quantitative PCR and Northern blotting, lenti- retro- and adenoviral systems of shRNA delivery, expression of exogenous proteins, and the Casp9/Crispr system. Experience in murine cell delivery and organ isolation is an advantage. Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing regenerative medicine products for the treatment of human disease, namely in inflammatory bowel disease.  The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter, CV and contact information for 3 references to:

Amy Lightner, MD, lightna@ccf.org 

02/26/2019 Brian Gastman, MD
gastmab@ccf.org

Immediate opening for a Postdoctoral Fellow position in the Gastman Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in immunology, molecular biology and biochemistry, and with expertise in cell, animal, or human models of cancer, and specifically cancer immunity are encouraged to apply. 

Must be familiar with immunologic assays (FACS, cytotoxicity, mouse tumor models, etc..), cultivation of multiple cell lines, Western blotting, and RNA based methods including quantitative PCR and Northern blotting,  expression of exogenous proteins, and the Casp9/Crispr system.    Experience with in vivo murine models is also important.  Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing the role of suppressor cells in the tumor microenvironment.  The applicant will have significant exposure to human specimens from a multitude of research protocols and clinical trials.  The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Our laboratory is highly collaborative and works closely with industry.  The prospective applicant would be expected to not only be involved in high level research, but also to act as an ambassador between our lab and our industry partners.  Thus, proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Brian Gastman, MD.; Department of Inflammation & Immunity; Lerner Research Institute / NE4-303; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-6950; gastmab@ccf.org

01/18/2019 Laura Nagy
nagyL3@ccf.org

A postdoctoral fellow position is available immediately in the laboratory of Dr. Laura Nagy in the Department of Inflammation and Immunity to study the effects of ethanol on the innate immune system, including toll-like receptor signal transduction and complement activation.  The research will focus on the effects of chronic ethanol on key signal transduction pathways in hepatic macrophages with a goal towards understanding the mechanism of development of chronic inflammatory responses in liver.  Projects related to miRNA regulation of cytokine expression, mechanisms of cell death and pathways of gut-liver or adipose-liver interactions are available. 

Experience in at least one of the following areas is desired:  cell biology, signal transduction, molecular biology, intestinal physiology, bioinformatics or macrophage biology. Experience in experimental design and data analysis in both cultured cells and animal models is preferred.  Strong written and oral communication skills are required.

Candidates should have a recent PhD in cell biology, immunology, biochemistry, or a related discipline and experience in signal transduction and cell biology. 

Interested applicants please submit a CV and names and contact information for three references to Dr. Laura Nagy, Department of Inflammation and Immunity (NE40) at Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland OH 44195 or via email to nagyL3@ccf.org

01/16/2019 Vidula Vachharajani, MD
vachhav@ccf.org

Immediate opening for a Postdoctoral Fellow position in the Vachharajani Laboratory in the Department of Inflammation & Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in molecular biology and biochemistry, and with expertise in cell, animal, or human models of diabetes and obesity are encouraged to apply.

Must be familiar with cultivation of multiple cell lines, Western blotting, and RNA based methods including quantitative PCR and Northern blotting, lenti- retro- and adenoviral systems of shRNA delivery, expression of exogenous proteins, and the Casp9/Crispr system. Experience in murine peritoneal macrophage isolation and analysis is an advantage. Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing inflammatory and metabolic changes during diet induced obesity with sepsi.  The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Vidula Vachharajani, MD; Department of Inflammation & Immunity; Lerner Research Institute / NC22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-7191, vachhav@ccf.org



Technical & Adminstrative

Applications for technical research positions and administrative positions at the Lerner Research Institute can be submitted on the Cleveland Clinic jobs web site.