Sensing Changes in Tissue Stiffness Central to Many Neurological Disorders
Dr. Byzova found that microglia sense and respond to changes in tissue stiffness, a hallmark of many neurological and retinal disorders, and identified a related signaling cascade that may be targeted to correct microglial response and potentially treat the associated disorders.
Neural Stem Cells: A Possible Link Between Pathology and Clinical Manifestations of MS
Dr. Suh found that demyelination of nerve cells in the brain stalls the early stages of hippocampal neurogenesis and neuronal integration, and that these brain changes ultimately result in the cognitive impairment characteristic of multiple sclerosis.
Modulating MicroRNA Expression Offers Potential New Strategy for Treating Multiple Sclerosis