In humans and other mammals, the adult retina has lost its ability to repair itself after injury. In contrast, more primitive vertebrates such as fish are capable of retinal repair and regeneration. Our laboratory aims to understand the cellular and molecular basis for this difference in hopes of developing new therapeutic tools for retinal repair.
Goals & Projects
The primary goal of Dr. Alex Yuan’s laboratory is to characterize the wound healing and regenerative response of the retina and to develop novel methods for retinal repair. The retina is comprised of a multi-layered, complex network of neurons that receive light stimuli and transmit that information to the brain. In response to mechanical, chemical, or photic damage, the retina forms scar tissue, which interrupts the normal connections between neurons. This disruption is permanent and once vision has been compromised, it cannot be restored. However, there are some organisms such as teleost fish that are capable of retinal repair following injury. Our lab is studying the retina repair process following laser induced retinal injury in fish. We hypothesize that there are molecular pathways that are modified or lost in mammals which, if restored, may allow the mammalian retina to regenerate or may facilitate the reintegration of transplanted cells into the normal retina.
View publications for Alex Yuan, MD, PhD
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Dhoot D.S. et al. Evaluation of choroidal thickness in retinitis pigmentosa using enhanced depth imaging optical coherence tomography. Br J Ophthalmol Oct 23, 2012 (epub ahead of print).
Yuan A., Ehlers J.P. Crystalline retinopathy from primary hyperoxaluria. Retina 32,1994-5, 2012.
Steinle N.C. et al. Oral rifampin utilization for the treatment of chronic multifocal central serous retinopathy. Br J Ophthalmol 96, 10-13, 2012.
Yuan A., Kaiser P.K. Emerging therapies for the treatment of neovascular age related macular degeneration. Seminar in Ophthalmology 26, 149-155, 2011.
Yuan A., Singh R.P. Radiation maculopathy treated with intravitreous ranibizumab. Journal of Clinical and Experimental Ophthalmology 2, 2011.
Yuan A., Singh R.P. Ranibizumab for the treatment of macular edema following retinal vein occlusion. Clinical Investigation 1, 1445-1454, 2011.