Dr. Thaddeus Stappenbeck Appointed to the Sherwick Endowed Chair in Inflammation and Immunity
06/10/2022

The Sherwick Endowed Chair provides impactful research opportunities to improve understanding of the immune system and inflammatory diseases and develop better preventive and therapeutic responses

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NIH Grant to Advance the Study of Cholestatic Liver Diseases
05/12/2022

Dr. Sakaguchi and his team will investigate the molecular mechanisms and malfunctions of the biliary system to develop new treatments for liver diseases.

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The STAR Consortium Awarded $5.3 Million from the Helmsley Charitable Trust to Develop Next Generation Biomarker Tools for Crohn’s Disease Patients
04/13/2022

The STAR consortium, led by coordinating PI Dr. Rieder, seeks to identify and develop novel biomarkers to help establish effective therapeutics for Crohn’s disease patients with fibrosis.

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NIH Funds Multi-Institutional Training Network to Support Kidney, Urologic and Hematologic Research
02/21/2022

Drs. Sedor and Boron are leading a collaboration of Cleveland biomedical institutions to address gaps in community health and training

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Adaptive Differentiation Drives Cell Repair in Diseased Tissues
01/12/2022

Dr. Stappenbeck’s group found a new cell type that is produced by intestinal epithelial stem and progenitor cells and provides rapid structural support to damaged, high-turnover tissue and a foundation for its proper healing.

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NIH Grant to Advance the Study of Chronic Kidney Disease in African Americans
11/30/2021

Drs. Bruggeman, Sedor and O’Toole will investigate the pathogenic mechanisms of chronic kidney disease to develop greater understanding of genetic susceptibility and develop new treatment strategies.

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Researchers Investigate Sex Differences in Systemic Lupus Erythematosus
11/29/2021

Dr. Jorgensen and team have uncovered the role of S100a9 as a molecule integral in determining sex-specific immune responses in lupus.

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New NIH Grant to Study the Effect of Alcohol on Sepsis
11/08/2021

Dr. Vachharajani and her team will study the immuno-metabolic mechanisms that trigger dysfunction in alcohol consumption with sepsis to identify new therapeutic targets for expanded treatments.

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Researchers Open Clinical Trial for Triple-Negative Breast Cancer Vaccine
10/26/2021

Dr. Tuohy and his research team will begin vaccinating patients in a phase I trial to study how their triple-negative breast cancer vaccine immunizes against the protein alpha-lactalbumin.

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Researchers Develop New Model to Test Mechanisms of Penetrating Fibrosis
08/17/2021

Dr. Stappenbeck’s team has found interconnectivity between inflammatory fibroblasts and the molecular features of penetrating fibrosis in Crohn’s disease.

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Myosin Family Protein Regulates Immunity
07/21/2021

Dr. Gupta and her team have uncovered a novel role for the protein Myo18A in restricting B cell antibody responses, indicating that this protein controls adaptive immunity

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NEI Awards $1.6M to Advance Research into Autoimmune Uveitis
07/14/2021

Dr. Lin and team will study T cells in the retina to understand the mechanisms that govern the onset and progression of autoimmune uveitis in preclinical models.

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NIH Grant Expands Investigator Training Program in Digestive Disease Sciences
05/21/2021

Drs. Fiocchi and Cominelli will lead Cleveland Clinic and Case Western Reserve University in an interdisciplinary program to train young investigators towards research independence.

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Western Diet Impairs Function of Immune Cells in the Gut
05/18/2021

Preclinical findings from Dr. Stappenbeck show that a western diet damages the immune system in the gut, which can lead to chronic inflammation and could increase the risk of inflammatory bowel disease.

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$3 Million NIH Grant to Support Research into Preventing Post-Transplant Organ Rejection
04/15/2021

Dr. Valujskikh will investigate how immune cell subpopulations produce pathogenic antibodies following organ transplant that can threaten outcomes, including organ acceptance and function and patient survival, in an effort to develop new therapies for antibody-mediated rejection.

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New Evidence of Microbial Infection That Impairs Healing in Crohn’s Disease
03/11/2021

Dr. Stappenbeck and his team found that the yeast D. hansenii, a type of fungus, is elevated in models of Crohn’s disease, particularly concentrated within intestinal wounds, suggesting that targeting this infection may be a viable approach to treat or prevent the disease.

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New NIH Grant Awarded to Study Macrophage Signaling in Lung Injury
02/24/2021

Dr. Scheraga will use the support to investigate novel signaling mechanisms that control macrophage function and protect the lung during trauma.

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New Risk Factors Related to Long-Term Lung Transplant Complications Identified
02/12/2021

Dr. McCurry and his team found that blood transfusion and lung weight play important roles in lung transplantation outcomes.

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Researchers Identify Protector of Intestinal Barrier
01/18/2021

Dr. Ivanov and his team have clarified the essential protective role of Β-actin in regulating the epithelial barrier and intestinal inflammation.

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Cleveland Clinic Study Finds No Association Between Influenza Vaccine and COVID-19 Risk
09/21/2020

Using patient data from Cleveland Clinic’s COVID-19 registry, Dr. Zein found that receiving the flu vaccine does not increase risk for COVID-19 or worsen associated disease outcomes, suggesting it is safe and advisable to receive the influenza vaccine this flu season.

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$2.6M Grant Awarded by NIH to Identify Possible Targets for Treating Alcohol-Related Organ Damage
09/18/2020

Dr. Cresci will explore how increasing levels of two molecules commonly depleted as a result of chronic alcohol exposure may help to rescue pathologies of alcohol use disorder, including bacterial imbalances, leaky gut and increased circulating toxins.

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Department of Defense Funds Research for Potential New Drug to Treat Obesity and Pre-Diabetes
09/14/2020

Investigating inter-organ cross-talk between the gut and immune system, Drs. de la Motte and Nagy will test HA35 as potential therapeutic for Western diet-induced metabolic syndrome.

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Study Finds Air Pollution Can Impact the Pathology of Respiratory Syncytial Virus Common in Children
09/01/2020

Dr. Rezaee showed that nanoparticles of titanium dioxide, a pollutant found in many household and personal care products, exacerbates RSV-associated airway inflammation and other disease-related changes.

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New NIH Grant Awarded to Interrogate a Novel Bronchodilator Candidate to Treat Asthma
08/31/2020

Dr. Ghosh will use the support to investigate for the first time how targeting the nitric oxide receptor may offer alternative bronchodilatory benefits that can help treat severe asthma.

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