Location: Cleveland Clinic Main Campus
Dr. Dasarathy's primary interest is in the management of patients waiting for liver transplantation and during the post--liver-transplant period. He has a special interest in the treatment of non-alcoholic fatty liver disease.
Dr. Dasarathy serves on the Educational Committee of the American Association of the Study of Liver Diseases.
Education & Fellowships
Residency - MetroHealth Medical Center
Cleveland, OH USA
Fellowship - MetroHealth Medical Center
Cleveland, OH USA
Internship - All India Institute of Medical Sciences
New Delhi, India
Medical Education - Jawaharlal Institute of Post Graduate Medical Education and Research
Awards & Honors
Our research program consists of a robust clinical, translational, and fundamental laboratory-based research that focuses on the skeletal muscle metabolic responses during chronic diseases including liver disease. Muscle loss is consistently observed in patients with chronic liver disease and other end stage organ diseases and adversely affects clinical outcomes.
Our team has identified unique cellular stress responses mediated by hyperammonemia, hypoxia and ethanol exposure as mediators of translational regulation and subcellular organelle dysfunction that contribute to muscle loss in disease. Our discoveries include the development of accelerated senescence in response to chronic cellular stress.
We use complementary state of the art approaches including integrated metabolic-molecular experimental studies, multiomics analyses and genome association studies in a comprehensive array cellular and rodent models as well as human disease subjects to dissect molecular regulation of metabolic plasticity in chronic diseases.
These studies have broad clinical applications because they lay the foundation for developing novel, mechanism-based targeted therapies to restore protein homeostasis and molecular and metabolic perturbations in chronic diseases.
View publications for Srinivasan Dasarathy, MD
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