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Jianjun Wu Laboratory

❮Immunotherapy & Precision Immuno-Oncology Jianjun Wu Laboratory
  • Jianjun Wu Laboratory
  • Principal Investigator
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  • Our Team
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Principal Investigator

Jianjun Wu Headshot

Jianjun Wu, PhD

Assistant Staff
Email: wuj9@ccf.org
Location: Cleveland Clinic Main Campus

Research

Our research focuses on understanding the fundamental mechanism of innate immunity and its impact on adaptive immunity, inflammation and cancer.


Biography

Coming soon.


Education & Professional Highlights

Appointed
2021

Education & Fellowships

Postdoctoral Fellowship - UT Southwestern Medical Center
Immunology
Dallas, TX USA
2018

Postdoctoral Fellowship - Florida State University
Virology & Immunology
Tallahassee, FL USA
2016

Graduate - Wuhan University
Molecular Biology
Wuhan, Hubei, China
2012

Undergraduate - Hubei University
Biotechnology
Wuhan, Hubei, China
2006

Awards & Honors

  • VeloSano Pilot Award, Cleveland Clinic
  • American Association of Immunologists Trainee Abstract Award
  • American Assocation of Immunologists Trainee Poster Award
  • Outstanding Youth Paper Award, Chinese Society for Cell Biology
  • Postgraduate Academic Innovation Award, Wuhan University

Research

Research

Our research focuses on understanding the fundamental mechanism of innate immunity and its impact on adaptive immunity, inflammation and cancer. Innate immune system mainly relies on pattern recognition receptors (PRRs) to detect invading pathogens and to mount robust anti-microbial immune responses. However, under certain circumstances, PRRs can be self-activated under sterile condition, leading to activation of adaptive immunity and thus triggering either protective immunity or immune disorders in different contexts. The main goal of the lab is to understand the molecular mechanism of innate immune control of adaptive immunity in cancer and inflammation. We aim to: 1) Study the molecular regulation of innate immunity in tumor microenvironment (TME), with the goal of harnessing innate immunity to improve cancer immunotherapy; 2) Understand how innate immunity is initiated in inflammatory environment, and its impact on inflammation and immune disorders.

Our Team

Our Team

Publications

Selected Publications

Wu, J., Dobbs, N., Yang, K., and Yan, N. (2020). Interferon-Independent Activities of Mammalian STING Mediate Antiviral Response and Tumor Immune Evasion. Immunity 53, 115-126 e115.

Pokatayev, V., Yang, K., Tu, X., Dobbs, N., Wu, J., Kalb, R.G., and Yan, N. (2020). Homeostatic regulation of STING protein at the resting state by stabilizer TOLLIP. Nat Immunol 21, 158-167.

Wu, J., Chen, Y.J., Dobbs, N., Sakai, T., Liou, J., Miner, J.J., and Yan, N. (2019). STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death. J Exp Med 216, 867-883.

Wu, J., and Yan, N. (2019). STIM1 moonlights as an anchor for STING. Nat Immunol 20, 112-114.

Warner, J.D., Irizarry-Caro, R.A., Bennion, B.G., Ai, T.L., Smith, A.M., Miner, C.A., Sakai, T., Gonugunta, V.K., Wu, J., Platt, D.J., et al. (2017). STING-associated vasculopathy develops independently of IRF3 in mice. J Exp Med 214, 3279-3292.

Gonugunta, V.K., Sakai, T., Pokatayev, V., Yang, K., Wu, J., Dobbs, N., and Yan, N. (2017). Trafficking-Mediated STING Degradation Requires Sorting to Acidified Endolysosomes and Can Be Targeted to Enhance Anti-tumor Response. Cell Rep 21, 3234-3242.

Li, W., Avey, D., Fu, B., Wu, J., Ma, S., Liu, X., and Zhu, F. (2016). Kaposi's Sarcoma-Associated Herpesvirus Inhibitor of cGAS (KicGAS), Encoded by ORF52, Is an Abundant Tegument Protein and Is Required for Production of Infectious Progeny Viruses. J Virol 90, 5329-5342.

Wu, J., Li, W., Shao, Y., Avey, D., Fu, B., Gillen, J., Hand, T., Ma, S., Liu, X., Miley, W., et al. (2015). Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein. Cell Host Microbe 18, 333-344.

Wu, J., Avey, D., Li, W., Gillen, J., Fu, B., Miley, W., Whitby, D., and Zhu, F. (2015). ORF33 and ORF38 of Kaposi's Sarcoma-Associated Herpesvirus Interact and Are Required for Optimal Production of Infectious Progeny Viruses. J Virol 90, 1741-1756.

Gillen, J., Li, W., Liang, Q., Avey, D., Wu, J., Wu, F., Myoung, J., and Zhu, F. (2015). A survey of the interactome of Kaposi's sarcoma-associated herpesvirus ORF45 revealed its binding to viral ORF33 and cellular USP7, resulting in stabilization of ORF33 that is required for production of progeny viruses. J Virol 89, 4918-4931.

Careers

Careers

The Wu Lab is actively seeking applicants for a postdoctoral fellow. Please see job details and required experience for the position at the link included below: 

Postdoctoral Fellow

If questions arise at any point, please contact Dr. Jianjun Wu (wuj9@ccf.org).


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