Research Associate and Project Staff

Careers

Current Research Associate and Project Staff opportunities are listed below.

Research Associate candidates will be expected to conduct research under the mentorship of a principal investigator in a predominantly independent manner. They will be expected to pursue testing of hypotheses by developing experimental designs, managing and processing data and interpreting and preparing results for publication in peer-reviewed journals. Research Associates will work closely with the principal investigator and will be expected to communicate effectively both in writing and in oral presentations. Qualified candidates will have successfully completed all requirements for the degree of doctorate in philosophy (PhD) or doctor in medicine (MD) in relevant scientific programs.

Project Staff candidates will have substantial experience at the Postdoctoral or Research Associate level and have established a respectable record of publication. They will work in collaboration with the principal investigator but work independently within the scientific framework of the principal investigator's laboratory. Project Staff may seek grant funding from extramural sources in support of their research projects with the consent of the principal investigator and department chair. This is a junior-level faculty position.

Please complete your application as directed and send to the investigator listed. We look forward to hearing from you!

# Date Contact Description
1 10/04/2022 Alex Riegelsberger
riegela3@ccf.org

Project Staff Imaging Researcher - Las Vegas, Nevada

Apply on Cleveland Clinic's career website.

The Lou Ruvo Center for Brain Health (LRCBH) at Cleveland Clinic Nevada is accepting applications for a doctoral-level brain imaging researcher to join the LRCBH professional staff and support multiple neuroimaging studies examining biomarkers of brain aging and dementia. The LRCBH is a highly productive and growing Center, with key areas of interest in healthy aging, Alzheimer’s disease and related dementias, neurodegenerative movement disorders, and multiple sclerosis.

This position will be responsible for organizing and managing brain imaging research data, including post-processing, data manipulation, quality assurance, and data analysis, as well as working with existing data teams to create, maintain, and update researchimaging databases. Current large datasets include an NIA-funded exploratory Alzheimer’s Disease Research Center and an NIGMS-funded Center for Biomedical Research Excellence, as well as internal investigator-initiated imaging research. Support for these projects, and collaboration with other LRCBH staff on grant applications and manuscript preparations, are expected.

Competitive candidates will have experience collaborating in an academic health care setting, with examples of creative analytic approaches to complex problems in brain health and aging through proven records of collaborative publications and/or grantsmanship. A basic understanding of neurodegenerative diseases and their impact on human aging is essential for success in this role.

Candidates must have excellent written and verbal skills with the ability and desire to conduct collaborative clinical and methodologic research. Successful candidates should also demonstrate an interest in developing an independent research portfolio that advances the science of brain aging and neurodegenerative imaging.

Opportunities for academic appointments are available and will be commensurate with experience of the candidate.

Job Requirements

  • Doctoral degree in neurology, psychiatry, neuroscience, cognitive science, or a related discipline
  • Experience in magnetic resonance imaging (MRI) is required, including (but not limited to) MRI, fMRI, diffusion tensor imaging, MR spectroscopy
  • Ability to work with other imaging modalities (e.g., positron emission tomography, single photon emission computerized tomography) will be highly valued
  • Demonstrated success with large, longitudinal, imaging databases with clinically relevant populations and/or patient-reported clinical, cognitive, biomarker, outcomes, or related data is required
  • Experience as a consultant and/or project leader supporting large multidisciplinary, collaborative research initiatives
  • Experience supervising and managing teams, including trainees, is highly desired

Apply on Cleveland Clinic's career website.


2 04/23/2022 Li Lily Wang
wangl9@ccf.org

Research Associate

 A Research Associate position is available in Dr. Li Lily Wang’s laboratory, in the department of Translational Hematology Oncology Research (THOR), https://www.lerner.ccf.org/thor/wang/  in the Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH. The Wang laboratory is engaging in cross-disciplinary studies by collaborating with basic and clinical researchers from LRI /CCF and the Case Comprehensive Cancer Center, affiliated with Case Western Reserve University.

Immune-checkpoint blockade (ICB) therapies have revolutionized the field of Cancer Immunotherapy. However, the low response rate in a majority of patients indicates the urgent need to identify and target additional checkpoint regulators. The Wang laboratory is among the first groups to demonstrate that the immune-checkpoint protein “V domain Immunoglobulin Suppressor of T cell Activation” (VISTA) is a promising target for cancer immunotherapy (1 – 6). Current projects are multi-disciplinary and involve elucidating the epigenetic and metabolic regulations by novel inhibitory receptors on tumor-associated cytotoxic T cells and tumor-associated macrophages or myeloid derived suppressor cells. We are also investigating the mechanisms of resistance following chimeric antigen receptor (CAR) T cell-based therapies in lymphoma patients.

We seek talented and committed candidates with a recent PhD and with research training and experience in Biochemistry, Cell Biology, and Immunology to join our team. Interested candidates should submit CV, a statement of research interests in a cover letter, and three references to Dr. Li Lily Wang, wangl9@ccf.org.

References:

 

  1.  Le Mercier I, Chen W, Lines JL, Day M, Li J, Sergent P, Noelle RJ, Wang L (2014) VISTA regulates the development of protective anti-tumor immunity. Cancer Research, 74:1933-1944. PMC4116689
  2. Wang L, Le Mercier I, Putra J, Chen W, Liu J, Schenk AD, Nowak EC, Suriawinata AA, Li J, Noelle RJ. (2014) Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity. PNAS.  (41):14846-51 PMC4205642
  3. Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller H, Guleria I, Barth RJ, Huang YH, Wang L (2015) Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. PNAS. 112(21):6682-7, PMC4450438
  4. Xu W, Tạ MH, Malarkannan S, Wang L(2018) Review: The structure, expression, and function of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation. Cellular & Molecular Immunology. 2018 May 15(5):438-446 PMC6068175
  5. Xu W, Dong J, Zheng Y, Zhou J, Yuan Y, Ta H, Miller H, Olson M, Rajasekaran K, Ernstoff M, Wang D, Malarkannan S, Wang L (2019) Immune checkpoint protein VISTA regulates antitumor immunity by controlling myeloid cell-mediated inflammation and immunosuppression. Cancer Immunology Research  PubMed PMID:31340983; NIHMSID:NIHMS1535762

 

 


3 04/23/2022 Li Lily Wang
wangl9@ccf.org

Postdoctoral Fellow

A Postdoctoral Research Fellow position is available in Dr. Li Lily Wang’s laboratory, in the department of Translational Hematology Oncology Research (THOR), https://www.lerner.ccf.org/thor/wang/  in the Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH. The Wang laboratory is engaging in cross-disciplinary studies by collaborating with basic and clinical researchers from LRI /CCF and the Case Comprehensive Cancer Center, affiliated with Case Western Reserve University.

Immune-checkpoint blockade (ICB) therapies have revolutionized the field of Cancer Immunotherapy. However, the low response rate in a majority of patients indicates the urgent need to identify and target additional checkpoint regulators. The Wang laboratory is among the first groups to demonstrate that the immune-checkpoint protein “V domain Immunoglobulin Suppressor of T cell Activation” (VISTA) is a promising target for cancer immunotherapy (1 – 6). Current projects are multi-disciplinary and involve elucidating the epigenetic and metabolic regulations by novel inhibitory receptors on tumor-associated cytotoxic T cells and tumor-associated macrophages or myeloid derived suppressor cells. We are also investigating the mechanisms of resistance following chimeric antigen receptor (CAR) T cell-based therapies in lymphoma patients.

We seek talented and committed candidates with a recent PhD and with research training and experience in Biochemistry, Cell Biology, and Immunology to join our team. Interested candidates should submit CV, a statement of research interests in a cover letter, and three references to Dr. Li Lily Wang, wangl9@ccf.org.

References:

 

  1.  Le Mercier I, Chen W, Lines JL, Day M, Li J, Sergent P, Noelle RJ, Wang L (2014) VISTA regulates the development of protective anti-tumor immunity. Cancer Research, 74:1933-1944. PMC4116689
  2. Wang L, Le Mercier I, Putra J, Chen W, Liu J, Schenk AD, Nowak EC, Suriawinata AA, Li J, Noelle RJ. (2014) Disruption of the immune-checkpoint VISTA gene imparts a proinflammatory phenotype with predisposition to the development of autoimmunity. PNAS.  (41):14846-51 PMC4205642
  3. Liu J, Yuan Y, Chen W, Putra J, Suriawinata AA, Schenk AD, Miller H, Guleria I, Barth RJ, Huang YH, Wang L (2015) Immune-checkpoint proteins VISTA and PD-1 nonredundantly regulate murine T-cell responses. PNAS. 112(21):6682-7, PMC4450438
  4. Xu W, Tạ MH, Malarkannan S, Wang L(2018) Review: The structure, expression, and function of immune-checkpoint protein VISTA as a critical regulator of anti-tumor immunity, autoimmunity, and inflammation. Cellular & Molecular Immunology. 2018 May 15(5):438-446 PMC6068175
  5. Xu W, Dong J, Zheng Y, Zhou J, Yuan Y, Ta H, Miller H, Olson M, Rajasekaran K, Ernstoff M, Wang D, Malarkannan S, Wang L (2019) Immune checkpoint protein VISTA regulates antitumor immunity by controlling myeloid cell-mediated inflammation and immunosuppression. Cancer Immunology Research  PubMed PMID:31340983; NIHMSID:NIHMS1535762