Claudio Fiocchi, M.D.

Claudio Fiocchi, M.D.

Staff, Department of Pathobiology
The Clifford and Jane Anthony Chair for Digestive Disease Research and Education

  • Department of Pathobiology
  • Lerner Research Institute (NC22)
  • The Cleveland Clinic Foundation
  • 9500 Euclid Avenue
  • Cleveland, Ohio 44195
  • Tel.: (216) 445-0895
  • Fax: (216) 636-0104
  • Email:
  • Residency - Cleveland Clinic
    Cleveland, OH
  • Medical School - Santa Casa de Medical School
  • 1991 Premier Physician Award, Crohn's and Colitis Foundation of America.
  • 1997 Certificate of Teaching Excellence, Internal Medicine
  • 1997 Residents, University Hospitals of Cleveland.
  • 1997 Intestinal Disease Research Unit Lecture Award. University of Calgary, Calgary, Canada.
  • 1999 Award of the "Agostinho Bettarello Medal" for contributions to gastroenterology research and teaching. University of S. Paulo School of Medicine, S. Paulo, Brazil.
  • 1999 Honorary Member, Brazilian Association for Ulcerative Colitis and Crohn's Disease (ABCD). S. Paulo, Brazil.
  • 1999 MERIT Award (R-37), NIDDK, NIH.
  • 2000 Adjunct Professor, Division of Gastroenterology, University of Padua School of Medicine, Padua, Italy.
  • 2000 Dean's Visiting Professor, West China University School of Medicine, Chengdu, Sichuan, P.R. China.
  • 2000 Million Dollar Professor, Case Western Reserve University School of Medicine.
  • 2001 Roy and Robert Kroc Distinguished Professor in Medicine and Immunology. University of California, Davis, School of Medicine.
  • 2005 Honorary Member, Portuguese Society of Gastroenterology.
  • 2005 Dr. Luois Zetzel Visiting Professor, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
  • 2007 The Clifford and Jane Anthony Endowed Chair in Digestive Disease Research and Education
  • 2010 Honorary Foreign Member of the National Academy of Medicine of Brazil
  • 2010 Janowitz Lifetime Achievement Award in IBD, Crohn's and Colitis Foundations of America
  • Gastroenterology
  • Inflammatory bowel disease
  • Mucosal immunity

PubMed Publications

  • Challenges in pediatric inflammatory bowel disease.
    Bousvaros A, Sylvester F, Kugathasan S, Szigethy E, Fiocchi C, Colletti R, Otley A, Amre D, Ferry G, Czinn SJ, Splawski JB, Oliva-Hemker M, Hyams JS, Faubion WA, Kirschner BS, Dubinsky MC,
    PubMed:16954808 :: 2005

Themes in fibrosis and gastrointestinal inflammation.
Claudio Fiocchi1 and P. Kay Lund2
AJP - GI May 2011 vol. 300 no. 5 G677-G683

Fiocchi C. Susceptibility genes and overall pathogenesis of inflammatory bowel disease: where do we stand? Dig Dis. 2009;27(3):226-35. Review.

Im E, Choi YJ, Kim CH, Fiocchi C, Pothoulakis C, Rhee SH. The angiogenic effect of probiotic Bacillus polyfermenticus on human intestinal microvascular endothelial cells is mediated by IL-8. Am J Physiol Gastrointest Liver Physiol. 2009 Sep 3.

de la Motte C, Nigro J, Vasanji A, Rho H, Kessler S, Bandyopadhyay S, Danese S, Fiocchi C, Stern R. Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines. Am J Pathol. 2009 Jun;174(6):2254-64.

Achkar JP, Fiocchi C. Gene-Gene Interactions in Inflammatory Bowel Disease: Biological and Clinical Implications. Am J Gastroenterol. 2009 May 12.

de la Motte C, Nigro J, Vasanji A, Rho H, Kessler S, Bandyopadhyay S, Danese S, Fiocchi C, Stern R. Platelet-derived hyaluronidase 2 cleaves hyaluronan into fragments that trigger monocyte-mediated production of proinflammatory cytokines. Am J Pathol. 2009 Jun;174(6):2254-64.

Rieder F, Fiocchi C. Intestinal fibrosis in IBD--a dynamic, multifactorial process. Nat Rev Gastroenterol Hepatol. 6(4):228-35. 2009

Scaldaferri F, Vetrano S, Sans M, Arena V, Straface G, Stigliano E, Repici A, Sturm A, Malesci A, Panes J, Yla-Herttuala S, Fiocchi C, Silvio D. VEGF-A Links Angiogenesis and Inflammation in Inflammatory Bowel Disease Pathogenesis. Gastroenterology. 136(2):585-95.e5. 2009

Rieder F, Fiocchi C. Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science. Curr Opin Gastroenterol. 24(4):462-8, 2008.

Fiocchi C. Future of IBD pathogenesis: How much work is left to do? Inflamm Bowel Dis. 14(S2):S145-S147, 2008.

Fiocchi C. What is "physiological" intestinal inflammation and how does it differ from "pathological" inflammation? Inflamm Bowel Dis. 14(S2):S77-S78, 2008.

Sturm A, de Souza HS, Fiocchi C. Mucosal T cell proliferation and apoptosis in inflammatory bowel disease. Curr Drug Targets. 9(5):381-7. Review, 2008.

Scaldaferri F, Fiocchi C. Inflammatory bowel disease: progress and current concepts of etiopathogenesis. J Dig Dis. 8(4):171-8. Review, 2007.

Kugathasan S, Saubermann LJ, Smith L, Kou D, Itoh J, Binion DG, Levine AD, Blumberg RS, Fiocchi C. Mucosal T-cell immunoregulation varies in early and late inflammatory bowel disease. Gut. 56(12):1696-705, 2007.

Kugathasan S, Fiocchi C. Progress in basic inflammatory bowel disease research. Semin Pediatr Surg. 16(3):146-53. Review, 2007.

Rieder F, Cheng L, Harnett KM, Chak A, Cooper GS, Isenberg G, Ray M, Katz JA, Catanzaro A, O'Shea R, Post AB, Wong R, Sivak MV, McCormick T, Phillips M, West GA, Willis JE, Biancani P, Fiocchi C. Gastroesophageal reflux disease-associated esophagitis induces endogenous cytokine production leading to motor abnormalities. Gastroenterology 132:154-165, 2007.

Sans M, Danese S, De La Motte C, de Souza HSP, Rivera-Reyes BM, West GA, Phillips M, Katz JA, Fiocchi C. Enhanced recruitment of CX3CR1+ T cells by mucosal endothelial cell-derived fractalkine in inflammatory bowel disease. Gastroenterology 132:139-153, 2007.

Danese S, et al. Critical role of the CD40 CD40-ligand pathway in regulating mucosal inflammation-driven angiogenesis in inflammatory bowel disease. Gut 2007;56:1248-56.

Danese S, et al. Angiogenesis blockade as a new therapeutic approach to experimental colitis. Gut 2007;56:855-62.

Danese S, Dejana E, Fiocchi C. Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation. J Immunol 2007;178:6017-22.

Fiocchi C. Probiotics in inflammatory bowel disease: yet another mechanism of action? Gastroenterology 131:2009-2012, 2006.

Danese S, Fiocchi C. The etiopathogenesis of inflammatory bowel diseases. World J Gastroenterology 14:4807-4812, 2006.

Danese S, Sans, M, de la Motte C, Graziani C, West G, Phillips MH, Pola R, Rivera-Reyes BM, Willis J, Gasbarrini A, Fiocchi C. Angiogenesis as a novel component of inflammatory bowel disease pathogenesis. Gastroenterology 130:2060-2073, 2006.

Fiocchi C. One commensal bacterial molecule - All we need for health? N Engl J Med 353:2078-2080, 2005.

Ina K, Kusugami K, Kawano Y, Nishiwaki T, Wen Z, Musso A, West GA, Ohta M, Goto H, Fiocchi C. Intestinal fibroblast-derived IL-10 increases survival of mucosal T-cells by inhibiting growth factor deprivation- and Fas-mediated apoptosis. J Immunol 175:2000-2009, 2005.

Fiocchi C. Closing fistulas in Crohn's disease - Should the accent be on maintenance or safety? N Engl J Med 350:934-936, 2004.

Sturm A, Leite AZ, Danese S, Krivacic KA, West GA, Mohr S, Jacobberger JW, Fiocchi C. Divergent cell cycle kinetics underlie the pathogenesis of chronic inflammatory diseases. Gut 53:1624-1631, 2004.

Vogel JD, West GA. Danese S, de la Motte C, Phillips MH, Strong SA, Willis J, Fiocchi C. CD40-mediated immune-nonimmune cell interactions trigger mucosal fibroblast chemokine production causing T-cell transmigration. Gastroenterology 126:63-80, 2004.

Lawrance IC, Wu F, Willis J, West GA, Fiocchi C, Chakravarti S. A murine model of chronic inflammation-induced intestinal fibrosis. Gastroenterology 125:1750-1761, 2003.

Danese S, de la Motte C, Sturm A, West GA, Strong SA, Katz JA, Fiocchi C. Platelets trigger a CD40-dependent inflammatory response in the microvasculature of inflammatory bowel disease patients. Gastroenterology 124:1249-1264, 2003.

Sturm A, Itoh J, Jacobberger JW, Fiocchi C. p53 acts as a negative regulator of intestinal immunity by delaying the cell cycle kinetics of mucosal T-cells. J Clin Invest 109:1481-1492, 2002.