Feng Lin, Ph.D.


Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195
Location: NE4-202
Email: linf2@ccf.org
Phone: (216) 445-6637


The complement system is an important part of the innate immunity. Complement activation products not only directly help to eliminate invading pathogens, but also participate in many immunological reactions, including clearance of immune complexes, antibody production, and T-cell regulation. Insufficient or excess complement activation has been shown to be important in a wide range of disease states, such as multiple sclerosis, myasthenia gravis, systemic lupus erythematosus, rheumatoid arthritis, and age-related macular degeneration, as well as in allograft rejection.

Using genetically engineered mice as disease models, my laboratory is interested in studying complement activation and regulation in these disease states, thus eventually developing novel therapies. In our latest work, for example, we have found evidence of a potentially clinically useful connection of complement in mesenchymal stem cell-based therapies, suggesting that complement is a valid target for improving the viability and function of mesenchymal stem cells, which are under extensive evaluation in clinical trials for treating many inflammatory and degenerative diseases.

For the past several years, we have been collaborating with Cleveland Clinic researchers, and as of January 2013, our laboratory relocated to the Lerner Research Institute. We welcome and look forward to forming many new collaborations, as well as identifying clinical applications for our work with complement in autoimmune diseases and transplant rejection.

Chun  Cao  Chun Cao
Research Scholar
Phone:(216) 445-8065
Yang  Dai  MD Yang Dai, MD
Research Scholar
Phone:(216) 445-8065
Ping  Huang  PhD Ping Huang, PhD
Senior Research Technologist
Phone:(216) 445-8065
Hye Mi  Kim  BS Hye Mi Kim, BS
Research Technician
Phone:(216) 445-3083
Yan  Li  MD Yan Li, MD
Project Staff
Phone:(216) 444-2862
Yu  Lun  Yu Lun
Predoctoral Fellow
Phone:(216) 445-8065
Lingjun  Zhang  PhD Lingjun Zhang, PhD
Research Associate
Phone:(216) 445-8065

Zhidan Tu, Yan Li, Dawn Smith, Nader Sheibani, Suber Huang, Timothy Kern and Feng Lin (2011):   Retinal pericytes inhibit activated T cell proliferation Invest Ophthalmol Vis Sci.  52(12):9005-10

Zhidan Tu, Yan Li, Dawn Smith, Catherine Doller, Sunao Sugita, Chi-Chao Chan, Shiguang Qian, John Fung, Rachel R Caspi, Lina Luand Feng Lin (2012) Myeloid suppressor cells induced by retinal pigment epithelial cells inhibit autoreactive T cell responses that lead to experimental autoimmune uveitis Invest Ophthalmol Vis Sci.    53(2):959-66.

Yan Li and Feng Lin  (2012)  Mesenchymal stem cells are attacked by complement after infusion Blood, 120(17):3436-43

Michael Strainic, Ethan Shevach, Fengqi An, Feng Lin, and Edward Medof (2012) Absent C3aR/C5aR signaling into CD4+ T cells enable auto-inductive TGF-β1 signaling and induction of foxp3+ T regulatory cells Nature Immunology,   14(2):162-71

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