Director of BioRepository Core
Location: Cleveland Clinic Main Campus
Dr Comhair's laboratory studies how inflammation and oxidative stress leads to the severity of asthma. Furthermore Dr Comhair's lab investigate if specific biomarkers can predict asthma and asthma control.
Dr. Comhair’s research is focused on the translational investigation of airway inflammation and oxidative stress in asthma. One of the primary objectives is to understand the mechanisms through which oxidative stress and metabolic changes contribute to disease progression and identify disease specific biomarkers with capacity of predicting disease development or control. Specifically, her laboratory has investigated superoxide dismutase, glutathione, and bromotyrosine as mediators of oxidative stress in asthma, and correlating these markers with asthma control, development and steroid responsiveness disease. Recently we have extended our efforts to understand the metabolic changes that occur in asthma. We are particularly interested in exploring new biochemical pathways unique to asthma through innovative metabolomics strategies so that we may develop biomarkers to characterize asthma phenotypes and identify new targets for therapeutic approaches.
Her laboratory also function as a biospecimen lab core and Biorepository Core for program projects, clinical trials and NIH U-awards. The purpose of the Core to collect, process, store, and analyze clinical samples such as blood, urine, sputum bone marrow and lung and heart tissue. Furthermore, the Core also provides primary cells to investigators, such as pulmonary arterial endothelial cells and smooth muscle cells, fibroblasts, and airway epithelial cells i.e. undifferentiated and differentiated.