Daniel M. Rotroff, PhD
Assistant Staff
Lerner Research Institute,
9500 Euclid Avenue, Cleveland, Ohio 44195
We use a wide-range of computational and experimental approaches to leverage -omics technologies and electronic health records (EHR) to investigate many aspects of precision medicine, such as biomarker or risk allele discovery for drug response and disease outcomes. As a KL2 Scholar, we have funding to develop methods that utilize genomic and clinical data to identify high-risk subtypes within type 2 diabetes. Additional funded projects include the integration of genomic, behavioral, and microbiome factors into a risk model for onset of chemotherapy induced nausea and vomiting, and the use of breath-based metabolomics as a screening tool for chronic liver diseases and hepatocellular carcinoma.
Lay Summary
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1. |
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Rotroff DM, Yee SW, Zhou K, Marvel SW, Shah HS, Jack JR, Havener TM, Hedderson MM, Kubo M, Herman MA, Gao H, Mychaleckyi JC, McLeod HL, Doria A, Giacomini KM, Pearson ER, Wagner MJ, Buse JB, Motsinger-Reif AA; MetGen Investigators; ACCORD/ACCORDion Investigators. |
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Diabetes. 2018 Jul;67(7):1428-1440. doi: 10.2337/db17-1164. Epub 2018 Apr 12. |
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PMID: 29650774 [PubMed - indexed for MEDLINE] Free Article |
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2. |
Targeted metabolomics and medication classification data from participants in the ADNI1 cohort. |
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St John-Williams L, Blach C, Toledo JB, Rotroff DM, Kim S, Klavins K, Baillie R, Han X, Mahmoudiandehkordi S, Jack J, Massaro TJ, Lucas JE, Louie G, Motsinger-Reif AA, Risacher SL; Alzheimer’s Disease Neuroimaging Initiative; Alzheimer’s Disease Metabolomics Consortium, Saykin AJ, Kastenmüller G, Arnold M, Koal T, Moseley MA, Mangravite LM, Peters MA, Tenenbaum JD, Thompson JW, Kaddurah-Daouk R. |
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Sci Data. 2017 Oct 17;4:170140. doi: 10.1038/sdata.2017.140. |
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PMID: 29039849 [PubMed - indexed for MEDLINE] Free PMC Article |
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3. |
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Rotroff DM, Pijut SS, Marvel SW, Jack JR, Havener TM, Pujol A, Schluter A, Graf GA, Ginsberg HN, Shah HS, Gao H, Morieri ML, Doria A, Mychaleckyi JC, McLeod HL, Buse JB, Wagner MJ, Motsinger-Reif AA; ACCORD/ACCORDion Investigators. |
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Clin Pharmacol Ther. 2018 Apr;103(4):712-721. doi: 10.1002/cpt.798. Epub 2017 Nov 3. |
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PMID: 28736931 [PubMed - in process] Free PMC Article |
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4. |
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Marvel SW, Rotroff DM, Wagner MJ, Buse JB, Havener TM, McLeod HL, Motsinger-Reif AA; The ACCORD/ACCORDion Investigators. |
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PeerJ. 2017 May 2;5:e3187. doi: 10.7717/peerj.3187. eCollection 2017. |
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PMID: 28480134 [PubMed] Free PMC Article |
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5. |
Metabolic network failures in Alzheimer's disease: A biochemical road map. |
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Toledo JB, Arnold M, Kastenmüller G, Chang R, Baillie RA, Han X, Thambisetty M, Tenenbaum JD, Suhre K, Thompson JW, John-Williams LS, MahmoudianDehkordi S, Rotroff DM, Jack JR, Motsinger-Reif A, Risacher SL, Blach C, Lucas JE, Massaro T, Louie G, Zhu H, Dallmann G, Klavins K, Koal T, Kim S, Nho K, Shen L, Casanova R, Varma S, Legido-Quigley C, Moseley MA, Zhu K, Henrion MYR, van der Lee SJ, Harms AC, Demirkan A, Hankemeier T, van Duijn CM, Trojanowski JQ, Shaw LM, Saykin AJ, Weiner MW, Doraiswamy PM, Kaddurah-Daouk R; Alzheimer's Disease Neuroimaging Initiative and the Alzheimer Disease Metabolomics Consortium. |
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Alzheimers Dement. 2017 Sep;13(9):965-984. doi: 10.1016/j.jalz.2017.01.020. Epub 2017 Mar 22. |
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PMID: 28341160 [PubMed - indexed for MEDLINE] Free PMC Article |
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6. |
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Rotroff DM, Joubert BR, Marvel SW, Håberg SE, Wu MC, Nilsen RM, Ueland PM, Nystad W, London SJ, Motsinger-Reif A. |
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BMC Genomics. 2016 Nov 25;17(1):976. |
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PMID: 27887572 [PubMed - indexed for MEDLINE] Free PMC Article |
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7. |
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Graham HT, Rotroff DM, Marvel SW, Buse JB, Havener TM, Wilson AG, Wagner MJ, Motsinger-Reif AA; ACCORD/ACCORDion Investigators. |
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Front Genet. 2016 Aug 17;7:138. eCollection 2016. |
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PMID: 27775101 [PubMed] Free PMC Article |
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8. |
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Rotroff DM, Corum DG, Motsinger-Reif A, Fiehn O, Bottrel N, Drevets WC, Singh J, Salvadore G, Kaddurah-Daouk R. |
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Transl Psychiatry. 2016 Sep 20;6(9):e894. doi: 10.1038/tp.2016.145. |
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PMID: 27648916 [PubMed - indexed for MEDLINE] Free PMC Article |
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9. |
Comprehensive genomic characterization of five canine lymphoid tumor cell lines. |
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Roode SC, Rotroff D, Richards KL, Moore P, Motsinger-Reif A, Okamura Y, Mizuno T, Tsujimoto H, Suter SE, Breen M. |
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BMC Vet Res. 2016 Sep 17;12:207. doi: 10.1186/s12917-016-0836-z. |
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PMID: 27639374 [PubMed - indexed for MEDLINE] Free PMC Article |
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10. |
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin. |
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Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L; MetGen Investigators; DPP Investigators; ACCORD Investigators, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER. |
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Nat Genet. 2016 Sep;48(9):1055-1059. doi: 10.1038/ng.3632. Epub 2016 Aug 8. |
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PMID: 27500523 [PubMed - indexed for MEDLINE] Free PMC Article |
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11. |
Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans. |
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Rotroff DM, Oki NO, Liang X, Yee SW, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini KM, Kaddurah-Daouk R. |
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Front Pharmacol. 2016 Jun 14;7:135. doi: 10.3389/fphar.2016.00135. eCollection 2016. |
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PMID: 27378919 [PubMed] Free PMC Article |
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12. |
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Irvin MR, Rotroff DM, Aslibekyan S, Zhi D, Hidalgo B, Motsinger-Reif A, Marvel S, Srinivasasainagendra V, Claas SA, Buse JB, Straka RJ, Ordovas JM, Borecki IB, Guo X, Chen IY, Rotter JI, Wagner MJ, Arnett DK. |
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Pharmacogenet Genomics. 2016 Jul;26(7):324-33. doi: 10.1097/FPC.0000000000000219. |
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PMID: 27002377 [PubMed - indexed for MEDLINE] Free PMC Article |
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13. |
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Rotroff DM, Shahin MH, Gurley SB, Zhu H, Motsinger-Reif A, Meisner M, Beitelshees AL, Fiehn O, Johnson JA, Elbadawi-Sidhu M, Frye RF, Gong Y, Weng L, Cooper-DeHoff RM, Kaddurah-Daouk R. |
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CPT Pharmacometrics Syst Pharmacol. 2015 Nov;4(11):669-79. doi: 10.1002/psp4.12017. Epub 2015 Oct 29. |
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PMID: 26783503 [PubMed] Free PMC Article |
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14. |
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Roode SC, Rotroff D, Avery AC, Suter SE, Bienzle D, Schiffman JD, Motsinger-Reif A, Breen M. |
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Chromosome Res. 2015 Dec;23(4):681-708. doi: 10.1007/s10577-015-9475-7. Epub 2015 Jun 3. |
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PMID: 26037708 [PubMed - indexed for MEDLINE] |
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15. |
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Rotroff DM, Martin MT, Dix DJ, Filer DL, Houck KA, Knudsen TB, Sipes NS, Reif DM, Xia M, Huang R, Judson RS. |
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Environ Sci Technol. 2014;48(15):8706-16. doi: 10.1021/es502676e. Epub 2014 Jul 10. |
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PMID: 24960280 [PubMed - indexed for MEDLINE] |
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16. |
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Jack J, Rotroff D, Motsinger-Reif A. |
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Curr Mol Med. 2014;14(7):833-40. |
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PMID: 25109794 [PubMed - indexed for MEDLINE] Free PMC Article |
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17. |
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Rotroff DM, Thomas R, Breen M, Motsinger-Reif AA. |
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Pharmacogenomics. 2013 Dec;14(16):1929-31. doi: 10.2217/pgs.13.178. No abstract available. |
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PMID: 24279843 [PubMed - indexed for MEDLINE] Free Article |
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18. |
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Rotroff DM, Dix DJ, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Reif DM, Richard AM, Sipes NS, Abassi YA, Jin C, Stampfl M, Judson RS. |
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Chem Res Toxicol. 2013 Jul 15;26(7):1097-107. doi: 10.1021/tx400117y. Epub 2013 Jun 10. |
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PMID: 23682706 [PubMed - indexed for MEDLINE] |
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19. |
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Rotroff DM, Dix DJ, Houck KA, Knudsen TB, Martin MT, McLaurin KW, Reif DM, Crofton KM, Singh AV, Xia M, Huang R, Judson RS. |
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Environ Health Perspect. 2013 Jan;121(1):7-14. doi: 10.1289/ehp.1205065. Epub 2012 Sep 28. |
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PMID: 23052129 [PubMed - indexed for MEDLINE] Free PMC Article |
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20. |
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Kavlock R, Chandler K, Houck K, Hunter S, Judson R, Kleinstreuer N, Knudsen T, Martin M, Padilla S, Reif D, Richard A, Rotroff D, Sipes N, Dix D. |
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Chem Res Toxicol. 2012 Jul 16;25(7):1287-302. doi: 10.1021/tx3000939. Epub 2012 May 15. |
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PMID: 22519603 [PubMed - indexed for MEDLINE] |
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21. |
Incorporating human dosimetry and exposure into high-throughput in vitro toxicity screening. |
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Rotroff DM, Wetmore BA, Dix DJ, Ferguson SS, Clewell HJ, Houck KA, Lecluyse EL, Andersen ME, Judson RS, Smith CM, Sochaski MA, Kavlock RJ, Boellmann F, Martin MT, Reif DM, Wambaugh JF, Thomas RS. |
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Toxicol Sci. 2010 Oct;117(2):348-58. doi: 10.1093/toxsci/kfq220. Epub 2010 Jul 16. Erratum in: Toxicol Sci. 2014 Feb;137(2):499. Dosage error in article text. |
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PMID: 20639261 [PubMed - indexed for MEDLINE] Free PMC Article |
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22. |
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Judson RS, Martin MT, Reif DM, Houck KA, Knudsen TB, Rotroff DM, Xia M, Sakamuru S, Huang R, Shinn P, Austin CP, Kavlock RJ, Dix DJ. |
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Environ Sci Technol. 2010 Aug 1;44(15):5979-85. doi: 10.1021/es102150z. |
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PMID: 20602530 [PubMed - indexed for MEDLINE] Free PMC Article |
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23. |
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Rotroff DM, Beam AL, Dix DJ, Farmer A, Freeman KM, Houck KA, Judson RS, LeCluyse EL, Martin MT, Reif DM, Ferguson SS. |
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J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):329-46. doi: 10.1080/10937404.2010.483949. |
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PMID: 20574906 [PubMed - indexed for MEDLINE] |
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24. |
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Judson RS, Houck KA, Kavlock RJ, Knudsen TB, Martin MT, Mortensen HM, Reif DM, Rotroff DM, Shah I, Richard AM, Dix DJ. |
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Environ Health Perspect. 2010 Apr;118(4):485-92. doi: 10.1289/ehp.0901392. |
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PMID: 20368123 [PubMed - indexed for MEDLINE] Free PMC Article |
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New Analysis of Previous Trial Results Offers Insights into Personalized Care for Type 2 Diabetes
Dr. Rotroff and team found that genetic variation may help to identify diabetes patients at risk for cardiovascular disease who may benefit from aggressive glycemia treatment.
Researchers Embark on New Study to Identify Predictors of Chemotherapy-Associated Pain Condition
Dr. Rotroff and clinical collaborator Dr. Foss will compare genetic, epigenetic and metabolomic data from breast cancer patients who experience the condition versus those who don’t in an effort to develop a predictive machine learning-based algorithm for personalized risk.
