Postdoctoral

Positions

Our postdoctoral programs give you hands-on experience at one of the nation’s top hospitals. Work alongside world-class investigators transforming groundbreaking discoveries in the laboratory to patients. Learn more about our postdoctoral programs and view current openings below.

Postdoctoral Fellow/Research Associate candidates will be expected to conduct research under the mentorship of a principal investigator in a predominantly independent manner. Fellows will be expected to pursue testing of hypotheses by developing experimental designs, managing and processing data and interpreting and preparing results for publication in peer-reviewed journals. Fellows will work closely with the principal investigator and will be expected to communicate effectively both in writing and in oral presentations. Qualified candidates will have successfully completed all requirements for the degree of doctorate in philosophy (PhD) or doctor in medicine (MD) in relevant scientific programs.

Project Scientist candidates will have substantial experience at the postdoctoral or research associate level and have established a respectable record of publication. Project Scientists will work in collaboration with the principal investigator but work independently within the scientific framework of the principal investigator's laboratory. Project Scientists may seek grant funding from extramural sources in support of their research projects with the consent of the principal investigator and department chair. Project Scientist is a junior-level faculty position.

Please complete your application as directed and send to the investigator listed. We look forward to hearing from you!

# Date Contact Description
1 01/13/2021 Angela Ting, PhD
tinga@ccf.org

Postdoctoral Fellow

A Postdoctoral Fellow position is available in the laboratory of Dr. Angela Ting (http://www.lerner.ccf.org/gmi/ting/) at the Cleveland Clinic Lerner Research Institute. Our research focuses on understanding the functional impact of abnormal DNA methylation in cancer. Most recently, we discovered a novel mechnism for how DNA methylation regulates transcriptome diversity (https://pubmed.ncbi.nlm.nih.gov/32333838/). We are recruiting motivated, creative individuals to help us expand upon this and other exciting obervations to understand the full impact of epigenetic regulation.

We employ next generation sequencing (NGS) technologies to identify epigenetic changes throughout the genome and carry out mechanistic studies to define the functions of these changes and their impact on the transcriptome and cancer biology. We are particularly interested in developing and testing hypotheses for novel alterations outside of the gene promoter context. We also leverage state-of-the-art single cell genomics to interogate these phenamenon at single cell reslution to delineate the heterogeneity observed in vivo.

Candidates must have scientific and technical expertise in computational biology, molecular biology, RNA biology, biochemistry, or transcription mechanisms. Additional requirements include a Ph.D. degree in biological sciences, a strong publication record, proficiency in spoken and written English, and the ability to work/troubleshoot independently as well as understanding and incorporating findings in the scientific literature into his/her research. The postdoctoral fellow will be expected to take a lead role in data generation, analysis, interpretation, visualization, and manuscript preparation.

Please send your curriculum vitae, a cover letter, and contact information for 3 references to Angela Ting (tinga@ccf.org).




2 01/11/2021 ahernp@ccf.org
ahernp@ccf.org

Postdoctoral Researcher

The Ahern Group (https://www.lerner.ccf.org/cms/ahern/), in the Department of Cardiovascular and Metabolic Sciences and the Center for Microbiome and Human Health (http://cmhh.ccf.org/) at the Cleveland Clinic Lerner Research Institute, seeks a postdoctoral researcher to study the interplay between the intestinal immune system and the gut microbiota in the development of intestinal immune tolerance.


ï‚· Our long-term goal is to advance efforts to leverage the microbiota for the promotion of immune tolerance for therapy. Critical to this objective is understanding immune-microbiota dialogue in the establishment and maintenance of intestinal homeostasis.


ï‚· Our immediate objective is to define the molecular basis through which gut microbes coordinate immune tolerance, and the nature of their interactions with the intestinal immune system.


ï‚· This will be addressed by leveraging cutting-edge microbiological and immunological techniques allied to metagenomics in gnotobiotic mouse models of IBD and allergy, to provide insights into the specific bacterial genes and pathways that drive the development of anti-inflammatory immune responses in the intestine.


ï‚· The ideal candidate will be a self-motivated individual who wants to drive their own research project while working in a collaborative environment.


ï‚· The candidate will have completed, or be close to completing, a Ph.D. degree (or M.D. with at least 3 years research experience), and be interested in microbiota research, specifically in working at the interface of microbiology and immunology.


ï‚· Experience in cellular or molecular immunology, and animal models of inflammatory disease is required. Familiarity with microbiology is desirable but not essential.

Interested candidates should submit a cover letter (1 page maximum) outlining their research interests, as well as a CV and the contact information for 3 references to Dr. Philip Ahern at ahernp@ccf.org 




3 01/08/2021 Scott Cameron
cameros3@ccf.org

Clinical Research Assistant

Clinical Research Assistant

Department of Cardiovascular Medicine

Cleveland Clinic

Job Summary:

A full-time Research Assistant needed to work in the Vascular Medicine Section of Cardiovascular Medicine assisting with the management and implementation of clinical research. 

Primary Responsibilities Include:

  • Enrolling and consenting patients for participation in disease registries and other research studies
  • Phlebotomy and specimen management
  • Conducting baseline and follow-up research visits
  • Administering research questionnaires 
  • Performing study procedures within the scope of training
  • Data abstraction and entry
  • Conducting literature searches
  • Maintaining research regulatory documents
  • Completion of IRB documentation 
  • Other research duties determined by supervising physicians

Position Offers:

-On-the-job training in medical research, phlebotomy, and other study procedures

-Exposure to all aspects of clinical research and to non-invasive vascular testing

-Opportunities for co-authorship of publications in peer-reviewed medical journals

-Exposure to the scientific peer-review publishing process

-Opprtunities to see and contribute to research in very rare diseases

-Opportunity to attend academic medical conferences

Qualifications:

The ideal candidate will have a strong science background and outstanding organizational and interpersonal skills. Ability to work with an interdisciplinary team to achieve research objectives is critical. A minimum one-year commitment is required.  This is an excellent position for someone interested in a career in medicine or clinical research.

This position will have a tentative February 2021 start date to accommodate  training. 

Please submit:

  1. A Resume/CV.
  2. A short letter of interest.
  3. Contact information for three referees.

Scott J. Cameron, M.D., Ph.D.

Section Head of Vascular Medicine

Email: cameros3@ccf.org




4 01/06/2021 Dr. Feng Lin
linf2@ccf.org

Post Doctoral Fellow

An immediate opening is available for a Postdoctoral Fellow position (or higher) in the Lin laboratory, Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute.  We are seeking highly motivated candidates who are interested in translational medical research. The lab is well-funded with multiple grants from the NIH and other sources. Candidates with prior experience and knowledge of techniques in Molecular Immunology, and with expertise in cell and animal models of autoimmune diseases and tumors are encouraged to apply.

Must be familiar with cultivation of multiple cell lines and primary cells.  Flow cytometry, western blotting, ELISA, lenti- retro- and adenoviral systems of shRNA delivery, expression of exogenous proteins, and the Casp9/Crispr system. Experience in murine models of autoimmune diseases such as EAE and/or EAU as well as tumor models is an advantage. The successful candidate will be expected to design, implement and manage research projects addressing roles of complement and/or CD6 in human diseases.

A Ph.D. or M.D. degree with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Candidates at both junior and senior levels are welcome to apply. Interested candidates should send a single PDF file, including 1) Cover letter indicating current and future research interests; 2)Expected starting date; 3)Curriculum vitae, and 4) Brief summary of previous research experience (2-3 pages) by email to Feng Lin, Ph.D., Department of Inflammation & Immunity; Lerner Research Institute / NE4; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. linf2@ccf.org




5 01/04/2021 Li Lily Wang
wangl9@ccf.org

Postdoctoral Research Fellow In Tumor Immunology

Postdoctoral fellow positions are available in Dr. Li Lily Wang’s laboratory, in the department of Translational Hematology Oncology Research (THOR), https://www.lerner.ccf.org/thor/wang/  in the Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH. The Wang laboratory is engaging in cross-disciplinary studies by collaborating with basic and clinical researchers from LRI /CCF and the Case Comprehensive Cancer Center, affiliated with Case Western Reserve University.

Immune-checkpoint blockade (ICB) therapies have revolutionized the field of Cancer Immunotherapy. However, the low response rate in a majority of patients indicates the urgent need to identify and target additional checkpoint regulators. The Wang laboratory is among the first group to demonstrate that the immune-checkpoint protein “V domain Immunoglobulin Suppressor of T cell Activation” (VISTA) is a promising target for cancer immunotherapy (1 – 6). Current projects are focusing on elucidating the signaling mechanisms of VISTA in regulating the expansion, metabolism, and effector function of tumor-associated T cells, tumor-associated macrophages, and myeloid-derived suppressor cells.

We seek talented and committed candidates with a recent PhD with research training and experience in Biochemistry, Cell Biology, and Immunology to join our team. Interested candidates should submit CV, a statement of research interests in a cover letter, and three references to Dr. Li Lily Wang, wangl9@ccf.org.

References:

 

1.Wang L, RubinsteinR, Lines LJ, Wasiuk A, AhonenC, GuoYX, LuLF, Gondek D, WangY, Fava RA, Fiser A, Almo S and Noelle RJ. (2011) ­­­VISTA, a novel Ig-superfamily ligand that negatively regulates T cell responses, J Exp Med. 208(3):577-92. PMC3058578

2. Le Mercier I, Chen W, Lines JL, Day M, Li J, Sergent P, Noelle RJ, Wang L (2014) VISTA regulates the development of protective anti-tumor immunity. Cancer Research, 74:1933-1944. PMC4116689

3. Wang L, Le Mercier I, Putra J, Chen W, Liu J, Schenk AD, Nowak EC, Suriawinata AA, Li J, Noelle RJ. (2014) Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity. PNAS.  (41):14846-51 PMC4205642

4. Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller H, Guleria I, Barth RJ, Huang YH, Wang L (2015) Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. PNAS. 112(21):6682-7, PMC4450438

5. Xu W, Tạ MH, Malarkannan S, Wang L(2018) Review: The structure, expression, and function of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation. Cellular & Molecular Immunology. 2018 May 15(5):438-446 PMC6068175

6. Xu W, Dong J, Zheng Y, Zhou J, Yuan Y, Ta H, Miller H, Olson M, Rajasekaran K, Ernstoff M, Wang D, Malarkannan S, Wang L (2019) Immune checkpoint protein VISTA regulates antitumor immunity by controlling myeloid cell-mediated inflammation and immunosuppression. Cancer Immunology Research  PubMed PMID:31340983; NIHMSID:NIHMS1535762

 

 




6 12/29/2020 Kurt Runge, PhD
rungek@ccf.org

Postdoctoral Research Fellow

Postdoctoral Research Fellow - Telomere Formation and DNA Damage Checkpoint Activation

An immediate opening for an NSF-funded Postdoctoral position to study telomere formation and DNA damage checkpoint suppression in fission yeast is available in the Runge lab at the Cleveland Clinic Lerner Research Institute.  Our lab uses a combination of molecular genetics, in vivo proximity labeling, proteomics and molecular biology to identify factors and pathways that distinguish telomeres from DNA double-strand breaks.  Individuals with experience in yeast and a strong background in molecular biology, genetics, and/or biochemistry are encouraged to apply.

Our lab developed a novel, rapidly inducible telomere formation system in the Schizosaccharomyces pombe.  We have used it to monitor the kinetics of telomere formation and the accompanying chromatin modifications (e.g. PubMed ID: 29784772).  We are combining this approach with our successful adaptation of proximity labeling for fission yeast to monitor the protein environment at the forming the telomere. This project provide a launching point for multiple new research directions in a system with strong similarities to human cells.

This project utilizes the state-of-the-art core facilities at the Cleveland Clinic and nearby Case Western Reserve University, and the active research communities in the Cleveland area.  Additional information about postdoctoral training at the Lerner Research Institute is available through links at www.lerner.ccf.org/education/postdoc/.

Applicants must have a Ph.D. with relevant laboratory experience and proficiency in written and spoken English.  To apply, please email a cover letter, CV, and contact information for 3 references to: Kurt Runge, Ph.D.; rungek@ccf.org; Department of Inflammation & Immunity.




7 12/29/2020 Dr. Rachel Scheraga
scherar@ccf.org

Post-Doctoral Fellow

A post-doctoral fellow position is available to perform basic and translational research in the laboratory of Dr. Scheraga at the Cleveland Clinic, Lerner Research Institute Department of Inflammation and Immunity. Our NIH-funded work is focused on the role of a mechanosensitive, calcium ion channel and innate immune cell biology in the lung. We are seeking a hardworking and motivated individual who has experience in cell and molecular biology techniques and managing mouse colonies. The position has salary and fringe compensation as per the NIH guidelines with additional fringe benefits. Please apply to this position with your current CV and three letters of reference to Dr. Rachel Scheraga (scherar@ccf.org).




8 12/23/2020 Rodrigo Lopez-Gonzalez
lopezgr@ccf.org

Postdoctoral Fellow, Neurosciences

The research group of Rodrigo Lopez-Gonzalez in the Department of Neurosciences at the Lerner Research Institute is looking for a talented and highly motivated postdoctoral fellow to participate in projects aiming to gain insight into the cellular and molecular pathogenic mechanisms of frontotemporal dementia and amyotrophic lateral sclerosis using human iPSCs derived neurons and brain organoids as experimental models. Our current research is built on papers from Lopez-Gonzalez et al., Neuron 2016; Yin et al., Cell Reports 2017; and Lopez Gonzalez et al., PNAS 2019.

We are looking for a candidate with a doctorate degree in the field of neurosciences, biomedical sciences, or related fields with a strong background in human iPSCs, neuronal and brain organoid differentiation. Preferably, with experience in epigenetics, molecular biology, RNA-seq, ChIP-seq and ATAC-seq. Then successful candidate is expected to have good communication skills, be a team player, with exceptional organizational skills and critical thinking aptitude.

To apply please send a CV, cover letter with a brief description of current and future research interests, publications and names and contact details from three references. Please contact: Dr. Lopez-Gonzalez:  lopezgr@ccf.org.




9 12/17/2020 Zihua Gong
gongz@ccf.org

Postdoctoral Fellow

We are currently seeking an ambitious, enthusiastic, and motivated Postdoctoral Fellow to join our research team in the Department of Cancer Biology at the Cleveland Clinic Lerner Research Institute. Our lab is focused on understanding the DNA repair pathways in cancer development and cancer treatment.

We seek candidates with strong qualifications in the following areas: mammalian cell culture, molecular biology, biochemistry and mouse models. Application Requirements: A Ph.D with relevant research experience is required. Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, cover letter, and contact information for three references. Please send applications and informal inquiries to Dr. Zihua Gong at  gongz@ccf.org.




10 12/16/2020 Dr. Nima Sharifi
sharifn@ccf.org

Postdoctoral Research Fellow

Molecular Mechanisms and Translational Oncology
Do you have a background in molecular, biochemical or chemical mechanisms yet are interested in translational medicine? Are you interested in taking your mechanistic findings rapidly to the bedside in a vibrant clinical research program? If so, a postdoctoral fellowship position supported by the National Institutes of Health and the Prostate Cancer Foundation is available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic.
Our laboratory focuses on mechanistic discovery to understand the metabolic and molecular mechanisms of androgen synthesis and androgen receptor gain-of-function that lead to resistance to hormonal therapy. Specific areas include:
1) Metabolic and genetic changes required for hormone therapy resistance in prostate cancer and tumor progression
2) Clinical validation in patients and clinical trials using innovative approaches
3) Animal models of advanced prostate cancer for translational and therapeutic studies
4) Identifying targets for the development of new pharmacologic therapies
We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013;154:1074-84). We also recently discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015;523:347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016;533:547-51) and that these events are a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chem Biol. 2017;24:825-32) and genetic determination of metabolite generation (Alyamani, et al. J Clin Invest. 2018;128:3333-40). View a quick summary of these discoveries here: https://www.youtube.com/watch?v=22dFzT4RFno
This position is ideal for an individual with a strong interest in rapid translation of basic mechanistic discoveries to the bedside as this is a principal goal of the Sharifi Laboratory. For example, we have shown that our discovery of a gain-of-function in a steroid-synthesizing enzyme is a predictive biomarker of poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016;17:1435-44; JAMA Oncol. 2018;4:558-62). We are currently evaluating this biomarker in an active clinical trial and are pursuing similar mechanisms and developing new treatment modalities based on these discoveries.
The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials. Further details are available at: http://www.lerner.ccf.org/cancerbio/sharifi/ and http://newsroom.clevelandclinic.org/?s=sharifi
The ideal candidate has a Ph.D. degree in biochemistry, chemistry or molecular biology; has the appropriate expertise in discovery of molecular, biochemical or chemical mechanisms; and is highly driven. Outstanding verbal and communication skills are required. Interested candidates should send their CV and contact information for 3 references to:
Nima Sharifi, M.D.
Kendrick Family Chair for Prostate Cancer Research
Director, GU Malignancies Research Center
sharifn@ccf.org




11 12/16/2020 Brian Gastman
gastmab@ccf.org

Post Doctoral Fellows

There are immediate openings for 2 positions as post-doctoral fellows or other clinical trainee levels (medical students, residents, fellows) in the Gastman Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute and Department of Plastic Surgery, Cleveland Clinic. Individuals with clinical experience and knowledge of cancer are encouraged to apply.  The ideal candidate would be a medical student, resident or fellow interested in translational research related to cancer and specifically skin malignancies like melanoma as well as surgery (including but not limited to surgical oncology and plastic surgery).  As these projects are highly translational there will be more emphasis on tissue handling, storing and shipping than basic science assays.  However, both projects will be involving proprietary devices and reagents as they relate to industry sponsored research.  There may be extensions of this research that will require collaboration with bioinformatics teams.  In addition as these projects mature there is likely need for studies requiring immunohistochemsty and flow based analyses.    Finally, there may also be extensions requiring in vivo modeling with cancer specimens and PDX models.  Applicants with a clinical background as mentioned and with appropriate basic science skills will be prioritized – however these positions to lend themselves to learning of these techniques.  Finally excellent communication skills is also a priority as there will be significant correspondences between our institution and the sponsors.    Given that this is for translational studies, there may be associated chart review and even review article type activities asked of those accepted to these positions.

Ph.D. or M.D./D.O. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Brian Gastman, MD.; Department of Inflammation & Immunity; Lerner Research Institute / NE40; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. gastmab@ccf.org.




12 12/15/2020 Dr. Jianjun Zhao
zhaoj4@ccf.org

Postdoctoral Research Fellow

Alternative NHEJ Mechanisms and Targeted Therapy in Multiple Myeloma

Our group at the Cleveland Clinic Lerner Research Institute Cancer Biology Department is seeking a highly motivated post-doctoral fellow to join our studies to develop novel treatment and treatment prediction markers in multiple myeloma.

Our laboratory focuses on the critical chromosomal translocations that drive multiple myeloma development, precision medicine, and disparities. Via mechanistic dissection of B cell Class Switch Recombination (CSR) especially the error prone alternative NHEJ pathway and/or somatic hyper mutation (SHM) pathway regulated by AICDA, we aim to develop novel therapeutic targets and treatment approaches and to identify biomarkers of response to targeted therapy. All projects involve conditional transgenic and xenograft mouse models of multiple myeloma and clinical validation of laboratory findings patient’s samples from multiple myeloma tissue bank and ongoing clinical trials. 

The position will provide a unique and multidisciplinary exposure to preclinical mouse models, molecular oncology, immune therapy, drug development and clinical trials.  Further details are available at:   https://www.lerner.ccf.org/cancerbio/zhao/  

The ideal candidate has a M.D. or Ph.D. degree in clinical medicine, biochemistry or molecular biology; has the appropriate expertise in mouse model is highly encouraged to apply.  Outstanding verbal and communication skills are required. Interested applicants should submit a CV and contact information for 3 references to Dr. Jianjun Zhao via email: zhaoj4@ccf.org.




13 12/15/2020 gottfra@ccf.org
buccinl@ccf.org

Research Development

Research Development Post-Doctoral Research Fellowship 

A Postdoctoral Research Fellow position is available within the Office of Research Development (ORD).  The postdoc will be a member of the Research Development team and will train under the direction of Dr. Laura Buccini (Director of ORD).

 General Background

 Research Development is a growing field of professionals that work to provide research scientists the support, guidance, resources and collaborations required to develop competitive, scientifically sound external research grant applications. These professionals initiate and nurture partnerships throughout the Institution and with external stakeholders. Interested applicants should have aspirations for a career as a research development professional.

Essential Functions

The Postdoc will be trained on a wide spectrum of activities that encompass the field of Research Development including but not limited to the following: 

  • Identify and disseminate funding opportunities;

  • Review and analyze funding opportunity announcements (FOA) or similar documents;

  • Project management of the grant development process (e.g. facilitation of team communication, identifying additional resources, developing timelines etc.);

  • Conduct non-technical review of the grant proposal;

  • Coordinate external grant reviewers as needed;

  • Work with principal investigators/team to develop non-scientific proposal sections;

  • Develop grant writing tools and templates for research investigators

  • Other tasks as assigned

Position Requirements and Preferences

Candidates should have Ph.D. (or similar terminal research degrees). The terminal degree can come from basic or clinical sciences. Successful candidates should be familiar with the structure and required components of federal grants (specifically NIH) and should have demonstrated experience with Federal grant writing, (either their own grants or assisting other investigators).

 Prospective candidates must be creative, self-motivated and capable of working independently. Candidates must be proficient in both spoken and written communication in English. Special consideration will be given to applicants with substantial grant related experience.

Interested Candidates

Interested candidates should submit a brief summary of their grant related research experience, curriculum vitae and contact information for 3 references to Dr. Laura Buccini (buccinl@ccf.org). 




14 12/14/2020 Florian Rieder
riederf@ccf.org

Postdoctoral Fellow - Rieder Lab

A Postdoctoral Fellow position is available in the Cleveland Clinic [Institute/Department]

Immediate opening for a Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute Department of Inflammation and Immunity. Individuals with experience and knowledge of techniques in tissue culture, primary human cell isolation, molecular biology techniques (qPCR, immunoblot, ELISA), IHC, confocal microscopy, mouse handling are encouraged to apply. This project includes animal husbandry, breeding, genotyping, animal models of colitis.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required. Please send your curriculum vitae and contact information for 3 references to Dr. Florian Rieder (riederf@ccf.org).

Please send your curriculum vitae and contact information for 3 references to [Name of Contact Person]




15 12/11/2020 Dawn Taylor, Ph.D.
taylord8@ccf.org

Postdoctoral Position In Brain-Machine Interfacing

We are seeking an outstanding postdoctoral candidate for research in brain-machine interfacing and restoration of movement after paralysis via electrical stimulation of the peripheral nerves. Our work is part of a larger government-funded clinical trial (ReHAB: Reconnecting the Hand and Arm to the Brain) to restore arm function to paralyzed individuals by using their intracortical brain signals to control peripheral nerve stimulators that reanimate their paralyzed muscles. The specific focus of our five-year NIH-funded project (PIs: Drs. Dawn Taylor and Bolu Ajiboye) is to improve brain-controlled limb movements by more effectively modulating limb stiffness (i.e. degree of co-contraction of antagonist muscle) to improve limb stability while also minimizing muscle fatigue.


Research activities include working with healthy animals using their brain signals to control a computer simulation of a paralyzed arm, as well as spinal cord-injured humans controlling their own paralyzed arm. Ideal candidates will have experience/familiarity with some or all of the following: intracortical recordings in animals and/or humans; peripheral nerve stimulation for restoration of movement; real-time neural signal processing; writing custom programs to control multiple pieces of hardware and control objects in a virtual environment (Matlab skills preferred); and computational or biomechanical modeling. An advanced degree in Biomedical Engineering, Computer Engineering, or Neurosciences is preferred, but other applicants will be considered.


This is a great opportunity to work with our large interdisciplinary team of researchers, engineers and clinicians to gain a wide range of skills beneficial for your future neural or rehab-related career. Interested candidates should submit their curriculum vitae to Dawn Taylor, PhD  (taylord8@ccf.org).




16 12/08/2020 Hoonkyo Suh
suhh2@ccf.org

Postdoctoral Fellow In Neurosciences

We are seeking a highly-motivated postdoctoral fellow to join Dr. Hoonkyo Suh’s laboratory in the Department of Neurosciences at the Cleveland Clinic.

The research goal is to understand hippocampal neurogenesis and neural circuits that underlie human mental behaviors and disease, with the hope that outcomes of our research will lead to the development of new therapeutic approaches to prevent, treat, and cure neuropsychiatric (i.e. cognitive deficits, depression, and anxiety) and neurological (i.e. epilepsy and addiction) disorders. A successful candidate will dissect neuronal connectivity and function of hippocampal neural circuits in normal and disease rodent models at the molecular, cellular, genetic, and circuitry levels.

The Suh lab is seeking highly-independent and creative individuals with a Ph.D. and/or M.D. degree, who are motivated to work in a diverse and collaborative research environment. We will consider candidates from a broad range of backgrounds including (but not limited to) molecular and cellular biology, genetics, as well as behavioral and systems neuroscience.

Applicants should send a cover letter, CV, and complete contact information for three references to Dr. Hoonkyo Suh at suhh2@ccf.org




17 12/07/2020 Dr. Dennis Stuehr
stuehrd@ccf.org

Postdoctoral Fellow

A NIH-funded postdoctoral fellow position is available in the laboratory of Dr. Dennis Stuehr in the Department of Inflammation and Immunity, Cleveland Clinic, USA. The scientific project aims to uncover the molecular mechanisms of heme trafficking in mammalian cells and the molecular mechanisms of heme insertion into biomedically-important heme proteins including soluble guanylyl cyclase, hemoglobin, myoglobin, cytochrome P450’s, and indoleamine and tryptophan dioxygenases. Our research approach combines biochemical, biophysical, and computational experiments on the purified proteins with confirmatory and exploratory experiments in cultured mammalian cells. Candidates with a recent or upcoming PhD with expertise in protein biochemistry, biophysics, or structural biology are invited to send their CV and names of three references to:

Dr. Dennis Stuehr stuehrd@ccf.org

For representative articles see:

Heat shock protein 90 associates with the Per-Arnt-Sim domain of heme-free soluble guanylyl cyclase: Implications for enzyme maturation. Sarkar A, Dai Y, Haque MM, Seeger F, Ghosh A, Garcin ED, Montfort WR, Hazen SL, Misra S, Stuehr DJ. (2015) J Biol Chem. 290:21615-28. PMID: 26134567

Heat shock protein 90 regulates soluble guanylyl cyclase by a dual mechanism. Dai Y, Schlanger S, Haque MM, Misra S, Stuehr DJ. (2019) J Biol Chem. 294: 12880-91. PMID: 31311859

Glyceraldehyde-3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells. Sweeny EA, Singh AB, Chakravarti R, Martinez-Guzman O, Saini A, Haque MM, Garee G, Dans PD, Hannibal L, Reddi AR, Stuehr DJ. (2018) J Biol Chem. 293:14557-14568. PMID: 30012884.

GAPDH delivers heme to soluble guanylyl cyclase. Dai Y, Sweeny EA, Schlanger S, Ghosh A, Stuehr DJ. J Biol Chem. (2020) 295:8145-8154. PMID: 32358060




18 12/03/2020 Dr. Khaled Hassan
hassank@ccf.org

Postdoctoral Research Fellow

The position is available in Cancer Biology at the Lerner Research Institute at the Cleveland Clinic. We are seeking a highly motivated and independent scientist to study mechanisms of resistance to targeted therapy in lung cancer. We have shown that resistant mutations are acquired through cytosine deaminase (1). We are utilizing different in vitro and in vivo approaches to:

1) Determine whether the same mechanism is responsible for new resistant mutations to inhibitors of various pathways.  

2) Determine whether a specific subpopulation has the ability to induce this mechanism of resistance.

3) Assess the role of cytosine deaminase in other resistant mechanisms.

4) Developing new pharmacologic therapies to prevent/delay resistance.

Candidates should have a recent PhD or MD and experience in molecular and cell biology, biochemistry and related disciplines. Excellent verbal and communication skills are required. The Cleveland Clinic Lerner Research Institute provides an excellent interactive environment with access to state-of-the-art equipment and facilities. Interested applicants please submit a CV and contact information for 3 references to Khaled Hassan, MD.MS. via email hassank@ccf.org.




19 11/30/2020 Christine O'Connor
oconnoc6@ccf.org

Post-doctoral Fellow

Postdoctoral Position: Virology/Infectious Disease

Job Summary:

We are seeking a highly motivated individual for a post-doctoral position in the laboratory of Christine O’Connor, PhD, in the Department of Genomic Medicine at the Cleveland Clinic. This position is for highly motivated, enthusiastic candidates with a strong background in molecular/cellular biology, virology, immunology, and/or related field. Research topics include understanding the function(s) of the human cytomegalovirus (HCMV) encoded G-protein coupled receptors (GPCRs) during latency and reactivation. Qualified individuals should hold a PhD and/or MD and have strong laboratory, analytical, and communication skills. Candidates with experience in virology and/or immunology are strongly encouraged to apply. 

Key responsibilities include:

  • conducting research aimed at understanding HCMV-encoded GPCR functions during viral latency and reactivation.
  • planning, organizing, performing, and monitoring daily activities related to the project protocols and goals.
  • preparing, collecting, and maintaining required research project documentation and data.
  • leading, assisting, and contributing to the preparation of internal and external presentations, reports, and manuscript publications.
  • participating and presenting in lab meetings, as well as departmental and institute seminars.

Ideal candidates have:

  • a PhD and/or MD in microbiology, virology, molecular biology, cell biology, or related field.
  • extensive experience in tissue culture and molecular/cellular biology techniques (e.g. RNA/DNA manipulation, cloning, protein analyses). Virology background is not required, but is preferred.
  • demonstrated ability to be highly motivated and organized, detail-oriented, a critical thinker, and able to work independently as well as in teams.
  • exceptional communication skills (both oral and written). 

Interested candidates should submit a current CV, description of past research experience and accomplishments, summary of current and future research interests, selected publication reprints, as well as the names and contact information of three referees to: Christine O’Connor, email: oconnoc6@ccf.org




20 11/25/2020 Li Lily Wang
wangl9@ccf.org

Postdoctoral Research Fellow -- In Cancer Immunology

 Postdoctoral Research Fellow --- in Cancer Immunology

 Postdoctoral fellow positions are available in Dr. Li Lily Wang’s laboratory, in the department of Translational Hematology Oncology Research (THOR), https://www.lerner.ccf.org/thor/wang/  in the Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH. The Wang laboratory is engaging in cross-disciplinary studies by collaborating with basic and clinical researchers from LRI /CCF and the Case Comprehensive Cancer Center, affiliated with Case Western Reserve University.

Immune-checkpoint blockade (ICB) therapies have revolutionized the field of Cancer Immunotherapy. However, the low response rate in a majority of patients indicates the urgent need to identify and target additional checkpoint regulators. The Wang laboratory is among the first group to demonstrate that the immune-checkpoint protein “V domain Immunoglobulin Suppressor of T cell Activation” (VISTA) is a promising target for cancer immunotherapy (1 – 6). Current projects are focusing on elucidating the signaling mechanisms of VISTA in regulating the expansion, metabolism, and effector function of tumor-associated T cells and myeloid suppressive cells.

We seek talented and committed candidates with a recent PhD with research training and experience in Biochemistry, Cell Biology, and Immunology to join our team. Interested candidates should submit CV, a statement of research interests in a cover letter, and three references to Dr. Li Lily Wang, wangl9@ccf.org.

References:

 

1.Wang L, RubinsteinR, Lines LJ, Wasiuk A, AhonenC, GuoYX, LuLF, Gondek D, WangY, Fava RA, Fiser A, Almo S and Noelle RJ. (2011) ­­­VISTA, a novel Ig-superfamily ligand that negatively regulates T cell responses, J Exp Med. 208(3):577-92. PMC3058578

2. Le Mercier I, Chen W, Lines JL, Day M, Li J, Sergent P, Noelle RJ, Wang L (2014) VISTA regulates the development of protective anti-tumor immunity. Cancer Research, 74:1933-1944. PMC4116689

3. Wang L, Le Mercier I, Putra J, Chen W, Liu J, Schenk AD, Nowak EC, Suriawinata AA, Li J, Noelle RJ. (2014) Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity. PNAS.  (41):14846-51 PMC4205642

4. Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller H, Guleria I, Barth RJ, Huang YH, Wang L (2015) Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. PNAS. 112(21):6682-7, PMC4450438

5. Xu W, Tạ MH, Malarkannan S, Wang L(2018) Review: The structure, expression, and function of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation. Cellular & Molecular Immunology. 2018 May 15(5):438-446 PMC6068175

6. Xu W, Dong J, Zheng Y, Zhou J, Yuan Y, Ta H, Miller H, Olson M, Rajasekaran K, Ernstoff M, Wang D, Malarkannan S, Wang L (2019) Immune checkpoint protein VISTA regulates antitumor immunity by controlling myeloid cell-mediated inflammation and immunosuppression. Cancer Immunology Research  PubMed PMID:31340983; NIHMSID:NIHMS1535762

 

 




21 11/13/2020 Ela Plow
plowe2@ccf.org

Postdoctoral Fellow

Engineering in the field of clinical neuroscience and neuro-rehabilitation. This is an exciting opportunity to join a laboratory that studies mechanisms of brain plasticity in neurologic populations and seeks to target those mechanisms with behavioral and neurostimulation interventions for promoting functional recovery.

The successful candidate will have the opportunity to participate in one or more ongoing NIH and DoD--funded clinical trials and neuroscientific studies in stroke and spinal cord injured (SCI) populations, including a multi-site phase I/II clinical trial of non-invasive (transcranial) brain stimulation combined with rehabilitation in persons with tetraplegia following incomplete cervical SCI.  

The position requires a highly creative, motivated and independent individual with a Ph.D. in kinesiology, rehabilitation science, exercise science/physiology, biomechanics, movement science, neuroscience, biomedical engineering or a related field. Candidates must demonstrate this experience through a record of relevant publications. Strong laboratory and clinical research skills, ability to lead and work well in a team, an understanding of human motor control, and basic knowledge of neuroanatomy and neurophysiology would be desirable. Past experience in patient research is not required, but candidates must be willing to perform experiments in clinical settings.

The successful candidate will be expected to interface with therapists, physicians, clinical coordinators, graduate students and other post-doctoral fellows. Candidates should be ready to start candidates can begin in Mar-Apr 2021.

Candidates should send a curriculum vitae, a research statement articulating track record and research interests and contact information of 3 references to Ela Plow PhD PT at plowe2@ccf.org




22 11/13/2020 Margot Damaser, PhD
damasem@ccf.org

BME Postdoctoral Fellow

A postdoctoral fellow position is available immediately in the laboratory of Dr. Margot Damaser in the Department of Biomedical Engineering of the Lerner Research Institute to refine and validate a wireless in vivo bowel sensor system. The research will focus on programming of bowel sensor prototype, enabling wireless battery charging, addition of features to the sensor such as adding new sensing modalities and enabling recording from multiple locations in the bowel simultaneously, benchtop and in vivo calibration and testing, and technology transfer to other research groups both local and national.

Candidates should have a PhD in Electrical Engineering or Biomedical Engineering and proficiency in at least one programming language (e.g. C++, Matlab) as well as experience debugging and developing custom electronic devices, testing and validation protocols, and experience with statistical data analysis & signal processing (e.g. filters).

The successful candidate will be able to work in a milestone-driven research environment (i.e. can adhere to a schedule of deliverables); will be comfortable studying physiological functions, such as bowel and bladder function; and will show initiative and take ownership of project, attention to detail particularly with regard to documentation and analysis, strong written and oral communication skills, ability to function in a multidisciplinary team, and work at multiple locations as needed.

Experience/expertise is one or more of the following areas is desired: Matlab & Labview software, embedded software for microcontrollers (e.g. C++, TI MSP series), low-power radio frequency communication methods, RF power amplifiers and/or wireless battery charging, circuit design/layout, circuit simulation, electromagnetic simulation, and experience with biocompatible polymers (e.g. silicones). Several years of hands-on laboratory research, development, and testing experience is also strongly desired.




23 11/02/2020 Dr. Timothy A. Chan and Allison Borrelli
chanlabrecruitment@ccf.org

Postdoctoral Fellow

POSTDOCOTAL FELLOW

JOB SUMMARY:

We seek an enthusiastic candidate for the position of postdoctoral fellow in the laboratory of Dr. Timothy Chan, the Chair of the Center for Immunotherapy at the Cleveland Clinic. The post-doctoral position is for highly motivated candidates with a background in molecular/cellular biology, immunology, and/or genetics to join a research group interested in cancer genomics and immunotherapy research.   Projects will involve using molecular biological and genomics strategies to identify and characterize genetic determinants of cancer progression and therapeutic response.  Applicants should hold a PhD and/or MD degree and have strong laboratory and analytical skills.  Experience in molecular biology, immunology, bioinformatics, or cancer genetics would be very helpful.

 KEY RESPONSIBILITIES:

-Conducts research focused on immunotherapy and cancer genomics.

-Plans, organizes, performs and monitors daily project protocols.

-Collects, prepares and maintains required research documentation, including informed consent records, case records, clinical notes and medical reports.

-Reports and assists with the management of protocol deviations, adverse events and other project-related issues.

-Assists with the preparation and delivery of internal/external presentations, conference reports/lectures, and publishing submissions.

EDUCATION:

PhD in an appropriate scientific field such as Biology, Biochemistry, Immunology, Chemistry, Microbiology, or other similar science major. 

COMPLEXITY OF WORK:

Requires critical thinking skills, decisive judgment and the ability to work with minimal supervision. Must be able to work in a stressful environment and take appropriate action.

Full applications including curriculum vitae, a summary of current and future research interests and expected availability date, a description of past research experience and accomplishments, selected reprints of publications and three references should be submitted to: Timothy A. Chan, MD/PhD, Chair, Center for Immunotherapy.  E-mail: ChanLabRecruitment@ccf.org




24 11/01/2020 Vijay Krishna
krishnv2@ccf.org

Postdoctoral Fellow

A Postdoctoral Fellow position is available in the laboratory of Dr. Vijay Krishna in the Department of Biomedical Engineering at the Lerner Research Institute, Cleveland Clinic to study the interaction of nanomaterials in animal models. The successful candidates will join a multidisciplinary team of investigators including clinicians for design and evaluation of nanomaterials for biomedical applications. Specifically, the position will focus on design of energy-gated nanoparticles and drug-loaded nanomaterials for targeted delivery. Along these same lines, the molecular, biochemical and immunological mechanisms will be deciphered.

Candidates should have Ph.D. in biomedical engineering, materials science, nanomedicine, molecular biology, chemical biology and/or biochemistry. Successful candidates should have demonstrated expertise in nanoparticle synthesis and characterization and molecular biology techniques. Special consideration will be given to applicants with additional expertise in murine models.

Prospective candidates must be creative, self-motivated and capable of working independently. Candidates must be proficient in both spoken and written communication in English. Candidates will be expected to design and conduct experiments, statistically analyze data and write manuscripts and reports.

Interested candidates should submit a brief summary of research expertise, curriculum vitae and contact information for 3 references to Dr. Vijay Krishna (krishnv2@ccf.org)




25 10/28/2020 Lynn M. Bekris
bekrisl@ccf.org

Postdoctoral Fellow - Biomarkers

The Bekris Laboratory is principally motivated by the question of how genetics and epigenetics influence biomarkers and how we can exploit this knowledge to prevent or diagnose neurodegenerative disorders. Our team aims to develop novel biomarker tools that will ultimately enhance therapeutic strategies for Alzheimer’s disease and Alzheimer’s disease related dementias.

The successful candidate will become a part of the Cleveland research community that includes the collaborative environment of the newly created Cleveland Alzheimer’s Disease Research Center. The candidate will work with clinical dementia specialists, computational biologists, genomics researchers, and others in a unique and collaborative intellectual environment of neurodegenerative disorder investigators at one of the world’s leading institutions for medical innovation.

The Bekris Laboratory is seeking an enthusiastic and energetic post-doctoral trainee to join our collaborative research effort.  Self-motivation and a strong interest in identifying and characterizing novel biomarkers for neurodegenerative disorders such as Alzheimer’s disease and Dementia with Lewy bodies, is essential. Candidate must have the ability to perform analytical reasoning to tease apart biological insights using data-driven approaches. This position requires a background in statistics and computer science with programming in a high-level language preferred (e.g., R) as well as previous experience with high-performance compute clusters and cloud computing platforms. 

This position is designed to prepare post-doctoral trainees for research careers in computational and experimental genomics, epigenetics and biomarker discovery.

Responsibilities:

• Exhibit command of chosen research area methodology.

• Provide status reports to the Principal Investigator on project(s).

• Present findings at group meetings and national conferences, as appropriate.

• Draft presentations, manuscripts, and contribute to funding proposals.

• Lead and co-author scientific manuscripts in peer-reviewed journals.

• Contribute to laboratory maintenance as part of the team.

Qualifications

• PhD

• Familiarity with genomic and epigenomic methodology and statistical approaches.

• Excellent analytic, critical thinking, quantitative skills including excellent English written and oral communication skills, and a track record of success in publications, presenting results, and representing research at meetings.

• Self-motivation and ability to take creative initiative, work independently, while learn new techniques.

• Collaborative and supportive team member.

• Strong organizational and laboratory skills, including the ability to keep detailed records, track samples and analysis pipelines.

The application should include a 1 page cover letter with a brief statement of interest, curriculum vitae, and contact information for three references. All application materials should be emailed to the primary investigator at bekrisl@ccf.org.




26 10/22/2020 Ryota Matsuoka
matsuor@ccf.org

Postdoctoral Fellow

The Matsuoka lab (https://www.lerner.ccf.org/cms/matsuoka/lab/) at the Cleveland Clinic Lerner Research Institute seeks 1-2 postdoctoral fellows to join our team. We study the genetic mechanisms underlying vascular and lymphatic morphogenesis in the central nervous system (CNS) using the zebrafish model. Specific areas of research in our laboratory include: 1) fenestrated vs non-fenestrated brain vascular development; 2) the mechanisms driving the generation of brain vessel heterogeneity; and 3) spatiotemporal regulation of CNS vascular patterning.

 

We are seeking highly motivated recent graduates with a Ph.D degree in biological sciences. The successful applicant(s) will get involved in NIH-funded research projects ongoing in the lab and is expected to apply for external fellowships, present data at scientific conferences, and prepare manuscripts for publication. Candidates with a publication record in developmental biology, genetics, neuroscience, or cell biology are preferred.

 

The contract will be renewed annually and extended for up to 5 years, dependent upon satisfactory progress and the lab’s funding situation. Interested individuals should submit a single PDF file containing: CV, including a list of publications and contact information for 3 referencesand a Cover letter describing research interests and career goals




27 10/15/2020 Abhishek Chakraborty
chakraa@ccf.org

Post-doctoral Fellow In Cancer Biology

Investigating Chromatin Dysregulation due to Aberrant Dioxygenase Function in Human Pathology

A postdoctoral fellowship position is available in Dr. Abhishek Chakraborty’s newly established laboratory in the Department of Cancer Biology at the Cleveland Clinic. The laboratory is part of Cleveland Clinic’s Genitourinary (GU) Malignancies Research Center and has close ties to both basic researchers as well as GU clinicians at the Cleveland Clinic and the broader Case Comprehensive Cancer Center.

We are interested in the relevance of oxygen- (and 2-oxo-glutarate) dependent dioxygenases in cellular physiology, particularly in oxygen sensing and human disease. Two notable publications highlight our contributions in these areas: 1) the demonstration that the H3K27 histone demethylase UTX/KDM6A is a novel cellular oxygen sensor that directly links physiological oxygen availability to transcriptional readout [Chakraborty AA et al. Science. 2019 (363) 1217] and 2) studies on profound chromatin dysregulation in kidney cancer, which led to the identification of the H3K27 histone methyltransferase EZH1 as a targetable dependency in kidney cancer [Chakraborty AA et al. Science Transl Med. 2017 (398). pii: eaal5272].

Ongoing work in the laboratory, based on epigenetic analysis and high-throughput screening data, continues to develop our previous findings. The techniques/areas of interest in the laboratory are Biochemistry [Protein purification and Enzymatic Assays], Molecular Biology [Cloning, Western Blotting, etc], Proteomics, Cancer Biology [in vitro and in vivo tumor models], Cellular Metabolism [steady state and flux-balance analysis], Pharmacology [drug discovery and delivery], Genomic analysis [RNA-Seq and ChIP-Seq data], Genetic Screens [CRISPR/Cas9 and ORF-based libraries], and Pharmacological Screens [Drug-based libraries].

The ideal candidate would have a M.D., Ph.D., or a M.D./Ph.D. degree with interests and expertise in one or more of these areas. We desire a self-motivated candidate who has the ability to spearhead their research projects. A collaborative and collegial work ethic, a strong commitment to basic cancer research, and outstanding verbal and communication skills are all essential qualities in the applicant.

The position provides a unique opportunity to study chromatin function, tumor metabolism, molecular oncology, drug development, and clinical collaborations, in a world class clinical/research center.

Candidates with an interest in the position should email their CV and contact information for 3 references to: 

Abhishek A. Chakraborty, Ph.D.

Dept of Cancer Biology

Lerner Research Institute

Cleveland Clinic, OH

chakraa@ccf.org




28 10/14/2020 Dr. Arnab Ghosh
ghosha3@ccf.org

Post-doctoral Fellow

A post-doctoral position is available immediately in the laboratory of Drs. Stuehr https:/ http://www.lerner.ccf.org/immuno/stuehr and Ghosh (https://www.lerner.ccf.org/immuno/ghosh) to work on an NIH funded project which relates to soluble guanalyl cyclase dysfunction in asthma. The desired candidate should have a PhD degree in Biochemistry/Life Sciences/ Immunology or in a related field with a good publication record in graduate study. Applicants should have excellent writing skills and should be well versed in current cell biology and molecular biology techniques, including proteomics and epigenetic modifications. Applicants will be preferred who have additional experience in working with and maintaining mouse colonies. Internationals applying would require a TOEFL score. The position has the pay and compensation as per NIH guidelines with additional fringe benefits. Please apply to this position with your current CV and three letters of reference to Drs. Dennis Stuehr (email: stuehrd@ccf.org) and Dr. Arnab Ghosh (e-mail: ghosha3@ccf.org).




29 10/06/2020 J. Mark Brown
brownm5@ccf.org

Postdoctoral Fellow

Title: Postdoctoral Fellowship Studying Diet-Microbe-Host Interactions Driving Cardiometabolic and Liver Disease.

Position Description: We are seeking highly motivated postdoctoral research associates to perform basic and translational research in the laboratory of Dr. J. Mark Brown, Director of Research at the Cleveland Clinic Center for Microbiome & Human Health and Associate Staff in the Department of Cardiovascular & Metabolic Sciences at the Cleveland Clinic Lerner Research Institute.

The goals of the Brown laboratory within the Cleveland Clinic Center for Microbiome and Human Health (cmhh.ccf.org), are to elucidate the roles of the varied microbiomes in human physiology and then exploit this knowledge to develop novel therapeutics and approaches to disease management to improve the health and wellness of our patients. To do this we are coupling clinical investigation with mechanistic cell and animal model studies to understand the fundamental aspects of how gut microbial nutrient metabolism produces small molecule metabolites that act in an endocrine manner to impact host cardiometabolic and liver disease. This position is funded by multiple NIH grants, and will involve collaborative research within large programmatic efforts (P01 and P50) focused on diet-microbe-host interactions. The active areas of investigation that you will be involved in are:

1) Metaorganismal Endocrinology: Gut Microbe-Derived Hormones in Cardiometabolic Disease. Microbes resident in the human intestine represent a key transmissible factor contributing to a wide variety of human diseases. Here we are studying how gut microbes generate an array of small molecule metabolites that impact host physiology and disease. This line of investigation is studying the role of diet-microbe-host interactions in the context of obesity, diabetes, and cardiovascular disease. Recent publications from our group in this area include: PMIDs: 30082863, 25600868, 26972052, 28683320, 32330092, 32778760, 32404422, 30102568.  

2) Diet and Gene Interactions Driving the Progression of Alcohol-Associated Liver Disease (AALD) and Non-Alcoholic Fatty Liver Disease (NAFLD).
The progression of AALD and NAFLD to advanced fibrosis and end stage liver disease is driven by a combination of diet and genetic factors. In this line of investigation we are studying the interaction between metaorganismal nutrient metabolism (i.e. microbe and host metabolism) and host genetics (i.e. common and rare genetic variants), with the hopes of identifying new therapeutic strategies for those suffering from advanced liver disease. Recent publications from our group in this area include: PMIDs: 31621579, 20620999, 24095738, 29074585, 27396333, 22228714, 23302688.

Postdoctoral research associates will be encouraged to submit applications for postdoctoral fellowship awards from relevant institutional, government and foundation organizations. Postdoctoral research associates will also have the opportunity to prepare and submit abstracts to attend national and international conferences, and will be involved in relevant P01 and P50 related group meetings to diversify the training experience.

Candidates should be self-motivated and have strong laboratory and analytical skills as demonstrated by a strong track record of relevant publications. A D.V.M., M.D. and/or Ph.D. in Nutrition, Biochemistry, Microbiology, Virology, Molecular Biology or other related fields is required. Outstanding communication skills in English as well as the ability to work well in a highly collaborative team environment are essential. Experience in working with rodent models of cardiometabolic or liver disease is desired, but outstanding candidates without such experience will be considered. Interested candidates should forward their curriculum vitae and names of three references to Dr. J. Mark Brown: brownm5@ccf.org.

The Cleveland Clinic Foundation is an Equal Opportunity/Affirmative Action employer in a smoke/drug free environment




30 10/06/2020 Antoine Louveau
louveaa@ccf.org

Postdoctoral Fellow

An immediate Postdoctoral Fellow position is available in the Cleveland Clinic in the Louveau laboratory in the Department of Neuroscience at the Cleveland Clinic Lerner Research Institute. Our lab investigate the role of the meningeal compartment in neurological disorders. We are currently seeking for motivated individuals to work on the role of the meningeal lymphatic vasculature in the context of neurodevelopment and autism spectrum disorders. Individuals with a Ph.D and knowledge of techniques in neuroscience and/or vascular biology in encouraged. 

Please send your curriculum vitae and contact information for 3 references to Antoine Louveau, Ph.D.: Department of Neuroscience, Lerner Research Institute, louveaa@ccf.org




31 09/29/2020 Dr. Michelle Longworth
longwom@ccf.org

Postdoctoral Fellow - Longworth Lab

Immediate opening for a postdoctoral fellow position in the Longworth laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Our lab investigates the role of DNA organizing complexes in innate immune responses to bacterial and viral infections, and to endogenous retrovirus and retrotransposon expression. We are seeking highly motivated individuals with experience and knowledge of techniques in molecular biology, genetics, and biochemistry. Candidate must be familiar with cultivation of cell lines. Familiarity with lenti- and retroviral based systems of nucleic acid delivery, with CRISPR/Cas9, and with chromatin based biochemical assays including ChIP-seq, ATAC-seq, and 4C-seq are advantages.

Ph.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required. Email cover letter, CV, and contact information for 3 references to Michelle Longworth, Ph.D.; Department of Inflammation and Immunity; Lerner Research Institute, longwom@ccf.org.




32 09/26/2020 Dr. Andrei Ivanov, PhD
ivanova2@ccf.org

Postdoctoral Fellow

We have an immediate opening for a Postdoctoral Fellow position in the Dr. Andrei Ivanov Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and interests in studying intercellular junctions, epithelial barriers, epithelial wound healing, actin cytoskeleton and epithelial responses during intestinal inflammation are encouraged to apply.

A highly motivated candidate will join a productive research team to participate in an NIH funded project focusing on the roles of the actin cytoskeleton and myosin motors in disassembly and reformation of tight and adherens junctions in the intestinal epithelium during mucosal inflammation and colonic tumorigenesis. The candidate should have a publication record demonstrating on-hand molecular biology and cell biology expertise, or experience with mouse models of inflammatory diseases.

Must be familiar with mammalian cell culture, Western blotting, and RNA based methods including quantitative RT-PCR and reporter assays, subcloning between different vectors, lenti- retro- and adenoviral systems for cDNA and shRNA delivery. Preference will be given to candidates with previous experience in epithelial cell biology, CRISPR/Cas9-dependent gene editing, confocal microscopy/cell imaging or mouse models of gut inflammation. Excellent communication skills and ability to work as a team are essential. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grant applications.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  E-mail cover letter and CV and contact information for 3 references to: Dr. Andrei Ivanov; Department of Inflammation and Immunity; Lerner Research Institute / NC22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 444-5620; E-mail: ivanova2@ccf.org.

 




33 09/23/2020 Daniel Blankenberg
blanked2@ccf.org

Postdoctoral Fellow

The Blankenberg Lab in the Genomic Medicine Institute at the Cleveland Clinic Lerner Research Institute has Postdoctoral Fellowships available. We utilize high-throughput omics technologies, such as next generation sequencing, and data-intensive computing to explore biomedical research questions. The PI is a founding member of the Galaxy Project (https://galaxyproject.org), a platform that is used throughout the world for large-scale data analysis.

We are particularly interested in individuals with extensive experience with statistics, data analysis, and visualization using Open Source frameworks. Candidates must be fluent in R and/or Python programming languages.

Additional preference will be given to individuals with experience in analysis of biological high-throughput datasets, especially sequencing and mass-spec based datasets, and to applicants with interest and experience in e.g. bioinformatics or computational biology in relation to cancer and metagenomic/microbiome derived datasets. Although previous, domain-specific experience is not strictly necessary.

Candidates will be highly motivated, ambitious, enthusiastic, and be able to work independently and in a collaborative environment.

Exceptional applicants should send a letter of application expressing their interest and containing links to GitHub accounts (or Bitbucket, GitLab, etc) or to portfolios of interactive visualization work, a curriculum vitae, statement of research interests, and complete contact information for 3 professional references as a single PDF to Dr. Daniel Blankenberg (blanked2@ccf.org).


keywords: statistics; R; Python; Shiny apps; computational biology; bioinformatics; data visualization; data analysis; data-intensive science; next generation sequencing; ngs; microbiome; metagenomics; genomics; omics; Galaxy;




34 09/23/2020 Jae Jung
jungj@ccf.org

Postdoctoral Research Fellow

Postdoctoral Positions at Cleveland Clinic Lerner Research Institute

 

Jae Jung Laboratory:  Cleveland Clinic has appointed Jae Jung, Ph.D., chair of Lerner Research Institute’s Department of Cancer Biology. He also serves as director of the new Center for Global and Emerging Pathogens Research.

The Jung laboratory is divided into four areas: (1) virus-induced cancer (gamma-2 herpesvirus and hepatitis B virus), (2) inflammation and immunity (host-pathogen standoff, programmed cell death, and lung/brain inflammation) (3) emerging pathogens (Flavivirus, Dengue virus and Zika virus; Bunyavirus, Severe Fever with Thrombocytopenia virus and Heartland virus; and Coronavirus, Severe acute respiratory syndrome coronavirus 2) and (4) viral vector and vaccine stabilization. Our research uses cutting-edge genomics, biochemistry, structural biology, immunology and bioinformatics for basic and translational researches (http://uscmmi.com/jaejunglab/)

 

Qualifications: Candidates should have a Ph.D., M.D., or equivalent degree, and expertise in any area of biology.

 

Position Description: Any clinically relevant exciting topics are welcome. Moreover, we have extensive collaborations with two new research centers, Center for Global and Emerging Pathogens Research and Center for Immunotherapy and Precision Immuno-Oncology.

 

To Apply: Applicants should send their curriculum vitae to Dr. Jae Jung at jungj@ccf.org.




35 09/21/2020 Dr. Fariba Rezaee
rezaeef@ccf.org

Postdoctoral Fellow - Dr. Rezaee Lab

We have an immediate opening for a motivated, and qualified Postdoctoral Fellow position in the Dr. Rezaee Laboratory, Center for Pediatric Research in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in all of the above listed technical skills are encouraged to apply.

Must be familiar with cultivation of multiple cell lines, primary airway epithelial cells, Western blotting, RNA based methods including quantitative PCR and reporter assays, subcloning between different vectors, and the Crispr/ Casp9 system. Must be familiar with working with rodents, including intratracheal inoculation, isolation of airway cells and immunohistochemistry.  Excellent communication skills in English are essential. The successful candidate will be expected to design, implement and manage research projects addressing cellular response to viral infection and pollutions. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. Ph.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Please send cover letter, CV, and contact information for 3 references to: Dr. Fariba Rezaee; Pediatrics/Department of Inflammation and Immunity; Lerner Research Institute / NC 22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-0564; rezaeef@ccf.org




36 09/16/2020 Olga A. Cherepanova
cherepol@ccf.org

Postdoctoral Research Fellow

A Postdoctoral Research Fellow position is available in Olga Cherepanova’s Laboratory in the Department of Cardiovascular&Metabolic Sciences at the Lerner Research Institute, Cleveland Clinic, to study the role of the pluripotency and innate immunity in vascular smooth muscle cells (SMC) and endothelial cells (EC) during atherosclerosis and after vascular injury. 
Our lab is interested in molecular and cellular mechanisms responsible for SMC and EC phenotypic transitions. We use a combination of animal and cell culture models in combination with the bioinformatic analyses such as bulk and single cells RNA-Sequencing to better understand these transitions, with the goal to develop novel therapeutic interventions for stabilizing atherosclerotic plaques in order to reduce the risk of plaque rupture with possible myocardial infarction or stroke.
Although outstanding candidates in all areas of biomedical science will be considered, special consideration will be given to individuals with substantial experience/expertise in: 1) working with transgenic and knockout animals; 2) studies of atherosclerosis and/or mouse vascular injury models; 3) studies of molecular mechanisms responsible for SMC phenotypic transitions and/or EC dysfunction.  
Applicant must have (or close to obtaining) a PhD degree or MD degree with relevant (no less than three years) laboratory experience, as well as proficient written and oral communication skills. The successful applicant is expected to apply for external fellowships, present results at scientific conferences, and prepare manuscripts for publication.
Review of applicants will start immediately and continue until the position is filled. The contract will be renewed annually and extended for a period of 3 years and possibly longer, dependent upon satisfactory progress and the lab’s funding situation.
Please send CV, a statement of research interests and long term scientific goals, and the names and contact information for 3 references as a single PDF file to Dr. Olga A. Cherepanova, cherepol@ccf.org.




37 09/15/2020 Ryota Matsuoka
matsuor@ccf.org

Postdoctoral Fellow Position

The Matsuoka lab (https://www.lerner.ccf.org/cms/matsuoka/lab/) at the Cleveland Clinic Lerner Research Institute seeks 1-2 research scholars to join our research team. We study the cellular and molecular basis of vascular and lymphatic assembly in the central nervous system (CNS) and meninges using the zebrafish model. Specific areas of research in our laboratory include: 1) fenestrated vs non-fenestrated brain vascular development; 2) the mechanisms driving the generation of brain vessel heterogeneity; 3) spatiotemporal regulation of CNS vascular patterning; and 4) congenital CNS vascular and lymphatic malformations.

We are seeking candidates with a Bachelor’s or Master’s degree in the field of biological sciences, who wish to spend a few years in gaining basic research experiences before starting Ph.D. program or medical school. The successful applicants will get involved in several research projects ongoing in the lab and be expected to work on her/his independent projects under the PI’s supervision.

Interested individuals should submit the following materials to Ryota Matsuoka (matsuor@ccf.org):

1) CV

2) Cover letter describing past research experiences and career plans




38 09/02/2020 Michaela Gack
gackm@ccf.org

Postdoctoral Fellow - Florida Research & Innovation Center

Individuals with experience in virology, molecular biology, biochemistry, or cell biology are strongly encouraged to send a CV, cover letter, and the contact details of three referees to:

Michaela U. Gack, Ph.D.

The Arthur and Marylin Levitt Endowed Chair
Scientific Director
Florida Research & Innovation Center
9801 SW Discovery Way
Port Saint Lucie, FL 34987

Email: gackm@ccf.org | Phone: 772.345.8114




39 08/26/2020 Brian Gastman
gastmab@ccf.org

Postdoctoral Fellow - Gastman Lab

Immediate opening for a Postdoctoral Fellow position in the Gastman Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in immunology, molecular biology and biochemistry, and with expertise in cell, animal, or human models of cancer, and specifically cancer immunity are encouraged to apply. 

Must be familiar with immunologic assays (FACS, cytotoxicity, mouse tumor models, etc..), cultivation of multiple cell lines, Western blotting, and RNA based methods including quantitative PCR and Northern blotting,  expression of exogenous proteins, and the Casp9/Crispr system.    Experience with in vivo murine models is also important.  Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing the role of suppressor cells in the tumor microenvironment.  The applicant will have significant exposure to human specimens from a multitude of research protocols and clinical trials.  The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Our laboratory is highly collaborative and works closely with industry.  The prospective applicant would be expected to not only be involved in high level research, but also to act as an ambassador between our lab and our industry partners.  Thus, proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Brian Gastman, MD.; Department of Inflammation & Immunity; Lerner Research Institute / NE4-303; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-6950; gastmab@ccf.org




40 08/26/2020 Dr. Hannelore Heemers
heemerh@ccf.org

Postdoctoral Research Fellow

Novel therapeutic vulnerabilities in prostate cancer

Our group at the Department of Cancer Biology at the Lerner Research Institute of the Cleveland Clinic is seeking a highly motivated and independent post-doctoral fellow to join our studies to overcome treatment resistance in prostate cancer.

Our laboratory focuses on the transcriptional processes and signal transduction cascades that drive lethal prostate cancer progression. Via mechanistic dissection of these pathways and/or complexes, we strive to develop novel therapeutic targets and treatment approaches and to isolate biomarkers of response to these novel treatments. Examples of research interests and recent studies from our NCI-funded research programs include: Wei et al. (European Urology, 2017), Liu et  al. (eLife, 2017), Kumari et al. (Endocrine-Related Cancer, 2017), Venkadakrishnan et al. (Oncogene, 2019).

Specific areas of current research interest include:

1)   Isolating and targeting critical molecular interactions in AR transcriptional complexes

2)   Targeting the action of kinases and identifying kinase substrates that can serve as biomarkers of treatment response

3)   Defining the impact of genomic markers on treatment response to personalize the administration of current prostate cancer drugs

All projects involve clinical validation of laboratory findings using archival and fresh patient specimens and animal models of advanced prostate cancer for translational and therapeutic studies. 

The ideal candidate is highly motived and driven to succeed in a translational science environment. The candidate should have a recent PhD and expertise in cell biology, molecular biology and preclinical animal studies, and is interested in extrapolating in vitro and in vivo findings to patient specimens and data. Outstanding verbal and communication skills are required. The Cleveland Clinic Lerner Research Institute provides an excellent interactive research environment with access to state-of-the-art equipment and facilities.

Interested applicants should submit a CV and contact information for 3 references to Dr. Hannelore Heemers via email: heemerh@ccf.org.




41 08/25/2020 Christina Stuart
stuartc2@ccf.org

Postdoctoral Fellow

Postdoctoral Associate/Fellow
Dr. Xianfang Wu Laboratory
Department of Cancer Biology

Dr. Xianfang Wu’s laboratory in the Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic is seeking enthusiastic and highly motivated postdoctoral associates/fellows for the following projects: (i) understanding the innate immunity regulation in human stem cells; (ii) modeling human diseases using pluripotent/multipotent stem cells-derived models. These projects will involve the use of many modern molecular techniques, including in vitro stem cell differentiation, CRISPR-Cas9 mediated genetic editing, 2D and 3D cell cultures, high-resolution cell imaging, and bioinformatic analysis (i.e. bulk and single cells RNA-Seq, ATAC-Seq). The strong conceptual and technological foundation along with compelling preliminary data presents a solid platform for these projects.

The ideal candidates should have a recent PhD or equivalent degree in molecular biology, extensive experience with mammalian cell culture, first-author publications in peer-reviewed journals, strong communication and analytical abilities, and enthusiasm for basic science research. The candidate with expertise in stem cell technology and mouse work will be preferred. 

Full applications should include curriculum vitae and contact information for three references.
Please send applications and informal inquiries to Dr. Xianfang Wu (xwu02@rockefeller.edu) and Christina Stuart (stuartc2@ccf.org).




42 08/18/2020 Srinivasan Dasarathy
dasaras@ccf.org

Post Doctoral Fellow

A Postdoctoral Fellow position is available in the Cleveland Clinic [Institute/Department]

Please send your curriculum vitae and contact information for 3 references to

dasaras@ccf.org

We have an immediate opening for a Postdoctoral Fellow position in the Dr. Dasarathy Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and interest in studying signal transduction during metabolic perturbations are encouraged to apply. The laboratory focus is on using integrated molecular metabolic approaches in a comprehensive array of cellular, mouse, and human models. 

A highly motivated candidate will join a productive research team to participate in NIH funded projects focusing on the molecular mechanisms of skeletal muscle loss and metabolic perturbations in disease. The candidate should have a publication record demonstrating on-hand molecular biology and cell biology expertise. 

Must be familiar with mesenchymal cell culture (preferably skeletal muscle), Western blotting, and RNA based methods including quantitative PCR and reporter assays, subcloning between different vectors, lenti- retro- and adenoviral systems for cDNA and shRNA delivery. Preference will be given to candidates with previous experience in skeletal muscle biology, CRISPR/Cas9-dependent gene editing, confocal microscopy/cell imaging or mouse models of muscle loss. Excellent communication skills in English are essential. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Dr. Srinivasan Dasarathy; Department of Pathobiology; Lerner Research Institute / NE4 208; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 636-0096; E-mail: dasaras@ccf.org.




43 08/17/2020 Neetu Gupta, Ph.D
guptan@ccf.org

Postdoctoral Fellow - Gupta Lab

Immediate opening for a Postdoctoral Fellow position in the Gupta Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with demonstrable experience in mechanistic immunology research, B cell biology, mouse models of autoimmunity and/or inflammation and/or infection, and a strong record of publication are encouraged to apply. The successful candidate will design, implement and manage exciting research projects addressing the regulation of B cell antibody response during infection and inflammation.

Must be proficient in immunological techniques (multicolor flow cytometry, ELISA), cell culture, and molecular biology methods (western blotting, quantitative PCR, lentiviral gene expression, and CRISPR/Cas9 gene modification). Prior experience in murine lung and colon isolation and analysis is an advantage, as is cellular imaging. Excellent verbal and written communication skills are essential. The appointee will be expected to take advantage of this career opportunity to further develop skills in manuscript publication and grantsmanship.

Applicants must have a Ph.D. or an M.D.,Ph.D degree in immunology, with strong motivation, a passion for science, ability to work as a team and design experiments independently, and a strong work ethic. Proficiency in spoken and written English is required. Send a cover letter describing research accomplishments, future interests and career goals, CV and contact information for 3 references to Dr. Neetu Gupta (guptan@ccf.org).




44 08/12/2020 Dr. Michelle Longworth
longwom@ccf.org

Postdoctoral Fellow - Longworth Lab

Immediate opening for a Postdoctoral Fellow position in the Longworth Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in molecular biology, genetics, and biochemistry, and with expertise in mitochondrial biology and metabolism research are encouraged to apply.

Candidate must be familiar with cultivation of cell lines; previous experience with organoid-based systems is desired, but not required.  Candidate must also be familiar with Western blotting, qRT-PCR, immunofluorescence assays, and various cloning techniques. Familiarity with lenti- and retroviral based systems of nucleic acid delivery, and expression of exogenous proteins is required. Experience using CRISPR/Cas9 and/or chromatin based techniques such as ChIP-seq, ATAC-seq, and 3C/4C-seq are advantages. Candidate will be expected to design, implement and manage research projects focused on newly discovered mechanisms that lead to Reactive Oxygen Species accumulation in epithelial stem cells and their role in tumor development. 

Ph.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Email cover letter, CV, and contact information for 3 references to: Michelle Longworth, Ph.D.; Department of Inflammation & Immunity; Lerner Research Institute, longwom@ccf.org.




45 08/12/2020 Feixiong Cheng
chengf@ccf.org

Postdoctoral Fellow

We are seeking 1-2 Postdoctoral Research Fellow to join the Network Medicine and Artificial Intelligence (AI) research group (https://www.lerner.ccf.org/gmi/cheng/) led by Dr. Feixiong Cheng at the Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, and Department of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University. The primary goal of Cheng group is to combine tools from electronic health record (EHR), genetics and genomics, chemical biology, network medicine, AI, bioinformatics, computational biology, and experimental systems biology assays (e.g., single-cell/nucleus sequencing and hiPSC-derived cardiomyocytes and neurons), to address the challenging questions toward understanding of complex diseases (including Alzheimer's disease [https://alzgps.lerner.ccf.org], Cardio-Oncology [https://mutanome.lerner.ccf.org], and COVID-19), which could have a major impact in identifying novel real-world data-driven diagnostic biomarkers and therapeutic targets for precision medicine.

A highly motivated candidate will join our NIH-funded research projects focusing on analyzing, visualizing, and mining data from real-world (e.g., EHRs and healthcare claims) and experiments that profile the molecular state of human cells and tissues by interactomics (protein-protein interactions), transcriptomics, genomics, proteomics, radiomics, and metabolomics for drug discovery and precision patient care. The postdoctoral fellow will have great opportunities to collaborate with diverse groups of physicians, genetics, and computational biologists, and get access the large-scale patient data at the Genomic Medicine Institute, Miller Family Heart & Vascular Institute, Taussig Cancer Institute at Cleveland Clinic, The Cleveland Alzheimer's Disease Research Center (CADRC) at the Cleveland Clinic Lou Ruvo Center for Brain Health, and Cas Comprehensive Cancer Center at Case Western Reserve University.

Requirements:

  1. Highly motivated candidates with a PhD/MD degree in systems biology, network science, computational biology, chemical biology, machine learning, natural language processing (NLP), bioinformatics, mathematical biology, data science, genome science, pharmacogenomics, and related fields are encouraged to apply.

  2. A strong computational background, proficiency in at least one programming language (e.g., R, Python, Perl, C++, Java) and knowledge of statistics and mathematics are required.

  3. Training experience in artificial intelligence (such as machine learning and deep learning), experience working in high computing cluster environment, experience working with TCGA, ICGC, GTEx, 1000 Genomes, UK-biobank, ENCODE, or ExAC, PDB, or other large-scale DNA/RNA-seq (including both bulk and single-cell/nucleus) data analysis is highly preferred.

  4. A good understanding of biology, genetics and genomics, cell signaling networks, pharmacokinetics/pharmacodynamics (PK/PD), and human protein-protein interactome is also preferred.

  5. Proficiency in spoken and written English is required.

How to Apply: Interested applicants should send a cover letter describing your research experience/skills and future research statement/plan (2-3 pages), a curriculum vitae and the contact information of three referees to Dr. Feixiong Cheng (chengf@ccf.org or feixiong.cheng@case.edu) with the subject line ‘Postdoc-Application - Your Name’.

Application Deadline: Positions are open immediately until filled

 




46 07/21/2020 Ryota Matsuoka
matsuor@ccf.org

Postdoctoral Fellow Position

A Postdoctoral Fellow position is available in the laboratory of Dr. Ryota Matsuoka (https://www.lerner.ccf.org/cms/matsuoka/lab/) in the Department of Cardiovascular and Metabolic Sciences at the Cleveland Clinic Lerner Research Institute. Our research projects focus on defining the cellular and molecular basis of vascular and lymphatic assembly in the central nervous system (CNS) and meninges using zebrafish as a model organism. Specific areas of research in our laboratory include: 1) fenestrated vs non-fenestrated brain vascular development; 2) the mechanisms driving the generation of heterogeneous brain vascular networks; 3) spatiotemporal regulation of CNS blood and lymphatic vasculature; and 4) congenital CNS vascular and lymphatic malformations.

 We are seeking a highly motivated recent graduate with a Ph.D degree in the field of biological sciences. The successful applicant is expected to apply for external fellowships, present data at scientific conferences, and prepare manuscripts for publication. Candidates with a publication record in developmental biology, genetics, neuroscience, or cell biology are preferred. Former experiences working with zebrafish or other animal models are a plus.

 Review of applicants will start immediately and continue until the position is filled. The contract will be renewed annually and extended for up to 5 years, dependent upon satisfactory progress and the lab’s funding situation. Interested individuals should submit a single PDF file containing the following materials to Ryota Matsuoka (matsuor@ccf.org):

1) CV, including a list of publications and contact information for 3 references

2) Cover letter describing previous research, research interests, and career goals