Postdoctoral

Positions

The current postdoctoral opportunities are listed below.

Postdoctoral Fellow/Research Associate candidates will be expected to conduct research under the mentorship of a principal investigator in a predominantly independent manner. Fellows will be expected to pursue testing of hypotheses by developing experimental designs, managing and processing data and interpreting and preparing results for publication in peer-reviewed journals. Fellows will work closely with the principal investigator and will be expected to communicate effectively both in writing and in oral presentations. Qualified candidates will have successfully completed all requirements for the degree of doctorate in philosophy (Ph.D.) or doctor in medicine (M.D.) in relevant scientific programs.

Project Scientist candidates will have substantial experience at the postdoctoral or research associate level and have established a respectable record of publication. Project Scientists will work in collaboration with the principal investigator but work independently within the scientific framework of the principal investigator's laboratory. Project Scientists may seek grant funding from extramural sources in support of their research projects with the consent of the principal investigator and department chair. Project Scientist is a junior-level faculty position.

Please complete your application as directed and send to the investigator listed. We look forward to hearing from you!

# Date Contact Description
1 09/29/2020 Dr. Michelle Longworth
longwom@ccf.org

Postdoctoral Fellow - Longworth Lab

Immediate opening for a postdoctoral fellow position in the Longworth laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Our lab investigates the role of DNA organizing complexes in innate immune responses to bacterial and viral infections, and to endogenous retrovirus and retrotransposon expression. We are seeking highly motivated individuals with experience and knowledge of techniques in molecular biology, genetics, and biochemistry. Candidate must be familiar with cultivation of cell lines. Familiarity with lenti- and retroviral based systems of nucleic acid delivery, with CRISPR/Cas9, and with chromatin based biochemical assays including ChIP-seq, ATAC-seq, and 4C-seq are advantages.

Ph.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required. Email cover letter, CV, and contact information for 3 references to Michelle Longworth, Ph.D.; Department of Inflammation and Immunity; Lerner Research Institute, longwom@ccf.org.


2 09/26/2020 Dr. Andrei Ivanov, PhD
ivanova2@ccf.org

Postdoctoral Fellow

We have an immediate opening for a Postdoctoral Fellow position in the Dr. Andrei Ivanov Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and interests in studying intercellular junctions, epithelial barriers, epithelial wound healing, actin cytoskeleton and epithelial responses during intestinal inflammation are encouraged to apply.

A highly motivated candidate will join a productive research team to participate in an NIH funded project focusing on the roles of the actin cytoskeleton and myosin motors in disassembly and reformation of tight and adherens junctions in the intestinal epithelium during mucosal inflammation and colonic tumorigenesis. The candidate should have a publication record demonstrating on-hand molecular biology and cell biology expertise, or experience with mouse models of inflammatory diseases.

Must be familiar with mammalian cell culture, Western blotting, and RNA based methods including quantitative RT-PCR and reporter assays, subcloning between different vectors, lenti- retro- and adenoviral systems for cDNA and shRNA delivery. Preference will be given to candidates with previous experience in epithelial cell biology, CRISPR/Cas9-dependent gene editing, confocal microscopy/cell imaging or mouse models of gut inflammation. Excellent communication skills and ability to work as a team are essential. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grant applications.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  E-mail cover letter and CV and contact information for 3 references to: Dr. Andrei Ivanov; Department of Inflammation and Immunity; Lerner Research Institute / NC22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 444-5620; E-mail: ivanova2@ccf.org.

 


3 09/23/2020 Daniel Blankenberg
blanked2@ccf.org

Postdoctoral Fellow

The Blankenberg Lab in the Genomic Medicine Institute at the Cleveland Clinic Lerner Research Institute has Postdoctoral Fellowships available. We utilize high-throughput omics technologies, such as next generation sequencing, and data-intensive computing to explore biomedical research questions. The PI is a founding member of the Galaxy Project (https://galaxyproject.org), a platform that is used throughout the world for large-scale data analysis.

We are particularly interested in individuals with extensive experience with statistics, data analysis, and visualization using Open Source frameworks. Candidates must be fluent in R and/or Python programming languages.

Additional preference will be given to individuals with experience in analysis of biological high-throughput datasets, especially sequencing and mass-spec based datasets, and to applicants with interest and experience in e.g. bioinformatics or computational biology in relation to cancer and metagenomic/microbiome derived datasets. Although previous, domain-specific experience is not strictly necessary.

Candidates will be highly motivated, ambitious, enthusiastic, and be able to work independently and in a collaborative environment.

Exceptional applicants should send a letter of application expressing their interest and containing links to GitHub accounts (or Bitbucket, GitLab, etc) or to portfolios of interactive visualization work, a curriculum vitae, statement of research interests, and complete contact information for 3 professional references as a single PDF to Dr. Daniel Blankenberg (blanked2@ccf.org).


keywords: statistics; R; Python; Shiny apps; computational biology; bioinformatics; data visualization; data analysis; data-intensive science; next generation sequencing; ngs; microbiome; metagenomics; genomics; omics; Galaxy;


4 09/23/2020 Jae Jung
jungj@ccf.org

Postdoctoral Research Fellow

Postdoctoral Positions at Cleveland Clinic Lerner Research Institute

 

Jae Jung Laboratory:  Cleveland Clinic has appointed Jae Jung, Ph.D., chair of Lerner Research Institute’s Department of Cancer Biology. He also serves as director of the new Center for Global and Emerging Pathogens Research.

The Jung laboratory is divided into four areas: (1) virus-induced cancer (gamma-2 herpesvirus and hepatitis B virus), (2) inflammation and immunity (host-pathogen standoff, programmed cell death, and lung/brain inflammation) (3) emerging pathogens (Flavivirus, Dengue virus and Zika virus; Bunyavirus, Severe Fever with Thrombocytopenia virus and Heartland virus; and Coronavirus, Severe acute respiratory syndrome coronavirus 2) and (4) viral vector and vaccine stabilization. Our research uses cutting-edge genomics, biochemistry, structural biology, immunology and bioinformatics for basic and translational researches (http://uscmmi.com/jaejunglab/)

 

Qualifications: Candidates should have a Ph.D., M.D., or equivalent degree, and expertise in any area of biology.

 

Position Description: Any clinically relevant exciting topics are welcome. Moreover, we have extensive collaborations with two new research centers, Center for Global and Emerging Pathogens Research and Center for Immunotherapy and Precision Immuno-Oncology.

 

To Apply: Applicants should send their curriculum vitae to Dr. Jae Jung at jungj@ccf.org.


5 09/21/2020 Dr. Fariba Rezaee
rezaeef@ccf.org

Postdoctoral Fellow - Dr. Rezaee Lab

We have an immediate opening for a motivated, and qualified Postdoctoral Fellow position in the Dr. Rezaee Laboratory, Center for Pediatric Research in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in all of the above listed technical skills are encouraged to apply.

Must be familiar with cultivation of multiple cell lines, primary airway epithelial cells, Western blotting, RNA based methods including quantitative PCR and reporter assays, subcloning between different vectors, and the Crispr/ Casp9 system. Must be familiar with working with rodents, including intratracheal inoculation, isolation of airway cells and immunohistochemistry.  Excellent communication skills in English are essential. The successful candidate will be expected to design, implement and manage research projects addressing cellular response to viral infection and pollutions. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. Ph.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Please send cover letter, CV, and contact information for 3 references to: Dr. Fariba Rezaee; Pediatrics/Department of Inflammation and Immunity; Lerner Research Institute / NC 22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-0564; rezaeef@ccf.org


6 09/16/2020 Olga A. Cherepanova
cherepol@ccf.org

Postdoctoral Research Fellow

A Postdoctoral Research Fellow position is available in Olga Cherepanova’s Laboratory in the Department of Cardiovascular&Metabolic Sciences at the Lerner Research Institute, Cleveland Clinic, to study the role of the pluripotency and innate immunity in vascular smooth muscle cells (SMC) and endothelial cells (EC) during atherosclerosis and after vascular injury. 
Our lab is interested in molecular and cellular mechanisms responsible for SMC and EC phenotypic transitions. We use a combination of animal and cell culture models in combination with the bioinformatic analyses such as bulk and single cells RNA-Sequencing to better understand these transitions, with the goal to develop novel therapeutic interventions for stabilizing atherosclerotic plaques in order to reduce the risk of plaque rupture with possible myocardial infarction or stroke.
Although outstanding candidates in all areas of biomedical science will be considered, special consideration will be given to individuals with substantial experience/expertise in: 1) working with transgenic and knockout animals; 2) studies of atherosclerosis and/or mouse vascular injury models; 3) studies of molecular mechanisms responsible for SMC phenotypic transitions and/or EC dysfunction.  
Applicant must have (or close to obtaining) a PhD degree or MD degree with relevant (no less than three years) laboratory experience, as well as proficient written and oral communication skills. The successful applicant is expected to apply for external fellowships, present results at scientific conferences, and prepare manuscripts for publication.
Review of applicants will start immediately and continue until the position is filled. The contract will be renewed annually and extended for a period of 3 years and possibly longer, dependent upon satisfactory progress and the lab’s funding situation.
Please send CV, a statement of research interests and long term scientific goals, and the names and contact information for 3 references as a single PDF file to Dr. Olga A. Cherepanova, cherepol@ccf.org.


7 09/15/2020 Ryota Matsuoka
matsuor@ccf.org

Postdoctoral Fellow Position

The Matsuoka lab (https://www.lerner.ccf.org/cms/matsuoka/lab/) at the Cleveland Clinic Lerner Research Institute seeks 1-2 research scholars to join our research team. We study the cellular and molecular basis of vascular and lymphatic assembly in the central nervous system (CNS) and meninges using the zebrafish model. Specific areas of research in our laboratory include: 1) fenestrated vs non-fenestrated brain vascular development; 2) the mechanisms driving the generation of brain vessel heterogeneity; 3) spatiotemporal regulation of CNS vascular patterning; and 4) congenital CNS vascular and lymphatic malformations.

We are seeking candidates with a Bachelor’s or Master’s degree in the field of biological sciences, who wish to spend a few years in gaining basic research experiences before starting Ph.D. program or medical school. The successful applicants will get involved in several research projects ongoing in the lab and be expected to work on her/his independent projects under the PI’s supervision.

Interested individuals should submit the following materials to Ryota Matsuoka (matsuor@ccf.org):

1) CV

2) Cover letter describing past research experiences and career plans


8 09/02/2020 Michaela Gack
gackm@ccf.org

Postdoctoral Fellow - Florida Research & Innovation Center

Individuals with experience in virology, molecular biology, biochemistry, or cell biology are strongly encouraged to send a CV, cover letter, and the contact details of three referees to:

Michaela U. Gack, Ph.D.

The Arthur and Marylin Levitt Endowed Chair
Scientific Director
Florida Research & Innovation Center
9801 SW Discovery Way
Port Saint Lucie, FL 34987

Email: gackm@ccf.org | Phone: 772.345.8114


9 08/26/2020 Dr. Hannelore Heemers
heemerh@ccf.org

Postdoctoral Research Fellow

Novel therapeutic vulnerabilities in prostate cancer

Our group at the Department of Cancer Biology at the Lerner Research Institute of the Cleveland Clinic is seeking a highly motivated and independent post-doctoral fellow to join our studies to overcome treatment resistance in prostate cancer.

Our laboratory focuses on the transcriptional processes and signal transduction cascades that drive lethal prostate cancer progression. Via mechanistic dissection of these pathways and/or complexes, we strive to develop novel therapeutic targets and treatment approaches and to isolate biomarkers of response to these novel treatments. Examples of research interests and recent studies from our NCI-funded research programs include: Wei et al. (European Urology, 2017), Liu et  al. (eLife, 2017), Kumari et al. (Endocrine-Related Cancer, 2017), Venkadakrishnan et al. (Oncogene, 2019).

Specific areas of current research interest include:

1)   Isolating and targeting critical molecular interactions in AR transcriptional complexes

2)   Targeting the action of kinases and identifying kinase substrates that can serve as biomarkers of treatment response

3)   Defining the impact of genomic markers on treatment response to personalize the administration of current prostate cancer drugs

All projects involve clinical validation of laboratory findings using archival and fresh patient specimens and animal models of advanced prostate cancer for translational and therapeutic studies. 

The ideal candidate is highly motived and driven to succeed in a translational science environment. The candidate should have a recent PhD and expertise in cell biology, molecular biology and preclinical animal studies, and is interested in extrapolating in vitro and in vivo findings to patient specimens and data. Outstanding verbal and communication skills are required. The Cleveland Clinic Lerner Research Institute provides an excellent interactive research environment with access to state-of-the-art equipment and facilities.

Interested applicants should submit a CV and contact information for 3 references to Dr. Hannelore Heemers via email: heemerh@ccf.org.


10 08/26/2020 Brian Gastman
gastmab@ccf.org

Postdoctoral Fellow - Gastman Lab

Immediate opening for a Postdoctoral Fellow position in the Gastman Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in immunology, molecular biology and biochemistry, and with expertise in cell, animal, or human models of cancer, and specifically cancer immunity are encouraged to apply. 

Must be familiar with immunologic assays (FACS, cytotoxicity, mouse tumor models, etc..), cultivation of multiple cell lines, Western blotting, and RNA based methods including quantitative PCR and Northern blotting,  expression of exogenous proteins, and the Casp9/Crispr system.    Experience with in vivo murine models is also important.  Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing the role of suppressor cells in the tumor microenvironment.  The applicant will have significant exposure to human specimens from a multitude of research protocols and clinical trials.  The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Our laboratory is highly collaborative and works closely with industry.  The prospective applicant would be expected to not only be involved in high level research, but also to act as an ambassador between our lab and our industry partners.  Thus, proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Brian Gastman, MD.; Department of Inflammation & Immunity; Lerner Research Institute / NE4-303; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-6950; gastmab@ccf.org


11 08/25/2020 Christina Stuart
stuartc2@ccf.org

Postdoctoral Fellow

Postdoctoral Associate/Fellow
Dr. Xianfang Wu Laboratory
Department of Cancer Biology

Dr. Xianfang Wu’s laboratory in the Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic is seeking enthusiastic and highly motivated postdoctoral associates/fellows for the following projects: (i) understanding the innate immunity regulation in human stem cells; (ii) modeling human diseases using pluripotent/multipotent stem cells-derived models. These projects will involve the use of many modern molecular techniques, including in vitro stem cell differentiation, CRISPR-Cas9 mediated genetic editing, 2D and 3D cell cultures, high-resolution cell imaging, and bioinformatic analysis (i.e. bulk and single cells RNA-Seq, ATAC-Seq). The strong conceptual and technological foundation along with compelling preliminary data presents a solid platform for these projects.

The ideal candidates should have a recent PhD or equivalent degree in molecular biology, extensive experience with mammalian cell culture, first-author publications in peer-reviewed journals, strong communication and analytical abilities, and enthusiasm for basic science research. The candidate with expertise in stem cell technology and mouse work will be preferred. 

Full applications should include curriculum vitae and contact information for three references.
Please send applications and informal inquiries to Dr. Xianfang Wu (xwu02@rockefeller.edu) and Christina Stuart (stuartc2@ccf.org).


12 08/18/2020 Srinivasan Dasarathy
dasaras@ccf.org

Post Doctoral Fellow

A Postdoctoral Fellow position is available in the Cleveland Clinic [Institute/Department]

Please send your curriculum vitae and contact information for 3 references to

dasaras@ccf.org

We have an immediate opening for a Postdoctoral Fellow position in the Dr. Dasarathy Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and interest in studying signal transduction during metabolic perturbations are encouraged to apply. The laboratory focus is on using integrated molecular metabolic approaches in a comprehensive array of cellular, mouse, and human models. 

A highly motivated candidate will join a productive research team to participate in NIH funded projects focusing on the molecular mechanisms of skeletal muscle loss and metabolic perturbations in disease. The candidate should have a publication record demonstrating on-hand molecular biology and cell biology expertise. 

Must be familiar with mesenchymal cell culture (preferably skeletal muscle), Western blotting, and RNA based methods including quantitative PCR and reporter assays, subcloning between different vectors, lenti- retro- and adenoviral systems for cDNA and shRNA delivery. Preference will be given to candidates with previous experience in skeletal muscle biology, CRISPR/Cas9-dependent gene editing, confocal microscopy/cell imaging or mouse models of muscle loss. Excellent communication skills in English are essential. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Dr. Srinivasan Dasarathy; Department of Pathobiology; Lerner Research Institute / NE4 208; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 636-0096; E-mail: dasaras@ccf.org.


13 08/17/2020 Neetu Gupta, Ph.D
guptan@ccf.org

Postdoctoral Fellow - Gupta Lab

Immediate opening for a Postdoctoral Fellow position in the Gupta Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with demonstrable experience in mechanistic immunology research, B cell biology, mouse models of autoimmunity and/or inflammation and/or infection, and a strong record of publication are encouraged to apply. The successful candidate will design, implement and manage exciting research projects addressing the regulation of B cell antibody response during infection and inflammation.

Must be proficient in immunological techniques (multicolor flow cytometry, ELISA), cell culture, and molecular biology methods (western blotting, quantitative PCR, lentiviral gene expression, and CRISPR/Cas9 gene modification). Prior experience in murine lung and colon isolation and analysis is an advantage, as is cellular imaging. Excellent verbal and written communication skills are essential. The appointee will be expected to take advantage of this career opportunity to further develop skills in manuscript publication and grantsmanship.

Applicants must have a Ph.D. or an M.D.,Ph.D degree in immunology, with strong motivation, a passion for science, ability to work as a team and design experiments independently, and a strong work ethic. Proficiency in spoken and written English is required. Send a cover letter describing research accomplishments, future interests and career goals, CV and contact information for 3 references to Dr. Neetu Gupta (guptan@ccf.org).


14 08/12/2020 Dr. Michelle Longworth
longwom@ccf.org

Postdoctoral Fellow - Longworth Lab

Immediate opening for a Postdoctoral Fellow position in the Longworth Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in molecular biology, genetics, and biochemistry, and with expertise in mitochondrial biology and metabolism research are encouraged to apply.

Candidate must be familiar with cultivation of cell lines; previous experience with organoid-based systems is desired, but not required.  Candidate must also be familiar with Western blotting, qRT-PCR, immunofluorescence assays, and various cloning techniques. Familiarity with lenti- and retroviral based systems of nucleic acid delivery, and expression of exogenous proteins is required. Experience using CRISPR/Cas9 and/or chromatin based techniques such as ChIP-seq, ATAC-seq, and 3C/4C-seq are advantages. Candidate will be expected to design, implement and manage research projects focused on newly discovered mechanisms that lead to Reactive Oxygen Species accumulation in epithelial stem cells and their role in tumor development. 

Ph.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Email cover letter, CV, and contact information for 3 references to: Michelle Longworth, Ph.D.; Department of Inflammation & Immunity; Lerner Research Institute, longwom@ccf.org.


15 08/12/2020 Feixiong Cheng
chengf@ccf.org

Postdoctoral Fellow

We are seeking 1-2 Postdoctoral Research Fellow to join the Network Medicine and Artificial Intelligence (AI) research group (https://www.lerner.ccf.org/gmi/cheng/) led by Dr. Feixiong Cheng at the Genomic Medicine Institute, Cleveland Clinic Lerner Research Institute, and Department of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University. The primary goal of Cheng group is to combine tools from electronic health record (EHR), genetics and genomics, chemical biology, network medicine, AI, bioinformatics, computational biology, and experimental systems biology assays (e.g., single-cell/nucleus sequencing and hiPSC-derived cardiomyocytes and neurons), to address the challenging questions toward understanding of complex diseases (including Alzheimer's disease [https://alzgps.lerner.ccf.org], Cardio-Oncology [https://mutanome.lerner.ccf.org], and COVID-19), which could have a major impact in identifying novel real-world data-driven diagnostic biomarkers and therapeutic targets for precision medicine.

A highly motivated candidate will join our NIH-funded research projects focusing on analyzing, visualizing, and mining data from real-world (e.g., EHRs and healthcare claims) and experiments that profile the molecular state of human cells and tissues by interactomics (protein-protein interactions), transcriptomics, genomics, proteomics, radiomics, and metabolomics for drug discovery and precision patient care. The postdoctoral fellow will have great opportunities to collaborate with diverse groups of physicians, genetics, and computational biologists, and get access the large-scale patient data at the Genomic Medicine Institute, Miller Family Heart & Vascular Institute, Taussig Cancer Institute at Cleveland Clinic, The Cleveland Alzheimer's Disease Research Center (CADRC) at the Cleveland Clinic Lou Ruvo Center for Brain Health, and Cas Comprehensive Cancer Center at Case Western Reserve University.

Requirements:

  1. Highly motivated candidates with a PhD/MD degree in systems biology, network science, computational biology, chemical biology, machine learning, natural language processing (NLP), bioinformatics, mathematical biology, data science, genome science, pharmacogenomics, and related fields are encouraged to apply.

  2. A strong computational background, proficiency in at least one programming language (e.g., R, Python, Perl, C++, Java) and knowledge of statistics and mathematics are required.

  3. Training experience in artificial intelligence (such as machine learning and deep learning), experience working in high computing cluster environment, experience working with TCGA, ICGC, GTEx, 1000 Genomes, UK-biobank, ENCODE, or ExAC, PDB, or other large-scale DNA/RNA-seq (including both bulk and single-cell/nucleus) data analysis is highly preferred.

  4. A good understanding of biology, genetics and genomics, cell signaling networks, pharmacokinetics/pharmacodynamics (PK/PD), and human protein-protein interactome is also preferred.

  5. Proficiency in spoken and written English is required.

How to Apply: Interested applicants should send a cover letter describing your research experience/skills and future research statement/plan (2-3 pages), a curriculum vitae and the contact information of three referees to Dr. Feixiong Cheng (chengf@ccf.org or feixiong.cheng@case.edu) with the subject line ‘Postdoc-Application - Your Name’.

Application Deadline: Positions are open immediately until filled

 


16 07/27/2020 Dr. Timothy A. Chan and Allison Borrelli
chanlabrecruitment@ccf.org

Postdoctoral Fellow

POSTDOCOTAL FELLOW

JOB SUMMARY:

We seek an enthusiastic candidate for the position of postdoctoral fellow in the laboratory of Dr. Timothy Chan, the Chair of the Center for Immunotherapy at the Cleveland Clinic. The post-doctoral position is for highly motivated candidates with a background in molecular/cellular biology, immunology, and/or genetics to join a research group interested in cancer genomics and immunotherapy research.   Projects will involve using molecular biological and genomics strategies to identify and characterize genetic determinants of cancer progression and therapeutic response.  Applicants should hold a PhD and/or MD degree and have strong laboratory and analytical skills.  Experience in molecular biology, immunology, bioinformatics, or cancer genetics would be very helpful.

 KEY RESPONSIBILITIES:

-Conducts research focused on immunotherapy and cancer genomics.

-Plans, organizes, performs and monitors daily project protocols.

-Collects, prepares and maintains required research documentation, including informed consent records, case records, clinical notes and medical reports.

-Reports and assists with the management of protocol deviations, adverse events and other project-related issues.

-Assists with the preparation and delivery of internal/external presentations, conference reports/lectures, and publishing submissions.

EDUCATION:

PhD in an appropriate scientific field such as Biology, Biochemistry, Immunology, Chemistry, Microbiology, or other similar science major. 

COMPLEXITY OF WORK:

Requires critical thinking skills, decisive judgment and the ability to work with minimal supervision. Must be able to work in a stressful environment and take appropriate action.

Full applications including curriculum vitae, a summary of current and future research interests and expected availability date, a description of past research experience and accomplishments, selected reprints of publications and three references should be submitted to: Timothy A. Chan, MD/PhD, Chair, Center for Immunotherapy.  E-mail: ChanLabRecruitment@ccf.org


17 07/21/2020 Ryota Matsuoka
matsuor@ccf.org

Postdoctoral Fellow Position

A Postdoctoral Fellow position is available in the laboratory of Dr. Ryota Matsuoka (https://www.lerner.ccf.org/cms/matsuoka/lab/) in the Department of Cardiovascular and Metabolic Sciences at the Cleveland Clinic Lerner Research Institute. Our research projects focus on defining the cellular and molecular basis of vascular and lymphatic assembly in the central nervous system (CNS) and meninges using zebrafish as a model organism. Specific areas of research in our laboratory include: 1) fenestrated vs non-fenestrated brain vascular development; 2) the mechanisms driving the generation of heterogeneous brain vascular networks; 3) spatiotemporal regulation of CNS blood and lymphatic vasculature; and 4) congenital CNS vascular and lymphatic malformations.

 We are seeking a highly motivated recent graduate with a Ph.D degree in the field of biological sciences. The successful applicant is expected to apply for external fellowships, present data at scientific conferences, and prepare manuscripts for publication. Candidates with a publication record in developmental biology, genetics, neuroscience, or cell biology are preferred. Former experiences working with zebrafish or other animal models are a plus.

 Review of applicants will start immediately and continue until the position is filled. The contract will be renewed annually and extended for up to 5 years, dependent upon satisfactory progress and the lab’s funding situation. Interested individuals should submit a single PDF file containing the following materials to Ryota Matsuoka (matsuor@ccf.org):

1) CV, including a list of publications and contact information for 3 references

2) Cover letter describing previous research, research interests, and career goals


18 07/03/2020 Zihua Gong
gongz@ccf.org

Postdoctoral Fellow

We are currently seeking an ambitious, enthusiastic, and motivated Postdoctoral Fellow to join our research team in the Department of Cancer Biology at the Cleveland Clinic Lerner Research Institute. Our lab is focused on understanding the DNA repair pathways in cancer development and cancer treatment.

We seek candidates with strong qualifications in the following areas: mammalian cell culture, molecular biology, biochemistry and mouse models. Application Requirements: A Ph.D with relevant research experience is required. Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, cover letter, and contact information for three references. Please send applications and informal inquiries to Dr. Zihua Gong at  gongz@ccf.org.


19 07/02/2020 Yu-Shang Lee
leey2@ccf.org

Post-doc Researcher

A postdoctoral position is immediately available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute to investigate the potential therapeutic interventions to promote the nerve regeneration and the functional (motor, sensory and autonomic) recovery after spinal cord injury or traumatic brain injury. The mechanisms (neuroprotection, inhibitory extracellular matrix molecules, neuroplasticity, etc) underlying these effects are also the topics of our studies. These studies are supported by funds from NIH R01, Department of Defense, and Foundations. This position offers an excellent work environment with competitive salary and benefits.

We are seeking a highly motivated, independent, flexible, and interactive researcher to work with.  Applicants with a strong background in neuroanatomy, neurophysiology, and neurobiology are encouraged to apply.  Significant experience in molecular biology/cellular biology skills (western blot, PCR, cell culture etc.) is highly desired in addition to demonstrated electrophysiological expertise and/or experience in data analysis software (MATLAB, photoshop).  Good English communication skills and a Ph.D.  or M.D. degree in a relevant discipline are required.

Interested applicants please submit a curriculum vitae, brief description of research interests and career goals, and contact information for three references who are familiar with the candidate’s work to Dr. Lee via email at: leey2@ccf.org


20 06/18/2020 Conni Bergmann, Ph.D.
bergmac@ccf.org

Postdoctoral Position: Neuroimmunology

Postdoctoral Fellow positions are available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute. The successful candidate(s) will work for Professor Conni Bergmann on a comprehensive NIH-funded research program studying virus encephalomyelitis in a rodent model. Areas of interest include: 1) Investigation of microglia and macrophage functions during neurotropic coronavirus-induced demyelination; and 2) Crosstalk between stromal cell functions and B cells in the central nervous system. Candidates should have a Ph.D. and/or M.D. in a relevant discipline and experience in neuroimmunology. Interested applicants should submit a curriculum vitae, a brief description of research interests and career goals, and contact information for three references to Dr. Conni Bergmann, Department of Neurosciences, via email at: bergmac@ccf.org.


21 06/16/2020 Takuya Sakaguchi, Ph.D.
sakagut2@ccf.org

Postdoctoral Fellow

A Postdoctoral Fellow position is available in the Cleveland Clinic.

 A Postdoctoral Fellow position is available to study liver organogenesis, physiology, and pathology in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. We use the zebrafish model to study the molecular pathologies of human liver diseases, including NASH and cholestatic liver disease. Research projects involve genetic, biochemical, and bioinformatic approaches utilizing the zebrafish model and human biospecimens.

We are seeking highly motivated recent graduates with a Ph.D. and/or MD with relevant research experience. Applicants should have research experience in cell biology, molecular biology, developmental biology, or a closely related field. The ideal candidate will have experience in developmental genetics. Proficiency in spoken and written English is required.

The Lerner Research Institute provides an excellent environment for biomedical science. Our postdoctoral training program (http://www.lerner.ccf.org/education/postdoc/) provides excellent support for career development.

Please send your CV and contact information of three references to Takuya Sakaguchi (sakagut2@ccf.org).


22 06/09/2020 Brian Gastman
gastmab@ccf.org

Postdoctoral Fellow - Gastman Lab

Immediate opening for a Postdoctoral Fellow position in the Gastman Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in immunology, molecular biology and biochemistry, and with expertise in cell, animal, or human models of cancer, and specifically cancer immunity are encouraged to apply. 

Must be familiar with immunologic assays (FACS, cytotoxicity, mouse tumor models, etc..), cultivation of multiple cell lines, Western blotting, and RNA based methods including quantitative PCR and Northern blotting,  expression of exogenous proteins, and the Casp9/Crispr system.    Experience with in vivo murine models is also important.  Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing the role of suppressor cells in the tumor microenvironment.  The applicant will have significant exposure to human specimens from a multitude of research protocols and clinical trials.  The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Our laboratory is highly collaborative and works closely with industry.  The prospective applicant would be expected to not only be involved in high level research, but also to act as an ambassador between our lab and our industry partners.  Thus, proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Brian Gastman, MD.; Department of Inflammation & Immunity; Lerner Research Institute / NE4-303; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-6950; gastmab@ccf.org


23 06/08/2020 Hoonkyo Suh
suhh2@ccf.org

Postdoctoral Fellow

We are seeking a highly-motivated postdoctoral fellow to join Dr. Hoonkyo Suh’s laboratory in the Department of Neurosciences at the Cleveland Clinic.

The research goal is to understand hippocampal neurogenesis and neural circuits that underlie human mental behaviors and disease, with the hope that outcomes of our research will lead to the development of new therapeutic approaches to prevent, treat, and cure neuropsychiatric (i.e. cognitive deficits, depression, and anxiety) and neurological (i.e. epilepsy and addiction) disorders. A successful candidate will dissect neuronal connectivity and function of hippocampal neural circuits in normal and disease rodent models at the molecular, cellular, genetic, and circuitry levels.

The Suh lab is seeking highly-independent and creative individuals with a Ph.D. and/or M.D. degree, who are motivated to work in a diverse and collaborative research environment. We will consider candidates from a broad range of backgrounds including (but not limited to) molecular and cellular biology, genetics, as well as behavioral and systems neuroscience.

Applicants should send a cover letter, CV, and complete contact information for three references to Dr. Hoonkyo Suh at suhh2@ccf.org


24 06/03/2020 Christine O'Connor
oconnoc6@ccf.org

Post-doctoral Fellow

Postdoctoral Position: Virology/Infectious Disease

Job Summary:

We are seeking a highly motivated individual for a post-doctoral position in the laboratory of Christine O’Connor, PhD, in the Department of Genomic Medicine at the Cleveland Clinic. This position is for highly motivated, enthusiastic candidates with a strong background in molecular/cellular biology, virology, immunology, and/or related field. Research topics include understanding the function(s) of the human cytomegalovirus (HCMV) encoded G-protein coupled receptors (GPCRs) during latency and reactivation. Qualified individuals should hold a PhD and/or MD and have strong laboratory, analytical, and communication skills. Candidates with experience in virology and/or immunology are strongly encouraged to apply. 

Key responsibilities include:

  • conducting research aimed at understanding HCMV-encoded GPCR functions during viral latency and reactivation.
  • planning, organizing, performing, and monitoring daily activities related to the project protocols and goals.
  • preparing, collecting, and maintaining required research project documentation and data.
  • leading, assisting, and contributing to the preparation of internal and external presentations, reports, and manuscript publications.
  • participating and presenting in lab meetings, as well as departmental and institute seminars.

Ideal candidates have:

  • PhD and/or MD in microbiology, virology, molecular biology, cell biology, or related field.
  • extensive experience in tissue culture and molecular/cellular biology techniques (e.g. RNA/DNA manipulation, cloning, protein analyses). Virology background is not required, but is preferred.
  • demonstrated ability to be highly motivated and organized, detail-oriented, a critical thinker, and able to work independently as well as in teams.
  • exceptional communication skills (both oral and written). 

Interested candidates should submit a current CV, description of past research experience and accomplishments, summary of current and future research interests, selected publication reprints, as well as the names and contact information of three referees to: Christine O’Connor, email: oconnoc6@ccf.org


25 06/02/2020 Connie Tam
tamk@ccf.org

Postdoctoral Research Fellow

Postdoctoral Research Fellows: Innate Immunity and Inflammation 

NIH-funded postdoctoral positions are immediately available in the laboratory of Dr. K. P. Connie Tam at the Department of Ophthalmic Research, Cleveland Clinic Cole Eye Institute and Lerner Research Institute. 

Environment: 

Cleveland is renowned for its world-class healthcare services and biomedical research. It is a great place for young professionals who enjoy sports, nature, fine dining, art and cultural events. The Clinic is consistently ranked in America’s top five hospitals over 21 years. The Research Education and Training Center at Lerner Research Institute strongly supports professional development for trainees. Our research community embraces diversity, collegiality and collaboration. State-of-the-art core facilities are easily accessible within the institute (http://www.lerner.ccf.org/cores/) and at the Case Western Reserve University. Our lab employs various cell and molecular biology techniques, biochemical assays, flow cytometry, fluorescence and live cell imaging, and mouse models of corneal infection, inflammation and wound healing.

Projects:

Fellows will conduct basic and translational research to delineate novel mechanisms of innate defense, inflammation regulation and wound healing at the corneal epithelial barrier. We are interested in developing new antimicrobial and anti-inflammatory therapeutics. Our projects are fully supported by NIH grants R01EY030577, R01EY030111 and R01EY031463 (project descriptions in projectreporter.nih.gov). A National Eye Institute T32 Institutional Research Training Grant is also available to qualified fellows.

Qualifications:

Applicants should hold a PhD or MD/PhD degree with a strong background in cell biology, cell signaling and/or immunology. Previous experience with mouse models of inflammatory diseases is desirable. The successful candidate is expected to be self-motivated, productive, diligent, competent in scientific presentation (verbal and written), and have the ability to work independently and collaboratively. 

To apply, please send (a) a cover letter highlighting your goals, experience, achievements, (b) a CV, and (c) contact information for three references to Dr. K. P. Connie Tam at tamk@ccf.org.


26 05/29/2020 Dr. Tatiana Byzova
byzovat@ccf.org

Postdoctoral Positions: Vascular Pathologies In Neurodegeneration

Postdoctoral Fellow positions are available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute. The successful candidate(s) will work for Endowed Chair in Angiogenesis Professor Tatiana Byzova on a comprehensive and clinically important NIH-funded research program. Areas of interest include: 1) role and mechanisms of innate immunity on vascular cells; 2) pathophysiological consequences of oxidative stress in neurodegeneration; and 3) roles of microglia and vasculature in neuropathologies (See Dudiki et al., 2020, Nature Communications). Candidates should have a Ph.D. and/or M.D. in a relevant discipline and a background in vascular biology, inflammation, and/or neuroscience. Interested applicants should submit a curriculum vitae, a brief description of research interests and career goals, and contact information for three references to Dr. Tatiana V. Byzova, via email at: byzovat@ccf.org


27 05/28/2020 Jan Claesen
claesej@ccf.org

Postdoctoral Fellow

Postdoctoral Fellow - Bioactive Molecules from the Microbiome

We have an immediate opening for a Postdoctoral Fellow excited about advancing our mechanistic understanding of the Human Microbiome. You will join the Claesen group at the Cleveland Clinic Lerner Research Institute and Center for Microbiome and Human Health: https://www.lerner.ccf.org/cms/claesen/

Our group’s aim is to functionally characterize molecular mechanisms that control bacterial interspecies and microbe-host interactions in the human microbiome. Bacteria use small molecule chemicals to mediate these interactions and the genetic information required for their production is typically encoded in one physical location of the bacterial chromosome, in biosynthetic gene clusters (BGCs). Using in silico techniques, we identified several widespread families of BGCs that we are now characterizing experimentally, prioritizing on the BGCs predicted to be involved in modulation of community composition or interaction with the host immune system. Our research will contribute to a better mechanistic understanding of the microbes that live in our body, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.

Your profile

You will have (or are close to obtaining) a PhD degree in a relevant biological or chemical subject and a good publication record in peer-reviewed scientific journals. You’re a motivated and creative scientist with hands-on experience with microbiological, molecular genetics and standard biochemical techniques is preferred. Prior experience in mouse infection/colonization models or microbiome science is desirable.

About us

The areas of expertise in the Claesen group include microbiology, bacterial genetics and synthetic biology, small molecule biosynthesis, biochemistry and animal models for gastrointestinal disease. We provide a stimulating, multidisciplinary training environment that will assist you in your successful scientific development. You will receive a competitive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute (http://www.lerner.ccf.org/), as well as plenty of opportunities for clinical collaboration at the Cleveland Clinic, the #2 Hospital in the Nation. Cleveland living is affordable and family friendly, offering a range in activities that include an amazing nature parks network, musea, major professional sports teams, an extensive theater district and a blooming microbrewery scene.

How to apply

Contact Dr. Jan Claesen (claesej@ccf.org) for more information. To apply, please email your CV, a brief summary of research interests (no more than 2 pages) and contact information for 3 references by Friday July 03, 2020. Thereafter, applications will be considered on a rolling basis.


28 05/26/2020 Aaron W Miller
millera25@ccf.org

Postdoctoral Fellow

Immediate opening for a Postdoctoral Fellow position in the Miller Laboratory in the Cardiovascular and Metabolic Sciences Department at the Cleveland Clinic Lerner Research Institute. The research will focus on interactions between the microbiome and urologic disease.  In particular, the work will seek to elucidate the mechanisms through which the gut microbiota processes dietary oxalate and how these processes impact host inflammation, gut barrier function, and plaque accumulation. Individuals with experience and knowledge of microbiology, microbiome, -omics techniques, bioinformatics, and animal studies are encouraged to apply.

Candidate must be familiar with traditional microbiology techniques with a preference for culturomics experience.  Experience in conducting animal studies, including ABSL-2 studies is preferred.  Candidate should also have some experience in microbiome studies including metagenomics, transcriptomics, or metabolomics. Candidate will be expected to design, implement and manage research projects focused on mechanisms associated with the host-microbe, diet-microbe, and microbe-microbe interactions that promote chronic disease. 

Ph.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Email cover letter, CV, and contact information for 3 references to: Aaron W. Miller, Ph.D.; Cardiovascular and Metabolic Sciences Department; Lerner Research Institute, millera25@ccf.org.


29 05/18/2020 Margot Damaser, PhD
damasem@ccf.org

Postdoctoral Fellow

A postdoctoral fellow position is available immediately in the laboratory of Dr. Margot Damaser in the Department of Biomedical Engineering of the Lerner Research Institute to refine and validate a wireless in vivo bowel sensor system. The research will focus on programming of bowel sensor prototype, enabling wireless battery charging, addition of features to the sensor such as adding new sensing modalities and enabling recording from multiple locations in the bowel simultaneously, benchtop and in vivo calibration and testing, and technology transfer to other research groups both local and national.

Candidates should have a PhD in Electrical Engineering or Biomedical Engineering and proficiency in at least one programming language (e.g. C++, Matlab) as well as experience debugging and developing custom electronic devices, testing and validation protocols, and experience with statistical data analysis & signal processing (e.g. filters).

The successful candidate will be able to work in a milestone-driven research environment (i.e. can adhere to a schedule of deliverables); will be comfortable studying physiological functions, such as bowel and bladder function; and will show initiative and take ownership of project, attention to detail particularly with regard to documentation and analysis, strong written and oral communication skills, ability to function in a multidisciplinary team, and work at multiple locations as needed.

Experience/expertise is one or more of the following areas is desired: Matlab & Labview software, embedded software for microcontrollers (e.g. C++, TI MSP series), low-power radio frequency communication methods, RF power amplifiers and/or wireless battery charging, circuit design/layout, circuit simulation, electromagnetic simulation, and experience with biocompatible polymers (e.g. silicones). Several years of hands-on laboratory research, development, and testing experience is also strongly desired. 


30 05/15/2020 chengf@ccf.org
chengf@ccf.org

Postdoctoral Research Fellow

We are seeking 1-2 Postdoctoral Research Fellow to join my Network Medicine and Artificial Intelligence research group (https://www.lerner.ccf.org/gmi/cheng/) in the Genomic Medicine Institute at the Cleveland Clinic Lerner Research Institute and Department of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University.

The primary goal of Cheng lab is to combine tools from electronic health record (EHR), genetics and genomics, chemical biology, network medicine, AI, bioinformatics, computational biology, and experimental systems biology assays (e.g., single-cell sequencing and iPS-derived cardiomyocytes), to address the challenging questions toward understanding of complex diseases (including Cardio-Oncology, COVID-19, and Alzheimer's disease), which could have a major impact in identifying novel real-world data-driven diagnostic biomarkers and therapeutic targets for precision medicine. A highly motivated candidate will join my NIH-funded research project focusing on analyzing, visualizing, and mining data from real world (e.g., EHRs and health care claims) and experiments that profile the molecular state of human cells and tissues by interactomics (protein-protein interactions), transcriptomics, genomics, proteomics, and metabolomics for drug discovery and precision patient care. The postdoctoral fellow will have great opportunities to collaborate with diverse groups of physicians and computational biologists, and get access the large-scale patient data at the Genomic Medicine Institute, Miller Family Heart & Vascular Institute, Taussig Cancer Institute at Cleveland Clinic, and CASE Comprehensive Cancer Center at Case Western Reserve University.

Requirements: Highly motivated candidates with a PhD/MD degree in systems biology, computational biology, machine learning, natural language processing, bioinformatics, mathematical biology, network science, data science, genome science, pharmacogenomics, or a related field are encouraged to apply. A strong computational background, proficiency in at least one programming language (e.g., R, Python, Perl, C++, Java) and knowledge of statistics and mathematics are required. Training experience in artificial intelligence (such as machine learning and deep learning), experience working in high computing cluster environment, experience working with TCGA, ICGC, GTEx, 1000 Genomes, UK-biobank, ENCODE, or ExAC, PDB, or other large-scale DNA-seq or RNA-seq data analysis is highly preferred. A good understanding of biology, genetics and genomics, pharmacokinetics/pharmacodynamics (PK/PD), cell signaling networks, and human protein-protein interactome is also preferred. Proficiency in spoken and written English is required.

How to Apply: Interested applicants should send a cover letter describing your research experience/skills and future research interests/plans (2-3 years), a curriculum vitae and the contact information of two or three references to Dr. Feixiong Cheng (chengf@ccf.org or feixiong.cheng@case.edu) with the subject line "Postdoc-Application - Your Name".

Application Deadline: Positions are open immediately until filled


31 05/05/2020 Ignacio Mata
matai@ccf.org

Postdoctoral Fellow

The Mata research group (https://www.lerner.ccf.org/gmi/mata/) focuses on understanding the genetic component of neurological disorders, in particular Parkinson’s disease (PD), Parkinson’s Disease Dementia (PDD) and Dementia with Lewy Bodies (DLB). The large patient and genetic data resource already available and the compelling evidence for the role of genetics in the development of PD have motivated us to launch a new collaborative analysis effort to decipher the disease etiology in Latino patients and to guide future therapeutic development and diagnostic tools. Dr. Mata is a world leader in genetic Parkinson research in the Latino population, and is looking for an exceptional candidate to join his PD genetics research program.

The successful candidate will join an interdisciplinary team of computational biologists, bioinformatics analysts (https://sites.google.com/view/lalresearchgroup/) and excellent clinicians who are working together to identify rare and common genetic variants that cause or confer risk to neurological disorders. The Mata lab is also part of a large collaborative worldwide effort in PD genetics (https://parkinsonsroadmap.org/gp2/) so the successful candidate will play an active role in this exciting project and will have ample opportunities to interact and learn from the best in the field. The responsibilities will include processing and quality control of genetic data sets, as well as statistical analysis of joint analysis of genetic variation and clinical phenotype data.

 Key Responsibilities:

  • Processing and quality control of large-scale DNA sequencing and genotyping data sets
  • Statistical analysis and methods development for the joint analysis of DNA variation and clinical phenotype data
  • Organizing, manipulating and integrating new datasets across different formats and robust synchronization with existing datasets and databases
  • Participating in a team to develop innovative analytical methods to enable collaborators to interpret results and design follow-up research
  • Providing support to clinicians and biological researchers to develop and implement data-analyses
  • Lead and contribute to manuscript preparation as well as internal and external project-team reports.
  • Actively participate and present in project team meetings.

 Ideal candidate should have:

  • Ph.D in genomics, computer science, mathematics, statistics, bioinformatics, or other quantitative biology.
  • Familiarity with next-generation sequencing and/or genotyping data analysis tools strongly preferred.
  • Demonstrated proficiency in at least one of the following technologies: R, Unix, Perl, Python, Java, Matlab, and experience in working in HPC and/or cloud-based environment.
  • Skill and experience with statistical analysis.
  • 1+ years of experience with biological datasets.
  • Demonstrated capability as highly organized, a creative problem-solver, detail-oriented, self-motivated, and able to work independently as well as within cross-functional teams; experience working in an interdisciplinary team with laboratory scientists and clinicians is a plus.
  • Ability to adapt to rapidly changing and high-demand environments.
  • Exceptional communication skills (oral and written).

Interested applicants should send a cover letter, CV and 2-3 reference letters to Dr Ignacio Mata at matai@ccf.org


32 04/29/2020 Kailash Gulshan
gulshak@ccf.org

Postdoc

A Postdoctoral Fellow position is available in the Cleveland Clinic [Lerner Research Institute/Cardiovascular & Metabolic Sciences]

Please send your curriculum vitae and contact information for 3 references to [Kailash Gulshan, gulshak@ccf.org]

Dr. Kailash Gulshan is seeking a Postdoctoral Fellow to perform research related to role of inflammation in progression of cardiovascular disease (CVD), specifically investigating role of NLRP3 inflammasome pathway in CVD. Dr. Gulshan's lab is located in the Department of Cardiovascular & Metabolic Sciences in Cleveland Clinic’s Lerner Research Institute. The project noted above is funded by the NIH-NHLBI. Highly motivated individuals with a strong background in inflammation, lipid/cholesterol metabolism, and atherosclerosis are encouraged to apply. Applicants must be recent Ph.D. or M.D./Ph.D in biological sciences with a strong publication record, proficiency in English, and the ability to design and execute experiments independently Prior experience in mouse models of hyperlipidemia and atherosclerosis, ABC transporters, protein expression and molecular biology, lentiviral based systems of nucleic acid delivery, and expression of exogenous proteins is preferred. Individuals with additional experience of mouse breeding, genotyping, flow cytometry, lipid biochemistry, qRT-PCR, and Crispr-Cas9 mediated genome modification are strongly encouraged to apply.

Interested applicants should send a CV, a cover letter that describes the current and future research interests and 3 references to Dr. Kailash Gulshan (gulshak@ccf.org)


33 04/01/2020 Omar Mian
miano@ccf.org

Post Doctoral Research Fellow

A Postdoctoral fellow position is available immediately in the Mian Laboratory, in the Department of Translational Hematology and Oncology Research (THOR) at the Cleveland Clinic’s Lerner Research Institute in Cleveland, OH.  

An fully funded position awaits a fellow looking to pursue a dynamic career in translational biomedical research! Our lab at the Cleveland Clinic studies epigenetic, metabolic, and endocrine determinants of response to DNA damage in a variety of cancers. The work involves characterization of innovative preclinical models using genome editing and molecular analysis methods. Clinical samples are readily available for validation studies. The position offers excellent opportunities for publication, career development and advancement. Candidates will join a stimulating academic environment within the Genitourinary Malignancies Research Center of the Lerner Research Institute. 

Highly motivated individuals with a strong background and interest in translational cancer research are encouraged to apply. Applicants must be recent Ph.D. or M.D./Ph.D. graduates in cell biology, molecular biology, cancer biology, molecular genetics, developmental biology or related fields. Prior experience in culture of human primary and cancer cell lines, molecular biology, as well as a track record of peer-reviewed publications is required. Individuals with additional experience in genome editing, mouse work or bioinformatics, are strongly encouraged to apply.

Interested applicants should send a CV, a cover letter/statement that describes career goals, and 3 references to Dr. Omar Mian (miano@ccf.org).