Using different neuropathic pain models, we investigate the pathophysiology to develop novel therapies for these clinically challenging pain syndromes. We are currently focusing on the complement system in these pain models. (See Laboratory tab for additional information).
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Jijun Xu, MD, PhD, holds joint appointments in theDepartment of Pain Management, Anesthesiology Institute, and the Department ofInflammation and Immunity, Lerner Research Institute at Cleveland Clinic. He isan Assistant Professor of Anesthesiology at the Cleveland Clinic Lerner Collegeof Medicine of Case Western Reserve University.Dr. Xu specializes in interventional pain management. Dr.Xu’s research interests include clinical outcomes and basic science of neuropathicpain. He is involved in multiple clinical trials at Cleveland Clinic. He is thePrincipal Investigator (PI) of the SENZA-PDN (Spinal cord stimulation forrefractory painful diabetic neuropathy) trial. He is also investigating the useof Ketamine and Nitrous Oxide in Complex Regional Pain Syndrome which he is aninvited speaker and book chapter contributor in this field. He is also the PIof a NIH-funded research to study the mechanisms underlyingChemotherapy-induced Peripheral Neuropathy. He serves on the Research Committee of theAmerican Association of Pain Medicine.Dr. Xu is interested in incorporating new advances in painmanagement into clinical practice and teaching residents and fellows. He wasselected as the “Best Teacher” and the “Cleveland Clinic Pain Medicine Staff ofthe Year” in 2016 and 2020.
Fellowship - Cleveland Clinic
Cleveland, OH USA
Residency - Cleveland Clinic
Cleveland, OH USA
Medical Education - University of Texas M.D. Anderson Cancer Center
Houston, TX USA
Medical Education - University of Texas Health Science Center at Houston
Neuroscience and Genes and Development
Houston, TX USA
Graduate School - Nanjing Medical College
Microbiology and Immunology
Residency - Nantong University College of Medicine
Medical Education - Nantong University College of Medicine
Ph.D. in Neuroscience and Genes & Development; Opioid tolerance, Graduate School of Biomedical Sciences (GSBS), The University of Texas Health Science Center at Houston, The University of Texas (UT) M.D. Anderson Cancer Center, Houston, TX 2002-2007
Postdoctoral Fellow, Inflammatory and Neuropathic Pain, Department of Anesthesiology and Pain Medicine, UT MD Anderson Cancer Center, TX 2007-2009
1.) Neuro-immune interaction and neuroinflammation in neuropathic pain
Using different neuropathic pain models, we investigate the pathophysiology to develop novel therapies for these clinically challenging pain syndromes. We are currently focusing on the complement system in these pain models.
A.) Chemotherapy-induced peripheral neuropathy. Administration of Taxol leads to complement activation and membrane attack complex (MAC) formation. These further induce local neuro-immune interactions in dorsal root ganglion (DRG), leading to DRG neuronal hypersensitivity and eventually peripheral neuropathy.
B.) Ischemia-induced chronic pain
2. Non-opioid therapies for chronic pain
We study the therapeutic potentials of the following drugs for chronic pain
A.) Ketamine. We are working on protocols to optimize Ketamineinfusion for chronic pain refractory to conventional treatments https://consultqd.clevelandclinic.org/guiding-research-on-ketamine-usage-for-crps/
B.) Nitrous oxide for complex regional pain syndrome. A clinical trial in under way. https://consultqd.clevelandclinic.org/study-will-look-at-nitrous-oxide-as-complex-regional-pain-syndrome-treatment/
3. Neuromodulation for chronic pain
We currently are studying the efficacy of neuromodulation (Spinal Cord Stimulation) on Diabetic Painful Neuropathy. Findings could potentially be appliedto other peripheral neuropathies.
View publications for Jijun Xu, MD, PhD
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