Fariba Rezaee, MD, FAAP
Center for Pediatric Pulmonary Medicine
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
Phone: (216) 445-3152
My lab is interested in investigating the impact of viral infection and environmental factors on airway epithelial barrier and inflammation. Regulation of airway epithelial barrier is one of the new frontiers in mucosal biology with relevance to respiratory viral infections and asthma.
My laboratory research primarily focuses on the signaling pathways responsible for the change in the integrity of airway epithelial junctional complexes following RSV infection, an area with many ambiguities.
Multiple epidemiologic studies report that exposure to environmental pollutants increases the risk of respiratory disease. However, the involved mechanisms remain unclear. Our study shows that disruption of the airway barrier by nanoparticles worsens RSV-induced airway injury and inflammation.
The goal of my research is to further identify further the molecular mechanisms of respiratory RSV-induced disruption of the airway epithelial barrier and how environmental pollutants exacerbate RSV infection and augment RSV-induced airway barrier disruption. We use combinations of studies using human airway epithelial cells as well as mouse models and to approach these problems.
In other words...
Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis in young children worldwide. More than 33 million occurrences of RSV-related bronchiolitis have been estimated globally, with 3 million children requiring hospitalization. RSV is also a significant source of morbidity and mortality in elderly and high-risk adults. There are strong associations between RSV, persistent wheezing, and childhood asthma. Despite extensive research, no effective treatment is available for RSV infection, aside from supportive care.
Nearly all children become infected with RSV by age 2, and while most experience a mild, self-limiting illness, some develop severe infection and persistent airway disease. While many host factors associated with disease severity such as prematurity, age, or underlying chronic lung diseases are well-described, the associations of RSV infection with many environmental exposures are not yet fully understood. For example, exposure to ambient particulate matter (PM) has been linked to pulmonary diseases such as asthma, bronchitis, otitis media, and severe viral infection in multiple epidemiologic studies.
My laboratory investigates the mechanisms by which RSV infection injures the epithelial cell lining of human airways, and how exposure to environmental pollution enhances the severity of that injury. Identifying the mechanisms by which RSV and air pollution affect the lungs will aid the design of agents that specifically target virus-mediated pathology, and will have a significant impact on the well-being of both children and adults suffering from RSV.
- E-cigarette or Vaping Product Use-Associated Lung Injury in Adolescents
Read Story on Cleveland Clinic Consult QD
- Study Finds Teen Vaping Use Can Lead to Acute Lung Injury
Read Story on Cleveland Clinic Newsroom and WKSU
- Rezaee, F. (2016) Airway Epithelial Barrier Dysfunction in Response to Respiratory Syncytial Virus: Readying the Research for Animal Model Replication. Pediatric Perspectives, 38-39.
- Rezaee F, Linfield LT, Harford TJ, Piedimonte G. (2017) Ongoing Developments in RSV Prophylaxis: A Clinician’s Analysis. Current opinion in virology. 24:70-78. Review. PubMed PMID: 28500974; PubMed Central PMCID: PMC5541395. The figure was selected for the journal cover.
- Rezaee F, Harford TJ, Linfield LT, Midura RJ, Ivanov AI, Piedimonte G. (2017) cAMP-Dependent Activation of Protein Kinase A Attenuates Respiratory Syncytial Virus-Induced Human Airway Epithelial Barrier Disruption. PLoS One. 12(7):e0181876. PubMed PMID: 28759570; PubMed Central PMCID: PMC5536269.
- Marquardsen FA, Baldin F, Wunderer F, Al-Herz W, Mikhael R, Lefranc G, Baz Z, Rezaee F, Hanna R, Kfir-Erenfeld S, Stepensky P, Meyer B, Jauch A, Bigler MB, Burgener AV, Higgins R, Navarini AA, Church JA, Chou J, Geha R, Notarangelo LD, Hess C, Berger CT, Bloch DB, Recher M. (2017) Detection of Sp110 by flow-cytometry and application to screening patients for veno-occlusive disease with immunodeficiency. J Clin Immunol. 37(7):707-714. PubMed PMID: 28825155; PubMed Central PMCID: PMC6069968.
- Manti S,Harford TJ, Rezaee F, Piedimonte G. (2018) High Mobility Group Box-1 Inhibition Protects Against Respiratory Syncytial Virus Infection. Pediatric Research. 83(5):1049-1056. PubMed PMID: 29329282; PubMed Central PMCID: PMC5959750.
- Smallcombe CC. Linfield DT, Harford TJ, Bokun V, Piedimonte G, Ivanov AI, Rezaee F. (2019) Disruption of the Airway Epithelial Barrier in a Murine Model of Respiratory Syncytial Virus Infection. Am J Physiol Lung Cell Mol Physiol. 316(2):L358-L368. PubMed PMID: 30489157; PubMed Central PMCID: PMC6397347.
- Corcoran A, Carl JC, Rezaee F(2020),The Importance of Anti-Vaping vigilance-EVALI in Seven Adolescent Pediatric Patients in Northeast Ohio
Study Finds Air Pollution Can Impact the Pathology of Respiratory Syncytial Virus Common in Children
In a new study published in the American Journal of Physiology, researchers led by physician-scientist Fariba Rezaee, MD, analyzed the impact of co-exposure to respiratory syncytial virus (RSV) and particulate matter to gain better insight into the impact of air pollution on disease course. Titanium dioxide, they found, intensified the effect of RSV on airway epithelial cell integrity and airway inflammation.
A new Cleveland Clinic study is the latest to find that teens who regularly vape THC were more likely to develop e-cigarette or vaping product use-associated lung injury (EVALI). The findings, published in the Journal of Pediatric Pulmonology, also suggests teens with mental health conditions were at the greatest risk for vaping.