Brian P. Hobbs,  PhD

Brian P. Hobbs, PhD

Associate Staff

Lerner Research Institute, 9500 Euclid Avenue, Cleveland, Ohio 44195
Location: CA6-160
Phone: (216) 444-3738
Fax: (216) 444-9464


Dr. Brian Hobbs joined Cleveland Clinic as Associate Staff and Section Head of Cancer Biostatistics in the Lerner Research Institute in 2017. He holds a joint appointment in Cleveland Clinic’s Taussig Cancer Institute. He also serves as Co-Director of the Biostatistics and Bioinformatics Core for the Case Comprehensive Cancer Center. His methodological expertise comprises Bayesian inference, subtyping, prediction, and trial design as well as cancer radiomics. Before joining Cleveland Clinic, Dr. Hobbs was a tenured Associate Professor in the Department of Biostatistics at The University of Texas MD Anderson Cancer Center in Houston, Texas. In 2010, he completed a doctoral degree in biostatistics at the University of Minnesota and then joined MD Anderson as a postdoctoral fellow. Eastern North American Region of International Biometric Society selected his thesis paper for the John Van Ryzin Award in 2010. In 2016, Dr. Hobbs was selected by The University of Minnesota for the Emerging Leader Award, an honor bestowed on alumni on the basis of impactful contributions within 10 years of graduating from one of The School of Public Health’s 20 programs. In 2017, Dr. Hobbs was invited to lead the publication of National Cancer Institute’s Clinical Trials Design Task Force with the goal of providing national, consensus recommendations for first-in-human cancer drug trials that use seamless designs.

Hobbs BP, Barata PC, Kanjanapan Y, Paller CJ, Perlmutter J, Pond GR, Prowell TM, Rubin EH, Seymour LK, Wages NA, Yap TA, Feltquate D, Garrett-Mayer E, Grossman W, Hong DS, Ivy SP, Siu LL, Reeves SA, Rosner GL (2018). Seamless Designs: Current Practice and Considerations for Early-Phase Drug Development in Oncology. JNCI: Journal of the National Cancer Institute, 111(2): 118-128. ;


Hobbs BP, Kane MJ, Hong DS, Landin R (2018). Statistical challenges posed by basket trials: sensitivity analysis of the Vemurafenib study. Annals of Oncology, 29(12): 2296-2301. ;


Hobbs BP and Landin R (2018). Bayesian basket trial design with exchangeability monitoring. Statistics in Medicine, 37(25): 3557-3572.;


Tang C, Hobbs B*, Amer A, Li X, Behrens C, Canales JR, Cuentas EP, Villalobos P, Chang J, Hong D, Welsh J, Sepesi B, Wistuba I, Koay E (2018). Development of an Immune-Pathology Informed Radiomics Model for Non-Small Cell Lung Cancer. Scientific Reports, 8(1) Article number: 1922.


Hobbs BP, Chen N, Lee JJ (2018). Controlled multi-arm platform design using predictive probability. Statistical Methods in Medical Research, 27(1): 65-78. Controlled multi-arm platform design using predictive probability. Statistical Methods in Medical Research, 27(1): 65-78.


Kaizer AM, Hobbs BP, Koopmeiners JS (2018). A Multi-source Adaptive Platform Design for Testing Sequential Combinatorial Therapeutic Strategies. Biometrics, 74(3): 1082-1094.


Kaizer AM, Koopmeiners JS, Hobbs BP (2017). Bayesian hierarchical modeling based on multi-source exchangeability. Biostatistics, 19(2): 169-184.


Azadeh S, Hobbs BP, Ma L, Nielsen D, Moeller FG, Baladandayuthapani V (2016). Integrative Bayesian Analysis of Neuroimaging-Genetic Data with Application to Cocaine Dependence. NeuroImage, 125: 813-824, e-Pub 10/2015.


Hobbs BP, Thall PF, Lin SH (2016). Bayesian group sequential clinical trial design using total toxicity burden and progression-free survival. Journal of the Royal Statistical Society: Series C, 65(2): 273-297, e-Pub 10/2015.


Ma J, Stingo FC, Hobbs BP (2016). Bayesian predictive modeling for genomic based personalized treatment selection. Biometrics, 72(2): 575-583, e-Pub 11/2015.


Hobbs BP, Carlin BP, Sargent DJ (2013). Adaptive adjustment of the randomization ratio using historical control data. Clinical Trials, 10: 430-440.

Hobbs BP, Carlin BP, Mandrekar S, Sargent DJ (2011). Hierarchical commensurate and power prior models for adaptive incorporation of historical information in clinical trials. Biometrics, 67: 1047–1056.

12/18/2018 |  

Statistics Expert Leads National Clinical Trials Task Force

Breakthroughs in cancer biology have defined new research programs emphasizing the development of therapies that target specific pathways in tumor cells or promote anti-cancer immunity. Innovations in clinical trials have followed with statistical designs devised to consolidate traditional phases of oncologic drug development as well as facilitate inclusive eligibility and evaluations of multiple indications. These so-called “seamless” trial designs have many potential benefits but have not yet been objectively considered.