Rachel Scheraga, MD
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
Overall areas of interest
- Host defense, infection, macrophage biology, mechanosensation, lung injury, repair and fibrosis
Tools and expertise of the lab
- Bacterial lung infection models (Scheraga et al, JI. 2020)
- Extracellular matrix-macrophage interaction model systems (Scheraga et al, JI. 2016 and 2020)
- Define mechanosensitive host defense cells/molecules
- Human macrophages from infected and lung injury patients (Scheraga et al, JI. 2020)
Examples of collaborators
- Mitchell Olman – Extracellular matrix-cell interactions, TRPV4
- Xiaoxia Li – TLR4/IRAK pathways
- Vidula Vachharajani – sepsis/infectious pathways
- Christine McDonald – NOD2 and pulmonary infection
- William Janssen – lung macrophage subset biology
- Identifying the role of TRPV4 in macrophage activation functions (Scheraga et al, JI. 2016 and 2020)
- Discovered the role of TRPV4 in bacterial clearance and cytokine secretion in P. aeruginosa pneumonia associated lung injury (Scheraga et al, JI. 2020)
How could these discoveries help patients?
- New therapies for lung injury
- Better understanding of innate immune cell-extracellular matrix interactions
- New therapies to change macrophage polarization to repair lung injury
- Cleveland.com: Experts caution against comparing Johnson & Johnson vaccine to others: ‘We have three effective vaccines’
- Cleveland.com: No good reason to say ‘No’ to the coronavirus vaccine: Ted Diadiun
- Fox 8: Cleveland Clinic doctor answers your COVID-19 vaccine questions
- Fox 8: COVID-19 vaccine in Ohio: frequently asked questions
- Eat This, Not That: Watch Out For This COVID Vaccine Side Effect, Says Dr. Fauci
- Parade Magazine: Do You Still Need to Wear a Mask After You've Been Fully Vaccinated? Cleveland Clinic's Top Docs Answer Your Top COVID-19 Questions
- Scheraga RG, Southern BD, Grove LM, Olman MA. The Role of TRPV4 in Regulating Innate Immune Cell Function in Lung Inflammation. Front Immunol. 2020 Jun 26. PMID: 32676078
- Scheraga RG*, Abraham S, Grove LM, Southern BD, Crish JF, Perelas A, McDonald C, Asosingh K, Hasday JD, Olman MA*. TRPV4 protects the lung from bacterial pneumonia via MAPK molecular pathway switching. J Immunol. 2020 Jan 22. PMID: 31969384
- Grove LM, Mohan ML, Abraham S, Scheraga RG, Southern BD, Crish JF, Naga Prasad SV, Olman MA. Biomolecular complex formation and translocation of TRPV4 with PI3Kγ drives myofibroblast transdifferentiation. Science Signaling. 2019 Nov 12. PMID: 31719171.
- Scheraga RG, Southern BD, Grove LM, Olman MA. The role of transient receptor potential vanilloid 4 in pulmonary inflammatory diseases. Front Immunol. 2017 May 4. PMID: 28523001.
- Scheraga RG, Abraham S, Niese KA, Southern BD, Grove LM, Hite RD, McDonald C, Hamilton TA, Olman MA. TRPV4 mechanosensitive ion channel regulates lipopolysaccharide-stimulated macrophage phagocytosis. J Immunol. 2016 Jan 1;196(1): 428-36. PMID: 26597012.
- Rahaman OS, Grove LM, Southern BD, Abraham S, Niese K, Scheraga RG, Olman MA. TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice. J Clin Invest. 2014 Dec;124(12):5225-38. PMID: 25365224.
Dr. Scheraga will use the support to investigate novel signaling mechanisms that control macrophage function and protect the lung during trauma.