Postdoctoral Positions

The Lerner Research Institute's Postdoctoral Fellowship includes a competitive salary and benefits package and an opportunity to work and advance in a state-of-the-art facility with more than 700,000 square feet of space.

The current postdoctoral opportunities are listed below.

Postdoctoral Fellow/Research Associate candidates will be expected to conduct research under the mentorship of a principal investigator in a predominantly independent manner. Fellows will be expected to pursue testing of hypotheses by developing experimental designs, managing and processing data and interpreting and preparing results for publication in peer-reviewed journals. Fellows will work closely with the principal investigator and will be expected to communicate effectively both in writing and in oral presentations. Qualified candidates will have successfully completed all requirements for the degree of doctorate in philosophy (Ph.D.) or doctor in medicine (M.D.) in relevant scientific programs.

Project Scientist candidates will have substantial experience at the postdoctoral or research associate level and have established a respectable record of publication. Project Scientists will work in collaboration with the principal investigator but work independently within the scientific framework of the principal investigator's laboratory. Project Scientists may seek grant funding from extramural sources in support of their research projects with the consent of the principal investigator and department chair. Project Scientist is a junior-level faculty position.

Please complete your application as directed and send to the investigator listed. We look forward to hearing from you!

# Date Contact Description
1 09/20/2018 Suneel Apte
aptes@ccf.org

A post-doctoral fellowship is available in Suneel Apte’s laboratory at the Cleveland Clinic Lerner Research Institute, Department of Biomedical Engineering. The project area will be extracellular matrix in vascular development and disease. The positions will suit PhDs, MD/PhDs or MDs with an interest in proteases, extracellular matrix, smooth muscle cell biology, mouse genetics, human vascular disease and proteomics.

 Applicants should send their curriculum vitae, a statement of research/career goals and the contact information for three references with an intimate knowledge of their work to aptes@ccf.org.


2 09/12/2018 Vijay Krishna, PhD
krishnv2@ccf.org

A Postdoctoral Research Fellow position is available in the Department of Biomedical Engineering at the Lerner Research Institute, Cleveland Clinic to study the interaction of nanomaterials with the immune system in animal models. The successful candidate will join a multidisciplinary team of investigators with primary focus on cancer immunology.

Candidates should have a Ph.D. in immunology, molecular biology, biochemistry, or a related field. The successful candidate should have demonstrated expertise in animal models of cancer and in immunological techniques, including immune cell isolation, flow cytometry and immunohistochemistry. Special consideration will be given to applicants with a background in the study of nanomaterial interactions with the immune system.

Preferred qualifications include an in-depth understanding of cancer immunotherapy; design of nanoparticles; and light-tissue and light-material interactions.

Prospective candidates must be creative, self-motivated, capable of working independently, proficient in both spoken and written communication in English. Candidates will be expected to design and conduct experiments, statistically analyze data and write manuscripts and reports.

Interested candidates should submit a brief summary of research expertise, curriculum vitae and contact information for 3 references to Dr. Vijay Krishna (krishnv2@ccf.org).


3 09/07/2018 Zihua Gong
gongz@ccf.org

Postdoctoral Fellow positions are available in the Cleveland Clinic Lerner Research Institute in the Department of Cancer Biology to investigate the DNA repair pathways in cancer development and cancer treatment.

We seek candidates with strong qualifications in the following areas: mammalian cell culture, molecular biology, biochemistry and mouse models. 

Application Requirements: A Ph.D and/or M.D. with relevant research experience is required. Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references.

Please send applications and informal inquiries to Dr. Zihua Gong at gongz@ccf.org.

The Cleveland Clinic is one of the top five medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes.


4 08/17/2018 Bruce Trapp
trappb@ccf.org

Postdoctoral Positions: Cellular/Molecular Mechanisms of Neurodegeneration and Altered Cognition in Multiple Sclerosis

Postdoctoral Fellow positions are available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute. The successful candidate(s) will work for Professor and Department Chairman Bruce Trapp on a comprehensive NIH R35-funded research program. Areas of interest include: 1) Investigation of the molecular events responsible for primary neuronal degeneration in a new subtype of multiple sclerosis. 2) Molecular and physiological consequences of learning impairment caused by hippocampal demyelination. Candidates should have a Ph.D. and/or M.D. in a relevant discipline and a background in neuroscience. Interested applicants should submit a curriculum vitae, a brief description of research interests and career goals, and contact information for three references to Dr. Bruce D. Trapp, Chairman, Department of Neurosciences, via email at: trappb@ccf.org.


5 08/16/2018 Yu-Shang Lee
leey2@ccf.org

A Postdoctoral Researcher position is available in the Department of Neurosciences at the Cleveland Clinic Lerner Research Institute to investigate the potential therapeutic intervention to promote the nerve regeneration and/or the motor, sensory and autonomic functional recovery after spinal cord injury or traumatic brain injury. The mechanisms (neuroprotection, macrophage polarization and/or demyelination) underlying these effects are also the topics of our studies. These studies are supported by fund from NIH R01, DOD and Foundation. This position offers an excellent work environment with competitive salary and benefits.

 We are seeking a highly motivated, independent, creative, and interactive scientist to work with.  Applicants with a strong background in neuroanatomy, neurophysiology, and molecular biology are encouraged to apply. Extensive experience in western blotting, real-time rtPCR, animal surgery, animal behavior, histological techniques, confocal microscopy, and related field is desirable. Applications with limited experience but highly motivated with strong work ethic may also be considered. Good English communication skills and a Ph.D. and / or M.D. in a relevant discipline are required.  Interested applicants please submit a curriculum vitae, brief description of research interests and career goals, and contact information for three references to Dr. Yu-Shang Lee via email at: leey2@ccf.org


6 08/15/2018 Florian Rieder, M.D.
riederf@ccf.org

We have an opening for a Postdoctoral Fellow position in the Dr. Florian Rieder Laboratory in the Department of Inflammation & Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and interest in studying intestinal inflammation and fibrosis and cell to extracellular matrix interactions are encouraged to apply.

A highly motivated candidate will join a productive research team to participate in NIH and industry funded projects focusing on the roles of the extracellular matrix and cell to matrix interactions during tissue inflammation and fibrosis of the intestine. The candidate should have a publication record demonstrating on-hand molecular biology and cell biology expertise.

The candidate should furthermore be familiar with primary human cell culture, Western blotting, and RNA based methods including quantitative PCR and reporter assays, immunohistochemistry and mouse models of gut inflammation. Excellent communication skills in English are essential. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Dr. Florian Rieder; Department of Pathobiology; Lerner Research Institute / NC22; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445 7156; E-mail: riederf@ccf.org.


7 08/06/2018 Philip Ahern
ahernp@ccf.org

The Ahern Group (http://www.lerner.ccf.org/cmm/ahern/), in the Department of Cellular and Molecular Medicine at the Cleveland Clinic Lerner Research Institute, seeks a postdoctoral researcher to study the interplay between the intestinal immune system and gut microbiota in the development of inflammatory bowel disease (IBD).

The gut microbiota has long been appreciated to be a major driver of the development and pathogenesis of IBD. Despite this, the specific members of the gut microbiota that are responsible for disease initiation and progression, and the molecular details of immune-microbiota interactions that promote IBD, have remained enigmatic. We have developed a strategy to systematically identify effector microbes that reside within complex microbial communities that are capable of modulating phenotypes of interest. We will leverage this approach, allied to cutting-edge microbiological and immunological techniques in gnotobiotic mouse models of IBD, to identify and characterize the microbes that contribute to the development and pathogenesis of IBD, and the mechanisms underlying these interactions. This position is ideally suited to candidates who are interested in working at the interface of immunology and microbiology in the context of inflammatory disease.

The candidate will have completed, or be close to completing, a Ph.D. degree (or M.D. with at least 3 years research experience), and have experience in cellular immunology and rodent models of inflammation OR intestinal microbiology, including genetic modification of intestinal microbes.

The candidate will join a dynamic research department (http://www.lerner.ccf.org/), whose areas of interest encompass a breadth of topics related to the cellular and molecular pathways that mediate disease. The Department is also home to a number of groups whose work focuses on the contributions of the microbiota to host health and pathology, as well as numerous state-of-the-art core facilities that facilitate these studies. Our group, and the Department as a whole, seeks to provide a stimulating and collaborative research environment, committed to the training and development of its trainees and enabling their growth as independent researchers. A competitive benefits and salary package is available.

Interested candidates should submit a cover letter (2 pages maximum) outlining their research interests, as well as a CV and the contact information for 3 references to Dr. Philip Ahern at ahernp@ccf.org   


8 08/03/2018 Ela Plow
plowe2@ccf.org

A postdoctoral fellow position is available at Cleveland Clinic’s Lerner Research Institute in the Department of Biomedical Engineering in the field of clinical neuroscience and neuro-rehabilitation. This is an exciting opportunity to join a laboratory that identifies mechanisms of plasticity and capitalizes on restorative mechanisms using rehabilitation and brain stimulation techniques to promote neurologic recovery.  

The successful candidate will have the opportunity to participate in one or more ongoing clinical trials and neuroscientific studies involving brain stimulation, rehabilitation/training and structural and functional neuroimaging.  The position requires a highly creative, motivated and independent individual with a Ph.D. in kinesiology, rehabilitation science, exercise science/physiology, biomechanics and movement science, neuroscience, or biomedical engineering or a related field. Candidates must demonstrate this experience through a record of relevant publications. Strong laboratory and clinical research skills, ability to lead as well as work well in a team, an understanding of human neuro-motor control in health and disease, and basic knowledge of human neuro-imaging would be desirable. Past experience in medical research is not required, but candidates must be willing to perform experiments in clinical settings. The successful candidate will be expected to interface with clinical staff, clinical coordinators, graduate students and fellows as well as participate in independent laboratory research. It would be desirable if candidates can begin in fall 2018.

Please send your curriculum vitae and contact information for 3 references to Ela Plow PhD PT at plowe2@ccf.org


9 07/31/2018 Olga Cherepanova, Ph.D.
cherepol@ccf.org

A Postdoctoral Fellow position is available at Cleveland Clinic's Lerner Research Institute Department of Molecular Cardiology in the Cherepanova Lab to study the role of the pluripotency/iPS factor OCT4 and its downstream signaling in vascular smooth muscle cells and endothelial cells during atherosclerosis and after vascular injury. 

Our lab is interested in molecular and cellular mechanisms responsible for smooth muscle cells and endothelial cells phenotypic transitions. We use a combination of animal and cell culture models to better understand these transitions, with the goal to develop novel therapeutic interventions for stabilizing atherosclerotic plaques in order to reduce the risk of plaque rupture with possible myocardial infarction or stroke.

Although outstanding candidates in all areas of biomedical science will be considered, special consideration will be given to individuals with strong experience/expertise in: 1) working with transgenic and knockout animals; 2) studies of atherosclerosis and/or mouse vascular injury models; 3) studies of molecular mechanisms responsible for smooth muscle cell phonotypic transitions and/or endothelial cell dysfunction.   

Applicants must have (or have nearly completed) a PhD degree or MD degree with relevant laboratory experience, as well as proficient written and oral communication skills.  The successful applicant is expected to apply for external fellowships, present results at scientific conferences, and prepare manuscripts for publication.

Review of applicants will begin immediately and continue until the position is filled. The contract will be renewed annually and extended for a period of 4 years or possibly longer, dependent upon satisfactory progress and the lab’s funding situation.

Applicants should send their CV, a statement of research interests and long term scientific goals, and the names and contact information for 3 references as a single PDF file to Dr. Olga A. Cherepanova at cherepol@ccf.org.


10 07/25/2018 Brian Gastman, M.D.
gastmanb@ccf.org

Postdoctoral Fellow or Research Associate– Tumor immunology and immunotherapeutics.

Immediate opening for a Postdoctoral Fellow position in the Gastman Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and knowledge of techniques in immunology, molecular biology and biochemistry, and with expertise in cell, animal, or human models of cancer, and specifically cancer immunity are encouraged to apply. 

Must be familiar with immunologic assays (FACS, cytotoxicity, mouse tumor models, etc..), cultivation of multiple cell lines, Western blotting, and RNA based methods including quantitative PCR and Northern blotting,  expression of exogenous proteins, and the Casp9/Crispr system.    Experience with in vivo murine models is also important.  Excellent writing skills are essential. The successful candidate will be expected to design, implement and manage research projects addressing the role of suppressor cells in the tumor microenvironment.  The applicant will have significant exposure to human specimens from a multitude of research protocols and clinical trials.  The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Our laboratory is highly collaborative and works closely with industry.  The prospective applicant would be expected to not only be involved in high level research, but also to act as an ambassador between our lab and our industry partners.  Thus, proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Brian Gastman, MD.; Department of Inflammation & Immunity; Lerner Research Institute / NE4-303; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445-6950; gastmab@ccf.org


11 07/19/2018 Feixiong Cheng
chengf@ccf.org

Postdoctoral Fellow – Network Medicine and Pharmacogenomics

We are seeking 1-2 Postdoctoral Research Fellow to join my Network Medicine and Pharmacogenomics research group in the Genomic Medicine Institute at the Cleveland Clinic Lerner Research Institute and Department of Molecular Medicine at the Cleveland Clinic Lerner College of Medicine, Case Western Reserve University. Although often described as a disease of the genome, it is perhaps more appropriate to describe cancer as a “disease of the human macromolecular interactome”. My group hypothesize that cellular networks gradually rewire throughout cancer initiation, progression and maintenance, leading to progressive shifts of local and global network properties and systems states, all of which in turn underlie tumorigenesis and disease progression. It follows that most steps of cancer initiation, progression, maintenance and metastasis should be understood by considering network models in which every perturbed interaction, biophysical, biochemical or functional, is taken into account. The primary goal of my group is to combine tools from genetics and genomics, chemical biology, network medicine, bioinformatics, computational biology, and experimental pharmacology and systems biology assays (e.g., single cell sequencing and iPS-derived cardiomyocytes), to address the challenging questions toward understanding of complex diseases (including cancer, cardiovascular disease, and Cardio-Oncology), which could have a major impact in identifying novel real-world data-driven diagnostic biomarkers and therapeutic targets for precision medicine. A highly motivated candidate will join my NIH-funded research project focusing on analyzing, visualizing, and mining data from real world (e.g., electronic health records, and health care claims) and experiments that profile the molecular state of human cells and tissues by interactomics, transcriptomics, genomics, proteomics, and metabolomics for drug discovery and precision patient care. The postdoctoral fellow will have great opportunities to collaborate with diverse groups of physicians and computational biologists, and get access the large-scale patient data at the Genomic Medicine Institute, Miller Family Heart & Vascular Institute, Taussig Cancer Institute at Cleveland Clinic, and CASE Comprehensive Cancer Center at Case Western Reserve University.

Requirements: Highly motivated candidates with a PhD/MD/PharmD degree in computational biology, bioinformatics, mathematical biology, network science, data science, genome science, pharmacogenomics, or a related field are encouraged to apply. A strong computational background, proficiency in at least one programming language (e.g., R, Python, Perl, C++, Java) and knowledge of statistics and mathematics are required. Training experience in artificial intelligence (such as machine learning and deep learning), experience working in high computing cluster environment, experience working with TCGA, ICGC, GTEx, 1000 Genomes, ENCODE, or ExAC, PDB, or other large-scale DNA-seq or RNA-seq data analysis is highly preferred. A good understanding of biology, genetics and genomics, pharmacokinetics/pharmacodynamics (PK/PD), cell signaling networks, and human protein-protein interactome is also preferred. Proficiency in spoken and written English is required.

How to Apply: Interested applicants should send a cover letter describing your research experience/skills and future research interests/plans, a curriculum vitae and the contact information of two or three references to Dr. Feixiong Cheng (chengf@ccf.org) with the subject line ‘Postdoc-Application - Your Name’.

Application Deadline: Open Until Filled


12 07/10/2018 Robert Silverman
silverr@ccf.org

Postdoctoral Fellow - Antiviral Innate Immunity and Tumor Suppression

 

A Postdoctoral Fellow position is available immediately in the Cleveland Clinic Lerner Research Institute, Department of Cancer Biology.  The area of study concerns the molecular basis for the antiviral and antitumor activities of interferon.  The OAS-RNase L system is a frontline host defense against pathogenic viruses that contributes to the survival of higher vertebrates.  Our studies aim to identify and investigate protein targets that mediate host cell resistance to viruses while minimizing the threat of excessive RNase L activation to the host. The data obtained may contribute to identifying therapeutic strategies for viral infections, cancer and a genetic disease that we have linked to the OAS-RNase L pathway.  An exceptional and interactive research environment with core facilities is available.  A Ph.D. with emphasis in virology, cancer biology, biochemistry, or related fields is required.  Expertise in protein and nucleic acid biochemistry is highly desirable.  The ideal candidate will be highly motivated and capable of substantial intellectual contributions to the research.   Please visit our website www.lerner.ccf.org/cancerbio/silverman/.  Send curriculum vitae including names and contact information for 3 references to: silverr@ccf.org


13 06/21/2018 Jan Claesen
claesej@ccf.org

Postdoctoral Fellow – Functional Microbiome

We are looking for a Postdoctoral Fellow excited about advancing our mechanistic understanding of the Human Microbiome, to join the Claesen group at the Cleveland Clinic Lerner Research Institute. http://www.lerner.ccf.org/cmm/claesen/

Our aim is to functionally characterize molecular mechanisms that control bacterial interspecies and microbe-host interactions in the human microbiome. Bacteria use small molecule chemicals to mediate these interactions and the genetic information required for their production is typically encoded in one physical location of the bacterial chromosome, in biosynthetic gene clusters (BGCs). Using in silico techniques, we identified several widespread families of BGCs that we are now characterizing experimentally, prioritizing on the BGCs predicted to be involved in modulation of community composition or interaction with the host immune system. Our research will contribute to a better mechanistic understanding of the microbes that live in our body, leading to the discovery of druggable small molecules, new targets for antibacterial therapy and beneficial bacterial strains that can be employed for intervention therapies.

Your profile

Candidates will have (or are close to obtaining) a PhD degree in a relevant biological or chemical subject and a good publication record in peer-reviewed scientific journals. Hands-on experience with microbiological, molecular genetics and standard biochemical techniques is required. Prior experience in mouse infection/colonization models is highly desirable.

About us

The areas of expertise in the Claesen group include microbiology, bacterial genetics and synthetic biology, small molecule biosynthesis and biochemistry. We provide a stimulating, multidisciplinary training environment that will assist you in your successful scientific development. You will receive a competitive salary and benefits package, and have access to state-of-the-art core facilities in the Lerner Research Institute (http://www.lerner.ccf.org/), as well as plenty of opportunities for clinical collaboration at the Cleveland Clinic, the #2 Hospital in the Nation.

How to apply

Interested applicants should submit a cover letter describing research accomplishments and interests (no more than 2 pages), a CV and contact information for 3 references to Dr. Jan Claesen (claesej@ccf.org) by Saturday September 1, 2018. Thereafter, applications will be considered on a rolling basis.


14 06/20/2018 Tatiana Byzova
byzovat@ccf.org

For many years, Cleveland Clinic and Lerner Research Institute have been at the forefront of biomedical research. Applicants are invited to fill two unique positions as Cleveland Clinic’s Molecular Cardiology Scholars.

We seek researchers with experience in molecular and cell biology, integrin and growth factor signaling and/or vascular biology and animal models. Applicants must document their success during their PhD or initial postdoctoral studies by first-author publications in reputable journals. The chosen candidates will have an opportunity to work with several PIs on projects interlinking Vascular Biology and Inflammation. The projects integrate molecular and cellular biology approaches (adhesions dynamics, migration in 3D, mechanotransduction) and state-of-the-art in vivo models and multi-photon imaging to address important biomedical problems. We emphasize motivation and productive work in a collegial environment and an opportunity for translational and clinical collaborations. For further details see published works: West et al, Nature, 2010; Ding et al., Cell Metab. 2012; Kerr et al.,  Sci Signal., 2013. Applications from motivated and skilled individuals with MS or BS degrees are also invited for a position of research technologist on these projects.

The institution has a history of offering outstanding benefits to its employees.

Applicants should send curriculum vitae and names and addresses of three references to:

Dr. Tatiana Byzova                           

Email: byzovat@ccf.org                          

Department of Molecular Cardiology

Angiogenesis Center

Taussig Cancer Center

The Cleveland Clinic

9500 Euclid Avenue, Cleveland, OH 44195

Phone: (216) 444-1019; Fax: (216) 445-8204


15 06/18/2018 Kenneth Baker
bakerk6@ccf.org

A Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute Neurosciences Department. The Neurosciences Department of the Cleveland Clinic Lerner Research Institute is seeking a postdoctoral fellow to support federally-funded projects exploring novel neurostimulation-based approaches for the treatment of Parkinson’s disease and acquired brain injury. The successful applicant will participate in work that combines behavior assessments of therapeutic efficacy with a systems-based approach to explore neurophysiological changes across the sensorimotor brain networks in both humans and preclinical models of disease. Ph.D. (or equivalent) students with relevant education or experience in neurophysiology, biomedical engineering, or motor control are invited to apply, though preference will be given to candidates with experience in array-based multi-unit neuronal or local field potential signal processing techniques.

Please send your curriculum vitae and contact information for 3 references to Dr. Kenneth Baker, Neurosciences Department (bakerk6@ccf.org).


16 06/13/2018 Omar Mian, MD, PhD
miano@ccf.org

Postdoctoral fellow positions are available in the laboratory of Omar Mian, M.D., Ph.D., in the Department of Translational Hematology and Oncology Research (THOR) at the Cleveland Clinic’s Lerner Research Institute in Cleveland, OH.  

Currently funded projects focus on studying epigenetic, metabolic, and endocrine determinants of response to DNA damage in a variety of cancers. The work involves characterization of innovative preclinical models using genome editing and molecular analysis methods. Clinical samples are readily available for validation studies. The position offers excellent opportunities for publication and career development in a stimulating academic environment.

Highly motivated individuals with a strong background and interest in translational cancer research, and with the ability to multitask in a fast-paced lab, are encouraged to apply. Applicants must be recent Ph.D. or M.D./Ph.D. graduates in cell biology, molecular biology, cancer biology, molecular genetics, developmental biology or related fields. Prior experience in culture of human primary and cancer cell lines, molecular biology, as well as a track record of peer-reviewed publications is required. Individuals with additional experience in genome editing, mouse work or bioinformatics, are strongly encouraged to apply.

Interested applicants should send a CV, a cover letter/statement that describes career goals, and 3 references to Dr. Omar Mian (miano@ccf.org).


17 06/11/2018 Mohamed Abazeed
abazeem@ccf.org

We are seeking a Postdoctoral Research Fellow to join our research team in the Department of Translational Hematology and Oncology Research at the Cleveland Clinic Lerner Research Institute.   Our NIH funded research program is focused on studying mechanisms that underliethe susceptibility of tumors to drugs and radiotherapy, clinicalresearch on newtreatments andtranslationalresearchto combinethese approachestoimprove outcomes of cancer patients.

Recent Ph.D. graduates or 1st year Postdoctoral Fellows who are looking for a dynamic science career and working in a multidisciplinary team with a background in molecular, cell and murine biology are encouraged to apply.  The candidate should have a publication record demonstrating hands-on experimental expertise. 

The candidate should be experienced in the following list of experimental techniques: primary human cell culture, Western blotting, quantitative PCR, high-content cellular profiling, immunohistochemistry and xenograft mouse models. Proficiency in spoken and written English are required. The appointee could take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship. 

Applicants are encouraged to send a cover letter and CV and contact information for 3 references to: Dr. Mohamed Abazeed/Department of Translational Hematology and Oncology Research/ Lerner Research Institute / NE6-258/ Cleveland Clinic/9500 Euclid Avenue/ Cleveland, Ohio. (216) 445-5268/E-mail: abazeem@ccf.org.


18 06/06/2018 Dr. Gail Cresci
dr. gail cresci

We have an opening for a Postdoctoral Research Fellow position in the Dr. Gail Cresci Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic.  Individuals with experience and interest in studying gut microbiome and metabolome on intestinal inflammation and immunity are encouraged to apply.  

A highly motivated candidate will join a productive research team to participate in NIH and industry funded projects focusing on the roles of altered intestinal microbiome and metabolome during antibiotic and pathogen exposure.  The candidate should have a publication record demonstrating hands-on microbiology, molecular biology and cell biology expertise. 

The candidate should furthermore be familiar with primary human cell culture, Western blotting, and RNA based methods including quantitative PCR and reporter assays, immunohistochemistry and mouse models of gut inflammation. Excellent communication skills in English are essential. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship. 

A recent (or close to obtaining) Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Dr. Gail Cresci; Department of Inflammation and Immunity; Lerner Research Institute / NB2; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 445 0874; E-mail: crescig@ccf.org.

 

 


19 06/05/2018 Qing Wang
WANGQ2@ccf.org
A senior experienced Postdoctoral Fellow/Research Associate is needed for a newly-created Director for the Animal Model Core in the Department of Molecular Cardiology at Cleveland Clinic Lerner Research Institute.  Applicants should have experience in mouse surgical procedures such as MI, TAC, thrombosis, vascular injury, and/or other models for cardiovascular diseases.  A successful applicant should have a Ph.D., M.D., or Ph.D./M.D. with excellent communications skills and an interest in independent as well as collaborative research opportunities with other faculty members in the instituteCandidates with a DVM and relevant research or mouse surgery experience will also be considered.

Applicants should send a CV as well as names and contact information of 2-3 referees to:

Dr Qing Wang, Department of Molecular Cardiology, Lerner Research Institute/NB50, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH 44195; Email: wangq2@ccf.org.  


20 06/05/2018 Dr. Daniel Rotroff
rotrofd@ccf.org

Position Title: Postdoctoral Research Fellow

Duties and Responsibilities: The Rotroff Lab in the Department of Quantitative Health Sciences (QHS) at the Cleveland Clinic is seeking one driven and enthusiastic applicant with an interest in using quantitative approaches to drive advancements in precision medicine. An ideal candidate should enjoy working in an interdisciplinary environment and have a background in bioinformatics, pharmacogenomics, statistics, biostatistics, or computational biology. 

Our work is focused on finding new and creative ways to develop predictive signatures of adverse outcomes and drug response in complex diseases. Exciting areas we are currently pursuing include new methods for identifying subtypes within disease classifications (e.g., type 2 diabetes) and developing whole genome prediction models. The successful applicant will have opportunities to lead projects, publish papers, occasionally be involved in grant writing, collaborate with clinicians and basic scientists, attend national conferences, develop novel methodology, and work with data from multiple -omics platforms including genomics, epigenomics, metabolomics, and data from electronic health records.

A highly supportive and dynamic environment will be provided to help in the transition to an independent research career. QHS is located in the Lerner Research Institute of the Cleveland Clinic and consists of an active group of >90 QHS faculty, biostatisticians, analysts, data scientists, and programmers working in diverse areas of biomedicine. The Cleveland Clinic is currently ranked as the No. 2 hospital in the country by U.S. News & World Report (2017-2018).

Position Qualifications: The application should have a Ph.D. degree in one of the following areas: Bioinformatics, Statistics, Genetics, Biostatistics, Computer Science, Computational Biology, or a related field. Programming experience in R or scripting languages such as Python/Perl on Unix/Linux is required. An ideal candidate will also have knowledge in genetics, pharmacology, and/or pathology, but is not required.  

Salary Range: Salary is competitive and commensurate with qualification. Benefits will be in accordance with Cleveland Clinic standard postdoctoral benefits.

Application Address: Interested applicants should send the following documents to Dr. Daniel Rotroff at rotrofd@ccf.org:

1.     A cover letter

2.     Statement of research interest

3.     Curriculum Vitae

4.     Contact information for at least three references

Application Deadline: Open until filled.


21 06/04/2018 Vijay Krishna
krishnv2@ccf.org

A Postdoctoral Research Fellow position is available in the Department of Biomedical Engineering at the Lerner Research Institute, Cleveland Clinic to study the interaction of nanomaterials with the immune system in animal models. The successful candidate will join a multidisciplinary team of investigators with primary focus on cancer immunology.

Candidates should have a Ph.D. in immunology, molecular biology, biochemistry, or a related field. The successful candidate should have demonstrated expertise in animal models of cancer and in immunological techniques, including immune cell isolation, flow cytometry and immunohistochemistry. Special consideration will be given to applicants with a background in the study of nanomaterial interactions with the immune system.

Preferred qualifications include an in-depth understanding of cancer immunotherapy; design of nanoparticles; and light-tissue and light-material interactions.

Prospective candidates must be creative, self-motivated, capable of working independently, proficient in both spoken and written communication in English. Candidates will be expected to design and conduct experiments, statistically analyze data and write manuscripts and reports.

Interested candidates should submit a brief summary of research expertise, curriculum vitae and contact information for 3 references to Dr. Vijay Krishna (krishnv2@ccf.org).


22 06/03/2018 Zihua Gong
gongz@ccf.org
We are currently seeking ambitious, enthusiastic, and motivated Postdoctoral Fellows to join our research team in the Department of Cancer Biology at the Cleveland Clinic Lerner Research Institute. Our lab is focused on understanding the DNA repair pathways in cancer development and cancer treatment. Current studies include DNA repair pathway choice in cancer treatment and various DNA damage proteins in replication stress. We seek candidates with strong qualifications in the following areas: mammalian cell culture, molecular biology, biochemistry and mouse models. Recent Ph.D. graduates or 1st year Postdoctoral Fellows who are committed to a dynamic career in science are especially encouraged to apply. Application Requirements: A Ph.D and/or M.D. with relevant research experience is required. Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references. Send applications and informal inquiries to Dr. Zihua Gong at gongz@ccf.org. The Cleveland Clinic is one of the top five medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes.
23 05/23/2018 Jessica Williams, PhD
williaj39@ccf.org

A Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute in the Department of Neurosciences to investigate adaptive immune responses in central nervous system (CNS) glia in the context of autoimmunity and repair. 
 
The successful candidate will help lead a multidisciplinary team to elucidate novel mechanisms that impact injury and recovery during CNS autoimmunity, focusing on Multiple Sclerosis. Research projects include: 1) elucidating cytokine-mediated intercellular communication networks in glia during CNS development and repair and 2) investigating the role of glia-specific cytokine signaling during neuroinflammation. A strong work ethic, proficiency in verbal and written English, and a PhD and/or MD are required. Experience with murine models of human disease and expertise in neuroscience and/or immunology are strongly preferred. 
 
Please send your curriculum vitae, a brief description of your research interests, and contact information for 3 references to Jessica Williams, PhD (williaj39@ccf.org).


24 05/18/2018 Dr. Hannelore Heemers
heemerh@ccf.org

We are currently seeking an ambitious, enthusiastic, and self-motivated Postdoctoral Fellow to join our research team in the Department of Cancer Biology at the Cleveland Clinic Lerner Research Institute.  Our NIH- and DOD-funded research program is focused on understanding the therapeutic potential of discrete mechanisms of androgen action in prostate cancer. Current studies include targeting contribution of coregulators to androgen action and inhibiting indirect mechanisms of androgen action. We seek candidates with strong qualifications in the following areas: molecular and cellular biology, genomics and human tissue culture techniques. Preferred candidates have a background in integrated cancer biology approaches, have previous experience with systems biology, and function well in a multidisciplinary team to ascertain the clinical applicability of bench results. Recent Ph.D. graduate or 1st year Postdoctoral Fellows who are committed to a dynamic career in science are especially encouraged to apply. A Ph.D and/or M.D. with relevant research experience is required.  Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references. Send applications and informal inquiries to Dr. Hannelore Heemers (heemerh@ccf.org). The Cleveland Clinic is one of the top medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes. 


25 05/09/2018 Kali Casale
casalek@ccf.org

Drug Discovery for Advanced Prostate Cancer

A postdoctoral fellowship position for drug discovery is available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic in the Department of Cancer Biology. 

Our laboratory and translational research program is focused on metabolic and molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy. 

A postdoctoral fellowship is available for drug discovery against a newly credentialed molecular target against prostate cancer.  The candidate will take a leading role in the development of a compound screening assay for the identification and validation of a lead inhibitor compound against the molecular target, defining the mechanism of compound interaction with the target and optimizing the properties and potency of the lead compound.

The ideal candidate has a Ph.D. degree in biochemistry, chemistry or molecular biology and has the appropriate expertise that can be applied to drug development.  Outstanding verbal and communication skills are required.

We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084), that we have shown drives poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016 17(10):1435-44; Hearn, et al. JAMA Oncol. 2017 Oct 12), yet serves as a tumor vulnerability to alternative steroid ablation inhibitors (Almassi, et al. JAMA Oncol. 2017 Oct 12). 

We recently also discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016 533(7604):547-51), and that this is a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chemical Biology. 2017 24, 1-8, July 20).   

The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials.  Further details are available at the following link: https://www.lerner.ccf.org/cancerbio/sharifi/#lab

Candidates with an interest in the position should send their CV and contact information for 3 references to: 

Nima Sharifi, M.D.

Kendrick Family Chair for Prostate Cancer Research

casalek@ccf.org

 

 

 


26 05/07/2018 Vijay Krishna, PhD
krishnv2@ccf.org

A Postdoctoral Fellow position is available in the Department of Biomedical Engineering at the Lerner Research Institute, Cleveland Clinic to study the interaction of nanomaterials with skin and tumor tissues in animal models. The successful candidate will join a multidisciplinary team of investigators with primary focus on design of cancer preventative agents.

Candidates should have a Ph.D. in molecular biology, biochemistry, biomedical engineering or a related field. The successful candidate should have demonstrated expertise in murine models of cancer and in molecular biology techniques, including histological analysis and immunohistochemistry. Special consideration will be given to applicants with additional expertise in synthesis of nanomaterials, design of drug formulation; and knowledge of light-tissue and light-material interactions.

Prospective candidates must be creative, self-motivated and capable of working independently and in a team. Candidates must be proficient in both spoken and written communication in English. Candidates will be expected to design and conduct experiments, statistically analyze data and write manuscripts and reports.

Interested candidates should submit a brief summary of research expertise, curriculum vitae and contact information for 3 references to Dr. Vijay Krishna (krishnv2@ccf.org)


27 05/07/2018 Steven E. Wilson, MD PI
wilsons4@ccf.org

A Postdoctoral Fellow position is available in Ophthalmic Research in the Cleveland Clinic Cole Eye Institute for applicants within 4 years of Ph.D. and/or M.D. degree to join group investigating corneal fibrosis (haze) in the cornea produced by myofibroblasts that differentiate from bone marrow-derived cells and resident fibroblastic cells, and also to study basement membrane regeneration and the role of the basement membrane in regulating cytokine-mediated epithelial-stromal cell interactions. Applicants must have expertise in cellular and molecular biology laboratory techniques, in addition to excellent proficiency in written and spoken English. Due to training grant funding source applicants must be a US citizen or permanent resident of the US.

Please send your curriculum vitae and contact information for 3 references to Steven E. Wilson, MD, Professor of Ophthalmology and Director of Corneal Research wilsons4@ccf.org


28 05/02/2018 Ryota Matsuoka
matsuor@ccf.org

A postdoctoral position is available in Ryota Matsuoka’s Laboratory in the Department of Molecular Cardiology at Cleveland Clinic Lerner Research Institute. This newly established group starting in April, 2018, aims to define the cellular and molecular basis of vascular and lymphatic assembly in the central nervous system (CNS) using zebrafish and mouse as model organisms. Dr. Matsuoka’s past work addressed how the vascularization of tissues surrounding the spinal cord is established in zebrafish (Matsuoka et al. eLife, 2016: PNAS, 2017) and how retinal neural circuits are organized in mouse (Matsuoka et al. Nature, 2011: Neuron, 2011). The future lab projects are directed towards understanding dynamic coordination of neuronal and vessel growth at the cellular and molecular level, which leads to the formation of the mature, functional CNS in vertebrates. The lab uses a combination of advanced 3D imaging, forward and reverse genetic approaches to uncover this coordinated process during development and regeneration, with the goal to reconstitute fully vascularized functional neuronal tissues following CNS disease/injury.

The successful applicant is expected to apply for external fellowships, present data at scientific conferences, and prepare manuscripts for publication. Candidates with a publication record in developmental biology, genetics, neuroscience, or cell biology are preferred. Former experiences working with zebrafish or other animal models are also preferred.

Review of applicants will start immediately and continue until the position is filled. The contract will be renewed annually and extended for a period of 4 years and possibly longer, dependent upon satisfactory progress and the lab’s funding situation. Interested individuals should submit a single PDF file containing the following materials to matsuor@ccf.org:

1) CV, including publication list and contact information for 2‐3 references

2) Cover letter describing previous research, research interests, and career goals


29 04/18/2018 amit anand
ananda@ccf.org

We are looking for a PhD level post-doctoral fellow researcher in brain imaging analysis. The researcher will work with the Principal Investigator in conducting research in neurobiological basis of neuropsychiatric disorders, using brain imaging and bioinformatics techniques to combine behavioral data, imaging data and human genetic datasets.  High degree of mathematical and programming expertise required.  Use operating systems such as Linux, Unix and Matlab as well as Brain Imaging Analysis software. Be able to use statistical packages such as SPSS, SAS or R to conduct analysis.   Coordinate data collection, organization and analysis and preparation of publications and grant applications. Ensure accurate and satisfactory implementation of research protocols and comply with requirements of all regulatory bodies. they can contact me at ananda@ccf.org

  No time frame; the position is available now. 


30 04/17/2018 Laura Nagy
nagyl3@ccf.org

A Postdoctoral Fellow position is available in the Cleveland Clinic in the laboratory of Dr. Laura Nagy in the Department of Inflammation and Immunity to study the effects of ethanol on the innate immune system, including toll-like receptor signal transduction and complement activation.  The research will focus on the effects of chronic ethanol on key signal transduction pathways in hepatic innate immune cells (macrophages, infiltrating monocytes, neutrophils, etc) with a goal towards understanding the mechanism of development of chronic inflammatory responses in liverin order to develop rationale therapeutic interventions.  Our recent work using next generation sequencing of miRNA indicates that ethanol targets multiple levels in the regulation of cytokine expression leading to the development of alcoholic liver disease. We are also interested in identifying biomarkersand genetic risk factors for disease severity in a cohort of patients with alcoholic liver disease.

Experience in at least one of the following areas is desired:  cell biology, signal transduction, molecular biology, bioinformatics or macrophage biology. Experience in experimental design and data analysis in both cultured cells and animal models is preferred.  Strong written and oral communication skills are required.

Candidates should have a recent PhD in cell biology, immunology, biochemistry, or a related discipline and experience in signal transduction and cell biology. 

Interested applicants please submit a CV and names and contact information for three references to Dr. Laura Nagy, Department of Inflammation and Immunity (NE40) at Lerner Research Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland OH 44195 or via email to nagyL3@ccf.org


31 03/28/2018 Ela Plow PhD PT
plowe2@ccf.org

A postdoctoral fellow position is available at Cleveland Clinic’s Lerner Research Institute in the Department of Biomedical Engineering in the field of clinical neuroscience and neuro-rehabilitation. This is an exciting opportunity to join a laboratory that studies mechanisms of brain plasticity in neurologic recovery and targets these mechanisms with the use of behavioral and neuro-stimulation interventions to promote recovery. The successful candidate will have the opportunity to participate in clinical trials and neuroscientific studies, including an ongoing FDA-regulated clinical trial combining the use of non-invasive (transcranial) and invasive (deep) brain stimulation, and stroke recovery studies involving movement rehabilitation and neuroimaging.  

The position requires a highly creative, motivated and independent individual with a Ph.D. in kinesiology, rehabilitation science, exercise science/physiology, biomechanics and movement science, neuroscience, biomedical engineering or a related field. Candidates must demonstrate this experience through a record of relevant publications. Strong laboratory and clinical research skills, ability to lead and work well in a team, an understanding of human motor control in health and disease, and basic knowledge of neuroimaging and neurophysiology would be desirable. Past medical research is not required, but candidates must be willing to perform experiments in clinical settings. The successful candidate will be expected to interface with clinical staff, clinical coordinators, graduate students and fellows as well as participate in independent laboratory research. It would be desirable if candidates can begin in spring/summer 2018.

Please send your curriculum vitae and contact information for 3 references to Ela Plow PhD PT at plowe2@ccf.org


32 03/27/2018 Srinivasan Dasarathy MD
dasaras@ccf.org

We have an immediate opening for a Postdoctoral Fellow position in the Dr. Dasarathy Laboratory in the Department of Inflammation and Immunity at the Cleveland Clinic Lerner Research Institute. Individuals with experience and interest in studying signal transduction during metabolic perturbations are encouraged to apply. The laboratory focus is on using integrated molecular metabolic approaches in a comprehensive array of cellular, mouse, and human models.

A highly motivated candidate will join a productive research team to participate in NIH funded projects focusing on the molecular mechanisms of skeletal muscle loss and metabolic perturbations in disease. The candidate should have a publication record demonstrating on-hand molecular biology and cell biology expertise.

Must be familiar with mesenchymal cell culture (preferably skeletal muscle), Western blotting, and RNA based methods including quantitative PCR and reporter assays, subcloning between different vectors, lenti- retro- and adenoviral systems for cDNA and shRNA delivery. Preference will be given to candidates with previous experience in skeletal muscle biology, CRISPR/Cas9-dependent gene editing, confocal microscopy/cell imaging or mouse models of muscle loss. Excellent communication skills in English are essential. The appointee will be expected to take advantage of this career opportunity to develop skills in manuscript publication and grantsmanship.

Ph.D. or M.D. with relevant laboratory experience is required. Proficiency in spoken and written English is required.  Send cover letter and CV and contact information for 3 references to: Dr. Srinivasan Dasarathy; Department of Pathobiology; Lerner Research Institute / NE4 208; Cleveland Clinic; 9500 Euclid Avenue; Cleveland, Ohio 44195. (216) 636-0096; E-mail: dasaras@ccf.org.



Submission of resumes will be considered an expression of interest in the available opportunity. Applicants who best meet the education and experience requirements of the position will be contacted by the interviewing department. Cleveland Clinic is proud to be an equal opportunity employer and a smoke-free/drug-free environment.