Postdoctoral Positions

The Lerner Research Institute is home to Cleveland Clinic's basic research departments and more than 2,000 scientists and support personnel. Research teams of more than 150 Faculty, 240 Postdoctoral Fellows and nearly 200 graduate students pursue a wide range of biomedical questions in our laboratories. The Institute's Postdoctoral Fellowship includes a competitive salary and benefits package and an opportunity to work and advance in a state-of-the-art facility with more than 700,000 square feet of space. Total annual research expenditures approached $250 million in 2011, including more than $110 million in federal funding.

The current postdoctoral opportunities are listed on the left. Please complete your application as directed and send to the investigator listed. We look forward to hearing from you!

Positions for Project Scientists, Research Associates and Postdoctoral Fellows posted by principal investigators.


#767 | Jessica Williams | Department of Neurosciences

  • Job Post Date: 10/19/2017
  • Job Title: Postdoctoral Fellow in the Williams Lab
  • Contact: Jessica Williams williaj39@ccf.org
  • Description:

    A Postdoctoral Fellow position is available at the Cleveland Clinic Lerner Research Institute in the Department of Neurosciences to investigate adaptive immune responses in central nervous system (CNS) glia in the context of autoimmunity and repair.

    The successful candidate will help lead a multidisciplinary team to elucidate novel mechanisms that impact recovery following autoimmune CNS injury. Research projects include: 1) elucidating cytokine-mediated intercellular communication networks in glia during CNS development and repair; and 2) investigating the role of glia-specific cytokine signaling during neuroinflammation. A strong work ethic, proficiency in verbal and written English, and a PhD and/or MD are required. Experience with murine models of human disease and expertise in neuroscience and/or immunology are strongly preferred.

    Please send your curriculum vitae, a brief description of your research interests, and contact information for 3 references to Jessica Williams, PhD (williaj39@ccf.org). 


#765 | Stacy Menser | Department of Molecular Cardiology

  • Job Post Date: 10/12/2017
  • Job Title: Molecular Cardiology Scholars
  • Contact: Stacy Menser mensers@ccf.org
  • Description:

    For many years, Cleveland Clinic and Lerner Research Institute has been at the forefront of biomedical research. Applications are invited to fill a unique position as the Cleveland Clinic’s Molecular Cardiology Scholars.

    We seek researchers with experience in molecular and cell biology and experience with murine models. Applicants must document their success during their PhD or initial postdoctoral studies by first-author publications in reputable international journals. The chosen candidates will have an opportunity to work with several PIs on the molecular mechanisms of angiogenesis, atherosclerosis and thrombosis. The projects integrate analytical chemistry, molecular and cellular biology and state-of-the-art in vivo models to address important biomedical problems. We emphasize motivation and productive work in a collegial environment and an opportunity for translational and clinical collaborations. For further details see published work: West et al, Nature, 2010 ; Ding et al., Cell Metab. 2012;  Kerr et al,  Sci Signal., 2013.   The institution has a history of offering outstanding benefits to its employees.

     

    Applicants should send curriculum vitae and names and addresses of three references to:

     Stacy Menser

    mensers@ccf.org

    216-445-9487

    Department of Molecular Cardiology,  NB50

    Cleveland Clinic

    9500 Euclid Avenue

    Cleveland, OH 44195


#764 | Zong-Ming Li, PhD | Department of Biomedical Engineering

  • Job Post Date: 10/11/2017
  • Job Title: Postdoctoral Fellow
  • Contact: Zong-Ming Li, PhD liz4@ccf.org
  • Description:

    Hand Biomechanics Postdoc Position

    A Postdoctoral Fellow position is available in the Hand Research Laboratory, Department of Biomedical Engineering of the Lerner Research Institute at Cleveland Clinic. The projects will involve investigating the biomechanics of the hand/wrist. Applicants must have (1) a Ph.D. demonstrating creative and independent research, (2) a background in biomechanics, biomedical engineering, orthopaedics, rehabilitation, or closely related field, and (3) excellent written and oral communication skills in English. It is expected that applicants are highly self-motivated, possess a good balance of technical expertise and analytical thinking, and can work well both independently and collaboratively on interdisciplinary projects. Applications for this position should be sent to Dr. Zong-Ming Li (liz4@ccf.org) and include a cover letter, CV, and contact information for three references. For more information about the Hand Research Laboratory, please visit www.handlab.org or www.lerner.ccf.org/bme/li/.


#763 | Ming Hu | Department of Quantitative Health Sciences

  • Job Post Date: 10/09/2017
  • Job Title: Postdoctoral Research Fellow
  • Contact: Ming Hu hum@ccf.org
  • Description:

     

    Position Title: Postdoctoral Research Fellow

    Duties & Responsibilities: We are seeking one motivated and creative applicant with quantitative research background in bioinformatics, computational biology, statistics, biostatistics or computer science to join an active and collegial research team, co-led by Dr. Ming Hu (Cleveland Clinic) and Dr. Bing Ren (University of California San Diego and Ludwig Institute for Cancer Research). Appointment would be in Department of Quantitative Health Sciences, Lerner Research Institute, and Cleveland Clinic. 

    This work is a key component of the cutting-edge 4D nucleosome project, funded by NIH, and involve the development and application of statistical methods and computational tools for the understanding of gene transcription regulation mechanism. The postdoc will also have great opportunities to collaborate with other researchers from the Cleveland Clinic. The postdoc will collaborate with researchers in 4D nucleosome, 1000 Genome, Roadmap Epigenomics and ENCODE projects. Dr. Hu and Dr. Ren will co-mentor the postdoc and provide highly supportive and dynamic environments to help in the transition to an independent researcher.

    Position Qualifications: The applicant should have a Ph.D. degree in one of the following areas: Bioinformatics, Computational Biology, Statistics, Biostatistics, Computer Science, or other discipline with strong quantitative background. Knowledge in biology or genetics is desired but not required. Programming experience in statistical program R and scripting languages such as Perl/Python on Unix/Linux systems is required. Experience with C/C++ is a strong plus. Applicants should have quantitative background with strong statistical and computational skills.

    Salary Range: Salary is competitive and commensurate with qualification. Benefits will be in accordance with Cleveland Clinic standard postdoctoral benefits.

    Application Address: Interested applicants should email the following materials to Dr. Ming Hu. Email address: afhuming@gmail.com and hum@ccf.org

    •       A cover letter;
    •       A statement of research interest;
    •       Curriculum Vitae;
    •       Sample codes from recent programming;
    •       Publication reprints;
    •       Contact information of at least three references.

    Review of applications starts immediately. Applications will be considered until the position is filled. The Department of Quantitative Health Sciences has over 90 members and provides an excellent environment for methodological and collaborative research. QHS faculty interact with researchers and clinicians across the Cleveland Clinic, one of the leading academic medical institutions in the world.  

    Application Deadline: 05/31/2018.


#762 | Bo Hu | Department of Quantitative Health Sciences

  • Job Post Date: 09/29/2017
  • Job Title: Postdoctoral Fellow
  • Contact: Bo Hu hub@ccf.org
  • Description:

    A Postdoctoral Fellow position is available in the Cleveland Clinic [LRI/Quantitative Health Sciences]

    Our team has access to “big data” from multiple platforms, including various omics data (WGS, mitochondrial sequencing, metabolomics, epigenetics, etc.), electronic health records and well-annotated clinical phenotypes. The candidate’s responsibilities involve developing novel statistical methods, machine learning algorithms and computational tools to identify disease biomarkers and networks, build predictive models and discover new therapeutic interventions. The postdoc will have great opportunities to collaborate with physicians and scientists at the Cleveland Clinic.  

    The applicant should have a Ph.D. degree in one of the following areas: Bioinformatics, Computational Biology, Statistics, Biostatistics, Computer Science, or other discipline with strong quantitative background. Knowledge in biology or genetics is desired but not required. The candidate should be familiar with program languages R, Perl or Python. Experience with C/C++ is a strong plus. 

     

    Please send your curriculum vitae and contact information for 3 references to Bo Hu (hub@ccf.org)


#761 | Xiaojuan Li | Department of Biomedical Engineering

  • Job Post Date: 09/06/2017
  • Job Title: Postdoctoral Fellow
  • Contact: Xiaojuan Li lix6@ccf.org
  • Description:

    The Lerner Research Institute, The Institute of Orthopaedics and Rheumatology, and the Imaging Institute at the Cleveland Clinic, is forming an exciting new Program in Advanced Musculoskeletal Imaging (PAMI).  PAMI will build upon nationally top-ranked clinical care and research in orthopaedics and rheumatology and outstanding resources for imaging research already available at Cleveland Clinic, and new collaborations across institutes within Cleveland Clinic and with investigators around the world. The mission of PAMI is to advance musculoskeletal imaging, in particular advanced quantitative imaging, in healthcare for orthopaedics and rheumatology through technology development, translational research and education.

     

    PAMI is looking for highly-motivated candidates for two post-doctoral research fellow/research staff positions in the field of musculoskeletal MR imaging and image processing. The research projects include development of novel pulse sequences of in vivo MSK MRI, image processing and analysis, and their clinical applications to musculoskeletal diseases. In particular, the sequence development will include developing advanced accelerated quantitative MSK imaging using cutting edge fingerprinting, compressed sensing and deep learning reconstruction. The image processing projects will develop advanced MSK imaging processing tools using classical techniques and cutting edge deep learning techniques. Successful candidates will join a multidisciplinary team with rich resources and strong support for a successful career development, and will have access to research dedicated MR systems (Siemens 3T and 7T), and other clinical scanners across different campus at CCF, as well as large outcome databases for patients in orthopaedics and rheumatology.

    Requirements: A PhD degree in physics, biomedical engineering, electrical engineering, computer science, biochemistry or related field; background in MRI or NMR; strong programming skills with C, C++, Matlab; strong communication skills in written and verbal English. Experience in MR pulse sequence programming or advanced image processing algorithm development is a plus.

    Applicants should email a CV, along with a brief letter outlining their research background and interests and a list of two to three references to Dr. Xiaojuan Li: lix6@ccf.org


#760 | Daniel Blankenberg | Genomic Medicine Institute

  • Job Post Date: 09/01/2017
  • Job Title: Postdoctoral Fellow
  • Contact: Daniel Blankenberg blanked2@ccf.org
  • Description:

    The Blankenberg Lab in the Genomic Medicine Institute at the Cleveland Clinic Lerner Research Institute has several Postdoctoral Fellowships available. We utilize high-throughput omics technologies, such as next generation sequencing, and data-intensive computing to explore biomedical research questions. The PI is a founding member of the Galaxy Project (https://galaxyproject.org), a platform that is used throughout the world for large-scale data analysis.

    Both wet lab and computational positions are available and opportunities for crossover exist. Candidates will be highly motivated, ambitious, enthusiastic, and be able to work independently and in a collaborative environment.

    Applicants must have experience in computational biology, bioinformatics, or experimental genomics. Preference will be given to those with previous experience in metagenomics or microbiome research. A strong publication record is required. Candidates with well-developed research plans will be considered particularly favorably.

    Exceptional applicants should send a letter of application, curriculum vitae, statement of research interests, and complete contact information for 3 professional references to Dr. Daniel Blankenberg (blanked2@ccf.org).


#759 | Anna Valujskikh | Department of Immunology

  • Job Post Date: 08/31/2017
  • Job Title: Postdoctoral Fellow
  • Contact: Anna Valujskikh valujsa@ccf.org
  • Description:

    A postdoctoral position is available in Dr. Anna Valujskikh’s lab in the Department of Immunology at the Cleveland Clinic. The research in the lab focuses on the immune responses following transplantation with the objective of developing strategies improving outcomes of solid organ transplants in high risk recipients. The group uses mouse model of heart and renal transplantation and a broad variety of cellular and molecular assays to evaluate alloimmunity. Funded projects investigate T cell reconstitution following lymphoablation in transplant recipients and the mechanisms of alloantibody generation and antibody-mediated rejection of renal allografts.

    The candidate should have a PhD or MD/PhD degree, background in cell biology or immunology, a good record of productivity, personal initiative and strong technical and communication skills. 


#758 | Richard Morton, Ph.D. | Department of Cellular and Molecular Medicine

  • Job Post Date: 08/29/2017
  • Job Title: Postdoctoral Fellow
  • Contact: Richard Morton, Ph.D. mortonr@ccf.org
  • Description:

    A Postdoctoral Fellow position is available in the Cleveland Clinic Lerner Research Institute's department of Cellular and Molecular Medicine to carry out studies investigating mechanisms that control high density lipoprotein (HDL) metabolism.  These NIH-funded studies investigate the role of Apolipoprotein F (ApoF) in regulating cholesterol transport.  ApoF is a regulator of cholesteryl ester transfer protein, which in turn is a major regulator of the distribution of cholesterol between low and high density lipoproteins. These studies will investigate the consequences of ApoF knockdown on cholesterol disposition in an animal model, quantify ApoF levels in human subjects and identify lipoprotein properties that cause ApoF to bind and subsequently inhibit cholesteryl ester transfer protein activity, and investigate the molecular mechanisms controlling ApoF gene expression.  Applicants should have a PhD in biochemistry, molecular biology, or related field that was awarded in the past 5 years.  Prior experience with lipoprotein / lipid biochemistry and/or gene regulation are preferred. 

    Please send your curriculum vitae and contact information for 3 references to Dr. Richard Morton


#756 | Brian Rubin, MD, PhD | Department of Cancer Biology

  • Job Post Date: 08/18/2017
  • Job Title: Postdoctoral Fellow
  • Contact: Brian Rubin, MD, PhD rubinb2@ccf.org
  • Description:

    A Postdoctoral Fellow position is available in the Cleveland Clinic Department of Cancer Biology in the Lerner Research Institute.

    The position involves charactizing mouse models of breast cancer and sarcoma including developmental defects caused by expression of oncogenes in the germline. A strong background working with genetically engineered mouse models is required. Salary is negotiable.

    Please send your curriculum vitae, a brief letter, and the names, addresses, and telephone numbers of three references  to Dr. Brian Rubin at rubinb2@ccf.org.


#755 | Ken Baker, Ph.D. | Department of Neurosciences

  • Job Post Date: 08/17/2017
  • Job Title: Postdoctoral Fellow
  • Contact: Ken Baker, Ph.D. bakerk6@ccf.org
  • Description:

    A Postdoctoral Fellow position is available immediately in the Cleveland Clinic Lerner Research Institute Department of Neurosciences to investigate the efficacy and mechanisms of novel deep brain stimulation approaches for the treatment of Parkinson’s disease. 

    The successful applicant will work on an NIH-funded project that involves the use of behavioral training, electrophysiological techniques, and deep brain stimulation in a non-human primate model of Parkinson's disease.  A strong work ethic, proficiency in English verbal and written communication skills, and a Ph.D. and / or M.D. with laboratory experience in a relevant discipline are required. Experience with non-human primates, in vivo electrophysiological recording, and/or signal processing techniques is desirable. Highly motivated applicants with a strong work ethic despite limited experience may also be considered.

    Please send your curriculum vitae, a brief description of research interests and career goals, and contact information for 3 references to Dr. Kenneth Baker, Department of Neurosciences, via email at: bakerk6@ccf.org


#754 | Suneel Apte | Department of Biomedical Engineering

  • Job Post Date: 07/25/2017
  • Job Title: Post-doctoral fellow
  • Contact: Suneel Apte aptes@ccf.org
  • Description:

    Postdoctoral fellowships are available in the laboratory of Dr. Suneel Apte to investigate the proteomics and biology of cardiovascular development and disease. These positions will suit recent PhDs, MD/PhDs, or MDs with a career interest in proteases, extracellular matrix, proteomics, mouse genetics, cardiovascular disease, and systems biology.

     

    The research project will involve the following:

    1. Proteomics of cardiovascular tissues.
    2. Cardiovascular disease, specifically, aortic aneurysms.
    3. Degradomics to identify substrates of ADAMTS proteases.
    4. Developmental biology using mouse models.
    5. Systems biology.
    6. Matrix biology, cell-matrix interactions, and biology of vascular smooth muscle cells.

     

    Applicants must be highly motivated, energetic, well-organized, and independent, with a well-developed ability and the appropriate temperament to work amicably and collaboratively within a multidisciplinary team. A strong work ethic, integrity, and professionalism are expected. Exceptional writing skills and a track record of relevant publications are preferred. Fellows will join a laboratory with expertise in mouse genetics, developmental biology, biochemistry, and cell biology (http://www.lerner.ccf.org/bme/apte/). Proteomics will utilize Orbitrap Fusion Lumos Tribrid and Orbitrap Elite LTQ mass spectrometers in the Lerner Research Institute’s Proteomics Core.

     

    The Lerner Research Institute (https://www.lerner.ccf.org/) is a large, leading biomedical research institute with diverse research activities, a strong academic program with local universities, a medical school and outstanding core facilities. Cleveland Clinic (https://my.clevelandclinic.org/) is ranked the number 2 hospital in the United States by U.S. News & World Report and has held the top rank for treatment of cardiovascular disease for 22 years. Cleveland is an affordable, medium-sized city with a wealth of cultural and outdoors opportunities.

     

    Interested applicants should submit:

    • A letter of application
    • Complete curriculum vitae
    • 1- to 2-page statement of research/career goals
    • Contact details of three references with intimate knowledge of their work

     

    Send the above materials and direct any inquiries to:

    Suneel S. Apte, MBBS, DPhil

    Department of Biomedical Engineering / ND20

    Cleveland Clinic

    9500 Euclid Avenue

    Cleveland, OH 44195

    E-mail:  aptes@ccf.org

     


#753 | J. Mark Brown | Department of Cellular and Molecular Medicine

  • Job Post Date: 07/25/2017
  • Job Title: Postdoctoral Fellow
  • Contact: J. Mark Brown brownm5@ccf.org
  • Description:

    Postdoctoral Fellow Position-Available Immediately

     

    Gut Microbe-Driven Mechanisms Promoting Liver Disease Progression

    A postdoctoral fellowship position supported by the National Institutes of Health are available in the laboratory of Dr. J. Mark Brown at the Cleveland Clinic Lerner Research Institute in the Department of Cellular and Molecular Medicine. Our laboratory is focused on identifying molecular mechanisms by gut microbe-derived metabolites promote human liver disease including both non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). Specific areas include:

    1)      Identification of novel gut microbial metabolites associated with human NAFLD and ALD.

    2)      Understanding the roles of gut microbial metabolites in animal models of NAFLD and ALD progression.

    3)      Identifying targets for the development of new pharmacologic therapies including drugging microbial    enzymes that generate disease-causing metabolites.

    Gut microbes represent a filter of our greatest environmental exposure – the foods we consume. In fact, it is now clear that we each experience a given meal differently, based on our unique gut microbial communities. Biologically active gut microbe-derived metabolites, such as short chain fatty acids, secondary bile acids, polysaccharide A, 4-ethylphenylsulfate, indoxyl-sulfate, p-cresyl-sulfate, and trimethylamine-N-oxide, are now recognized as contributors to type 2 diabetes and related kidney disease and cardiovascular disease (CVD). However, mechanistic insights into how microbe-derived metabolites promote these chronic diseases are largely unknown. The focus of this position will be to examine mechanistic links between gut microbial metabolites and liver disease progression using a highly translational approach.

    The position will provide a unique and multidisciplinary exposure to in vivo gut microbiome studies, lipid/lipoprotein metabolism, metabolomics, and drug development. Further details are available at the following link: http://www.lerner.ccf.org/cmm/brown/. A list of publications from the Brown laboratory can found here: https://www.ncbi.nlm.nih.gov/pubmed/?term=j+mark+brown

    Candidates should hold a recent doctoral degree with a background in molecular biology, metabolism or microbiome areas.  Candidates must have proficiency in verbal and written English.  Candidates with an interest in the position should send their CV and contact information for 3 references to: 

    J. Mark Brown, Ph.D.

    Associate Staff

    Cleveland Clinic Lerner Research Institute

    Department of Cellular and Molecular Medicine

    9500 Euclid Avenue

    Cleveland, Ohio 44195

    Office: (216)-444-8340

    Fax: (216)-444-9404

    brownm5@ccf.org

     


#752 | Zihua Gong | Department of Cancer Biology

  • Job Post Date: 07/19/2017
  • Job Title: Postdoctoral Fellow
  • Contact: Zihua Gong gongz@ccf.org
  • Description:

    We are currently seeking an ambitious, enthusiastic, and motivated Postdoctoral Fellow to join our research team in the Department of Cancer Biology at the Cleveland Clinic Lerner Research Institute. Our lab is focused on understanding the DNA repair pathways in cancer development and cancer treatment (see our publications: Genes Dev, 2693-8, 2014; Mol Cell, 667-78, 2013; Mol Cell, 438-46, 2010). Current studies include DNA repair pathway choice in cancer treatment and various DNA damage proteins in replication stress. We seek candidates with strong qualifications in the following areas: mammalian cell culture, molecular biology, biochemistry and mouse models.

    Application Requirements:

    A Ph.D and/or M.D. with relevant research experience is required. Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references. Send applications and informal inquiries to Dr. Zihua Gong at gongz@ccf.org.

    The Cleveland Clinic is one of the top five medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes.


#750 | Nima Sharifi, M.D. | Department of Cancer Biology

  • Job Post Date: 06/26/2017
  • Job Title: Postdoctoral Fellow
  • Contact: Nima Sharifi, M.D. sharifn@ccf.org
  • Description:

    Molecular Mechanisms and Translational Investigations of Advanced Prostate Cancer

    A postdoctoral fellowship position supported by the National Institutes of Health and the Prostate Cancer Foundation are available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic Lerner Research Institute in the Department of Cancer Biology. 

    Our laboratory is focused on metabolic and molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy.  Specific areas include:

    1)      Metabolic and genetic changes required for androgen synthesis

    2)      Clinical validation in patients and clinical trials utilizing innovative approaches

    3)      Animal models of advanced prostate cancer for translational and therapeutic studies

    4)      Identifying targets for the development of new pharmacologic therapies


    We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084) and that we have shown in a predictive biomarker of poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016 17(10):1435-44).  We are current evaluating this biomarker in a clinical trial and are pursuing similar mechanisms and developing new treatment modalities based on these discoveries. 

    We recently also discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016 533(7604):547-51), and that this is a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chemical Biology. 2017 24, 1-8, July 20).   We are currently working toward defining the relationship between metabolite generation and treatment response in patients and identifying new chemical entities that are determinants of treatment response.

    Previously, we discovered that prostate cancer becomes resistant to hormonal therapy by the synthesis of dihydrotestosterone through a pathway that circumvents testosterone, instead requiring 5α-androstanedione, a previously underappreciated intermediate metabolite.  This metabolic pathway occurs in patient tumors (Chang, et al. Proc Natl Acad Sci USA. 2011 Aug 16;108(33):13728-33). 

    The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials.  Further details are available at the following link: https://www.lerner.ccf.org/cancerbio/sharifi/#lab

    Candidates should hold a doctoral degree with a background in molecular biology, metabolism or cancer biology.  Candidates must have proficiency in verbal and written English.  Candidates with an interest in the position should send their CV and contact information for 3 references to: 

    Nima Sharifi, M.D.

    Kendrick Family Chair for Prostate Cancer Research

    sharifn@ccf.og


#747 | Keith McCrae | Lerner Research Institute

  • Job Post Date: 06/13/2017
  • Job Title: Postdoctoral fellow
  • Contact: Keith McCrae mccraek@ccf.org
  • Description:

    A Postdoctoral Fellow position is available immediately in the Cleveland Clinic Department of Cellular and Molecular Medicine. This position will focus primarily upon characterization of extracellular vesicles from cancer cell lines and patients with cancer. The association of these vesicles with activation of the coagulation system and cancer outcomes will be pursued through parallel laboratory studies and clinical databases. Biorepositories obtained from several types of cancers have been developed and are available for study. We would like to fill this position soon to allow overlap with the current postdoctoral scientist working on this project who will be leaving.

    Please send your curriculum vitae and contact information for 3 references to Keith McCrae, email mccraek@ccf.org


#746 | Tae Hyun Hwang | Department of Quantitative Health Sciences

  • Job Post Date: 06/09/2017
  • Job Title: Bioinformatics Project Staff
  • Contact: Tae Hyun Hwang qhsjobsearchprojectstaff@ccf.org
  • Description:

    Project Staff Scientist for
    Cleveland Clinic Department of Quantitative Health Sciences

    The Department of Quantitative Health Sciences at the Cleveland Clinic main campus is searching for a full-time Project Staff Scientist to collaborate with researchers in the Lerner Research Institute at Cleveland Clinic. The successful candidate will join an active team of over 90 QHS biostatisticians, bioinformaticians, computational biologist, epidemiologist, outcomes researchers, analysts, database developers and programmers working in a wide range of clinical areas and computational/statistical methodologies. The Project Scientist will work independently to develop, implement, and execute a variety of activities essential for the continuous success of our operations in bioinformatics, computational biology, and precision medicine research. The appointee will also be responsible for the development, validation, and implementation of new research techniques and protocols.

    JobRequirements

    In the cover letter, the applicant should speak to his or herskills and experience in any of the following areas:

    1.       Able to develop an algorithm to identify non-human genomes from metagenomics sequencing data for rapid diagnosis and treatment in an infected patient.
    2.       Able to develop a probabilistic mapping algorithm to align bisulfited sequencing reads such that it can be useful for human epigenetics studies by providing more robust and accurate methylation profiles.
    3.       Able to develop an algorithm to identify human disease-causing variant or gene prioritization with whole-exome/genome sequencing and patient phenotypes (e.g., by integrating with EMR data).
    4.       Able to apply methods of basic/some advanced machine learning algorithms and some statistical methods (e.g., dynamic programming, Hidden Markov model, Support Vector Machines, Non-negative Matrix Factorization, spectral clustering, gaussian process, etc.) to complex and big data.
    5.       Practical knowledge of human genetics and biological science/concept
    6.       Experience with the following different types of high-throughputsequencing data and publicly available genomics data. 1) Germline (constitutional) DNASeq from Illumina MiSeq/HiSeq 2500 in either a targeted panel covering 3,000 genes or whole exome sequencing covering 22,000 genes.  2) In-silico DNA metagenomic sequencing dataset.  3) In-silico stranded/non-stranded RNASeq. 4) Bisulfited sequencing dataset. 5) SNPs. 6) Biological network databases. 7) Various public databases such as NCBI, EMBL, UCSC, etc.
    7.       Experience with many state-of-the art publicly available bioinformatics. Often modify and adapt the existing software to an application of interest.
    8.       Gained some experience in modeling data architecture (MySQL) and Django framework to support large-scale NGS samples and to track analysis results.

    The ideal candidate will have a PhD degree in computer science, electrical engineering, mathematics, or statistics with a computational programing background and an equivalent qualification and proven record of accomplishment in bioinformatics or computational biology or a closely related discipline. Applicants must have a strong understanding of the application of genome technologies, biology and bioinformatics in the context of genomics, epigenome, microbiome and electronic health records and practical experience with the processing, developing, deploying and analysis of large genomic, epigenomic, and/or microbiome preferably next-generation sequencing datasets. The candidate is expected to participate in writing collaborative research proposals, grant applications, and manuscripts. Independent PhD level methodological research in a related area is expected. While the level of appointment is open, candidates must have at least 3 years of experience beyond the doctoral degree. The ability to communicate effectively in a multi-disciplinary research environment is essential. Experience of staff supervision will be advantageous.

    Interested candidates should e-mail their curriculum vitae, the names of at least three references and a letter summarizing their experience and interest to qhsjobsearchprojectstaff@ccf.org

    Cleveland Clinic is pleased to be an equal employment/affirmative action employer: Women/Minorities/Veterans/Individuals with Disabilities.
    Smoke/drug free environment.


#745 | Takuya Sakaguchi, Ph.D. | Department of Stem Cell Biology and Regenerative Medicine

  • Job Post Date: 06/06/2017
  • Job Title: Postdoctoral Fellow
  • Contact: Takuya Sakaguchi, Ph.D. sakagut2@ccf.org
  • Description:

    A Postdoctoral Fellow position is available in the Cleveland Clinic [Institute/Department]

    A Postdoctoral Fellow position is available to study liver organogenesis, physiology and pathology in the Department of Stem Cell Biology and Regenerative Medicine at the Cleveland Clinic Lerner Research Institute.  We use zebrafish as a model and focus on liver formation and disease modeling.  Research projects involve genetic, biochemical and bioinformatic analysis utilizing the zebrafish model  (http://www.lerner.ccf.org/stemcellbio/sakaguchi/).

    We are seeking highly motivated recent graduates with a PhD and/or MD with relevant research experience.  Applicants should have research experience in cell biology, molecular biology, developmental biology or a closely related field.  The ideal candidate will have experience in developmental genetics.  Proficiency in spoken and written English is required.

    The Lerner Research Institute provides an excellent environment for biomedical science.  Our postdoctoral training program (http://www.lerner.ccf.org/education/postdoc/) provides excellent support for career development in science.   

    Please send your CV and contact information for three references to Takuya Sakaguchi, Ph.D. (sakagut2@ccf.org).

     

     

    Please send your curriculum vitae and contact information for 3 references to [Name of Contact Person]


#744 | Mina Chung | Department of Molecular Cardiology

  • Job Post Date: 05/23/2017
  • Job Title: Postdoctoral Fellow/Research Associate
  • Contact: Mina Chung chungm@ccf.org
  • Description:

    Our research team focuses on understanding the mechanisms underlying atrial fibrillation, the most common cardiac arrhythmia, and translating findings to clinical utility. We have built a research infrastructure that includes large biorepositories of well characterized human samples with genomic data, embryonic and patient-specific pluripotent stem cells differentiated into cardiomyocytes, and an embryonic stem cell line with stably transfected Cas9 for CRISPR editing. This infrastructure has been used to study gene targets for atrial fibrillation identified by genome-wide association studies and transcriptomic analyses. Under the Center for Cardiovascular Translation and Genomics (CCTG) we are leveraging the infrastructure to identify mechanisms and druggable targets for other cardiovascular conditions and mutations identified from inherited arrhythmias and other heritable cardiovascular diseases.

    We are seeking a motivated, independent postdoctoral fellow or research associate who will help lead investigations into the functional mechanisms of atrial fibrillation and other cardiovascular diseases in human cells. Specifically, we are seeking an individual with a solid background in molecular biology and cell culture. Experience in iPS cell programming and differentiation is strongly desired.  Applicants must have a Ph.D. or M.D., excellent verbal and written communication skills in English, a strong publication record, the ability to work and troubleshoot independently, and to design, implement and analyze researh projects. The selected candidate will have opportunities for collaboration with clinicians in the Heart & Vascular Institute and development of core facilities.

    Please send your cover letter, curriculum vitae, and contact information for 3 references to Mina Chung, M.D. (chungm@ccf.org)


#742 | Hannelore Heemers | Department of Cancer Biology

  • Job Post Date: 05/18/2017
  • Job Title: Post-doctoral Research Fellow
  • Contact: Hannelore Heemers heemerh@ccf.org
  • Description:

    We are currently seeking an ambitious, enthusiastic, and self-motivated Postdoctoral Fellow to join our research team in the Department of Cancer Biology at the Cleveland Clinic Lerner Research Institute.  Our NIH- and DOD-funded research program is focused on understanding the therapeutic potential of discrete mechanisms of androgen action in prostate cancer. Current studies include targeting the contribution of coregulators to androgen action and inhibiting indirect mechanisms of androgen action.

    We seek candidates with strong qualifications in the following areas: molecular and cellular biology, genomics and human tissue culture techniques. Preferred candidates have a background in integrated cancer biology approaches, have previous experience with systems biology, and function well in a multidisciplinary team to ascertain the clinical applicability of bench results. Recent Ph.D. graduates or 1st year Postdoctoral Fellows who are committed to a dynamic career in science are especially encouraged to apply.

    A Ph.D. and/or M.D. with relevant research experience is required.  Proficiency in spoken and written English is also required. Full applications should include curriculum vitae, expected availability date, a description of past research experience and accomplishments, and contact information for three references.

    Send applications and informal inquiries to Dr. Hannelore Heemers (heemerh@ccf.org). The Cleveland Clinic is one of the top medical institutions in the United States (per US News and World Report Best Hospitals ranking), and the Lerner Research Institute is consistently ranked in the top ten in terms of NIH funding for Research Institutes. 


Submission of resumes will be considered an expression of interest in the available opportunity. Applicants who best meet the education and experience requirements of the position will be contacted by the interviewing department and invited to formally apply for consideration. Cleveland Clinic is proud to be an equal opportunity employer and a smoke-free/drug-free environment.