Researchers Develop New Model to Test Mechanisms of Penetrating Fibrosis
Dr. Stappenbeck’s team has found interconnectivity between inflammatory fibroblasts and the molecular features of penetrating fibrosis in Crohn’s disease.
Myosin Family Protein Regulates Immunity
Dr. Gupta and her team have uncovered a novel role for the protein Myo18A in restricting B cell antibody responses, indicating that this protein controls adaptive immunity
NEI Awards $1.6M to Advance Research into Autoimmune Uveitis
Dr. Lin and team will study T cells in the retina to understand the mechanisms that govern the onset and progression of autoimmune uveitis in preclinical models.
NIH Grant Expands Investigator Training Program in Digestive Disease Sciences
Drs. Fiocchi and Cominelli will lead Cleveland Clinic and Case Western Reserve University in an interdisciplinary program to train young investigators towards research independence.
Western Diet Impairs Function of Immune Cells in the Gut
Preclinical findings from Dr. Stappenbeck show that a western diet damages the immune system in the gut, which can lead to chronic inflammation and could increase the risk of inflammatory bowel disease.
$3 Million NIH Grant to Support Research into Preventing Post-Transplant Organ Rejection
Dr. Valujskikh will investigate how immune cell subpopulations produce pathogenic antibodies following organ transplant that can threaten outcomes, including organ acceptance and function and patient survival, in an effort to develop new therapies for antibody-mediated rejection.
New Evidence of Microbial Infection That Impairs Healing in Crohn’s Disease
Dr. Stappenbeck and his team found that the yeast D. hansenii, a type of fungus, is elevated in models of Crohn’s disease, particularly concentrated within intestinal wounds, suggesting that targeting this infection may be a viable approach to treat or prevent the disease.
New NIH Grant Awarded to Study Macrophage Signaling in Lung Injury
Dr. Scheraga will use the support to investigate novel signaling mechanisms that control macrophage function and protect the lung during trauma.
New Risk Factors Related to Long-Term Lung Transplant Complications Identified
Dr. McCurry and his team found that blood transfusion and lung weight play important roles in lung transplantation outcomes.
Researchers Identify Protector of Intestinal Barrier
Dr. Ivanov and his team have clarified the essential protective role of Β-actin in regulating the epithelial barrier and intestinal inflammation.
Cleveland Clinic Study Finds No Association Between Influenza Vaccine and COVID-19 Risk
Using patient data from Cleveland Clinic’s COVID-19 registry, Dr. Zein found that receiving the flu vaccine does not increase risk for COVID-19 or worsen associated disease outcomes, suggesting it is safe and advisable to receive the influenza vaccine this flu season.
$2.6M Grant Awarded by NIH to Identify Possible Targets for Treating Alcohol-Related Organ Damage
Dr. Cresci will explore how increasing levels of two molecules commonly depleted as a result of chronic alcohol exposure may help to rescue pathologies of alcohol use disorder, including bacterial imbalances, leaky gut and increased circulating toxins.
Department of Defense Funds Research for Potential New Drug to Treat Obesity and Pre-Diabetes
Investigating inter-organ cross-talk between the gut and immune system, Drs. de la Motte and Nagy will test HA35 as potential therapeutic for Western diet-induced metabolic syndrome.
Study Finds Air Pollution Can Impact the Pathology of Respiratory Syncytial Virus Common in Children
Dr. Rezaee showed that nanoparticles of titanium dioxide, a pollutant found in many household and personal care products, exacerbates RSV-associated airway inflammation and other disease-related changes.
New NIH Grant Awarded to Interrogate a Novel Bronchodilator Candidate to Treat Asthma
Dr. Ghosh will use the support to investigate for the first time how targeting the nitric oxide receptor may offer alternative bronchodilatory benefits that can help treat severe asthma.
NIH Awards Grant to Study Creeping Fat and Develop Crohn’s Disease Treatments
Dr. Rieder seeks to identify new mechanisms responsible for fibrosis and stricture formation that leads to the development of novel preventive and therapeutic treatments for Crohn’s disease.
Potential New Drug Target for Steroid-Resistant Inflammatory Diseases Uncovered
Dr. Min and colleagues uncovered a key contribution of regulatory T cells during glucocorticoid-mediated treatment of inflammation, elucidating a possible new, related target for treating aggressive inflammatory diseases.
A Possible Genetic Cause for Racial Disparities in Preeclampsia
Dr. Bruggeman shows in a new study that genetic variants to the APOL1 gene are associated with increased risk for pregnancy-induced hypertension in African American women.
Chronic E-Cigarette Use Linked with Long-Term Lung Injury in Teens, Reports New Study
New research led by Dr. Rezaee builds upon a growing body of evidence that points to vaping products containing THC as most harmful for teens and adolescents.
Characterizing Copper’s Role in Colon Cancer Progression
Researchers led by Dr. Li identified a novel signaling cascade that links inflammation and colorectal cancer, where elevated levels of the pro-inflammatory protein interleukin 17 leads to an accumulation of intracellular copper and ultimately disrupts anti-tumoral defenses.
Loss-of-Function APOL1 Variants and Environmental Stress Together May Drive Chronic Kidney Disease
By studying a model of HIV-associated nephropathy, a group of kidney disease researchers and clinicians discovered that in patients with the APOL1 risk gene, the presence of an environmental stressor, like a virus, can trigger cell changes that lead to chronic kidney diseases.
A New Approach to Treating Infectious Disease
Florian Rieder Honored for IBD Research and Care With Sherman Prize
New Chair Named for Department of Inflammation & Immunity