Postdoctoral Positions

The Lerner Research Institute is home to Cleveland Clinic's basic research departments and more than 2,000 scientists and support personnel. Research teams of more than 150 Faculty, 240 Postdoctoral Fellows and nearly 200 graduate students pursue a wide range of biomedical questions in our laboratories. The Institute's Postdoctoral Fellowship includes a competitive salary and benefits package and an opportunity to work and advance in a state-of-the-art facility with more than 700,000 square feet of space. Total annual research expenditures approached $250 million in 2011, including more than $110 million in federal funding.

The current postdoctoral opportunities are listed on the left. Please complete your application as directed and send to the investigator listed. We look forward to hearing from you!

Positions for Project Scientists, Research Associates and Postdoctoral Fellows posted by principal investigators.

Date Contact Description
02/16/2018 Takuya Sakaguchi, Ph.D.
sakagut2@ccf.org

A Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute.

A Postdoctoral Fellow position is available to study liver organogenesis, physiology and pathology in the Department of Stem Cell Biology and Regenerative Medicine at the Cleveland Clinic Lerner Research Institute.  We use zebrafish as a model and focus on human digestive disease modeling.  Research projects involve genetic, biochemical and bioinformatic approaches utilizing the zebrafish model and human biospecimens (http://www.lerner.ccf.org/stemcellbio/sakaguchi/).

We are seeking highly motivated recent graduates with a PhD and/or MD with relevant research experience.  Applicants should have research experience in cell biology, molecular biology, developmental biology or a closely related field.  The ideal candidate will have experience in developmental genetics.  Proficiency in spoken and written English is required.

The Lerner Research Institute provides an excellent environment for biomedical science.  Our postdoctoral training program (http://www.lerner.ccf.org/education/postdoc/) provides excellent support for career development in science.   

Please send your CV and contact information of three references to Takuya Sakaguchi (sakagut2@ccf.org).

02/15/2018 Philip Ahern
ahernp@ccf.org

The Ahern Group (http://www.lerner.ccf.org/cmm/ahern/), in the Department of Cellular and Molecular Medicine at the Cleveland Clinic Lerner Research Institute, seeks a postdoctoral researcher to study the interplay between the intestinal immune system and gut microbiota, and the contribution of these interactions to inflammatory bowel disease (IBD).

The gut microbiota has long been appreciated to be a major driver of the development and pathogenesis of IBD. Despite this, the specific members of the gut microbiota that are responsible have remained enigmatic, hampering our ability to target components of the microbiota for the treatment of IBD. We have developed a strategy to systematically identify effector microbes that reside within complex microbial communities that are capable of modulating phenotypes of interest. We will leverage this approach, allied to cutting-edge microbiological and immunological techniques in gnotobiotic mouse models of IBD, to identify and characterize the microbes that contribute to the development and pathogenesis of IBD, and the mechanisms underlying these interactions. This position is ideally suited to candidates who are interested in working at the interface of immunology and microbiology in the context of inflammatory disease.

 

The candidate will have completed, or be close to completing, a Ph.D. degree (or M.D. with at least 3 years research experience), and have experience in cellular immunology and rodent models of inflammation. Familiarity with microbiological techniques is desirable, but not essential.

 

The candidate will join a dynamic research department (http://www.lerner.ccf.org/), whose areas of interest encompass a breadth of topics related to the cellular and molecular pathways that mediate disease. The Department is also home to a number of groups whose work focuses on the contributions of the microbiota to host health and pathology, as well as numerous state-of-the-art core facilities that facilitate these studies. Our group, and the Department as a whole, seeks to provide a stimulating and collaborative research environment, committed to the training and development of its trainees and enabling their growth as independent researchers. A competitive benefits and salary package is available.

 

Interested candidates should submit a cover letter (2 pages maximum) outlining their research interests, as well as a CV and the contact information for 3 references to Dr. Philip Ahern at ahernp@ccf.org   

 

 

 

 

02/01/2018 Jasmine Thomas
thomasj15@ccf.org

Postdoctoral research fellowship openings are available (actual start dates are open) on an NIH-funded training program in kidney biology and disease research.  Successful applicants will have the opportunity to train with nationally recognized, NIH-funded faculty from the Departments of Medicine, Immunology, Pathology, Pediatrics, Physiology and Biophysics, Quantitative Health Sciences, Population Health and Epidemiology, whose research interests include renal cell biology, basic and clinical transplantation immunology, human and mouse genetics, developmental biology, polycystic kidney disease, and transport physiology.

Candidates must have a PhD or MD, or equivalent degree.  PhD applicants must be less than 3 years post award of their terminal degree.  M.D. candidates generally have completed internal medicine residency training and wish nephrology specialty training.  An additional year of clinical nephrology training is available for qualified M.D. trainees.  Applicants must be United States citizens or permanent residents.    

Please send a cover letter and CV with the names of 3 references to:

John Sedor, M.D.

Department of Nephrology and Hypertension

Glickman Institute, Cleveland Clinic

Professor of Molecular Medicine

Lerner College of Medicine, Case Western Reserve University

Email to: Jasmine Thomas at THOMASJ15@ccf.org

01/31/2018 Mohamed Abazeed, MD, PhD
abazeem@ccf.org

The Abazeed laboratory at Cleveland Clinic has an immediate opening for highly motivated individualswith expertise in genomic and machine learning informatics. Thisposition is supported by multi-sourced grants.

Fellow will lead the design and implementation of data analysis projects addressing fundamental biological questions about the causes and consequences of inter- and intra-tumoral genetic variation in cancer. These projects involve integrated analysis of high-volume genomic, epigenomic, and gene expression data (next-generation sequencing – WES/WGS, RNA-seq, Bisulfite-seq, etc.). Successful candidate will work independently and take a leading role in data analysis, interpretation, and visualization, and drafting of manuscripts for publication.

This position offer a competitive salary and stimulating work environment, with opportunities for advancement. The Cleveland Clinic offers highly competitive salaries, a robust benefits package and a collegial work environment.

Recent PhDs in computer science, bioinformatics, computational biology, and related fields will be considered. A strong background in statistics, and programming experience in a UNIX/Linux environment using programming languages such as Perl are required. Experience in high-throughput analysis of next-generation sequencing data and familiarity with widely-used genomic databases and software are advantageous.

Candidate must have excellent verbal and written communication skills and be capable of working within a team of biologists and programmers. No biological background is required, but the ideal candidate will have some familiarity with genetics and genomics. This opportunity could present an outstanding training experience for someone with a solid computer science background who wishes to break into bioinformatics.

To apply, submit your CV, statement of research interests, and names and contact information of three references to: Mohamed E. Abazeed, MD, PhD, Department of Translational Hematology Oncology Research, Cleveland Clinic Foundation, 9500 Euclid Avenue, M3-029, 44195; E-mail: abazeem@ccf.org.

Cleveland Clinic is an equal opportunity, equal access employer.

12/12/2017 Jan Claesen
claesej@ccf.org

We are looking for a Postdoctoral Fellow excited about advancing our mechanistic understanding of the Human Microbiome, to join the newly established Claesen group at the Cleveland Clinic Lerner Research Institute. http://www.lerner.ccf.org/cmm/claesen/

Our aim is to functionally characterize molecular mechanisms that control bacterial interspecies and microbe-host interactions in the human microbiome. Bacteria use small molecule chemicals to mediate these interactions and the genetic information required for their production is typically encoded in one physical location of the bacterial chromosome, in biosynthetic gene clusters (BGCs). Using in silico techniques, we identified several widespread families of BGCs that we are now characterizing experimentally, prioritizing on the BGCs predicted to be involved in modulation of community composition or interaction with the host immune system. Our research will contribute to a better mechanistic understanding of the microbes that live in our body, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.

Your profile

Candidates will have (or are close to obtaining) a PhD degree in a relevant biological or chemical subject and a good publication record in peer-reviewed scientific journals. Hands-on experience with microbiological, molecular genetics and standard biochemical techniques is required. Prior experience in manipulation of anaerobic microbes, mouse infection models, analytical chemistry or bioinformatics are desirable (but not required).

About us

The areas of expertise in the Claesen group include microbiology, bacterial genetics and synthetic biology, small molecule biosynthesis and biochemistry. We provide a stimulating, multidisciplinary training environment that will assist you in your successful scientific development. You will receive a competitive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute (http://www.lerner.ccf.org/), as well as plenty of opportunities for clinical collaboration at the Cleveland Clinic.

How to apply

Interested applicants should submit a cover letter describing research accomplishments and interests (no more than 2 pages), a CV and contact information for 3 references to Dr. Jan Claesen (claesej@ccf.org) by Friday January 19, 2018. Thereafter, applications will be considered on a rolling basis.

12/11/2017 Feng Lin
linf2@ccf.org

A postdoctoral position is available in the laboratory of Dr. Feng Lin in the Department of Immunology at the Cleveland Clinic Lerner Research Institute.

The ideal candidate will have a strong basic research background as evidenced by recent publications, and a keen interest in inflammation research. Proficiency in common immunological and/or molecular biology techniques − ELISA,  flow cytometry, DNA and protein electrophoresis, western blotting, PCR, transfection and mouse models of human diseases is required. 

 The selected candidate will receive a competitive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute, with opportunities for career advancement and multiple avenues for collaboration with clinicians at the Cleveland Clinic. More information about Lin Lab’s research may be found at www.lerner.ccf.org/immuno/lin/. Additional information about postdoctoral training at the Lerner Research Institute is available at www.lerner.ccf.org/education/postdoc/.

 The candidate must have (or be close to finishing) a PhD or MD/PhD degree.

 Highly motivated and qualified individuals should submit a cover letter describing research accomplishments and interests (no more than 2 pages), a CV and contact information for 3 references to Dr. Feng Lin (linf2@ccf.org). 

12/05/2017 Neetu Gupta
guptan@ccf.org

A postdoctoral position is available in the laboratory of Dr. Neetu Gupta in the Department of Immunology at the Cleveland Clinic Lerner Research Institute.

 

The ideal candidate will have a strong background in lung biology as evidenced by recent publications, and a keen interest in investigating asthma pathology. Proficiency in common immunological and molecular biology techniques − ELISA, multi-color flow cytometry, DNA and protein electrophoresis, western blotting, PCR, transfection − and mouse models of asthma is required. Additional experience in fluorescence microscopy/histology is desirable (but not required). The successful candidate will join a dynamic team of basic and translational immunology researchers to investigate novel regulators of airway inflammation and hyperresponsiveness.

 

The selected candidate will receive an attractive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute, with opportunities for career advancement and multiple avenues for collaboration with clinicians at the Cleveland Clinic. More information about Gupta Lab’s research may be found at www.lerner.ccf.org/immuno/gupta/. Additional information about postdoctoral training at the Lerner Research Institute is available at www.lerner.ccf.org/education/postdoc/.

 

The candidate must have (or be close to finishing) a PhD or MD/PhD degree. Proficiency in spoken and written English is required.

 

Highly motivated and qualified individuals should submit a cover letter describing research accomplishments and interests (no more than 2 pages), a CV and contact information for 3 references to Dr. Neetu Gupta (guptan@ccf.org). 

 

12/04/2017 Neetu Gupta
guptan@ccf.org

A postdoctoral position is immediately available in the laboratory of Dr. Neetu Gupta in the Department of Immunology at the Cleveland Clinic Lerner Research Institute.

 

The ideal candidate will have a strong background in cellular immunology with deep interest in and understanding of B cell biology and signal transduction as evidenced by recent publications. Proficiency in common immunological and molecular biology techniques (including, but not limited to, ELISA, multi-color flow cytometry, DNA and protein electrophoresis, western blotting, PCR, transfection), and mouse models of disease is required. Additional experience with confocal and/or TIRF microscopy is highly desirable. The successful candidate will join a dynamic team of basic and translational immunology researchers to investigate molecular mechanisms regulating B lymphocyte effector functions in the context of inflammation and autoimmunity.

 

The selected candidate will receive an attractive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute, with opportunities for career advancement and multiple avenues for collaboration with clinicians at the Cleveland Clinic. More information about Gupta Lab’s research may be found at www.lerner.ccf.org/immuno/gupta/. Additional information about postdoctoral training at the Lerner Research Institute is available at www.lerner.ccf.org/education/postdoc/.

 

The candidate must have (or be close to finishing) a PhD or MD/PhD degree.  Proficiency in spoken and written English is required.

 

Highly motivated and qualified individuals should submit a cover letter describing research accomplishments and interests (no more than 2 pages), a CV and contact information for 3 references to Dr. Neetu Gupta (guptan@ccf.org). 

11/15/2017 Jianguo Cheng, MD, PhD
chengj@ccf.org

A Senior Postdoctoral Fellow/Research Associate position is available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute. The successful candidate(s) will work for Dr. Jianguo Cheng, Professor of Anesthesiology, Staff in the Department of Neurosciences, and Director of the Cleveland Clinic Multidisciplinary Pain Medicine Fellowship Program. Areas of interest include 1) investigating how a nerve injury causes persistent pain behavior and neuroinflammation in the CNS and PNS; 2) investigating how stem cells modulate neuroinflammation, reduce neuropathic pain, and prevent and/or reverse opioid tolerance; and 3) investigating the feasibility and optimizing the key parameters of applying stem cell therapy in patients with chronic pain. The successful candidate(s) will help lead a multidisciplinary approach that combines behavioral, electrophysiological, molecular, and immunohistochemistry techniques to address important research questions. A Ph.D. and/or M.D. in a relevant discipline and research experience in a pain, neuroinflammation, or stem cell-related field are required.

Interested applicants should submit a curriculum vitae, a brief description of research interests and career goals, and contact information for three references to Dr. Jianguo Cheng, Department of Neurosciences, via email at: chengj@ccf.org.

 

11/01/2017 Anand Ramamurthi, PhD
ramamua@ccf.org

Postdoctoral Fellow in Aortic Aneurysm Research

Ramamurthi Lab at the Cleveland Clinic Lerner Research Institute, Cleveland, OH

Job Description

Dynamic and highly motivated candidates are sought to fill a postdoctoral research associate position in the Cardiovascular Matrix Engineering Laboratory directed by Dr. Anand Ramamurthi in the Department of Biomedical Engineering at the Cleveland Clinic (https://www.lerner.ccf.org/bme/ramamurthi/). The Ramamurthi lab investigates extracellular matrix (ECM) regenerative therapies for abdominal aortic aneurysms (AAAs). The candidate will investigate new therapeutic targets for multimodal downstream effects on vascular smooth muscle cell biology, proteolytic cascades, and regeneration and repair of the ECM, specifically the elastic matrix. The research project will involve vascular cell and ECM biology and cell-matrix interactions, proteases, small animal models for AAAs, and drug delivery. This position is funded by an award from the National Institutes of Health.

Candidate Experience

Candidates must have an MD, MD/PhD, or PhD in Biomedical Engineering, Cell or Molecular Biology, Pharmacology, or other related disciplines. Significant experience in molecular biology, and small animal cardiovascular disease models/treatment and rodent microsurgery is required. Familiarity with human tissue handling and processing, sterile cell culture, histology, confocal and electron microscopy and is a plus. The candidate is expected to be significantly independent, have strong communication skills, actively participate in exploring new research avenues and interdisciplinary collaborations, develop and write research grants, and participate in training and mentoring of junior lab personnel.

Application Process

Interested individuals should forward their electronic application dossier via email to Dr. Ramamurthi at ramamua@ccf.org. The dossier should include a cover letter summarizing research experience relevant to the position, curriculum vita, a one page statement of research interests and long-term career goals, and a list of 3 professional referees.  Review of applications will begin on November 15, 2017 and will continue until the position is filled.

About Us

The Cleveland Clinic (https://my.clevelandclinic.org/) is ranked the # 2 hospital in the United States by U.S. News & World Report and has held the top rank for treatment of cardiovascular disease for 22 years. The Lerner Research Institute (LRI; (https://www.lerner.ccf.org/) is home to all basic, translational and clinical research at Cleveland Clinic. With nearly 1,500 researchers and support personnel in 175 laboratories in 12 departments, the LRI is one of the largest research institutes in the nation, consistently ranking in the top 10 in National Institutes of Health funding, a benchmark of research success. The LRI maintains a strong academic program in collaboration with local universities, a medical school and has outstanding research core facilities. The Clinic is located in the famed University Circle area of Cleveland in close proximity to Case Western Reserve University and University Hospitals. Cleveland is an affordable, medium-sized city with a wealth of opportunities for cultural and outdoor activities.

11/01/2017 George Lawrence
lawreng@ccf.org

Postdoctoral Fellow Position-Available Immediately

 

Our research team focuses on understanding the mechanisms of thermo-modelling and thermo-modulation in the human brain, mainly related to the diagnosis and treatment of medically refractory epilepsy, and translating findings to clinical utility. We have built a research infrastructure that provides capabilities in experimentation, prototyping and computational modeling & simulation. Among other results, the research activities will generate safety data, prototype implementations and results, which will likely culminate in a pilot human trial. The lab is a collaborative translational effort between the Department of Biomedical Engineering and the Neurological Institute.

 

Requirements

We are seeking a motivated, independent postdoctoral fellow or research associate who will help lead investigations into the functional mechanisms of thermo-coagulation in the human brain. Specifically, we are seeking an individual with a solid background in biomedical engineering and/or neuroscience, in particular the use of computational modelling for development of treatment strategies and devices for neurological disorders. Applicants must have a Ph.D. or M.D., excellent verbal and written communication skills in English, a strong publication record, the ability to work and troubleshoot independently, and to design, implement and analyze research projects. The selected candidate will have opportunities for collaboration and career development with clinicians in the Neurological Institute and scientists at the Department of Biomedical Engineering at Lerner Research Institute.

11/01/2017 Anand Ramamurthi, PhD
ramamua@ccf.org

Postdoctoral Fellow in Aortic Aneurysm Research

Ramamurthi Lab at the Cleveland Clinic Lerner Research Institute, Cleveland, OH

Job Description

Dynamic and highly motivated candidates are sought to fill a postdoctoral research associate position in the Cardiovascular Matrix Engineering Laboratory directed by Dr. Anand Ramamurthi in the Department of Biomedical Engineering at the Cleveland Clinic (https://www.lerner.ccf.org/bme/ramamurthi/). The Ramamurthi lab investigates extracellular matrix (ECM) regenerative therapies for abdominal aortic aneurysms (AAAs). The candidate will investigate new therapeutic targets for multimodal downstream effects on vascular smooth muscle cell biology, proteolytic cascades, and regeneration and repair of the ECM, specifically the elastic matrix. The research project will involve vascular cell and ECM biology and cell-matrix interactions, proteases, small animal models for AAAs, and drug delivery. This position is funded by an award from the National Institutes of Health.

Candidate Experience

Candidates must have an MD, MD/PhD, or PhD in Biomedical Engineering, Cell or Molecular Biology, Pharmacology, or other related disciplines. Significant experience in molecular biology, and small animal cardiovascular disease models/treatment and rodent microsurgery is required. Familiarity with human tissue handling and processing, sterile cell culture, histology, confocal and electron microscopy and is a plus. The candidate is expected to be significantly independent, have strong communication skills, actively participate in exploring new research avenues and interdisciplinary collaborations, develop and write research grants, and participate in training and mentoring of junior lab personnel.

Application Process

Interested individuals should forward their electronic application dossier via email to Dr. Ramamurthi at ramamua@ccf.org. The dossier should include a cover letter summarizing research experience relevant to the position, curriculum vita, a one page statement of research interests and long-term career goals, and a list of 3 professional referees.  Review of applications will begin on November 15, 2017 and will continue until the position is filled.

About Us

The Cleveland Clinic (https://my.clevelandclinic.org/) is ranked the # 2 hospital in the United States by U.S. News & World Report and has held the top rank for treatment of cardiovascular disease for 22 years. The Lerner Research Institute (LRI; (https://www.lerner.ccf.org/) is home to all basic, translational and clinical research at Cleveland Clinic. With nearly 1,500 researchers and support personnel in 175 laboratories in 12 departments, the LRI is one of the largest research institutes in the nation, consistently ranking in the top 10 in National Institutes of Health funding, a benchmark of research success. The LRI maintains a strong academic program in collaboration with local universities, a medical school and has outstanding research core facilities. The Clinic is located in the famed University Circle area of Cleveland in close proximity to Case Western Reserve University and University Hospitals. Cleveland is an affordable, medium-sized city with a wealth of opportunities for cultural and outdoor activities.

10/26/2017 Anand Ramamurthi, PhD
ramamua@ccf.org

Postdoctoral Fellow in Nanomedicine

Ramamurthi Lab at the Cleveland Clinic Lerner Research Institute, Cleveland, OH

Job Description

We are seeking dynamic and highly motivated candidates to fill a postdoctoral research associate position in the laboratory of Dr. Anand Ramamurthi at the Department of Biomedical Engineering at the Cleveland Clinic (https://www.lerner.ccf.org/bme/ramamurthi/). The position is funded by a grant from the NHLBI/National Center for Accelerated Innovations-Cleveland Clinic (NCAI-CC). The Ramamurthi lab seeks to develop technologies for biomimetic regeneration and repair of structural extracellular matrix in tissues compromised by proteolytic disorders. The candidate will lead efforts to design, synthesize, and characterize novel bioresponsive nanoparticles for gene silencing- and drug-induced matrix repair primarily in vascular disease. The project will involve testing nanoparticle efficacy in in vitro cell culture models and in vivo small animal models of disease.

Candidate Experience

Candidates must have a PhD in Biomedical Engineering, Chemical Engineering, Material Science, Chemistry or a related discipline. Significant experience in polymer chemistry and synthesis, characterization of drug delivery nanoparticles, and their testing in biological systems (cell culture, in vivo) is required. Familiarity with sterile cell culture, molecular biology techniques, histology, confocal and electron microscopy, and rodent microsurgery is highly desired. The candidate is expected to be significantly independent, have strong communication skills, actively participate in exploring new research avenues and interdisciplinary collaborations, develop and write research grants, and participate in training and mentoring of junior lab personnel.

Application Process

Interested individuals should forward their electronic application dossier via email to Dr. Ramamurthi at ramamua@ccf.org. The dossier should include a cover letter summarizing research experience relevant to the position, curriculum vita, a one page statement of research interests and long-term career goals, and a list of 3 professional referees.  Review of applications will begin on November 15, 2017 and will continue until the position is filled.

About Us

The Cleveland Clinic (https://my.clevelandclinic.org/) is ranked the # 2 hospital in the United States by U.S. News & World Report and has held the top rank for treatment of cardiovascular disease for 22 years. The Lerner Research Institute (LRI; (https://www.lerner.ccf.org/) is home to all basic, translational and clinical research at Cleveland Clinic. With nearly 1,500 researchers and support personnel in 175 laboratories in 12 departments, the LRI is one of the largest research institutes in the nation, consistently ranking in the top 10 in National Institutes of Health funding, a benchmark of research success. The LRI maintains a strong academic program in collaboration with local universities, a medical school and has outstanding research core facilities. The Clinic is located in the famed University Circle area of Cleveland in close proximity to Case Western Reserve University and University Hospitals. Cleveland is an affordable, medium-sized city with a wealth of opportunities for cultural and outdoor activities.

10/25/2017 Kali Casale
casalek@ccf.org

Drug Discovery for Advanced Prostate Cancer

A postdoctoral fellowship position for drug discovery is available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic in the Department of Cancer Biology. 

Our laboratory and translational research program is focused on metabolic and molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy. 

A postdoctoral fellowship is available for drug discovery against a newly credentialed molecular target against prostate cancer.  The candidate will take a leading role in the development of a compound screening assay for the identification and validation of a lead inhibitor compound against the molecular target, defining the mechanism of compound interaction with the target and optimizing the properties and potency of the lead compound.

The ideal candidate has a Ph.D. degree in biochemistry, chemistry or molecular biology and has the appropriate expertise that can be applied to drug development.  Outstanding verbal and communication skills are required.

We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084), that we have shown drives poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016 17(10):1435-44; Hearn, et al. JAMA Oncol. 2017 Oct 12), yet serves as a tumor vulnerability to alternative steroid ablation inhibitors (Almassi, et al. JAMA Oncol. 2017 Oct 12). 

We recently also discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016 533(7604):547-51), and that this is a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chemical Biology. 2017 24, 1-8, July 20).   

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials.  Further details are available at the following link: https://www.lerner.ccf.org/cancerbio/sharifi/#lab

Candidates with an interest in the position should send their CV and contact information for 3 references to: 

Nima Sharifi, M.D.

Kendrick Family Chair for Prostate Cancer Research

casalek@ccf.org

10/23/2017 Veronique Lefebvre
lefebvv@ccf.org

A Postdoctoral Fellow position is available in the Cleveland Clinic [Institute/Department]

The Lefebvre laboratory in the Department of Cellular & Molecular Medicine at the Cleveland Clinic Lerner Research Institute is seeking to hire a postdoctoral fellow committed to a dynamic career in musculoskeletal and translational research.

The fellow will drive a new project focusing on molecular mechanisms controlling the identity, self-renewal, and differentiation potential of skeletal stem cells. The project will test the hypothesis that the SOXC transcription factors have key roles in these cells, similar to those of SOX2 in pluripotent stem cells. It will make use of cutting-edge approaches in vivo and in vitro, including mouse genetic models and next-generation sequencing of RNA and immunoprecipitated chromatin (RNA-seq and ChIP-seq). It is anticipated that new findings will help uncover mechanisms underlying human skeletal diseases, including osteoporosis, and will help develop novel approaches to prevent and treat these diseases. Thus, successful accomplishment of the project will allow the fellow to launch a promising research career in stem cell and molecular genetics relevant to inherited and acquired human skeletal diseases.  

Expertise in at least one of the following areas is desired: bone biology, stem cell biology, mouse models, and high-throughput sequencing approaches for RNA and chromatin.

Candidates must have a recent Ph.D. degree in biological sciences and a strong publication record in top-tier scientific journals. They should demonstrate proficiency in written and spoken English and in communicating scientific research findings accurately and efficiently. First-rate interpersonal and organizational skills are also recommended.

The Lerner Research Institute participates in multiple career-development programs for trainees and provides an exceptionally interactive and front-line scientific environment with state-of-the-art research core facilities. The Cleveland Clinic recognizes the power of a diverse community and encourages applications from individuals with varied experiences, perspectives, and backgrounds.

Interested candidates should send a CV, a description of research interests and career goals, and contact information for three references to Dr. Veronique Lefebvre (lefebvv@ccf.org).

Please send your curriculum vitae and contact information for 3 references to [Name of Contact Person]

10/12/2017 Stacy Menser
mensers@ccf.org

For many years, Cleveland Clinic and Lerner Research Institute has been at the forefront of biomedical research. Applications are invited to fill a unique position as the Cleveland Clinic’s Molecular Cardiology Scholars.

We seek researchers with experience in molecular and cell biology and experience with murine models. Applicants must document their success during their PhD or initial postdoctoral studies by first-author publications in reputable international journals. The chosen candidates will have an opportunity to work with several PIs on the molecular mechanisms of angiogenesis, atherosclerosis and thrombosis. The projects integrate analytical chemistry, molecular and cellular biology and state-of-the-art in vivo models to address important biomedical problems. We emphasize motivation and productive work in a collegial environment and an opportunity for translational and clinical collaborations. For further details see published work: West et al, Nature, 2010 ; Ding et al., Cell Metab. 2012;  Kerr et al,  Sci Signal., 2013.   The institution has a history of offering outstanding benefits to its employees.

 

Applicants should send curriculum vitae and names and addresses of three references to:

 Stacy Menser

mensers@ccf.org

216-445-9487

Department of Molecular Cardiology,  NB50

Cleveland Clinic

9500 Euclid Avenue

Cleveland, OH 44195

10/11/2017 Zong-Ming Li, PhD
liz4@ccf.org

Hand Biomechanics Postdoc Position

A Postdoctoral Fellow position is available in the Hand Research Laboratory, Department of Biomedical Engineering of the Lerner Research Institute at Cleveland Clinic. The projects will involve investigating the biomechanics of the hand/wrist. Applicants must have (1) a Ph.D. demonstrating creative and independent research, (2) a background in biomechanics, biomedical engineering, orthopaedics, rehabilitation, or closely related field, and (3) excellent written and oral communication skills in English. It is expected that applicants are highly self-motivated, possess a good balance of technical expertise and analytical thinking, and can work well both independently and collaboratively on interdisciplinary projects. Applications for this position should be sent to Dr. Zong-Ming Li (liz4@ccf.org) and include a cover letter, CV, and contact information for three references. For more information about the Hand Research Laboratory, please visit www.handlab.org or www.lerner.ccf.org/bme/li/.

10/09/2017 Ming Hu
hum@ccf.org

 

Position Title: Postdoctoral Research Fellow

Duties & Responsibilities: We are seeking one motivated and creative applicant with quantitative research background in bioinformatics, computational biology, statistics, biostatistics or computer science to join an active and collegial research team, co-led by Dr. Ming Hu (Cleveland Clinic) and Dr. Bing Ren (University of California San Diego and Ludwig Institute for Cancer Research). Appointment would be in Department of Quantitative Health Sciences, Lerner Research Institute, and Cleveland Clinic. 

This work is a key component of the cutting-edge 4D nucleosome project, funded by NIH, and involve the development and application of statistical methods and computational tools for the understanding of gene transcription regulation mechanism. The postdoc will also have great opportunities to collaborate with other researchers from the Cleveland Clinic. The postdoc will collaborate with researchers in 4D nucleosome, 1000 Genome, Roadmap Epigenomics and ENCODE projects. Dr. Hu and Dr. Ren will co-mentor the postdoc and provide highly supportive and dynamic environments to help in the transition to an independent researcher.

Position Qualifications: The applicant should have a Ph.D. degree in one of the following areas: Bioinformatics, Computational Biology, Statistics, Biostatistics, Computer Science, or other discipline with strong quantitative background. Knowledge in biology or genetics is desired but not required. Programming experience in statistical program R and scripting languages such as Perl/Python on Unix/Linux systems is required. Experience with C/C++ is a strong plus. Applicants should have quantitative background with strong statistical and computational skills.

Salary Range: Salary is competitive and commensurate with qualification. Benefits will be in accordance with Cleveland Clinic standard postdoctoral benefits.

Application Address: Interested applicants should email the following materials to Dr. Ming Hu. Email address: afhuming@gmail.com and hum@ccf.org

  •       A cover letter;
  •       A statement of research interest;
  •       Curriculum Vitae;
  •       Sample codes from recent programming;
  •       Publication reprints;
  •       Contact information of at least three references.

Review of applications starts immediately. Applications will be considered until the position is filled. The Department of Quantitative Health Sciences has over 90 members and provides an excellent environment for methodological and collaborative research. QHS faculty interact with researchers and clinicians across the Cleveland Clinic, one of the leading academic medical institutions in the world.  

Application Deadline: 05/31/2018.

09/29/2017 Bo Hu
hub@ccf.org

A Postdoctoral Fellow position is available in the Cleveland Clinic [LRI/Quantitative Health Sciences]

Our team has access to “big data” from multiple platforms, including various omics data (WGS, mitochondrial sequencing, metabolomics, epigenetics, etc.), electronic health records and well-annotated clinical phenotypes. The candidate’s responsibilities involve developing novel statistical methods, machine learning algorithms and computational tools to identify disease biomarkers and networks, build predictive models and discover new therapeutic interventions. The postdoc will have great opportunities to collaborate with physicians and scientists at the Cleveland Clinic.  

The applicant should have a Ph.D. degree in one of the following areas: Bioinformatics, Computational Biology, Statistics, Biostatistics, Computer Science, or other discipline with strong quantitative background. Knowledge in biology or genetics is desired but not required. The candidate should be familiar with program languages R, Perl or Python. Experience with C/C++ is a strong plus. 

 

Please send your curriculum vitae and contact information for 3 references to Bo Hu (hub@ccf.org)

09/06/2017 Xiaojuan Li
lix6@ccf.org

The Lerner Research Institute, The Institute of Orthopaedics and Rheumatology, and the Imaging Institute at the Cleveland Clinic, is forming an exciting new Program in Advanced Musculoskeletal Imaging (PAMI).  PAMI will build upon nationally top-ranked clinical care and research in orthopaedics and rheumatology and outstanding resources for imaging research already available at Cleveland Clinic, and new collaborations across institutes within Cleveland Clinic and with investigators around the world. The mission of PAMI is to advance musculoskeletal imaging, in particular advanced quantitative imaging, in healthcare for orthopaedics and rheumatology through technology development, translational research and education.

 

PAMI is looking for highly-motivated candidates for two post-doctoral research fellow/research staff positions in the field of musculoskeletal MR imaging and image processing. The research projects include development of novel pulse sequences of in vivo MSK MRI, image processing and analysis, and their clinical applications to musculoskeletal diseases. In particular, the sequence development will include developing advanced accelerated quantitative MSK imaging using cutting edge fingerprinting, compressed sensing and deep learning reconstruction. The image processing projects will develop advanced MSK imaging processing tools using classical techniques and cutting edge deep learning techniques. Successful candidates will join a multidisciplinary team with rich resources and strong support for a successful career development, and will have access to research dedicated MR systems (Siemens 3T and 7T), and other clinical scanners across different campus at CCF, as well as large outcome databases for patients in orthopaedics and rheumatology.

Requirements: A PhD degree in physics, biomedical engineering, electrical engineering, computer science, biochemistry or related field; background in MRI or NMR; strong programming skills with C, C++, Matlab; strong communication skills in written and verbal English. Experience in MR pulse sequence programming or advanced image processing algorithm development is a plus.

Applicants should email a CV, along with a brief letter outlining their research background and interests and a list of two to three references to Dr. Xiaojuan Li: lix6@ccf.org

09/01/2017 Daniel Blankenberg
blanked2@ccf.org

The Blankenberg Lab in the Genomic Medicine Institute at the Cleveland Clinic Lerner Research Institute has several Postdoctoral Fellowships available. We utilize high-throughput omics technologies, such as next generation sequencing, and data-intensive computing to explore biomedical research questions. The PI is a founding member of the Galaxy Project (https://galaxyproject.org), a platform that is used throughout the world for large-scale data analysis.

Both wet lab and computational positions are available and opportunities for crossover exist. Candidates will be highly motivated, ambitious, enthusiastic, and be able to work independently and in a collaborative environment.

Applicants must have experience in computational biology, bioinformatics, or experimental genomics. Preference will be given to those with previous experience in metagenomics or microbiome research. A strong publication record is required. Candidates with well-developed research plans will be considered particularly favorably.

Exceptional applicants should send a letter of application, curriculum vitae, statement of research interests, and complete contact information for 3 professional references to Dr. Daniel Blankenberg (blanked2@ccf.org).

08/31/2017 Anna Valujskikh
valujsa@ccf.org

A postdoctoral position is available in Dr. Anna Valujskikh’s lab in the Department of Immunology at the Cleveland Clinic. The research in the lab focuses on the immune responses following transplantation with the objective of developing strategies improving outcomes of solid organ transplants in high risk recipients. The group uses mouse model of heart and renal transplantation and a broad variety of cellular and molecular assays to evaluate alloimmunity. Funded projects investigate T cell reconstitution following lymphoablation in transplant recipients and the mechanisms of alloantibody generation and antibody-mediated rejection of renal allografts.

The candidate should have a PhD or MD/PhD degree, background in cell biology or immunology, a good record of productivity, personal initiative and strong technical and communication skills. 

08/29/2017 Richard Morton, Ph.D.
mortonr@ccf.org

A Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute's department of Cellular and Molecular Medicine to carry out studies investigating mechanisms that control high density lipoprotein (HDL) metabolism.  These NIH-funded studies investigate the role of Apolipoprotein F (ApoF) in regulating cholesterol transport.  ApoF is a regulator of cholesteryl ester transfer protein, which in turn is a major regulator of the distribution of cholesterol between low and high density lipoproteins. These studies will investigate the consequences of ApoF knockdown on cholesterol disposition in an animal model, quantify ApoF levels in human subjects and identify lipoprotein properties that cause ApoF to bind and subsequently inhibit cholesteryl ester transfer protein activity, and investigate the molecular mechanisms controlling ApoF gene expression.  Applicants should have a PhD in biochemistry, molecular biology, or related field that was awarded in the past 5 years.  Prior experience with lipoprotein / lipid biochemistry and/or gene regulation are preferred. 

Please send your curriculum vitae and contact information for 3 references to Dr. Richard Morton


Submission of resumes will be considered an expression of interest in the available opportunity. Applicants who best meet the education and experience requirements of the position will be contacted by the interviewing department and invited to formally apply for consideration. Cleveland Clinic is proud to be an equal opportunity employer and a smoke-free/drug-free environment.