Vidula Vachharajani, MD, FCCP, FCCM
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
The Vachharajani lab investigates immuno-metabolic response in sepsis and septic shock with specific interest in the role of sirtuin nutrient sensors. The team focuses on immuno-metabolic pathways that dysregulate host response to pathogen during early and late phases of sepsis, with the goal of developing effective therapies to reduce immune dysfunction and sepsis-related mortality.
The current NIH-funded projects using human biospecimen and laboratory models of sepsis, focus on the effect of high fat diet and alcohol consumption on the immune response in sepsis and septic shock.
Dr. Vachharajani and her team will study the immuno-metabolic mechanisms that trigger dysfunction in alcohol consumption with sepsis to identify new therapeutic targets for expanded treatments.