Neurosciences : Seminars
The Department of Neurosciences at Cleveland Clinic's Lerner Research Institute comprises a group of internationally recognized scientists who are committed to understanding the mechanisms of brain development and function, as well as better understanding the causes of neurodegenerative diseases and developing and improving therapeutic strategies.
Title: "The reversible inhibition of hippocampal neurogenesis in a cuprizone-induced de- and remyelination model"
Hai Zhang, Ph.D., Laboratory of Dr. Hoonkyo Suh
Title: "A novel biomaterial-based ischemic stroke model of rat"
Hiu Nam Chan, Ph.D., Laboratory of Dr. Andre Machado
A small and localized ischemic stroke model of rat is achieved by infusing a small dose of endothelin 1 (ET-1) into the targeted area, such as the motor cortex. The lesion size is determined by the number of injections of ET-1 created, which is a very time-consuming process. In this study, we developed a novel delivery mechanism of ET-1 by using biomaterials to achieve a quick procedure, but resulting in a more efficient ischemic model of stroke. The new stroke model was characterized behaviorally and histologically.
Title: "Infection, autoimmunity and the brain: Lessons learned from rare diseases"
Tory P. Johnson, PhD, Assistant Professor of Neurology, Johns Hopkins University, School of Medicine
Hosted by Dr. Bruce Trapp
Title: "Consequences of Microglial-Mediated Recruitment of Inflammatory Monocytes to the Brain with Psychological Stress"
Jonathan Godbout, PhD, Professor, Department of Neuroscience, Institute for Behavioral Medicine Research, Center for Brain and Spinal Cord Repair, The Ohio State University
Hosted by: Jessica Williams
Title: "Thalamic MRI, histopathologic, and clinical correlations in multiple sclerosis"
Kedar R. Mahajan, MD, PhD, Associate Staff, Neurological Institute, Cleveland Clinic
Hosted by: Bruce Trapp