Postdoctoral Positions

The Lerner Research Institute's Postdoctoral Fellowship includes a competitive salary and benefits package and an opportunity to work and advance in a state-of-the-art facility with more than 700,000 square feet of space.

The current postdoctoral opportunities are listed below.

Postdoctoral Fellow/Research Associate candidates will be expected to conduct research under the mentorship of a principal investigator in a predominantly independent manner. Fellows will be expected to pursue testing of hypotheses by developing experimental designs, managing and processing data and interpreting and preparing results for publication in peer-reviewed journals. Fellows will work closely with the principal investigator and will be expected to communicate effectively both in writing and in oral presentations. Qualified candidates will have successfully completed all requirements for the degree of doctorate in philosophy (Ph.D.) or doctor in medicine (M.D.) in relevant scientific programs.

Project Scientist candidates will have substantial experience at the postdoctoral or research associate level and have established a respectable record of publication. Project Scientists will work in collaboration with the principal investigator but work independently within the scientific framework of the principal investigator's laboratory. Project Scientists may seek grant funding from extramural sources in support of their research projects with the consent of the principal investigator and department chair. Project Scientist is a junior-level faculty position.

Please complete your application as directed and send to the investigator listed. We look forward to hearing from you!

# Date Contact Description
1 03/18/2019 Tara M. DeSilva, Ph.D.
desilvt@ccf.org

Postdoctoral Research Fellow In Neurosciences

An R01-funded position for a Postdoctoral Fellow is available immediately in the Department of Neurosciences at the Lerner Research Institute. The project focuses on the role of neuroinflammatory processes underlying neurodegeneration. The project entails the use of genetically-modified rodent models and a variety of molecular and cell biological approaches, including immunology. Special consideration will be given to applicants with expertise in animal models of neurodegeneration. To apply, Please submit a CV along with a cover letter indicating areas of expertise and a brief statement of research interests to Dr. DeSilva at desilvt@ccf.org.


2 03/12/2019 Amy Lightner, MD
lightna@ccf.org

Project Scientist

Immediate opening for a project scientist position in the Lightner Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in regenerative medicine, with expertise in mesenchymal stem cell culture, extracellular/exesome extraction, murine models of colitis/Crohn’s disease are encouraged to apply.

Must be familiar with cultivation of multiple cell lines, Western blotting, and RNA based methods including quantitative PCR and Northern blotting, lenti- retro- and adenoviral systems of shRNA delivery, expression of exogenous proteins, and the Casp9/Crispr system. Experience in murine cell delivery and organ isolation is an advantage. Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing regenerative medicine products for the treatment of human disease, namely in inflammatory bowel disease.  The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter, CV and contact information for 3 references to:

Amy Lightner, MD, lightna@ccf.org 


3 03/07/2019 Jan Claesen
claesej@ccf.org

Postdoctoral Fellow - Functional Microbiome

Postdoctoral Fellow - Functional Microbiome

We are looking for a Postdoctoral Fellow excited about advancing our mechanistic understanding of the Human Microbiome, to join the Claesen group at the Cleveland Clinic Lerner Research Institute. https://www.lerner.ccf.org/cms/claesen/

Our aim is to functionally characterize molecular mechanisms that control bacterial interspecies and microbe-host interactions in the human microbiome. Bacteria use small molecule chemicals to mediate these interactions and the genetic information required for their production is typically encoded in one physical location of the bacterial chromosome, in biosynthetic gene clusters (BGCs). Using in silico techniques, we identified several widespread families of BGCs that we are now characterizing experimentally, prioritizing on the BGCs predicted to be involved in modulation of community composition or interaction with the host immune system. Our research will contribute to a better mechanistic understanding of the microbes that live in our body, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.

Your profile

Candidates will have (or are close to obtaining) a PhD degree in a relevant biological or chemical subject and a good publication record in peer-reviewed scientific journals. Hands-on experience with microbiological, molecular genetics and standard biochemical techniques is required. Prior experience in mouse infection/colonization models is highly desirable.

About us

The areas of expertise in the Claesen group include microbiology, bacterial genetics and synthetic biology, small molecule biosynthesis and biochemistry. We provide a stimulating, multidisciplinary training environment that will assist you in your successful scientific development. You will receive a competitive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute (http://www.lerner.ccf.org/), as well as plenty of opportunities for clinical collaboration at the Cleveland Clinic, the #2 Hospital in the Nation.

How to apply

Interested applicants should submit their CV, a brief summary of research interests (no more than 2 pages) and contact information for 3 references to Dr. Jan Claesen (claesej@ccf.org) by Friday May 3, 2019. Thereafter, applications will be considered on a rolling basis.


4 02/28/2019 Kali Casale
casalek@ccf.org

Post Doctoral Fellow

Investigating Chromatin Dysregulation due to Aberrant Dioxygenase Function in Human Pathology

A postdoctoral fellowship position is available in Dr. Abhishek Chakraborty’s newly established laboratory in the Department of Cancer Biology at the Cleveland Clinic. The laboratory is part of Cleveland Clinic’s GU Malignancies Research Center and has close ties to both basic researchers as well as GU clinicians at the Cleveland Clinic and the broader Case Comprehensive Cancer Center.

The laboratory is interested in the relevance of oxygen- (and 2-oxo-glutarate) dependent dioxygenases in cellular physiology, particularly in oxygen sensing and human disease. The laboratory is especially interested in studying the oxygen-dependent JmjC histone demethylases (e.g. KDMs) to 1) fundamentally understand the regulation and biological importance of hypoxia-dependent changes in chromatin; and 2) exploit dioxygenase dysfunction to identify therapeutically targetable vulnerabilities in human cancer, particularly kidney cancer.

Two notable publications highlight our contributions in these areas. First, we discovered that the H3K27 histone demethylase UTX/KDM6A is a novel cellular oxygen sensor that directly links physiological oxygen availability to transcriptional readout. KDM6A function, therefore, governs critical oxygen-dependent biological programs, including the regulation of cell state [Chakraborty AA et al. Science. In Press]. Second, by studying the compensatory mechanisms that allow kidney cancer cells to survive even in the face of profound chromatin dysregulation, we identified the H3K27 histone methyltransferase EZH1 as a targetable dependency in kidney cancer [Chakraborty AA et al. Science Transl Med. 2017 (398). pii: eaal5272]. This work is now being developed to begin exploring the feasibility of clinically targeting EZH1 in kidney cancer patients.

In addition to these discoveries, the laboratory has recently uncovered that the chromatin dysfunction in kidney cancer routinely affects enhancer-dense genomic regions called “Super-enhancers”. In other biological contexts, including other cancers, Super-enhancers have been shown to mark some of the most important genes involved in determining cellular state. These findings have motivated studies in the Chakraborty laboratory to identify Super-enhancer targets whose function is essential for kidney cancer cells, with the hope that, in time, (some of) these candidates could be nominated as potential therapeutic targets in kidney cancer.

The major techniques/areas of interest in the laboratory are Biochemistry [Protein purification and Enzymatic Assays], Molecular Biology [Cloning, Western Blotting, etc], Proteomics, Cancer Biology [in vitro and in vivo tumor models], Cellular Metabolism [steady state and flux-balance analysis], Pharmacology [drug discovery and delivery], Genomic analysis [RNA-Seq and ChIP-Seq data], and Whole-genome and Custom (mini-pool)Genetic Screens [both positive selection (gain-of-function) and negative selection (loss-of-function) screens].

The ideal candidate would have a M.D., Ph.D., or M.D./Ph.D. degree with interests and expertise in one or more of these areas. A collaborative and collegial work ethic, a strong commitment to basic cancer research, and outstanding verbal and communication skills are all required.

The position will provide a unique and multidisciplinary exposure to chromatin function, tumor metabolism, molecular oncology, drug development, and clinical collaborations.

Candidates with an interest in the position should email their CV and contact information for 3 references to: 

Abhishek A. Chakraborty, Ph.D.

GU Malignancies Research Center

Lerner Research Institute

Cleveland Clinic, OH

casalek@ccf.org


5 02/26/2019 Brian Gastman, MD
gastmab@ccf.org

Postdoctoral Research Fellow

Immediate opening for a Postdoctoral Fellow position in the Gastman Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in immunology, molecular biology and biochemistry, and with expertise in cell, animal, or human models of cancer, and specifically cancer immunity are encouraged to apply. 

Must be familiar with immunologic assays (FACS, cytotoxicity, mouse tumor models, etc..), cultivation of multiple cell lines, Western blotting, and RNA based methods including quantitative PCR and Northern blotting,  expression of exogenous proteins, and the Casp9/Crispr system.    Experience with in vivo murine models is also important.  Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing the role of suppressor cells in the tumor microenvironment.  The applicant will have significant exposure to human specimens from a multitude of research protocols and clinical trials.  The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Our laboratory is highly collaborative and works closely with industry.  The prospective applicant would be expected to not only be involved in high level research, but also to act as an ambassador between our lab and our industry partners.  Thus, proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Brian Gastman, MD.; Department of Inflammation & Immunity; Lerner Research Institute / NE4-303; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-6950; gastmab@ccf.org


6 02/26/2019 Jennifer Yu
yuj2@ccf.org

Post-doctoral Fellow

We are seeking a highly motivated postdoctoral fellow to join the Yu lab which focuses on cancer stem cell biology and mechanisms of radiation resistance at the Cleveland Clinic.  Cancer stem cells play an important role in therapeutic resistance.  Cancer stem cells reside in different niches including the perivascular and hypoxic niches. Our laboratory is interested in uncovering molecular mechanisms by which stemness in maintained in these different niches, with the long-term goal of targeting these pathways.  We focus on glioblastoma, a primary brain tumor, and brain metastases.  To this end, we utilize a combination of molecular biology and mouse modeling approaches.  Because Dr. Yu is a physician-scientist, we aim to translate our research to the clinic. Applicants must have a PhD in cancer biology or related field and be highly motivated.  For more information about our laboratory, please visit our website: http://www.lerner.ccf.org/stemcellbio/yu/.  Interested applicants should send their application to yuj2@ccf.org.   


7 02/18/2019 Ming Hu
hum@ccf.org

Postdoctoral Research Fellow

Company Information: Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic.

Position Title: Postdoctoral Research Fellow

Duties & Responsibilities: We are seeking one motivated and creative applicant with quantitative research background in bioinformatics, computational biology, statistics, biostatistics or computer science to join an active and collegial research team, co-led by Dr. Ming Hu (Cleveland Clinic) and Dr. Bing Ren (University of California San Diego and Ludwig Institute for Cancer Research). Appointment would be in Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic.

This work is a key component of the cutting-edge 4D nucleosome project, funded by NIH, and involve the development and application of statistical methods and computational tools for the understanding of gene transcription regulation mechanism. The postdoc will also have great opportunities to collaborate with other researchers from Cleveland Clinic Foundation. The postdoc will collaborate with researchers in 4D nucleosome, 1000 Genome, Roadmap Epigenomics and ENCODE projects. Dr. Hu and Dr. Ren will co-mentor the postdoc and provide highly supportive and dynamic environments to help in the transition to an independent researcher.

Position Qualifications: The applicant should have a Ph.D. degree in one of the following areas: Bioinformatics, Computational Biology, Statistics, Biostatistics, Computer Science, or other discipline with strong quantitative background. Knowledge in biology or genetics is desired but not required. Programming experience in statistical program R and scripting languages such as Perl/Python on Unix/Linux systems is required. Experience with C/C++ is a strong plus. Applicants should have quantitative background with strong statistical and computational skills.

Salary Range: Salary is competitive and commensurate with qualification. Benefits will be in accordance with Cleveland Clinic standard postdoctoral benefits.

Application Address: Interested applicants should email the following materials to Dr. Ming Hu. Email address: hum@ccf.org.

  • · A cover letter;
  • · A statement of research interest;
  • · Curriculum Vitae;
  • · Sample codes from recent programming;
  • · Publication reprints;
  • · Contact information of at least three references.

Review of applications starts immediately. Applications will be considered until the position is filled. The Department of Quantitative Health Sciences has over 90 members and provides an excellent environment for methodological and collaborative research. QHS faculty interact with researchers and clinicians across the Cleveland Clinic, one of the leading academic medical institutions in the world.

Application Deadline: 6/30/2019.


8 02/14/2019 Ming Hu
hum@ccf.org

Postdoctoral Research Fellow

Duties & Responsibilities: We are seeking one motivated and creative applicant with quantitative research background in bioinformatics, computational biology, statistics, biostatistics or computer science to join an active and collegial research team, co-led by Dr. Ming Hu (Cleveland Clinic) and Dr. Bing Ren (University of California San Diego and Ludwig Institute for Cancer Research). Appointment would be in Department of Quantitative Health Sciences, Lerner Research Institute, Cleveland Clinic.

This work is a key component of the cutting-edge 4D nucleosome project, funded by NIH, and involve the development and application of statistical methods and computational tools for the understanding of gene transcription regulation mechanism. The postdoc will also have great opportunities to collaborate with other researchers from Cleveland Clinic Foundation. The postdoc will collaborate with researchers in 4D nucleosome, 1000 Genome, Roadmap Epigenomics and ENCODE projects. Dr. Hu and Dr. Ren will co-mentor the postdoc and provide highly supportive and dynamic environments to help in the transition to an independent researcher.

Position Qualifications: The applicant should have a Ph.D. degree in one of the following areas: Bioinformatics, Computational Biology, Statistics, Biostatistics, Computer Science, or other discipline with strong quantitative background. Knowledge in biology or genetics is desired but not required. Programming experience in statistical program R and scripting languages such as Perl/Python on Unix/Linux systems is required. Experience with C/C++ is a strong plus. Applicants should have quantitative background with strong statistical and computational skills.

Salary Range: Salary is competitive and commensurate with qualification. Benefits will be in accordance with Cleveland Clinic standard postdoctoral benefits.

Application Address: Interested applicants should email the following materials to Dr. Ming Hu. Email address: hum@ccf.org.

  • · A cover letter;
  • · A statement of research interest;
  • · Curriculum Vitae;
  • · Sample codes from recent programming;
  • · Publication reprints;
  • · Contact information of at least three references.

Review of applications starts immediately. Applications will be considered until the position is filled. The Department of Quantitative Health Sciences has over 90 members and provides an excellent environment for methodological and collaborative research. QHS faculty interact with researchers and clinicians across the Cleveland Clinic, one of the leading academic medical institutions in the world.

Application Deadline: 8/31/2019.


9 02/14/2019 Jianguo Cheng, MD, PhD
chengj@ccf.org

Senior Postdoctoral Position: Chronic Pain And Neuroinflammation

A Senior Postdoctoral Fellow/Research Associate position is available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute. The successful candidate(s) will work for Dr. Jianguo Cheng, Professor of Anesthesiology, Staff in the Department of Neurosciences, and Director of the Cleveland Clinic Multidisciplinary Pain Medicine Fellowship Program. Areas of interest include 1) investigating how a nerve injury causes persistent pain behavior and neuroinflammation in the CNS and PNS; 2) investigating how stem cells modulate neuroinflammation, reduce neuropathic pain, and prevent and/or reverse opioid tolerance; and 3) investigating the feasibility and optimizing the key parameters of applying stem cell therapy in patients with chronic pain. The successful candidate(s) will help lead a multidisciplinary approach that combines behavioral, electrophysiological, molecular, and immunohistochemistry techniques to address important research questions. A Ph.D. and/or M.D. in a relevant discipline and research experience in a pain-, neuroinflammation-, or stem cell-related field are required. Interested applicants should submit a curriculum vitae, a brief description of research interests and career goals, and contact information for three references to Dr. Jianguo Cheng, Department of Neurosciences, via email at: chengj@ccf.org.


10 02/13/2019 Antoine Louveau
louveaa@ccf.org

Postdoctoral Fellow

A Postdoctoral Fellow position is available in the Cleveland Clinic Neuroscience Deparment

The research goal is to understand the anatomical and functional organization of the meninges and their impact on physiological and pathological brain function, with a hope to develop new strategies to prevent, treat and cure neurological disorders.

The candidate will focus on understanding the role of the meningeal lymphatic vasculature in brain maturation in normal and disease rodent models.

Our lab is seeking highly motivated, independent, curious and creative individuals with a Ph.D. and/or M.D. degree with laboratory expertise in neuroscience and/or immunology and/or bioinformatics or related fields. Experience in animal experiment is strongly recommended. Candidates are expected to lead a project and establish a collaborative research and must have excellent verbal and written communication skills

Please send your curriculum vitae and contact information for 3 references to Dr Antoine Louveau at louveaa@ccf.orf


11 02/01/2019 Margot Damaser
damasem@ccf.org

Postdoctoral Fellow Position

A postdoctoral fellow position is available immediately in the laboratory of Dr. Margot Damaser in the Department of Biomedical Engineering of the Lerner Research Institute to Refine and validate a wireless in vivo bowel sensor system. The research will focus on programming of bowel sensor prototype, enabling wireless battery charging, addition of features to the sensor such as adding new sensing modalities and enabling recording from multiple locations in the bowel simultaneously, benchtop and in vivo calibration and testing, and technology transfer to other research groups both local and national.

Candidates should have a PhD in Electrical Engineering or Biomedical Engineering and proficiency in at least one programming language (e.g. C++, Matlab) as well as experience debugging and developing custom electronic devices, testing and validation protocols, and experience with statistical data analysis & signal processing (e.g. filters).

The successful candidate will be able to work in a milestone-driven research environment (i.e. can adhere to a schedule of deliverables); will be comfortable studying physiological functions, such as bowel and bladder function; and will show initiative and take ownership of project, attention to detail particularly with regard to documentation and analysis, strong written and oral communication skills, ability to function in a multidisciplinary team, and work at multiple locations as needed.

Experience/expertise is one or more of the following areas is desired: Matlab & Labview software, embedded software for microcontrollers (e.g. C++, TI MSP series), low-power radio frequency communication methods, RF power amplifiers and/or wireless battery charging, circuit design/layout, circuit simulation, electromagnetic simulation, and experience with biocompatible polymers (e.g. silicones).


12 01/21/2019 Hoonkyo Suh
suhh2@ccf.org

Postdoctoral Fellow

A Postdoctoral Fellow position is available in the Department of Neurosciences at the Cleveland Clinic.

The research goal is to understand the anatomical and functional organization of hippocampal neural circuits that underlie human mental behavior, with a hope that the outcomes of our research will lead to the development of new therapeutic approaches to prevent, treat, and cure neuropsychiatric disorders. A successful candidate will focus on understanding neuronal connectivity and function of hippocampal neural circuits in normal and diseased brains by using viral and genetic reagents in rodent models.

Our lab is seeking highly motivated, independent, and creative individuals with a Ph.D. and/or M.D. degree with laboratory expertise in neuroscience, genetics or related fields. Extensive experience in animal experiments is strongly recommended. Candidates are expected to lead a project, contribute to establish a collaborative research environment and must have excellent verbal and written communication skills. Applicants should send a cover letter, CV, and complete contact information for three references to Dr. Hoonkyo Suh at suhh2@ccf.org


13 01/18/2019 Laura Nagy
nagyL3@ccf.org

Post-doc Or Research Associate

A postdoctoral fellow position is available immediately in the laboratory of Dr. Laura Nagy in the Department of Inflammation and Immunity to study the effects of ethanol on the innate immune system, including toll-like receptor signal transduction and complement activation.  The research will focus on the effects of chronic ethanol on key signal transduction pathways in hepatic macrophages with a goal towards understanding the mechanism of development of chronic inflammatory responses in liver.  Projects related to miRNA regulation of cytokine expression, mechanisms of cell death and pathways of gut-liver or adipose-liver interactions are available. 

Experience in at least one of the following areas is desired:  cell biology, signal transduction, molecular biology, intestinal physiology, bioinformatics or macrophage biology. Experience in experimental design and data analysis in both cultured cells and animal models is preferred.  Strong written and oral communication skills are required.

Candidates should have a recent PhD in cell biology, immunology, biochemistry, or a related discipline and experience in signal transduction and cell biology. 

Interested applicants please submit a CV and names and contact information for three references to Dr. Laura Nagy, Department of Inflammation and Immunity (NE40) at Lerner Research Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland OH 44195 or via email to nagyL3@ccf.org


14 01/16/2019 Ignacio Fernandez Mata
matai@ccf.org

Postdoctoral Fellow

Dr. Ignacio Mata is seeking a highly motivated Postdoctoral fellow to help develop a neurogenetics program at the Genomic Medicine Institute – Lerner Research Institute of Cleveland Clinic.

The Mata research group (https://www.lerner.ccf.org/gmi/mata/) just moved to the Cleveland Clinic where it will continue his quest to try to understand the genetic component of neurological disorders, in particular Parkinson’s disease (PD), Parkinson’s Disease Dementia (PDD) and Dementia with Lewy Bodies (DLB). Dr. Mata is a world leader in genetic Parkinson research in the Latino population, and is looking for an exceptional candidate to join his PD genetics research program.

The successful candidate will join an interdisciplinary team of computational biologists, bioinformatics analysts (https://sites.google.com/view/lalresearchgroup/) and excellent clinicians who are working together to identify rare and common genetic variants that cause or confer risk to neurological disorders. The candidate will join the Mata lab to perform data analysis and to collaborate with software engineers who are developing computational tools. The responsibilities will include processing and quality control of genetic data sets, as well as statistical analysis of joint analysis of genetic variation and clinical phenotype data.

 

Applicants should have a recent PhD degreein genomics, computer science, statistics, bioinformatics, or a related field with excellent verbal and written communication skills in English and a proven track record of first-author publications. Experience working with biological datasets and proficiency in at least two of the following technologies: R, Unix, Perl, Python, Java, Matlab, C, C++ and experience in working in HPC and/or cloud-based environment are preferred.

 

Interested applicants should send a cover letter, CV and 2-3 reference letters to Dr Ignacio Mata at matai@ccf.org.


15 01/16/2019 Vidula Vachharajani, MD
vachhav@ccf.org

Postdoctoral Research Fellow

Immediate opening for a Postdoctoral Fellow position in the Vachharajani Laboratory in the Department of Inflammation & Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in molecular biology and biochemistry, and with expertise in cell, animal, or human models of diabetes and obesity are encouraged to apply.

Must be familiar with cultivation of multiple cell lines, Western blotting, and RNA based methods including quantitative PCR and Northern blotting, lenti- retro- and adenoviral systems of shRNA delivery, expression of exogenous proteins, and the Casp9/Crispr system. Experience in murine peritoneal macrophage isolation and analysis is an advantage. Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing inflammatory and metabolic changes during diet induced obesity with sepsi.  The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Vidula Vachharajani, MD; Department of Inflammation & Immunity; Lerner Research Institute / NC22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-7191, vachhav@ccf.org


16 01/15/2019 Chaitali Ghosh, PhD
GHOSHC@ccf.org

Postdoctoral Fellow

Dr. Chaitali Ghosh is seeking a Postdoctoral Fellow to perform research related to the blood-brain barrier and epilepsy, specifically investigating vascular mechanisms and enzyme-regulated pathophysiological alterations to the neurovascular biology affecting drug bioavailability across the blood-brain barrier. Dr. Ghosh's lab is in the Department of Biomedical Engineering in Cleveland Clinic’s Lerner Research Institute.  Studies in this laboratory, including the current epilepsy project noted above funded by the National Institutes of Health.

Applicants should have a recent MD or PhD degree in neuroscience, biochemistry, pharmacology or a related field, with excellent verbal and written communication skills in English and a proven track record of first-author publications. Applicants should demonstrate skills in cellular and molecular biology and analytical chemistry techniques. Preference will be given to highly motivated candidates with previous experience with rodent models and surgery, human brain cells/tissue culture, and biomedical engineering. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.  For candidates outside the United States, there are English language fluency requirements. For more information about our laboratory, please visit our website: http://www.lerner.ccf.org/bme/ghosh/ 

Interested applicants should immediately send their CV, contact details for three references, and a cover letter outlining their research interests and career goals to Chaitali Ghosh, PhD, GHOSHC@ccf.org.


17 12/11/2018 hobbsb@ccf.org
hobbsb@ccf.org

Postdoctoral Fellow-Cancer Biostatistics

Postdoctoral Fellow – Cancer Biostatistics

 

Advances in biology and immunology continue to refine our understanding of cancer pathogenesis, elucidating potential mechanisms of tumor-cell growth, survival, angiogenesis and the systematic suppression of cancer immunity progressing toward precision medicine. Implicit to the concept of precision medicine is heterogeneity of treatment benefit among patients and patient sub-populations. Yet, precision medicine presents challenges to traditional paradigms of clinical translational for which estimates of population-averaged effects are used as the basis for selecting dose-scheduling strategies as well as demonstrating comparative benefit with randomized study.

 

Aspects of the traditional clinical research paradigm may not ideally suit the development of non-cytotoxics that challenge its foundational assumptions pertaining to dose-response and inter-patient exchangeability. Tumor biology and/or host immunity may better delineate target treatment populations than histology. Several emerging molecularly targeted and immunotherapeutic agents have produced durable responses in first-in-human trials. The U.S. regulatory landscape has also changed, with a growing number of accelerated approvals on the basis of single-arm trials. Collectively, these phenomena have prompted innovations with drug development strategies devised to consolidate phases in the traditional paradigm and rapidly expand accrual with “seamless” trial designs.

 

This postdoctoral fellowship is devised to develop analytical and computational technology for optimal designs of trials and drug development strategies for non-cytotoxic oncology treatments that span multiple indications. With the mentorship of Dr. Brian Hobbs (Cleveland Clinic) the trainee will research techniques for effectively identifying sources of subpopulation heterogeneity from real-world databases as well as optimal designs of master protocols and seamless trials that enroll potentially non-exchangeable patients.

 

The fellow will interact regularly with researchers of Amgen’s Statistical Innovation Team. Additionally, it is expected that the fellow will publish their findings in peer-reviewed academic journals as well as disseminate the ideas to both clinical and data science academic communities at conferences.

 

Interested candidates should send a cover letter, CV and 2-3 reference letters to Dr Brian Hobbs at Hobbsb@ccf.org.

 

 

 

Brian P. Hobbs, PhD

Cancer Biostatistics Section Head; Associate Staff,

Taussig Cancer Institute and Lerner Research Institute,

Cleveland Clinic


18 12/07/2018 Zihua Gong
gongz@ccf.org

Postdoctoral Fellow

Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute in the Department of Cancer Biology to investigate the DNA repair pathways in cancer development and cancer treatment.

We seek candidates with strong qualifications in the following areas: mammalian cell culture, molecular biology, biochemistry and mouse models. 

Application Requirements: A Ph.D and/or M.D. with relevant research experience is required. Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references.

Please send applications and informal inquiries to Dr. Zihua Gong at gongz@ccf.org.

The Cleveland Clinic is one of the top five medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes.


19 11/30/2018 John Pellecchia
pellecj@ccf.org

Postdoctoral Research Fellow In Cancer Immunology

Postdoctoral research fellow positions will be available in the laboratory of Dr. Li (Lily) Wang at the Cleveland Clinic Taussig Cancer Institute’s Department of Translational Hematology & Oncology Research (THOR), https://my.clevelandclinic.org/departments/cancer/depts/thor), located within the Lerner Research Institute (LRI), Cleveland Clinic Foundation, Cleveland, OH. The Wang laboratory is relocating from the Medical College of Wisconsin, Milwaukee, WI to Cleveland Clinic, and will be engaging in cross-disciplinary studies by collaborating with basic and clinical researchers from LRI including the Department of Inflammation and Immunology (https://www.lerner.ccf.org/immuno/), and the Case Comprehensive Cancer Center, affiliated with Case Western Reserve University.

Immune-checkpoint blockade (ICB) therapies have revolutionized the field of Cancer Immunotherapy. However, the low response rate in a majority of patients indicates the urgent need to identify and target additional checkpoint regulators. The Wang lab was the first group to demonstrate that a new immune-checkpoint protein “V domain Immunoglobulin Suppressor of T cell Activation” (VISTA) is a promising target for cancer immunotherapy (1 – 5). Our studies show that VISTA regulates the effector functions of cytotoxic T cells, myeloid-derived suppressor cells (MDSC), and myeloid inflammatory DCs. Current projects are focusing on elucidating the molecular signaling mechanisms of VISTA and design innovative approaches to target this checkpoint protein for cancer therapy.

We therefore seek talented and committed candidates with a recent Ph.D. in Biochemistry, Cell Biology, Immunology, or other relevant branches of biological sciences to join our team and make significant contributions to the field of Cancer Immunotherapy. Interested candidates should submit CV, a statement of research interests in a cover letter, and three references to John Pellecchia MS, Department Administrator, at pellecj@ccf.org

References:

 

1.Wang L, RubinsteinR, Lines LJ, Wasiuk A, AhonenC, GuoYX, LuLF, Gondek D, WangY, Fava RA, Fiser A, Almo S and Noelle RJ. (2011) ­­­VISTA, a novel Ig-superfamily ligand that negatively regulates T cell responses, J Exp Med. 208(3):577-92. PMC3058578

2. Le Mercier I, Chen W, Lines JL, Day M, Li J, Sergent P, Noelle RJ, Wang L (2014) VISTA regulates the development of protective anti-tumor immunity. Cancer Research, 74:1933-1944. PMC4116689

3. Wang L, Le Mercier I, Putra J, Chen W, Liu J, Schenk AD, Nowak EC, Suriawinata AA, Li J, Noelle RJ. (2014) Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity. PNAS.  (41):14846-51 PMC4205642

4. Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller H, Guleria I, Barth RJ, Huang YH, Wang L (2015) Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. PNAS. 112(21):6682-7, PMC4450438

5. Xu W, Tạ MH, Malarkannan S, Wang L(2018) Review: The structure, expression, and function of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation. Cellular & Molecular Immunology. 2018 May 15(5):438-446PMC6068175


20 11/28/2018 Lynn Bekris
bekrisl@ccf.org

Postdoctoral Fellow

A postdoctoral fellow position is available in the Genomic Medicine Institute at the Cleveland Clinic Lerner Research Institute. The successful candidate(s) will work in the Bekris lab which is supported by multiple grants and funding resources. Bekris lab research is focused on identifying and evaluating the functional impact of genetic and epigenetic factors in Alzheimer’s disease and other neurodegenerative disorders.

Recent PhDs with a degree in molecular biology or related field as well as a background in experimental genomics and epigenomics utilizing cellular models will be considered. Experience in high-throughput analysis of next-generation sequencing data and familiarity with widely-used genomic/epigenomic databases and related software is a plus.

The candidate must have excellent verbal and written communication skills as well as a publication record. In addition, the candidate must be capable of working within a team of molecular biologists, bioinformaticians, statisticians and clinicians.

Please email your CV, a brief statement of your research interests and three references to 

Dr. Lynn Bekris (bekrisl@ccf.org). 


21 11/26/2018 Ken Baker, Ph.D.
bakerk6@ccf.org

Postdoctoral Position In Neurophysiology

The Department of Neurosciences of the Cleveland Clinic’s Lerner Research Institute seeks to hire a postdoctoral fellow to support federally-funded projects exploring novel neuromodulation approaches for the treatment of stroke and Parkinson’s disease. The position forms part of our interdisciplinary program that brings together Neuroscientists, Biomedical Engineers, as well as physician-scientists from the Center for Neurological Restoration and the Department of Radiology within the number two-ranked hospital in the United States. The successful applicant will participate in work that combines behavioral assessments of therapeutic efficacy with both invasive (i.e., deep brain stimulation) and non-invasive neurostimulation techniques to carry-out a systems-based approach to understanding neurophysiological changes across the sensorimotor brain networks in both humans and preclinical models of disease.  Ph.D. (or equivalent) students with relevant education or experience in neurophysiology, biomedical engineering, or motor control are invited to apply, though preference will be given to candidates with experience in array-based multi-unit neuronal or local field potential signal processing techniques.

The neuroscience research community at Cleveland Clinic spans the research and clinical institutes and includes neuroscientists, biomedical engineers, physicists, mathematicians, geneticists, molecular biologists, and physician-scientists. Investigators within the neuroscience community are supported by one of the top and largest clinical neurological institutes in the country, comprised of more than 200 medical and surgical specialists dedicated to the treatment of neurological and psychiatric disorders. Neuroscience research is supported by state-of-the-art molecular biology labs, small and large animal neurophysiology labs, small-animal MRI, the largest single center repository of human intracranial electrophysiology data bank from patients with epilepsy (subdural grids and SEEG depth electrodes), and one of the most active and integrated neuromodulation centers in the country. Exceptional collaboration possibilities between laboratory and clinical scientists, and access to large populations of patients, provide a unique opportunity for translational investigations.

Please send your curriculum vitae, a brief description of research interests and career goals, and contact information for three references to Dr. Kenneth Baker, Department of Neurosciences, via email at: bakerk6@ccf.org.


22 11/21/2018 Ranjan Dutta, Ph.D.
duttar@ccf.org

Postdoctoral Position In Neurosciences

A Postdoctoral Fellow position is available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute to work on an NIH-funded study to investigate the role of cell-specific proteome in altering the disease response in multiple sclerosis (MS). 
 
The successful candidate will join a multidisciplinary team to elucidate novel mechanisms that impact neuro-axonal injury and as well as remyelination during MS. Experience with large-scale data, including RNA and proteomic analyses, is required. A strong work ethic, proficiency in verbal and written English, and a PhD and/or MD are required. Experience with handling human tissue and/or a background in multiple sclerosis research will be advantageous. 
 
Please send your curriculum vitae, a brief description of your research interests, and contact information for 3 references to Ranjan Dutta, Ph.D. (
duttar@ccf.org)


23 11/16/2018 Selva Baltan, MD, PhD
baltans@ccf.org

Postdoctoral Positions: Mechanisms Of White-Matter Injury

Postdoctoral Fellow positions are available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute. The successful candidate(s) will work for Selva Baltan, MD, PhD on a comprehensive NIH R01-funded research program. Areas of interest include: 1) Investigation of the epigenetic mechanisms of white-matter injury; 2) Physiology of aging in white matter; and 3) mechanisms of mitochondrial dysfunction in white-matter stroke as a function of aging. Interested applicants should submit a curriculum vitae, a brief description of research interests and career goals, and contact information for three references to Dr. Selva Baltan via email at: baltans@ccf.org


24 11/07/2018 mccraek@ccf.org
mccraek@ccf.org

Postdoctoral Fellow

A Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute Department of Cellular and Molecular Medicine. Several project are underway including defining the effects of plasma kininogen on tumor angiogenesis and cancer stem cells, the role of extracellular vesicles in vascular complications of cancer, the structural biology of beta2-glycoprotein 1 and its role as an autoantigen and mediator of endothelial cell activation in patients with the antiphospholipid antibody syndrome, and the responses of endothelial cells differentiated from iPSC to inflammatory stimuli.  

Experience in cell culture, animal models, immunoprecipitation, analysis of signaling pathways, receptor identification, gene knockdown approaches required. Experience with bioinformatics would be a plus. A strong work ethic and ability to function in a team environment is essential.

Please send your curriculum vitae and contact information for 3 references to Keith McCrae, M.D., mccraek@ccf.org


25 11/04/2018 Mohamed Abazeed
abazeem@ccf.org

Postdoctoral Research Fellow

We are seeking a Postdoctoral Research Fellow to join our research team in the Department of Translational Hematology and Oncology Research at the Cleveland Clinic Lerner Research Institute.  Our NIH funded research program is focused on studying mechanisms that underliethe susceptibility of tumors to radiotherapy, clinicalresearch on newtreatments andtranslationalresearchto combinethese approachestoimprove the outcomes of cancer patients 

Our multi-faceted research program includes experts in computational, murine and cellular biology. We are seeking to augment our depth by hiring a dynamic scientist who enjoys working in a trans-disciplinary team environment with multi-faceted mentorship and career development opportunities.

Recent Ph.D. graduates or postdoctoral fellows with a background in molecular, cell and murine biology are encouraged to apply. The candidate should have a publication record demonstrating hands-on experimental expertise and experience in several labs skills including but not limited to: primary human cell culture, PCR, Western blotting, CRISPR, high-content cellular profiling and several murine tasks (breeding, genotyping, xenografting, administration of drugs [I.P. or by gavage] and radiation, et cetera).

Proficiency in spoken and written English are also required.

To apply, submit your CV, statement of research interests, and names and contact information of three references to: Mohamed E. Abazeed, MD, PhD, Department of Translational Hematology Oncology Research, Cleveland Clinic Foundation, 2111 East 96th St/NE6, 44195; E-mail: abazeem@ccf.org.


26 11/04/2018 Mohamed Abazeed
abazeem@ccf.org

Postdoctoral Research Fellow

The Abazeed laboratory at the Cleveland Clinic Foundation has an immediate opening for a highly motivated individual with expertise in genomic and machine learning informatics. These positions are supported by multi-sourced grants.

Fellows will lead the design and implementation of data analysis projects addressing fundamental biological questions about the causes and consequences of inter- and intra-tumoral genetic variation in cancer. These projects involve integrated analysis of high-volume genomic, epigenomic, and gene expression data (next-generation sequencing – WES/WGS, RNA-seq, Bisulfite-seq, etc.). Successful candidates will work independently and take a leading role in data analysis, interpretation, and visualization, and drafting of manuscripts for publication.

Recent PhDs in computer science, bioinformatics, computational biology, and related fields will be considered. A strong background in statistics, and programming experience in a UNIX/Linux environment using programming languages such as Perl are required. Experience in high-throughput analysis of next-generation sequencing data and familiarity with widely-used genomic databases and software are advantageous.

The candidate must have excellent verbal and written communication skills and be capable of working within a team of biologists and programmers. A background in biology is not required, but the ideal candidate will have some familiarity with genetics and genomics. This opportunity could present an outstanding training experience for someone with a solid computer science background who wishes to break into bioinformatics.

To apply, submit your CV, statement of research interests, and names and contact information of three references to: Mohamed E. Abazeed, MD, PhD, Department of Translational Hematology Oncology Research, Cleveland Clinic Foundation, 2111 East 96th St/NE6, 44195; E-mail: abazeem@ccf.org.


27 11/01/2018 Kali Casale
casalek@ccf.org

Postdoctoral Fellowship

Molecular Mechanisms and Translational Investigation of Advanced Prostate Cancer

A postdoctoral fellowship position supported by the National Institutes of Health and the Prostate Cancer Foundation are available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic. 

Our laboratory is focused on metabolic and molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy.  Specific areas include:

1)      Metabolic and genetic changes required for hormone therapy resistance in prostate cancer and tumor progression

2)      Clinical validation in patients and clinical trials utilizing innovative approaches

3)      Animal models of advanced prostate cancer for translational and therapeutic studies

4)      Identifying targets for the development of new pharmacologic therapies

We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084) and that we have shown in a predictive biomarker of poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016 17(10):1435-44; Hearn, et al. JAMA Oncol. 2018 Apr 1;4(4):558-562).  We are current evaluating this biomarker in a clinical trial and are pursuing similar mechanisms and developing new treatment modalities based on these discoveries. 

We recently also discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016 533(7604):547-51), that this is a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chemical Biology. 2017 24, 1-8, July 20) and genetic determination of metabolite generation (Alyamani, et al. J Clin Invest. 2018 Aug 1;128(8):3333-3340).

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials.  Further details are available at the following link: https://www.lerner.ccf.org/cancerbio/sharifi/#lab

Candidates should hold a doctoral degree with a background in molecular biology, chemistry, metabolism or cancer biology.  Candidates must have proficiency in verbal and written English.  Candidates with an interest in the position should send their CV and contact information for 3 references to: 

Nima Sharifi, M.D.

Kendrick Family Chair for Prostate Cancer Research

casalek@ccf.org


28 10/29/2018 Angela Ting
tinga@ccf.org

Computational Biology Postdoctoral Fellow

A Computational Biology Postdoctoral Fellow position is available in the laboratory of Dr. Angela Ting (http://www.lerner.ccf.org/gmi/ting/) at the Cleveland Clinic Lerner Research Institute. Our research focuses on understanding the functional impact of abnormal DNA methylation in cancer. We employ next generation sequencing (NGS) technologies, including Illumina short reads, PacBio, and Oxford Nanopore, to identify epigenetic changes throughout the genome and carry out mechanistic studies to define the functions of these changes and their impact on the transcriptome and cancer biology. We are particularly interested in developing and testing hypotheses for novel alterations outside of the gene promoter context as well as delineating the origin of aberrant DNA methylation in oncogenesis.

Candidates must have scientific and technical expertise in computational biology, bioinformatics, or systems biology. Preference will be given to those with experience in analysis of next generation sequencing data. Additional requirements include a Ph.D. degree in biological sciences or computer science, a strong publication record, proficiency in spoken and written English, and the ability to work/troubleshoot independently as well as understanding and incorporating findings in the scientific literature into his/her research. The postdoctoral fellow will be expected to take a lead role in data analysis, interpretation, visualization, and manuscript preparation.

Please send your curriculum vitae and contact information for 3 references to Angela Ting (tinga@ccf.org).


29 10/29/2018 Angela Ting
tinga@ccf.org

Postdoctoral Fellow

A Postdoctoral Fellow position is available in the laboratory of Dr. Angela Ting (http://www.lerner.ccf.org/gmi/ting/) at the Cleveland Clinic Lerner Research Institute. Our research focuses on understanding the functional impact of abnormal DNA methylation in cancer. We employ next generation sequencing (NGS) technologies to identify epigenetic changes throughout the genome and carry out mechanistic studies to define the functions of these changes and their impact on the transcriptome and cancer biology. We are particularly interested in developing and testing hypotheses for novel alterations outside of the gene promoter context.

Candidates must have scientific and technical expertise in molecular biology, RNA biology, biochemistry, transcription mechanisms, or gene delivery by transfection and lentivirus. Additional requirements include a Ph.D. degree in biological sciences, a strong publication record, proficiency in spoken and written English, and the ability to work/troubleshoot independently as well as understanding and incorporating findings in the scientific literature into his/her research. The postdoctoral fellow will be expected to take a lead role in data generation, analysis, interpretation, visualization, and manuscript preparation.

Please send your curriculum vitae and contact information for 3 references to Angela Ting (tinga@ccf.org).