Professor, Anesthesiology, CCLCM-CWRU
Medical Director, Cleveland Clinic Consortium for Pain
Location: Cleveland Clinic Main Campus
Chronic pain is common and often difficult to treat. We are interested in identifying safe, efficacious, and cost-effective therapies to relieve the suffering of patients. We are particularly interested in new therapeutic modalities that may help to relieve debilitating pain that originates from lesion, injury, or disease of the nervous system, such as postherpetic neuralgia, peripheral neuropathy, and nerve entrapment syndromes. We aim to achieve our goals by using animal models to better understand the mechanisms of pain and to test new and promising treatments. Our projects include analgesic cell therapy based on stem cell technology, medications that modulate the interaction between neurons, glia cells, and immune cells in the nervous system, and interventional procedures that can modulate or block painful signals transmitted to the central nervous system. We also conduct clinical studies to test and compare the efficacy of different treatment modalities to guide clinical practice. A unique aspect of our research is that we use a combination of laboratory investigation and clinical study to address important problems that the patients present everyday. Our research was initiated with grants support from the National Institutes of Health and is currently sponsored by the Department of Defense.
Jianguo Cheng, MD, PhD, is Professor of Anesthesiology and Director of the Cleveland Clinic Multidisciplinary Pain Medicine Fellowship Program. He is past President of American Academy of Pain Medicine (AAPM) and past Chair of the US Section of World Institute of Pain. He served the US Department of Health and Human Services (HHS) Pain Management Best PracticesInter-agency Task Force (PMTF) to identify gaps in pain management and make recommendations to the U.S. Congress. Dr. Cheng is member of the National Academy of Medicine (NAM) Action Collaborative on Countering the Opioid Epidemic and member of the Centers for Medicare & Medicaid Services (CMS) Expert Work Group (EWG) todevelop, specify, and maintain clinical quality measures. As a clinician, Dr. Cheng was recognized by Best Doctors in America (Best Doctors Inc.), 70 Best Pain Management Physicians in the US (Becker's ASC Review), and Top Doctors (International Association of Anesthesiologists). As a physician investigator, Dr. Cheng has received research grants of more than $4 million from the National Institutes of Health (NIH), the Department of Defense, and other agencies to conduct basic science, translational, and clinical investigations of stem cells, opioid tolerance, and chronic pain. He has made several innovations/patents and published more than 260 research papers, review articles, abstracts, and book chapters. Dr. Cheng is Safety Officer of Data and Safety Monitoring Board (DSMB), National Institutes of Health/National Institute of Arthritis andMusculoskeletal and Skin Diseases (NIAMS), and member of grant review panels/committees for the NIH and the Department of Defense. As aneducator, Dr. Cheng has published two textbooks: Fundamentals of Pain Medicine (Springer-Nature, 2018) and Neuropathic Pain (Oxford University Press, 2019). He has given more than 200 lectures/presentations world-wide. Dr. Cheng directs the largest and one of most prestigious pain medicine training programs in the US and has trained more than 180 clinical pain fellows and postdoctoral research fellows. He is recognized as Best Teacher of the Year, as well as Staff of the Year, of Anesthesiology/Pain Medicine in Cleveland Clinic. His program is the recipient of American Academy of Pain Medicine Pain Medicine Fellowship Excellence Award. In addition, Dr. Cheng has played active leadership roles in the Association of University Anesthesiologists (AUA), American Board of Anesthesiology (ABA), American Society of Anesthesiologists (ASA), and American Academy of Regenerative Medicine. He hasserved as Senior Editor, Associate Editor, and Section Editor for the scientific journals of “Pain Medicine”, “Pain Practice”, and “Pain Physician”. Dr. Cheng was trained in Pain Medicine at Harvard University (Fellowship atMassachusetts General Hospital), Surgery and Anesthesiology at University of Louisville (Residency), Neurology at the Qingdao University, and Neurosciences at the University of Guelph (PhD, Biophysics), University of Manitoba, and University of Alberta (PDF) in Canada.
Dr. Cheng has received more than 60 awards and honors from institutions, societies, and government agencies. Dr. Cheng has extensive research interests and clinical expertise, including the mechanisms and therapeutic strategies of chronic pain, sensory-motor integration in the spinal cord, clinical applications of neuromodulation, and stem cell biology and applications in pain medicine.
Fellowship - Massachusetts General Hospital
Boston, MA USA
Residency - University of Louisville Hospital
Louisville, KY USA
Internship - University of Louisville Hospital
Louisville, KY USA
Medical Education - University of Guelph
biophysics and neuroscience
Residency - Qingdao Medical College
Medical Education - Qingdao Medical College
Bachelor of Medicine
Clinical Achievement Award, announced by Dr. Toby Cosgrove,the President and CEO of Cleveland Clinic Foundation, in his 2012 State ofthe Cleveland Clinic Address.
My research interests focus on motor control and pain mechanisms and treatment. Our pain research involves basic and clinical studies on the mechanisms and therapeutic interventions of common neuropathic pain conditions. We use animal models to study the mechanisms and therapeutic strategies of neuropathic pain. Specifically, we are interested in the interaction of the immune and nervous systems in pain and identification of new therapeutic targets. We are particularly interested in studies that help translate basic research findings to safe, efficacious, and cost-effective care of patients. We also conduct a large number of clinical studies of innovative treatment modalities for chronic pain conditions. In motor control, we study the interneuronal mechanisms for the control of locomotion. Paraplegic patients dream to be able to walk again after spinal cord injuries. A practical issue concerns the feasibility to reactivate the spared spinal neural circuitry to control some of the lost locomotor functions. It is critical to understand the properties of interneurons and their interactions within the spinal circuitry in order to unlock this potential. Intracellular recording are performed in the in vitro mudpuppy spinal cord-forelimb preparation during walking-like movement of the limbs. Four classes of interneurons are identified within the recently identified flexor and extensor centers of the mudpuppy. The goals are to unravel common principles that govern the organization and operation of the neural circuitry for walking.
View publications for Jianguo Cheng, MD, PhD
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Cheng J. Is it time to redefine neuropathic pain? Pain Med. 22(12):2801-2802. PMID: 33988721
Blanco C, Clark KJ, Baker R, Beier D, Bonnie R, Chappell K, Chaudhry HJ, Cheng J, Edmonds KP, Gifford J, Harrington N, Hines L, Jones CM, King K, Larsen K, Madras BK, Mariano E, Mitchell R, Nelson VG, Rich R, Sandbrink F, Singer S. The National Academy of Medicine’s Action Collaborative on Countering the U.S. Opioid Epidemic Research Agenda. 2021.
Xu J, Sun Z, Wu J, Garza J, Rana M, Zhu AC, Chakravarthy KV, Abd-Elsayed A, Rosenquist E, Basi H, Christo P, Cheng J. Peripheral Nerve Stimulation in Pain Management: A Systematic Review. Pain Physician, 2021;24:E131-E152.
Buchheit T, Huh Y, Maixner W, Cheng J, Ji RR. Neuroimmune modulation of pain and Regenerative Pain Medicine. Journal of Clinical Investigation. 2020;130(5):2164-2176.
Cheng J. Rutherford M, Singh VM. The HHS Pain Management Best Practice Inter-Agency Task Force Report calls for patient-centered and individualized care. Editorial. Pain Medicine, 2020;21:1-3.
Hale J, Cheng J. Spinal cord stimulation for neurogenic thoracic outlet syndrome: A case report. A&A Practice, 2020;14(6):e01194.
Hale J, Bailey-Classen A, Cheng J. Spinal cord stimulation for refractory angina pectoris. Pain Medicine, 2020;21:198-200. Featured in the cover of the journal and highlighted by an editorial.
Xu J, Casserly E, Yin Y, Cheng J. (2019) A Systematic Review of Growth Hormone in Pain Medicine: From Rodents to Humans. Pain Med. Jan 5. doi: 10.1093/pm/pny280.PMID: 30615177
Li F, Liu L, Cheng K, Chen Z, Cheng J. (2018) The Use of Stem Cell Therapy to Reverse Opioid Tolerance. Clin Pharmacol Ther. 103(6):971-974. PMID: 29285750
Liu L, Yin Y, Li F, Malhotra C, Cheng J. (2017) Flow cytometry analysis of inflammatory cells isolated from the sciatic nerve and DRG after chronic constriction injury in mice. J Neurosci Methods 284:47-56. PMID: 28445708
Liu L, Hua Z, Shen J, Yin Y, Yang J, Cheng K, Liu A, Wang L, Cheng J. (2017) Comparative Efficacy of Multiple Variables of Mesenchymal Stem Cell Transplantation for the Treatment of Neuropathic Pain in Rats. Mil Med. 182(S1):175-184. PMID: 28291470
Wang F, Zhou Q, Xiao L, Yang J, Xong D, Li D, Liu L, Ancha S, Cheng J. (2016) A Randomized Comparative Study of Pulsed Radiofrequency Treatment With or Without Selective Nerve Root Block for Chronic Cervical Radicular Pain. Pain Pract, in press. PMID: 27739217
Cheng J, Chen SL, Zimmerman N, Dalton JE, LaSalle G, Rosenquist R. (2016) A New Radiofrequency Ablation Procedure to Treat Sacroiliac Joint Pain. Pain Physician 19(8):603-615. PMID: 27906939
Hua Z, Liu L, Shen J, Cheng K, Liu A, Yang J, Wang L, Qu T, Yang H, Li Y, Wu H, Narouze J, Yin Y, Cheng J. (2016) Mesenchymal Stem Cells Reversed Morphine Tolerance and Opioid-induced Hyperalgesia. Sci Rep 6:32096. PMID: 27554341; PMCID: PMC4995471
Lavrov I, Fox L, Shen J, Han Y, Cheng J. (2016) Gap Junctions Contribute to the Regulation of Walking-Like Activity in the Adult Mudpuppy (Necturus Maculatus). PLoS One 11(3):e0152650. PMID: 27023006; PMCID: PMC4811563
Bautista A, Dadabayev A, Rosenquist E, Cheng J. (2016) Bipolar Radiofrequency Neurotomy to Treat Neck and Back Pain in Patients with Automatic Implantable Cardioverter Defibrillator. Pain Physician 19(3):E505-9. PMID: 27008309
Xu J, Yang J, Lin P, Rosenquist E, Cheng J. (2016) Intravenous Therapies for Complex Regional Pain Syndrome: A Systematic Review. Anesth Analg 122(3):843-56. PMID: 26891396
Xiao L, Li J, Li D, Yan D, Yang J, Wang D, Cheng J. (2015) A posterior approach to cervical nerve root block and pulsed radiofrequency treatment for cervical radicular pain: a retrospective study. J Clin Anesth 27(6):486-91. PMID: 26051825