Neurosciences : Seminars

The Department of Neurosciences at Cleveland Clinic's Lerner Research Institute comprises a group of internationally recognized scientists who are committed to understanding the mechanisms of brain development and function, as well as better understanding the causes of neurodegenerative diseases and developing and improving therapeutic strategies.


Tuesday, 02 Apr 2019 16:00
Department of Neurosciences

Location: NC1-202
Title: "Chronic Parkinson's disease model in non-human primates (NHP) for long-term behavioral and electrophysiological assessment"

Felipe Branco de Paiva, M.D., Laboratory of Dr. Ken Baker

Deep brain stimulation (DBS) is a well-established treatment for late-stage Parkinson’s disease (PD) that entails delivering isochronal, continuous high-frequency electrical stimulation to deep brain targets. While effective, traditional DBS’ efficacy can be limited by both motor and non-motor side effects. Novel DBS paradigms are being explored in an effort to improve both the safety and efficacy profile of DBS treatment. In order to investigate novel DBS strategies in a systematic, controlled manner, we have developed a chronic non-human primate model of PD that allows for long-term behavioral and electrophysiological assessment.

Tuesday, 09 Apr 2019 16:00
Department of Neurosciences

Location: NC1-202
Title: "The Role of Microglia in Normal Brain Development"

Ashley Nemes, Ph.D., Laboratory of Dr. Tara DeSilva

Microglia are the resident immune cells of the brain. They are responsible for cleaning debris, destroying pathogens, and regulating inflammation in order to protect the central nervous system. Recent studies provide evidence that microglia are also essential for proper neurodevelopment and refinement. Microglia rewire the brain through phagocytosis of synapses during development as well as by pruning neural progenitor cells during neurogenesis. Relatively little is known about the role of microglia in white matter development. The goal of these studies is to investigate how altering microglial interactions with oligodendrocytes during development ultimately impacts myelination.

Tuesday, 16 Apr 2019 16:00
Department of Neurosciences

Location: NC1-202
Title: "Improving Direct Brain Control of a Paralyzed Arm Model"

Tyler Johnson, Laboratory of Dr. Dawn Taylor

We are working on a method of controlling upper limb reaching after paralysis where cortical signals are put directly in control of muscle stimulators that reanimate the paralyzed limb. Our methodology converts cortical spiking activity into muscle activations via a linear mapping matrix. The resulting activations are sent to a Dynamic Arm Simulator (DAS) (R. Kirsch lab) which realistically simulates the movements of a paralyzed human arm activated via functional electrical stimulation (FES). Subjects are then able to control this arm model by thinking about moving their own limbs while receiving visual feedback in the form of a cursor moving on a screen corresponding to the fingertip location of the model arm.

Friday, 19 Apr 2019 12:00
Department of Neurosciences

Location: NC1-202
Title: "Cochlear infections during development and contributions to hearing outcomes"

Keiko Hirose, MD, Professor, Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO

Hosted by: Dr. Bruce Trapp

Tuesday, 23 Apr 2019 16:00
Department of Neurosciences

Location: NC1-202
Title: "IL-10 signaling in macrophages limits demyelination during CNS coronavirus infection"

Ángel Reyes-Rodríguez, Ph.D., Laboratory of Dr. Conni Bergmann

Wednesday, 24 Apr 2019 10:00
Department of Neurosciences

Location: NE1-205
Title: "Injury and repair in the CNS"

Eng Lo, PhD, Professor of Neurology and Radiology, Director, Neuroprotection Research Laboratories, Massachusetts General Hospital

Hosted by: Dr. Selva Baltan

Wednesday, 01 May 2019 10:00
Department of Neurosciences

Location: NE1-205
Title: "Neuropathogenesis of the California Serogroup of Orthobunyaviruses"

Karin E. Peterson, PhD, Chief, Neuroimmunology Section, Rocky Mountain Laboratories, NIAID, NIH

Hosted by: Dr. Conni Bergmann

Wednesday, 08 May 2019 10:00
Department of Neurosciences

Location: NE1-205
Title: "Twists and turns (non helical) on the transcriptional road to oxidative neuronal death: implications for brain protection and repair"

Rajiv Ratan, MD, PhD, Burke Professor of Neurology and Neuroscience, Associate Dean, Weill Cornell Medical College, Executive Director, Burke Neurological Institute

Hosted by: Dr. Selva Baltan

Wednesday, 15 May 2019 10:00
Department of Neurosciences

Location: NE1-205
Title: "Intracranial Arteriopathy in Young Adult"

Shumei Man, MD, PhD, Associate Staff, Department of General Neurology, Cerebrovascular Center, Neurological Institute, Department of Neurosciences, LRI

Hosted by: Dr. Bruce Trapp

Wednesday, 22 May 2019 14:00
Department of Neurosciences

Location: NC1-202
Title: "Deep Brain Stimulation: A Systems-level Approach to Treating Neurological Disorders"

Ken Baker, PhD, Assistant Staff, Department of Neurosciences