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Hyun Jung Kim Laboratory

❮Inflammation & Immunity Hyun Jung Kim Laboratory
  • Hyun Jung Kim Laboratory
  • Principal Investigator
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  • Our Team
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Principal Investigator

Hyun Jung Kim Headshot

Hyun Jung Kim, PhD

Assistant Staff
Email: kimh19@ccf.org
Location: Cleveland Clinic Main Campus

Research

My research group, Biomimetic MicroEngineering (BioME) laboratory, has focused on innovating bioinspired engineering principles to uncover the fundamental mechanism in human health and diseases. The human Organ-on-a-Chip, also known as the Microphysiological System (MPS), has emerged as an alternative experimental model to accurately recapitulate the host-microbiome ecosystem and predict human physiological responses. We have created novel biomimicry to reconstitute the three-dimensional (3D) physical structure, physiological functions, and dynamic biomechanics of the living human gut.


Biography

Hyun Jung Kim, PhD, is the Principal Investigator of The Biomimetic Microengineering (BioME) Laboratory in the Department of Inflammation and Immunity at Cleveland Clinic. He has focused on innovating microphysiological platform technologies to uncover fundamental questions in human health and diseases. By leveraging the miniaturized human “Gut-on-a-chip” microsystem, Dr. Kim has developed paradigm-shifting models that reconstitute the physical structure, physiological function, and mechanical dynamics of the living human intestine (Nat. Protoc. 2022; PNAS 2018; iScience, 2019 & 2020; PNAS, 2016). His research group has been particularly interested in emulating a host-microbiome ecosystem that orchestrates human health and diseases by integrating transdisciplinary approaches of clinical microbiology, microfluidics, and tissue engineering. He has spearheaded to develop a “Patient’s Avatar” model by integrating patient-derived organoids, fecal microbiota, and tissue-specific immune cells to emulate the pathophysiology of inflammatory bowel disease (IBD) including Crohn’s disease (CD) and ulcerative colitis (UC) and colorectal cancer (CRC).


Education & Professional Highlights

 ACADEMIC & PROFESSIONAL APPOINTMENT

07/2022 – present   Cleveland Clinic, Cleveland, OH, USA, Assistant Staff, Department of Inflammation and Immunity, Lerner Research Institute

01/2015 – 06/2022   The University of Texas at Austin, Austin, TX, USA, Assistant Professor, Department of Biomedical Engineering

03/2018 – 12/2021   Yonsei University, Seoul, Republic of Korea, Visiting Professor, Department of Medical Engineering, College of Medicine

09/2015 – 08/2017   Pusan National University, Yangsan, Republic of Korea, Adjunct Professor, School of Medicine  

 

EDUCATION & TRAINING

Harvard University, Boston, MA, USA

09/2012 – 12/2014   Technology Development Fellow, Wyss Institute for Biologically Inspired Engineering

07/2009 – 08/2012   Postdoctoral Fellow, Wyss Institute for Biologically Inspired Engineering (Advisor: Donald E. Ingber, MD, PhD)

The University of Chicago, Chicago, IL, USA

03/2007 – 06/2009   Postdoctoral Scholar, Department of Chemistry (Advisor: Rustem F. Ismagilov, PhD)

Yonsei University, Seoul, Republic of Korea

09/2005 – 02/2007   Research Associate, Institute of Life Science and Biotechnology

09/2000 – 08/2005   PhD in Biotechnology (Advisor: Chul Soo Shin, PhD)

03/1998 – 08/2000   MS in Biotechnology

03/1994 – 02/1998   BE in Biotechnology  

 

AWARDS & HONORS (Selected)

2022                     Career Development Program Award, Lerner Research Institute, Cleveland Clinic, USA

2021                     2020 Research Excellence in Korean Biomedical Science, Medical Research Information Center, Korea

2018                     Technology Impact Award, Cancer Research Institute (CRI), USA

2017                     Poster of Distinction, The Programming Committee of the GI & Liver Section of the APS, USA

2017                     Texas 4000 Seed Grant Award, Dept. of Biomedical Engineering, UT Austin, USA

2016                     Innovator Awards, Kenneth Rainin Foundation, USA

2015                     Vice President for Research Grant Award, The University of Texas at Austin

2015                     Featured Designer for Organs-on-Chips, Museum of Modern Art (MoMA), New York, USA

2014                     The Faculty STARs Program Award, The University of Texas at Austin, USA

2013                     Abcam Discovery 15 Contest Finalist ($1,000 credit), USA

2013                     2013 Invented Here! Honoree. New England’s Breakthrough Inventions and Inventors. Boston, MA, USA

2013                     Best Paper Award. ALine, Inc., 2013 ASME (NEMB 2013). Feb 4-6, 2013, Boston, MA, USA

2012 - 2014          Wyss Technology Development Fellowship, Wyss Institute, Harvard University, USA

2012                     Best Presentation Award for Postdocs. The Korean Toxicologists Association in America. SOT 2012, San Francisco, CA, USA

2012                     Postdoctoral Award (1st place). In Vitro and Alternative Methods Special Section, SOT 2012, San Francisco, CA, USA

2007 - 2008          Leo Kadanoff and Stuart Rice Postdoctoral Fellowship, The University of Chicago, USA

2003 - 2004          Fellowship for Young Scientist, Korea Research Foundation, Korea

2001                     Scholarship for Excellent Student, Yonsei University, Seoul, Korea

1994                     Yonsei Special Award for the Freshman in Matriculation, Yonsei University, Seoul, Korea

Research

Research

Overview

My research group, Biomimetic MicroEngineering (BioME) laboratory, has focused on innovating bioinspired engineering principles to uncover the fundamental mechanism in human health and diseases. The human Organ-on-a-Chip, also known as the Microphysiological System (MPS), has emerged as an alternative experimental model to accurately recapitulate the host-microbiome ecosystem and predict human physiological responses. We have created novel biomimicry to reconstitute the three-dimensional (3D) physical structure, physiological functions, and dynamic biomechanics of the living human gut.

We are particularly interested in emulating the host-microbiome interactions that orchestrate intestinal homeostasis and disease development. In collaboration with clinicians, our breakthrough technology enables us to develop unprecedented "Personalized Disease-on-a-Chip" models by integrating patient-derived organoids, microbiome, and immune cells. Using this model, we have delved into the pathological contribution of the gut microbiome in gastrointestinal diseases such as inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC), colorectal cancer (CRC), and infectious diseases.

Our overarching goal is to understand causality vs. consequence of the host-microbiome crosstalk at various disease milieus by leveraging a patient-specific Disease-on-a-Chip. We will continually innovate our disruptive technology to manipulate pathophysiological manifestation in human oral cavity, nasal path, vagina, placenta, skin, liver, and the gut-brain axis. Finally, we will disseminate our cutting-edge technology to contribute to scientific, clinical, and pharmaceutical communities by unraveling high-risk medical problems.

Our Team

Our Team

Publications

Selected Publications

View publications for Hyun Jung Kim, PhD
(Disclaimer: This search is powered by PubMed, a service of the U.S. National Library of Medicine. PubMed is a third-party website with no affiliation with Cleveland Clinic.)


1- Woojung Shin and Hyun Jung Kim. 3D In Vitro Morphogenesis of Human Intestinal Organoids or Caco-2 Cells in a Gut-on-a-chip or a Hybrid Chip with a Cell Culture Insert. Nat. Protoc. 2022, 17, 910-939. (Published online on Feb 2, 2022; IF 13.491)

  • Highlighted in BRIC on Feb 10, 2022.
  • Featured in UT News, on Feb 15, 2022.

2- Woojung Shin, Alexander Wu, Soyoun Min, Yong Cheol Shin, R. Y. Declan Fleming, S. Gail Eckhardt, and Hyun Jung Kim. Spatiotemporal gradient and instability of Wnt induce heterogeneous growth and differentiation of human intestinal organoids. iScience 2020, 23, 101372. (Published online: Aug 21, 2020; IF 5.08)

  • Highlighted at UT CSE as New Discovery Helps Researchers Rethink Organoid Cultures.

3- Yong Cheol Shin*, Woojung Shin*, Yoko M. Ambrosini, Domin Koh, Alexander Wu, Soyoun Min, S. Gail Eckhardt, R. Y. Declan Fleming, Seung Kim, Sowon Park, Hong Koh, Tae Kyung Yoo, and Hyun Jung Kim. Three-dimensional regeneration of patient-derived intestinal organoid epithelium in a physiodynamic mucosal interface-on-a-chip. Micromachines 2020, 11, 663. (*Equally contributed; Published online: Jul 7, 2020; IF 2.942)

4- Woojung Shin, Christopher D. Hinojosa, Donald E. Ingber, and Hyun Jung Kim, Human intestinal morphogenesis controlled by transepithelial morphogen gradient and flow-dependent physical cues in a microengineered gut-on-a-chip. iScience 2019, 15, 391-406. (Published online: May 31, 2019; IF 5.08)

5- Woojung Shin*, Alexander Wu*, Miles Massidda*, Charlie Foster, Newin Thomas, Dong-Woo Lee, Hong Koh, Youngwon Ju, Joohoon Kim, and Hyun Jung Kim. A robust longitudinal co-culture of obligate anaerobic gut microbiome with human intestinal epithelium in an anoxic-oxic interface-on-a-chip. Front. Bioeng. Biotechnol. 2019, 7, 13. (*Equally contributed; Published online: Feb 7, 2019; IF 3.644)

  • Published as part of “Medical and Industrial Applications of Microfluidic-based Cell/Tissue Culture and Organs-on-a-Chip”.
  • Featured in “Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer”, iScience 2020, 23, 101878.

6- Woojung Shin and Hyun Jung Kim. Intestinal barrier dysfunction orchestrates the onset of inflammatory host-microbiome cross-talk in a human gut inflammation-on-a-chip. Proc. Natl. Acad. Sci. U.S.A. 2018, 115, E10539-E10547. (Published online: Oct 22, 2018; IF 9.412)

  • Highlighted in EurekAlert “Probiotics are not always ‘good bacteria’”.
  • Featured in Editor’s Choice, “Model for maintaining integrity”, Science, 2018, 362, 907.
  • Press release in UT News, Medical Xpress, ScienceDaily, GEN, R&D, News Medical, Technology Network, BRIC, News1, BioSpectator, Donga, Donga Science, Medical News Bulletin,
  • Interviewed at the KUT Austin NPR station, “How Probiotics Could Be Problematic For Those With Damaged Guts”
  • Highlighted in National Anti-Vivisection Society (NAVS).
  • Highlighted in Alliance of Advanced Biomedical Engineering (by ASME)
  • Highlighted in Medical Research Information Center Korea

 7- Hyun Jung Kim, Hu Li, James J. Collins,and Donald E. Ingber. Contributions of microbiome and mechanical deformation to intestinal bacterial overgrowth and inflammation in a human gut-on-a-chip. Proc. Natl. Acad. Sci. U.S.A. 2016,113, E7-E15. (Published online: Dec 14, 2015)

  • Highlights from Early Edition (PNAS)
  • Human Gut-on-a-chip model offers hope for IBD sufferers (Harvard Gazette)
  • Harvard’s Wyss Institute unveils human ‘gut-on-a-chip’ (FierceBiotech)
  • Gut-on-a-Chip Technology Provides Breakthrough in Microbiome Research (IBD News Today)
  • "Gut-on-a-Chip" Could Lead to Better Treatments for Intestinal Disorders (KUT)
  • Featured in ‘Human Gut-on-a-Chip Microdevice May Help Overcome Limitations of Animal Models’, National Anti-Vivisection Society (NAVS), Dec 28, 2015.
  • Highlighted in Commentary, Cell, Mar 10, 2016.
  • Highlighted in The Spotlight, ACS Chemical Research in Toxicology, 2016, 29, 135.
  • Featured in “Reverse Engineering Human Pathophysiology with Organs-on-Chips”, Cell, 2016, 164, 1105-1109.
  • Featured in “The role of gut microbiota in health and disease: In vitro modeling of host-microbe interactions at the aerobe-anaerobe interphase of the human gut”, Anaerobe, 2017, 44, 3-12.
  • Featured in “Harnessing Tissue Engineering Tools to Interrogate Host-Microbiota Crosstalk in Cancer”, iScience, 2020, 23, 101878.

 8- Hyun Jung Kim and Donald E. Ingber. Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation. Integr. Biol. 2013, 5, 1130-1140. (Published online: Jun 26 2013)

  • Selected on the Back Cover of ‘Organs-on-chips’ themed issue on Integrative Biology, Iss. 9 (Sep 1, 2013).
  • Published as part of ‘Organs-on-chips’ joint themed issues of Integrative Biologyand Lab on a Chip (Sep 1, 2013).
  • Selected as the most downloaded article in Integrative Biology from Jul 2013 to Feb 2014.
  • Selected as Top Ten most accessed article in Integrative Biology at the 3rd quarter of 2013.
  • Selected as Top Ten most accessed article in Integrative Biology at the 4th quarter of 2013.

9- Hyun Jung Kim and Donald E. Ingber. Gut-on-a-Chip microenvironment induces human intestinal cells to undergo villus differentiation. Integr. Biol. 2013, 5, 1130-1140. (Published online: Jun 26 2013)

  • Selected on the Back Cover of ‘Organs-on-chips’ themed issue on Integrative Biology, Iss. 9 (Sep 1, 2013).
  • Published as part of ‘Organs-on-chips’ joint themed issues of Integrative Biologyand Lab on a Chip (Sep 1, 2013).
  • Selected as the most downloaded article in Integrative Biology from Jul 2013 to Feb 2014.
  • Selected as Top Ten most accessed article in Integrative Biology at the 3rd quarter of 2013.
  • Selected as Top Ten most accessed article in Integrative Biology at the 4th quarter of 2013.
  • Featured in ‘Microfluidic technologies for accelerating the clinical translation of nanoparticles’, Nat. Nanotechnol. 2012, 7, 623-629.
  • Featured in MIT Technology Review, “Building an Organ on a Chip”, Jul/Aug 2012.
  • Featured in ‘Microfluidics-assisted in vitro drug screening and carrier production’, Adv. Drug Deliver. Rev. 2013. 65, 1575-1588.
  • Featured in 'Workshop meeting report Organs-on-Chips: human disease models’, Lab Chip 2013, 13, 3349-3470.
  • Featured in New Scientist, “Gut-on-a-chip takes bellyache out of digestion studies”, Iss. 2859 (3 Apr 2012).
  • Highlighted in Year in Review of the Nat. Rev. Gatroenterol. Hepatol., “Gut Microbiota in 2019”.
  • Press releases (selected): The Harvard Crimson, IEEE Spectrum, Discovery News, CNET, ZD Net, EurekaAlert, Science Daily, Med Gadget, Gizmag.

10- Hyun Jung Kim*, James Q. Boedicker*, Jang Wook Choi, and Rustem F. Ismagilov. Defined spatial structure stabilizes a synthetic multispecies bacterial community. Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 18188-18193. (*Equally contributed; Published online: Nov 14, 2008)

  • Highlighted in In This Issue. PNAS, 2008, 105, 18073.
  • Highlighted in Commentary “Building communities one bacterium at a time”. PNAS 2008, 105, 18075-18076.
  • Highlighted in Spotlight, “Microbes need their space” ACS Chem. Biol. 2009, 4(1), 9.
  • Featured in ‘Ecological perspectives on synthetic biology: insights from microbial population biology’, Front. Microbiol., 2015, 6, 1-10.
  • Featured in ‘Microfluidic technologies for studying synthetic circuits’, Curr. Opin. Chem. Biol. 2012, 16, 1-11.
  • Featured in ‘Dynamics in the mixed microbial concourse’, Genes Dev. 2010, 24, 2603-2614.
  • Featured in ‘Engineering ecosystems and synthetic ecologies’, Mol. BioSyst. 2012, 8, 2470-2483.
  • Featured in ‘Nanofabricated structures and microfluidic devices for bacteria: from techniques to biology’, Chem. Soc. Rev. 2016, 45, 268-280.
  • Features in ‘Microfluidic cultivation and analysis tools for interaction studies in microbial co-cultures’, Curr. Opin. Biotechnol., 2020, 62, 106-115.
  • Featured as ‘Evaluated Articles’ in Faculty of 1000 (Jan 2009, Nov 2008).

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