Thaddeus Stappenbeck, MD, PhD
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
Phone: (216) 444-3082
My lab is interested in discovering host and environmental factors that impact inflammation and wound repair at mucosal surfaces. These processes impact the pathogenesis of a number of disease states including inflammatory bowel disease. We use combinations of studies using human cells and tissues as well as mouse and in vitro models to approach these problems. The focal point of these studies is often the intestinal epithelial barrier. To make advances in this area, we have developed novel methods to model these cells under a variety of relevant conditions. We then study mechanisms by which the diet/microbiome as well as select stromal/immune cells impact this system. Our overarching goal is to understand combinations of genetic and environmental factors that affect specific epithelial cell function and thus predispose individuals to develop active intestinal inflammation.
The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS.
Cell. 2016 Nov 3;167(4):1137. doi: 10.1016/j.cell.2016.10.034
Thaddeus (Thad) Stappenbeck, MD, PhD, joins Lerner Research Institute as the newly appointed Chair of the Department of Inflammation & Immunity. A digestive disease expert, he will lead a department of more than 50 principal investigators studying the origins and manifestations of a range of diseases, including infectious, autoimmune, and inflammatory diseases like asthma and transplant rejection.