Brittany Lapin, PhD
(Joint appointment in the Center for Neuro-Restoration/NI)
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
Phone: (216) 445-5729
My general research interest lies in optimizing the clinical utility of patient-reported outcome measurements (PROMs). Cleveland Clinic collects over 100,000 PROMs per month, which our team analyzes to track conditions over time, evaluate effectiveness of interventions, and determine the value of care. More specifically, my research is focused on developing and optimizing methodology to improve the utilization and interpretation of PROMs for both patient-centered care and for clinical research.
I am particularly interested in 6 main areas:
A. Determination of the value of patient-reported outcomes measurements (PROMs)
The added value of PROMs to clinical-reported measures:
- Katzan L, Thompson NR, Lapin B, Uchino K. Added Value of Patient-Reported Outcome Measures in Stroke Clinical Practice Journal of the American Heart Association vol. 6,7 e005356. 21 Jul. 2017, doi:10.1161/JAHA.116.005356
B. Optimization of the clinical utility of PROMs
Linking two common PROMs in clinical practice to assess global health in patients with spine disorder
- Lapin BR, Kinzy TG, Thompson NR, Krishnaney A, Katzan IL. Accuracy of Linking VR-12 and PROMIS Global Health Scores in Clinical Practice. Value Health. 2018 Oct;21(10):1226-1233. doi: 10.1016/j.jval.2018.03.011. Epub 2018 Apr 26=
Validating the PROMIS Global Health in stroke patients:
- Katzan IL, Lapin B. PROMIS GH (Patient-Reported Outcomes Measurement Information System Global Health) Scale in Stroke: A Validation Study. Stroke. 2018 Jan;49(1):147-154
Accurate methodology for linking two common PROMs to assess global health:
- Thompson NR, Lapin BR, Katzan IL. Mapping PROMIS Global Health Items to EuroQol (EQ-5D) Utility Scores Using Linear and Equipercentile Equating. Pharmacoeconomics. 2017 Nov;35(11):1167-1176.
C. Application of item response theory models to improve PROMs
Demonstrating the unidimensionality of the Epworth Sleepiness Scale:
- Lapin BR, Bena JF, Walia HK, Moul DE. The Epworth Sleepiness Scale: Validation of One-Dimensional Factor Structure in a Large Clinical Sample. J Clin Sleep Med. 2018 Aug 15;14(8):1293-1301
D. Evaluation of patient conditions and interventions through PROMs
PROMs across stroke type:
- Katzan IL, Schuster A, Newey C, Uchino K, Lapin BR. Patient-reported outcomes across cerebrovascular event types: More similar than different. Neurology. 2018 Dec 4;91(23):e2182-e2191
Affected health domains after ischemic stroke:
- Katzan IL, Thompson NR, Uchino K, Lapin BR. The most affected health domains after ischemic stroke. Neurology. 2018 Apr 17;90(16):e1364-e1371
A Markov modeling approach to assessing ALS progression:
- Thakore NJ, Lapin BR, Kinzy TG, Pioro EP. Deconstructing progression of amyotrophic lateral sclerosis in stages: a Markov modeling approach. Amyotroph Lateral Scler Frontotemporal Degener. 2018 Nov;19(7-8):483-494
Trajectories of impairments in ALS:
- Thakore NJ, Lapin BR, Pioro EP. Trajectories of impairment in amyotrophic lateral sclerosis: Insights from the Pooled Resource Open-Access ALS Clinical Trials cohort. Muscle Nerve. 2018 Jun;57(6):937-945
Cognitive impairments in adult patients with epilepsy:
- Feldman L, Lapin BR, Busch RM, Bautista JF. Evaluating subjective cognitive impairment in the adult epilepsy clinic: Effects of depression, number of antiepileptic medications, and seizure frequency. Epilepsy Behav. 2018 Apr;81:18-24.
E. Assessment of patient-reported depression across conditions
Depression across neurological conditions:
- Viguera AC, Fan Y, Thompson NR, Lapin BR, Chaitoff A, Griffith SD, Miller DM, Jehi L, Katzan IL. Prevalence and Predictors of Depression Among Patients With Epilepsy, Stroke, and Multiple Sclerosis Using the Cleveland Clinic Knowledge Program Within the Neurological Institute. Psychosomatics. 2018 Jul - Aug;59(4):369-378.
Depression in bariatric surgery patients with multiple sclerosis:
- Fisher CJ, Heinberg LJ, Lapin BR, Aminian A, Sullivan AB. Depressive Symptoms in Bariatric Surgery Patients with Multiple Sclerosis. Obes Surg. 2018 Apr;28(4):1091-1097.
F. Quantification of patient and provider experience
Patient experience with PROMs:
- Lapin BR, Udeh B, Bautista JF, Katzan IL. Patient experience with patient-reported outcome measures in neurologic practice. Neurology. 2018 Sep 18;91(12):e1135-e1151.
Provider experience with PROMs:
- Katzan IL, Thompson NR, Dunphy C, Urchek J, Lapin BR. Neurologic provider views on patient-reported outcomes including depression screening. Neurol Clin Pract. 2018 Apr;8(2):86-92.
Patient interest in health information technology:
- Featherall J, Lapin BR, Chaitoff A, Havele SA, Thompson N, Katzan I. Characterization of Patient Interest in Provider-Based Consumer Health Information Technology: Survey Study. J Med Internet Res. 2018 Apr 19;20(4):e128.
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